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Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3.0 star property
Hotel in Jacksonville with a 24-hour fitness center and an outdoor pool

Choose dates to view prices

Photo gallery for Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Lobby
Bar (on property)
Reception
Exterior
Reception

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Pet friendly
  • Parking included
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
4905 SAN PABLO ROAD SOUTH, Jacksonville, FL, 32224
  • Place, Mayo Clinic Florida
    ‪17 min walk‬
  • Place, University of North Florida
    ‪5 min drive‬
  • Place, St. Johns Town Center
    ‪7 min drive‬
  • Airport, Jacksonville, FL (JAX-Jacksonville Intl.)
    ‪33 min drive‬

Room options

View all photos for Studio, 1 King Bed with Sofa bed, Corner

In-room safe, desk, laptop workspace, blackout drapes

Studio, 1 King Bed with Sofa bed, Corner

9.8 out of 10
Exceptional
(6 reviews)
  • 533 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 Bedroom, Corner

Studio Suite, 1 Bedroom, Corner | In-room safe, desk, laptop workspace, blackout drapes

Studio Suite, 1 Bedroom, Corner

10.0 out of 10
Exceptional
(3 reviews)
  • 646 sq ft
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed

View all photos for Studio Suite, 1 King Bed with Sofa bed

Fridge, microwave, stovetop, dishwasher

Studio Suite, 1 King Bed with Sofa bed

9.6 out of 10
Exceptional
(83 reviews)
  • 407 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 Bedroom

Studio Suite, 1 Bedroom | Living room | 55-inch Smart TV with cable channels, TV, Netflix

Studio Suite, 1 Bedroom

9.8 out of 10
Exceptional
(17 reviews)
  • 560 sq ft
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed

View all photos for Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Tub)

In-room safe, desk, laptop workspace, blackout drapes

Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Tub)

8.0 out of 10
Very good
(4 reviews)
  • 409 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 King Bed with Sofa bed (Hearing Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Studio Suite, 1 King Bed with Sofa bed (Hearing Accessible)

8.0 out of 10
Very good
(1 review)
  • 391 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Roll-In Shower)

In-room safe, desk, laptop workspace, blackout drapes

Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Roll-In Shower)

  • 391 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 Bedroom (Hearing Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Studio Suite, 1 Bedroom (Hearing Accessible)

8.0 out of 10
Very good
(1 review)
  • 569 sq ft
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed

View all photos for Studio, 1 King Bed with Sofa bed, Corner (Hearing Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Studio, 1 King Bed with Sofa bed, Corner (Hearing Accessible)

9.0 out of 10
Wonderful
(2 reviews)
  • 538 sq ft
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 Bedroom, Corner (Mobility/Hearing Access, Roll-In Shwr)

In-room safe, desk, laptop workspace, blackout drapes

Studio Suite, 1 Bedroom, Corner (Mobility/Hearing Access, Roll-In Shwr)

  • 641 sq ft
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed

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About the neighborhood

Jacksonville

Located in Isle of Palms within a mile (2 km) of Mayo Clinic Florida, Residence Inn By Marriott Jacksonville - Mayo Clinic Area is within 2 miles (3 km) of Harbor City Municipal Golf Course. This 3-star hotel has 155 guestrooms and offers conveniences like free breakfast, an outdoor pool, and a 24-hour gym.

What's nearby

  • Mayo Clinic Florida - 17 min walk - 0.9 miles
  • University of North Florida - 5 min drive - 5.6 miles
  • St. Johns Town Center - 7 min drive - 7.2 miles
  • Mayport Naval Station - 17 min drive - 11.4 miles
  • Jacksonville Naval Air Station - 29 min drive - 29.6 miles

Getting around

  • Jacksonville, FL (CRG-Jacksonville Executive at Craig) - 17 min drive

Restaurants

  • ‪Culver’s - ‬4 min drive
  • ‪Starbucks - ‬4 min drive
  • ‪Circle K - ‬9 min walk
  • ‪M Brothers at Mayo - ‬17 min walk
  • ‪Starbucks - ‬3 min drive

