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Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3.0 star property

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Photo gallery for Residence Inn By Marriott Jacksonville - Mayo Clinic Area

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.
A modern kitchen with a bar area, seating, and a view of the outdoors.
An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.
A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Pet friendly
  • Parking included
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
4905 SAN PABLO ROAD SOUTH, Jacksonville, FL, 32224
  • Place, University of North Florida
    ‪5 min drive‬
  • Place, St. Johns Town Center
    ‪8 min drive‬
  • Place, Mayport Naval Station
    ‪21 min drive‬
  • Airport, Jacksonville, FL (JAX-Jacksonville Intl.)
    ‪34 min drive‬

Room options

View all photos for Studio, 1 King Bed with Sofa bed, Corner

A modern hotel room with a bed, desk, chair, TV, and large windows with curtains.

Studio, 1 King Bed with Sofa bed, Corner

9.8 out of 10
Exceptional
(6 reviews)
  • 533 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 Bedroom, Corner

A modern kitchen with wooden cabinets, a dishwasher, and a countertop with kitchenware. There is a dining area with a table and chairs, and a living room with a sofa and a TV on the wall.

Studio Suite, 1 Bedroom, Corner

10.0 out of 10
Exceptional
(3 reviews)
  • 646 sq ft
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 King Bed with Sofa bed

A modern kitchen with wooden cabinets, a built-in microwave, and a dishwasher.

Studio Suite, 1 King Bed with Sofa bed

9.6 out of 10
Exceptional
(98 reviews)
  • 407 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 Bedroom

A modern hotel room with a grey sofa, a small round table, a desk with a chair, and a flat-screen TV mounted on the wall.

Studio Suite, 1 Bedroom

9.8 out of 10
Exceptional
(23 reviews)
  • 560 sq ft
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Tub)

A hotel room with a large bed, two bedside tables, and a nightstand with a phone.

Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Tub)

9.0 out of 10
Wonderful
(8 reviews)
  • 409 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 King Bed with Sofa bed (Hearing Accessible)

A hotel room with a large bed, two bedside tables, and a nightstand with a phone.

Studio Suite, 1 King Bed with Sofa bed (Hearing Accessible)

9.0 out of 10
Wonderful
(2 reviews)
  • 391 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Roll-In Shower)

A hotel room with a large bed, two bedside tables, and a nightstand with a phone.

Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Roll-In Shower)

  • 391 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 Bedroom (Hearing Accessible)

A modern hotel room with a sofa, desk, and kitchenette.

Studio Suite, 1 Bedroom (Hearing Accessible)

8.0 out of 10
Very good
(1 review)
  • 569 sq ft
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio, 1 King Bed with Sofa bed, Corner (Hearing Accessible)

A modern hotel room with a bed, desk, chair, TV, and large windows with curtains.

Studio, 1 King Bed with Sofa bed, Corner (Hearing Accessible)

9.0 out of 10
Wonderful
(2 reviews)
  • 538 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed
  • Free WiFi

View all photos for Studio Suite, 1 Bedroom, Corner (Mobility/Hearing Access, Roll-In Shwr)

A modern hotel room with a sofa, desk, and kitchenette.

Studio Suite, 1 Bedroom, Corner (Mobility/Hearing Access, Roll-In Shwr)

  • 641 sq ft
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed
  • Free WiFi

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About the neighborhood

Jacksonville

Located in Isle of Palms within a short stroll of Mayo Clinic Florida, Residence Inn By Marriott Jacksonville - Mayo Clinic Area is within a 10-minute drive St. Johns Town Center. This 3-star hotel has 155 guestrooms and offers conveniences like free breakfast, an outdoor pool, and a 24-hour gym.

