Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Hotel in Jacksonville with free breakfast and a 24-hour fitness center

Choose dates to view prices

Where to?

Dates

October 2025

November 2025

Overview
Rooms
Location
Policies

Exceptional

Popular amenities

Bar
Housekeeping
Kitchen
Laundry

Explore the area

4905 SAN PABLO ROAD SOUTH, Jacksonville, FL, 32224

Place, Mayo Clinic Florida
‪17 min walk‬
Place, University of North Florida
‪7 min drive‬
Place, St. Johns Town Center
‪8 min drive‬
Airport, Jacksonville, FL (JAX-Jacksonville Intl.)
‪35 min drive‬

Room options

In-room safe, desk, laptop workspace, blackout drapes

Studio, 1 King Bed with Sofa bed, Non Smoking, Corner

Exceptional

533 sq ft
Sleeps 3
1 King Bed and 1 Double Sofa Bed

Studio Suite, 1 Bedroom, Non Smoking, Corner

Exceptional

646 sq ft
Sleeps 5
2 Queen Beds and 1 Double Sofa Bed

Studio Suite, 1 King Bed with Sofa bed, Non Smoking

Exceptional

407 sq ft
Sleeps 3
1 King Bed and 1 Double Sofa Bed

Studio Suite, 1 Bedroom, Non Smoking

Exceptional

560 sq ft
Sleeps 5
2 Queen Beds and 1 Double Sofa Bed

Studio Suite, 1 King Bed with Sofa bed, Non Smoking (Mobility Accessible, Tub)

Very good

409 sq ft
Sleeps 3
1 King Bed and 1 Double Sofa Bed

Studio Suite, 1 King Bed with Sofa bed, Non Smoking (Hearing Accessible)

Very good

391 sq ft
Sleeps 3
1 King Bed and 1 Double Sofa Bed

Studio Suite, 1 King Bed with Sofa bed, Non Smoking (Mobility Accessible, Roll-In Shower)

391 sq ft
Sleeps 3
1 King Bed and 1 Double Sofa Bed

Studio Suite, 1 Bedroom, Non Smoking (Hearing Accessible)

Very good

569 sq ft
Sleeps 5
2 Queen Beds and 1 Double Sofa Bed

Studio, 1 King Bed with Sofa bed, Non Smoking, Corner (Hearing Accessible)

Very good

538 sq ft
Sleeps 3
1 King Bed and 1 Double Sofa Bed

Studio Suite, 1 Bedroom, Non Smoking, Corner (Mobility/Hearing Access, Roll-In Shwr)

641 sq ft
Sleeps 5
2 Queen Beds and 1 Double Sofa Bed

About the neighborhood

Jacksonville

Located in Isle of Palms, Residence Inn By Marriott Jacksonville - Mayo Clinic Area is within a mile (2 km) of sights such as Mayo Clinic Florida and Harbor City Municipal Golf Course. This 3-star hotel has 155 guestrooms and offers conveniences like free breakfast, an outdoor pool, and a 24-hour gym.

What's nearby

Mayo Clinic Florida - 17 min walk - 0.9 miles
University of North Florida - 7 min drive - 6.0 miles
St. Johns Town Center - 8 min drive - 7.2 miles
Jacksonville Beach Pier - 10 min drive - 5.9 miles
TPC Sawgrass - 14 min drive - 8.7 miles

Getting around

Jacksonville, FL (CRG-Jacksonville Executive at Craig) - 13 min drive

Restaurants

‪Culver's #964 - ‬4 min drive
‪M Brothers at Mayo - ‬18 min walk
‪Starbucks - ‬4 min drive
‪Circle K - ‬10 min walk
‪Mayo Clinic - Employee Cafeteria - ‬18 min walk

About this property

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Hotel in Jacksonville with free breakfast and a 24-hour fitness center

At Residence Inn By Marriott Jacksonville - Mayo Clinic Area, guests enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, put free parking to good use. The front desk has multilingual staff on hand 24/7 to help with dry cleaning/laundry, securing valuables, and concierge services. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.