About this property

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Hotel in Jacksonville with a 24-hour fitness center and an outdoor pool
At Residence Inn By Marriott Jacksonville - Mayo Clinic Area, guests enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, put free parking to good use. The front desk has multilingual staff on hand 24/7 to help with luggage storage, concierge services, and dry cleaning/laundry. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.
Guests can expect to find free WiFi and 55-inch Smart TVs with cable channels and Netflix. Bathrooms offer hair dryers and free toiletries. Other standard amenities include kitchens, dining areas, and sitting areas. Housekeeping is available on request.
Recreational amenities at the hotel include an outdoor pool and a 24-hour fitness center.

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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Free uncovered self parking on site
  • Wheelchair-accessible parking and van parking available

Food and drink

  • Free buffet breakfast available 6:30 AM to 9:00 AM on weekdays and 7:00 AM to 9:30 AM on weekends
  • A bar/lounge
  • A poolside bar
  • Coffee and tea in common areas

Things to do

  • 24-hour gym
  • Outdoor pool
  • TV in common areas

Family friendly

  • Grocery/convenience store
  • In-room kitchen
  • In-room microwave
  • In-room refrigerator
  • Laundry facilities
  • Outdoor pool
  • Separate in-room dining area

Conveniences

  • 24-hour front desk
  • Free newspapers in lobby
  • Grocery/convenience store
  • Laundry facilities
  • Luggage storage
  • Safe at front desk
  • Water dispenser

Guest services

  • Change of bedsheets (on request)
  • Concierge services
  • Dry cleaning/laundry service
  • Free grocery shopping service
  • Housekeeping (daily)
  • Multilingual staff
  • Wedding services

Business services

  • 2 meeting rooms
  • 2,678 square feet of conference space
  • 24-hour business center
  • Computer station
  • Coworking space

Outdoors

  • Barbecue grill
  • Garden
  • Picnic area
  • Pool loungers

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Accessible bathtub
  • Assistive listening devices
  • Assistive listening devices in meeting rooms
  • Bathroom emergency pull cord
  • Braille/raised signage
  • Elevator
  • Grab bar near toilet
  • Hand-held showerhead
  • Handrails in stairways
  • Height-adjustable showerhead
  • Lever door handles
  • Low-height bed
  • Low-height counter and sink
  • Low-height door lock
  • Low-height electrical outlets in bathroom
  • Low-height view port in door
  • Phone accessibility kit
  • Pool hoist on site
  • Raised toilet seat
  • Stair-free path to entrance
  • Vibrating pillow alarm
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible business center
  • Wheelchair-accessible concierge desk
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to elevator
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible van parking
  • Wheelchair-width doorways

More

  • 1 building
  • 7 floors
  • At least 80% lighting from LEDs
  • Ballroom
  • Banquet hall
  • Biodegradable coffee stirrers available
  • Built in 2020
  • Communal living room
  • Comprehensive food waste policy
  • Comprehensive recycling policy
  • Double-glazed windows
  • Fireplace in lobby
  • No plastic coffee stirrers
  • Smoking not allowed
  • Traditional architecture
  • Vegan dining options
  • Vegetarian breakfast available
  • Vegetarian dining options

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathtub or shower
  • Free toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Food and drink

  • Coffee/tea maker
  • Cookware, dishware, and utensils
  • Dishwasher
  • Kitchen
  • Microwave
  • Refrigerator
  • Separate dining area
  • Stovetop
  • Toaster

More

  • Air conditioning
  • Connecting rooms available
  • Desk
  • Energy-saving switches in guestrooms
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Mobile key entry
  • Phone
  • Recycling
  • Separate sitting area
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 6:00 AM
Contactless check-in available
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM
Contactless check-out available
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 150 per accommodation, per stay
  • Dogs and cats only
  • 2 total (40 lbs is the maximum weight per pet)
  • Restrictions apply
  • For more information, guests can reach out to the property at the number on the booking confirmation
  • Service animals exempt from fees

Property payment types

Important information

Fees

You'll be asked to pay these charges at the property:

  • Deposit: USD 125 per accommodation, per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Pet fee: USD 150 per accommodation, per stay
  • Service animals are exempt from fees

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Cashless transactions are available
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, and window guards
This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Marriott)
  • Check-in: 4:00 PM
  • Check-out: 11:00 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day, and checking out is easy with express services. Driving? This property offers free parking.