What's nearby

  • University of North Florida - 5 min drive - 5.6 miles
  • St. Johns Town Center - 8 min drive - 7.9 miles
  • Jacksonville Beach Pier - 12 min drive - 6.5 miles
  • Mayport Naval Station - 21 min drive - 11.6 miles
  • EverBank Stadium - 21 min drive - 18.8 miles

Getting around

  • Jacksonville, FL (CRG-Jacksonville Executive at Craig) - 17 min drive

Restaurants

  • ‪Culver’s - ‬4 min drive
  • ‪Circle K - ‬9 min walk
  • ‪Starbucks - ‬4 min drive
  • ‪Mayo Clinic - Employee Cafeteria - ‬18 min walk
  • ‪M Brothers at Mayo - ‬17 min walk

About this property

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

At Residence Inn By Marriott Jacksonville - Mayo Clinic Area, guests enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, put free parking to good use. The front desk has multilingual staff on hand 24/7 to help with concierge services, luggage storage, and dry cleaning/laundry. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.
Guests can expect to find free WiFi and 55-inch Smart TVs with cable channels and Netflix. Bathrooms offer hair dryers and free toiletries. Other standard amenities include kitchens, dining areas, and sitting areas. Housekeeping is available on request.
Recreational amenities at the hotel include an outdoor pool and a 24-hour fitness center.

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Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Golden Glades - The Woods
  • Pool
  • Breakfast included
  • Pet friendly
  • Parking included
9.0 out of 10, Wonderful, 1,003 reviews
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Jul 26 - Jul 27
Total with taxes and fees
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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Free uncovered self parking on site
  • Wheelchair-accessible parking and van parking available

Food and drink

  • Free buffet breakfast available 6:30 AM to 9:00 AM on weekdays and 7:00 AM to 9:30 AM on weekends
  • A bar/lounge
  • A poolside bar
  • Coffee and tea in common areas

Things to do

  • 24-hour gym
  • Outdoor pool
  • TV in common areas

Family friendly

  • Grocery/convenience store
  • In-room kitchen
  • In-room microwave
  • In-room refrigerator
  • Laundry facilities
  • Outdoor pool
  • Separate in-room dining area

Conveniences

  • 24-hour front desk
  • Free newspapers in lobby
  • Grocery/convenience store
  • Laundry facilities
  • Luggage storage
  • Safe at front desk
  • Water dispenser

Guest services

  • Change of bedsheets (on request)
  • Concierge services
  • Dry cleaning/laundry service
  • Free grocery shopping service
  • Housekeeping (daily)
  • Multilingual staff
  • Wedding services

Business services

  • 2 meeting rooms
  • 2,678 square feet of conference space
  • 24-hour business center
  • Computer station
  • Coworking space

Outdoors

  • Barbecue grill
  • Garden
  • Picnic area
  • Pool loungers

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Accessible bathtub
  • Assistive listening devices
  • Assistive listening devices in meeting rooms
  • Bathroom emergency pull cord
  • Braille/raised signage
  • Elevator
  • Grab bar near toilet
  • Hand-held showerhead
  • Handrails in stairways
  • Height-adjustable showerhead
  • Lever door handles
  • Low-height bed
  • Low-height counter and sink
  • Low-height door lock
  • Low-height electrical outlets in bathroom
  • Low-height view port in door
  • Phone accessibility kit
  • Pool hoist on site
  • Raised toilet seat
  • Stair-free path to entrance
  • Vibrating pillow alarm
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible business center
  • Wheelchair-accessible concierge desk
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to elevator
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible van parking
  • Wheelchair-width doorways

More

  • 1 building
  • 7 floors
  • Ballroom
  • Banquet hall
  • Built in 2020
  • Communal living room
  • Comprehensive food waste policy
  • Double-glazed windows
  • Fireplace in lobby
  • No plastic coffee stirrers
  • Non-plastic coffee stirrers available
  • Smoking not allowed
  • Some LED lighting used
  • Traditional architecture
  • Vegan dining options
  • Vegetarian breakfast available
  • Vegetarian dining options

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathtub or shower
  • Free toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Food and drink

  • Coffee/tea maker
  • Cookware, dishware, and utensils
  • Dishwasher
  • Kitchen
  • Microwave
  • Refrigerator
  • Separate dining area
  • Stovetop
  • Toaster