Guests can expect to find free WiFi and 55-inch Smart TVs with cable channels and Netflix. Bathrooms offer hair dryers and free toiletries. Other standard amenities include kitchens, dining areas, and sitting areas. Housekeeping is available on request.

Recreational amenities at the hotel include an outdoor pool and a 24-hour fitness center.

Similar properties

Pool
Parking included
Free WiFi
Restaurant

$161 nightly

Oct 25 - Oct 26

Total with taxes and fees

Property amenities

Internet

Available in all rooms: Free WiFi
Available in some public areas: Free WiFi

Parking and transportation

Free uncovered self parking on site
Wheelchair-accessible parking and van parking available

Food and drink

Free buffet breakfast available 6:30 AM to 9:00 AM on weekdays and 7:00 AM to 9:30 AM on weekends
A bar/lounge
A poolside bar
Coffee and tea in common areas

Things to do

24-hour gym
Outdoor pool
TV in common areas

Family friendly

Grocery/convenience store
In-room kitchen
In-room microwave
In-room refrigerator
Laundry facilities
Outdoor pool
Separate in-room dining area

Conveniences

24-hour front desk
Free newspapers in lobby
Grocery/convenience store
Laundry facilities
Luggage storage
Safe at front desk
Water dispenser

Guest services

Change of bedsheets (on request)
Concierge services
Dry cleaning/laundry service
Free grocery shopping service
Housekeeping (daily)
Multilingual staff
Wedding services

Business services

2 meeting rooms
2,678 square feet of conference space
24-hour business center
Computer station
Coworking space

Outdoors

Barbecue grill
Garden
Picnic area
Pool loungers

Accessibility

If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
Accessible bathtub
Assistive listening devices
Assistive listening devices in meeting rooms
Bathroom emergency pull cord
Braille/raised signage
Elevator
Grab bar near toilet
Hand-held showerhead
Handrails in stairways
Height-adjustable showerhead
Lever door handles
Low-height bed
Low-height counter and sink
Low-height door lock
Low-height electrical outlets in bathroom
Low-height view port in door
Phone accessibility kit
Pool hoist on site
Raised toilet seat
Stair-free path to entrance
Vibrating pillow alarm
Visual fire alarm
Well-lit path to entrance
Wheelchair accessibility
Wheelchair accessible (may have limitations)
Wheelchair-accessible business center
Wheelchair-accessible concierge desk
Wheelchair-accessible gym
Wheelchair-accessible lounge
Wheelchair-accessible parking
Wheelchair-accessible path of travel
Wheelchair-accessible path to elevator
Wheelchair-accessible pool
Wheelchair-accessible public washroom
Wheelchair-accessible registration desk
Wheelchair-accessible restaurant
Wheelchair-accessible van parking
Wheelchair-width doorways

1 building
7 floors
At least 80% lighting from LEDs
Ballroom
Banquet hall
Biodegradable coffee stirrers available
Built in 2020
Communal living room
Comprehensive food waste policy
Comprehensive recycling policy
Double-glazed windows
Fireplace in lobby
No plastic coffee stirrers
Smoking not allowed
Traditional architecture
Vegan dining options
Vegetarian breakfast available
Vegetarian dining options

Room amenities

Bedroom

Bedsheets provided
Blackout drapes

Bathroom

Bathtub or shower
Free toiletries
Hair dryer
Private bathroom
Shampoo
Soap
Toilet paper
Towels provided

Entertainment

55-inch smart TV with premium cable channels
Netflix
Streaming services

Food and drink

Coffee/tea maker
Cookware, dishware, and utensils
Dishwasher
Kitchen
Microwave
Refrigerator
Separate dining area
Stovetop
Toaster

Air conditioning
Connecting rooms available
Desk
Energy-saving switches in guestrooms
Heating
Iron/ironing board
Laptop workspace
Laptop-compatible safe
LED lighting
Mobile key entry
Phone
Recycling
Separate sitting area
Water-efficient showers