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • Onsite safety features include a carbon monoxide detector, a fire extinguisher, a smoke detector, and window guards.
  • Cashless payment methods are available for all transactions and guests can access their rooms with a mobile device.
  • This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Marriott).

Additional information about polices, regulations, and more:

  • Registered guests are the only ones allowed in guestrooms.
  • Connecting or adjoining rooms can be requested, but all rooms are subject to availability. Contact the property using the phone number on your booking confirmation.
  • No cribs or infant beds are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Residence INN BY Marriott Jacksonville
Residence Inn by Marriott Jacksonville East
Residence Inn Jacksonville Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic Area Hotel

Frequently asked questions

Are free cancellation options available at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area provides free cancellation on select room rates. If you'd like to learn more, look at the cancellation policy on Orbitz.

How much does it cost to stay at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

As of Feb 16, 2026, prices found for a 1-night stay for 2 adults at Residence Inn By Marriott Jacksonville - Mayo Clinic Area on Feb 21, 2026 start from $193.0, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What's there to do near Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

This hotel is situated in Isle of Palms, close to St. Johns Town Center and TPC Sawgrass. You'll also find Adventure Landing and Huguenot Park within a short drive.

Is parking available on site at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Yes, uncovered self parking is offered for free at the hotel. Accessible parking is also available for guests.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area feature a casino on the premises?

No, Residence Inn By Marriott Jacksonville - Mayo Clinic Area doesn't have a casino.

Is there an indoor pool at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

No, this hotel doesn't have an indoor pool; however, there is an outdoor pool.

What do couples enjoy most about Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Couples staying at this hotel will appreciate amenities like a kitchen and Netflix as well as a poolside bar.

Are there hot tubs at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

No, there isn't a spa tub at this hotel.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area feature a restaurant that includes a breakfast menu?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area offers free buffet breakfast each morning though there is no restaurant.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area allow pets to stay free of charge?

Although they can't stay for free, cats and dogs are welcome at Residence Inn By Marriott Jacksonville - Mayo Clinic Area for a fee of USD 150 per accommodation, per stay.

Are there connecting rooms at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Yes, this hotel has connecting guestrooms you can book for your group event or vacation.

What is the closest airport to Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

The closest major airport to Residence Inn By Marriott Jacksonville - Mayo Clinic Area is Jacksonville, FL (CRG-Jacksonville Executive at Craig), which is 11.2 mi away (17 minutes by car). Another top airport is Jacksonville International Airport (JAX), which is located 27.5 mi away (33-minute drive).

Can I book a room with a balcony at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

No, there aren't any guestrooms with balconies at Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area offer wedding services?

Take advantage of the wedding venue at Residence Inn By Marriott Jacksonville - Mayo Clinic Area if you plan to say "I do" during your trip.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 366 out of 464 reviews
Rating 8 - Good. 68 out of 464 reviews
Rating 6 - Okay. 13 out of 464 reviews
Rating 4 - Poor. 13 out of 464 reviews
Rating 2 - Terrible. 4 out of 464 reviews

9.6/10

Cleanliness

9.6/10

Staff & service

9.0/10

Amenities

9.6/10

Property conditions & facilities

Reviews

10/10 Excellent

Jamie

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Great
Stayed 1 night in Nov 2025

10/10 Excellent

Bonnie, Ormond Beach

Liked: Cleanliness, staff & service, property conditions & facilities
Very nice hotel - clean, quiet and the most convenient to the Mayo Clinic.
Stayed 1 night in Nov 2025

10/10 Excellent

Jacob

All was good
Stayed 1 night in Nov 2025

6/10 Okay

David

Liked: Cleanliness, property conditions & facilities
Marriot… a room refresh does not include making the bed? WTAF?! Also, no smoking means no smoking. A man smoked a cigar in the court yard without any interference from the staff. It’s too bad, the room was spacious and clean but the follow through in non existent.
Stayed 3 nights in Nov 2025