More

  • Air conditioning
  • Connecting rooms available
  • Desk
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Mobile key entry
  • Phone
  • Recycling
  • Separate sitting area
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 6:00 AM
Contactless check-in available
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM
Contactless check-out available
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 150 per accommodation, per stay
  • Dogs and cats only
  • 2 total (40 lbs is the maximum weight per pet)
  • Restrictions apply
  • For more information, guests can reach out to the property at the number on the booking confirmation
  • Service animals exempt from fees

Property payment types

Important information

Fees

You'll be asked to pay these charges at the property:

  • Deposit: USD 125 per accommodation, per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Pet fee: USD 150 per accommodation, per stay
  • Service animals are exempt from fees

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Cashless transactions are available
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, and window guards
This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Marriott)
  • Check-in: 4:00 PM
  • Check-out: 11:00 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day, and checking out is easy with express services. Driving? This property offers free parking.

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • Onsite safety features include a carbon monoxide detector, a fire extinguisher, a smoke detector, and window guards.
  • Cashless payment methods are available for all transactions and guests can access their rooms with a mobile device.
  • This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Marriott).

Additional information about polices, regulations, and more:

  • Registered guests are the only ones allowed in guestrooms.
  • Connecting or adjoining rooms can be requested, but all rooms are subject to availability. Contact the property using the phone number on your booking confirmation.
  • No cribs or infant beds are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Residence INN BY Marriott Jacksonville
Residence Inn by Marriott Jacksonville East
Residence Inn Jacksonville Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic Area Hotel

Frequently asked questions

Are free cancellation options available at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area provides free cancellation on select room rates. If you'd like to learn more, look at the cancellation policy on Orbitz.

How much does it cost to stay at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

As of Jul 17, 2026, prices found for a 1-night stay for 2 adults at Residence Inn By Marriott Jacksonville - Mayo Clinic Area on Aug 8, 2026 start from $150, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What's there to do near Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

This hotel is situated in Isle of Palms, close to St. Johns Town Center and TPC Sawgrass. You'll also find South Beach Park and Sunshine Playground and Atlantic Beach within a short drive.

Is there parking available at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Yes, uncovered self parking is offered for free at the hotel. Wheelchair-accessible van parking is also available for guests.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area feature a casino on the premises?

No, Residence Inn By Marriott Jacksonville - Mayo Clinic Area doesn't have a casino.

Is there an indoor pool at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

No, this hotel doesn't have an indoor pool; however, there is an outdoor pool.

Is Residence Inn By Marriott Jacksonville - Mayo Clinic Area good for couples?

Couples staying at this hotel will appreciate amenities like Netflix and a kitchen as well as a poolside bar.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area have a hot tub?

No, this hotel doesn't have a spa tub.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area feature a restaurant that includes a breakfast menu?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area offers free buffet breakfast each morning though there is no restaurant.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area allow pets to stay free of charge?

Although they can't stay for free, cats and dogs are welcome at Residence Inn By Marriott Jacksonville - Mayo Clinic Area for a fee of USD 150 per accommodation, per stay.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area have connecting rooms available?

Yes, this hotel has connecting rooms you can book for your group event or vacation.

What is the closest airport to Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

The closest major airport to Residence Inn By Marriott Jacksonville - Mayo Clinic Area is Jacksonville, FL (CRG-Jacksonville Executive at Craig), which is 11.2 mi away (17 minutes by car). Another top airport is Jacksonville International Airport (JAX), which is located 27.5 mi away (33-minute drive).

Are there rooms with balconies at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

No, there aren't any guestrooms at Residence Inn By Marriott Jacksonville - Mayo Clinic Area that offer a balcony.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area offer wedding services?

