Cheap flights from TYS to SAN (McGhee Tyson to San Diego Intl.)

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Cheap Flights from TYS to SAN starting at $176 One Way, $377 Round Trip

Prices starting at $377 for return flights and $176 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Oct 3 - Sat, Oct 10
TYS
Knoxville
SAN
San Diego
$377 Roundtrip, found 6 days ago
$377
Roundtrip
found 6 days ago
Select United flight, departing Sat, Oct 3 from Knoxville to San Diego, returning Sat, Oct 10, priced at $377 found 6 days ago
Sat, Oct 3 - Sat, Oct 10
TYS
Knoxville
SAN
San Diego
$386 Roundtrip, found 6 days ago
$386
Roundtrip
found 6 days ago
Select United flight, departing Sat, Oct 3 from Knoxville to San Diego, returning Sat, Oct 10, priced at $386 found 6 days ago
Sat, Oct 3 - Sat, Oct 10
TYS
Knoxville
SAN
San Diego
$392 Roundtrip, found 6 days ago
$392
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Oct 3 from Knoxville to San Diego, returning Sat, Oct 10, priced at $392 found 6 days ago
Fri, Oct 9 - Mon, Oct 12
TYS
Knoxville
SAN
San Diego
$397 Roundtrip, found 4 days ago
$397
Roundtrip
found 4 days ago
Select Delta flight, departing Fri, Oct 9 from Knoxville to San Diego, returning Mon, Oct 12, priced at $397 found 4 days ago
Fri, Oct 9 - Mon, Oct 12
TYS
Knoxville
SAN
San Diego
$403 Roundtrip, found 4 days ago
$403
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Fri, Oct 9 from Knoxville to San Diego, returning Mon, Oct 12, priced at $403 found 4 days ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$213 nightly
The price is $245 total per night from Sep 27 to Sep 28
$245 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.6/10 Excellent! (3,671 reviews)
"Our stay was good, not what I expected, but decent. Our room had marina view, which was nice, but we were sent to another tower some what far from the main. The jacuzzi did not work and the pool was freezing cold. Our room needs to be updated, needs renovation, but the room looked clean. Parking ..."

Reviewed on Sep 8, 2026

Sheraton San Diego Resort
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
$296 nightly
The price is $343 total per night from Sep 11 to Sep 12
$343 total
Sep 11 - Sep 12
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
9/10 Wonderful! (2,831 reviews)
"Would absolutely stay again!"

Reviewed on Sep 8, 2026

Manchester Grand Hyatt San Diego
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Sep 20 to Sep 21
$211 total
Sep 20 - Sep 21
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
$296 nightly
The price is $343 total per night from Sep 11 to Sep 12
$343 total
Sep 11 - Sep 12
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
9/10 Wonderful! (2,831 reviews)
"Would absolutely stay again!"

Reviewed on Sep 8, 2026

Manchester Grand Hyatt San Diego
California Suites Hotel

California Suites Hotel

2 out of 5
5415 Clairemont Mesa Blvd San Diego CA
$89 nightly
The price is $102 total per night from Sep 20 to Sep 21
$102 total
Sep 20 - Sep 21
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the ...
7.8/10 Good! (2,947 reviews)
"At first I was a little skeptical upon arrival with the location but the staff and the people who stayed there made everything immensely better! They don’t serve breakfast but had fresh coffee and hot cocoa and tea all the time! You can cook in your hotel room to save money and once inside (it was ..."

Reviewed on Sep 8, 2026

California Suites Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Sep 20 to Sep 21
$211 total
Sep 20 - Sep 21
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Sep 20 to Sep 21
$211 total
Sep 20 - Sep 21
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$213 nightly
The price is $245 total per night from Sep 27 to Sep 28
$245 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.6/10 Excellent! (3,671 reviews)
"Our stay was good, not what I expected, but decent. Our room had marina view, which was nice, but we were sent to another tower some what far from the main. The jacuzzi did not work and the pool was freezing cold. Our room needs to be updated, needs renovation, but the room looked clean. Parking ..."

Reviewed on Sep 8, 2026

Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 out of 5
1955 San Diego Ave San Diego CA
$141 nightly
The price is $162 total per night from Sep 23 to Sep 24
$162 total
Sep 23 - Sep 24
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn

Pleasant Inn

2.5 out of 5
5550 Clairemont Mesa Blvd San Diego CA
$76 nightly
The price is $87 total per night from Sep 9 to Sep 10
$87 total
Sep 9 - Sep 10
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
8.6/10 Excellent! (1,560 reviews)
"Great staff and clean room."

Reviewed on Sep 8, 2026

Pleasant Inn
E-Z 8 Motel Old Town

E-Z 8 Motel Old Town

2.5 out of 5
4747 Pacific Highway San Diego CA
$71 nightly
The price is $81 total per night from Sep 9 to Sep 10
$81 total
Sep 9 - Sep 10
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
E-Z 8 Motel Old Town
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
$108 nightly
The price is $123 total per night from Sep 13 to Sep 14
$123 total
Sep 13 - Sep 14
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
$267 nightly
The price is $307 total per night from Sep 30 to Oct 1
$307 total
Sep 30 - Oct 1
Total with taxes and fees
Book a stay at this business-friendly resort in San Diego. Enjoy breakfast (surcharge), 24-hour room service, and a fitness center. Our guests praise the pool ...
8.6/10 Excellent! (2,391 reviews)
"Overall experience was good. I would go back in future."

Reviewed on Sep 8, 2026

Bahia Resort Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
$186 nightly
The price is $213 total per night from Sep 29 to Sep 30
$213 total
Sep 29 - Sep 30
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
The Dana on Mission Bay
Catamaran Resort and Spa

Catamaran Resort and Spa

4 out of 5
3999 Mission Boulevard San Diego CA
$268 nightly
The price is $308 total per night from Sep 9 to Sep 10
$308 total
Sep 9 - Sep 10
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TYS to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from TYS to San Diego Airport?
You're going to need to swap planes if you're planning to get from McGhee Tyson Airport (TYS) to SAN. Several airlines offer services on this route with only one stopover, including American Airlines, United Airlines and Delta Air Lines.
What is the shortest flight from Knoxville Airport to San Diego Airport?
The shortest flight time from Knoxville Airport to San Diego Airport is 6 hours and 39 minutes. Order a refreshment from the drink trolley, write in your travel journal or finish that podcast — you'll have the time on this medium-haul journey.
How many hours flight from McGhee Tyson Airport (TYS) to San Diego Airport?
From TYS to SAN, you'll be in your seat for roughly 6 hours and 45 minutes. Settle back, order a wine and take out your noise-canceling earphones. It's time to rewatch your favorite TV shows.
What airlines have the most flights from Knoxville Airport to San Diego Airport?
If you're wanting to book with an airline that operates direct flights from TYS to SAN, you won't have much luck. You'll need to book a flight with at least one stopover to get to San Diego.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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