10/10 Excellent

Teresa

Stayed 1 night in Nov 2025

10/10 Excellent

Kimberly

Business traveler, Traveled with partner, Traveled with pets
Liked: Cleanliness, amenities, property conditions & facilities
Yes room was clean!! We appreciate being able to add an additional nights stay, as we encountered an emergency overnight Stay at the hospital. Mayo Clinic patient.
Stayed 3 nights in Oct 2025

10/10 Excellent

Danielle

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Nov 2025

10/10 Excellent

Nia

Stayed 3 nights in Oct 2025

10/10 Excellent

Kay

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Always comfortable, beautiful rooms, great beds, great service, spotless clean
Stayed 1 night in Oct 2025

10/10 Excellent

JEFF

Liked: Cleanliness
Stayed 3 nights in Oct 2025

4/10 Poor

Daniel

Liked: Cleanliness
Once again upon arrival we were given a room in a lower category than the one we had booked. This is very disappointing and we will not be staying at this hotel again.
Stayed 1 night in Oct 2025

6/10 Okay

Rebecca

Business traveler, Traveled with family
Liked: Staff & service
I typically stay at this hotel whenever I am at Mayo Clinic for treatments of medical conditions. Normally I don’t seem to have many issues with the hotel especially considering how much newer it is. This visit I had some issues with cleanliness and conditions with my room. The bathroom had random hairs in the shower and on the floor. The bed frame seemed to be broken because of the very loud squeak any time I moved in bed. There was some trash behind the desk on the window sill. I’m used to better standards at this location; especially given the price per stay. There are other new hotels that have been built around Mayo Clinic that I will try during my next visit to the area.
Stayed 1 night in Oct 2025

10/10 Excellent

Dan

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
The lights seem to be out in the parking lot. It was extremely dark in the morning and hard to see to get to car. Seems unsafe. Lights need to be turned on. Otherwise, excellent stay
Stayed 1 night in Oct 2025

10/10 Excellent

Dave

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 2 nights in Oct 2025

10/10 Excellent

Curtis

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Yes, everything was great
Stayed 7 nights in Aug 2025

10/10 Excellent

Helmuth

Traveled with partner
Liked: Cleanliness, staff & service, property conditions & facilities
We stayed there for 6 days. Our room was quiet, very clean, nice view to the woods. It was nice that they had a free shuttle to Mayo Clinic. The only problem was that one day we did’t had our room clean because the person in charge of doing it forgot. I have to go back to Mayo Clinic and my stay at the hotel was so good that I already made my reservation for the Residence Inn
Stayed 7 nights in Sep 2025

10/10 Excellent

Tyler

Stayed 2 nights in Sep 2025

8/10 Good

TASHA D.

Business traveler, Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This property is closed to the Mayo Clinic
Stayed 1 night in Aug 2025

10/10 Excellent

Gary

Business traveler, Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great facility to stay.
Stayed 1 night in Sep 2025

10/10 Excellent

DANIEL

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

8/10 Good

Gerard

Business traveler
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Often stay there. Great value. The only area of friction is how they do room service. You have to call the front desk who takes your order. They pass it on to the restaurant. Multiple times things get mixed up or forgotten. A direct line to the restaurant would be a better solution. Also a menu in the room or accessible through the tv or smartphone would be helpful. If you forget to ask the front desk for a menu then you are on your own. I will say the food is very good.
Stayed 1 night in Aug 2025

10/10 Excellent

Robert

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Jul 2025

10/10 Excellent

Gerald

Business traveler, Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The room and bedroom was very well done
Stayed 2 nights in Aug 2025

10/10 Excellent

Tyeisha

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Terrific Stay 10/10

I had an amazing stay. The staff was friendly, the room was spotless. All the attractions were minutes away. The hotel felt like home away from home. Highly recommended. I will be back.
Stayed 2 nights in Aug 2025

10/10 Excellent

Joseph

Stayed 3 nights in Aug 2025

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