Take advantage of the wedding venue at Residence Inn By Marriott Jacksonville - Mayo Clinic Area if you plan to say "I do" during your trip.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 448 out of 558 reviews
Rating 8 - Good. 74 out of 558 reviews
Rating 6 - Okay. 14 out of 558 reviews
Rating 4 - Poor. 14 out of 558 reviews
Rating 2 - Terrible. 8 out of 558 reviews

9.6/10

Cleanliness

9.6/10

Staff & service

9.2/10

Amenities

9.6/10

Property conditions & facilities

Reviews

Verified

8/10 Good

Nancy

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean room, staff were very helpful, room was comfortable
Stayed 2 nights in Apr 2026
Verified

10/10 Excellent

Sabrena

Great stay! Clean room, friendly staff.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Vashti

Liked: Cleanliness, staff & service, property conditions & facilities
Good breakfast
Stayed 4 nights in Apr 2026
Verified

10/10 Excellent

STEVEN

Liked: Cleanliness, staff & service, amenities
Conveniently located, clean rooms, excellent breakfast
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

Darlene

Liked: Cleanliness, amenities, property conditions & facilities
Clean room, amazing staff great location
Stayed 1 night in Dec 2025
Verified

10/10 Excellent

Anthony

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean and well equipped room. Very good buffet breakfast
Stayed 3 nights in Apr 2026
Verified

8/10 Good

M

Liked: Cleanliness, staff & service, property conditions & facilities
Good location to multiple attractions in the city. Love the free and easily accessible parking.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

JOHN

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Breakfast was ok nothing special but the staff were all helpful and upbeat. Would highly recommend this property especially if you’re going to Mayo Clinic.
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

clipper

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Large well laid out rooms!
Stayed 2 nights in Apr 2026
Verified

10/10 Excellent

Teresa

Liked: Amenities, property conditions & facilities
Everything was wonderful. I recommend this property.
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Astraes

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Loved the size of the rooms, the kitchen, the amazing breakfast and the helpful staff. Only complaint would be to have more towels available.
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Vivien

Liked: Cleanliness, amenities, property conditions & facilities
Gret Hotel
Stayed 6 nights in Feb 2026
Verified

10/10 Excellent

Raymond

Liked: Cleanliness, staff & service, amenities
Wonderful room, clean and comfortable. The staff is great
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

james

Liked: Cleanliness, staff & service, property conditions & facilities
Excellent place to Stay!!
Stayed 1 night in Jul 2025
Verified

10/10 Excellent

Priscilla

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Quality throughout the hotel. Open front lounge area with comfortable seating and lighting. Parking lot has great lighting and access to facility. Transportation available to and from Mayo Clinic.
Stayed 2 nights in Apr 2026
Verified

10/10 Excellent

Stephen

Liked: Cleanliness, amenities, property conditions & facilities
Great room
Stayed 1 night in Feb 2026
Verified

8/10 Good

Kimberly

Liked: Cleanliness, staff & service, amenities
Clean rooms and amenities.
Stayed 4 nights in Jan 2026
Verified

10/10 Excellent

Gary

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great facility to stay.
Stayed 1 night in Sep 2025
Verified

10/10 Excellent

Dennis

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Na
Stayed 2 nights in May 2026
Verified

10/10 Excellent

Kay

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Always comfortable, beautiful rooms, great beds, great service, spotless clean
Stayed 1 night in Oct 2025
Verified

10/10 Excellent

Bonnie

Liked: Cleanliness, staff & service, property conditions & facilities
Very nice hotel - clean, quiet and the most convenient to the Mayo Clinic.
Stayed 1 night in Nov 2025
Verified

8/10 Good

Kimberly

Liked: Cleanliness
Staff and amenities
Stayed 5 nights in Jan 2026
Verified

10/10 Excellent

Wayne

Liked: Cleanliness, amenities, property conditions & facilities
The staff was great at check in and the bar. Room was very clean, but the couch needed to be replaced.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Joseph

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Clean, convenient to interstate, Mayo Hospital, 10 minutes from numerous restaurants and shopping. The staff was friendly.
Stayed 1 night in Dec 2025
Verified

8/10 Good

Gerard

Liked: Cleanliness, staff & service, property conditions & facilities
Was perfect place to stay on my visit to Mayo.
Stayed 2 nights in Dec 2024

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