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 6:00 AM

Contactless check-in available

Late check-in subject to availability

Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Contactless check-out available

Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property

If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation

Access methods

Staffed front desk

Pets

This property welcomes pets for USD 150 per accommodation, per stay
Dogs and cats only
2 total (40 lbs is the maximum weight per pet)
Restrictions apply
For more information, guests can reach out to the property at the number on the booking confirmation
Service animals exempt from fees

Property payment types

Important information

Fees

You'll be asked to pay these charges at the property:

Deposit: USD 125 per accommodation, per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

Pet fee: USD 150 per accommodation, per stay
Service animals are exempt from fees

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy

Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges

Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed

This property accepts credit cards; cash is not accepted

Cashless transactions are available

Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, and window guards

This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Marriott)

Check-in: 4:00 PM
Check-out: 11:00 AM
Minimum check-in age: 21

The front desk is open 24 hours a day, and checking out is easy with express services. Driving? This property offers free parking.

We should mention

Details about charges, deposits, or other important information:

This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
Charges for extra guests may apply and vary depending on the property's policy.
A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
This property accepts credit cards. Cash is not accepted.
Onsite safety features include a carbon monoxide detector, a fire extinguisher, a smoke detector, and window guards.
Cashless payment methods are available for all transactions and guests can access their rooms with a mobile device.
This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Marriott).

Additional information about polices, regulations, and more:

Registered guests are the only ones allowed in guestrooms.
Connecting or adjoining rooms can be requested, but all rooms are subject to availability. Contact the property using the phone number on your booking confirmation.
No cribs or infant beds are available.
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Residence INN BY Marriott Jacksonville

Residence Inn by Marriott Jacksonville East

Residence Inn Jacksonville Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area Hotel

Frequently asked questions

Are free cancellation options available at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area provides free cancellation on select room rates. If you'd like to learn more, look at the cancellation policy on Orbitz.

How much does it cost to stay at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

As of Oct 14, 2025, prices found for a 1-night stay for 2 adults at Residence Inn By Marriott Jacksonville - Mayo Clinic Area on Oct 24, 2025 start from $175.0, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What's there to do near Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

This hotel is situated in Isle of Palms within a short 18-minute walk of Harbor City Municipal Golf Course. You'll also find Adventure Landing and Atlantic Beach within a short drive.

Will I be able to park at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Yes, uncovered self parking is offered for free at the hotel. Accessible parking is also available for guests.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area feature a casino on the premises?

No, Residence Inn By Marriott Jacksonville - Mayo Clinic Area doesn't have a casino.

Is there an indoor pool at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

No, this hotel doesn't have an indoor pool; however, there is an outdoor pool.

What will couples enjoy most about a stay at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Couples staying at this hotel will appreciate amenities like a kitchen and Netflix as well as a poolside bar.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area have a hot tub?

No, this hotel doesn't have a spa tub.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area feature a restaurant that includes a breakfast menu?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area offers free buffet breakfast each morning though there is no restaurant.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area allow pets to stay free of charge?

Although they can't stay for free, cats and dogs are welcome at Residence Inn By Marriott Jacksonville - Mayo Clinic Area for a fee of USD 150 per accommodation, per stay.

Are there connecting rooms at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Yes, this hotel has connecting guestrooms you can book for your group event or vacation.

What is the closest airport to Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

The closest major airport to Residence Inn By Marriott Jacksonville - Mayo Clinic Area is Jacksonville, FL (CRG-Jacksonville Executive at Craig), which is 11.1 mi away (13 minutes by car). Another top airport is St. Augustine, FL (UST-Northeast Florida Regional), which is located 29.2 mi away (32-minute drive).

Are there rooms with balconies at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

No, at Residence Inn By Marriott Jacksonville - Mayo Clinic Area, there aren't any guestrooms that list a balcony.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area offer wedding services?

Take advantage of the wedding venue at Residence Inn By Marriott Jacksonville - Mayo Clinic Area if you plan to say "I do" during your trip.