Cheap flights from TYS to EYW (McGhee Tyson to Key West Intl.)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
Cheap Flights from TYS to EYW starting at $269 One Way, $309 Round Trip
Prices starting at $309 for return flights and $269 for one-way flights to Key West Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
TYS
Knoxville
EYW
Key West
$309 Roundtrip, found 1 day ago
$309
Roundtrip
found 1 day ago
TYS
Knoxville
EYW
Key West
$309 Roundtrip, found 1 day ago
$309
Roundtrip
found 1 day ago
TYS
Knoxville
EYW
Key West
$316 Roundtrip, found 1 day ago
$316
Roundtrip
found 1 day ago
TYS
Knoxville
EYW
Key West
$323 Roundtrip, found 1 day ago
$323
Roundtrip
found 1 day ago
TYS
Knoxville
EYW
Key West
$352 Roundtrip, found 1 day ago
$352
Roundtrip
found 1 day ago
Hotel Ideas near Key West Intl.
Airport Hotels near Key West Intl.
Hyatt Vacation Club at Windward Pointe, Key West
3675 South Roosevelt Boulevard Key West FL
$407 nightly
The price is $458 total per night from Jul 27 to Jul 28
$458 total
Jul 27 - Jul 28
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, free parking, and a snack bar/deli. Our guests praise the pool and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,175 reviews)
"The property was very well maintained"
Reviewed on Jul 6, 2026
Hampton Inn Key West FL
3755 S Roosevelt Blvd Key West FL
$189 nightly
The price is $213 total per night from Jul 8 to Jul 9
$213 total
Jul 8 - Jul 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,419 reviews)
"Excellent"
Reviewed on Jul 5, 2026
DoubleTree Resort by Hilton Grand Key - Key West
3990 S Roosevelt Blvd Key West FL
$169 nightly
The price is $190 total per night from Jul 13 to Jul 14
$190 total
Jul 13 - Jul 14
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,047 reviews)
"I wish the pool was open later. Especially on weekends and holidays"
Reviewed on Jul 6, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels In Key West
Beachside Resort & Residences
3841 N Roosevelt Blvd Key West FL
$195 nightly
The price is $219 total per night from Jul 8 to Jul 9
$219 total
Jul 8 - Jul 9
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 2 restaurants, and a private beach. Our guests praise the pool and the helpful staff in our reviews. ...
8.6/10 Excellent! (2,330 reviews)
"The room was cleaned the food was good there's no beach a man made beach with dirty water no working elevators"
Reviewed on Jul 7, 2026
Blue Flamingo Resort Key West
3820 North Roosevelt Boulevard Key West FL
$175 nightly
The price is $197 total per night from Jul 8 to Jul 9
$197 total
Jul 8 - Jul 9
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,499 reviews)
"Need to have breakfast"
Reviewed on Jul 6, 2026
Southernmost Beach Resort and Guesthouses
1319 Duval Street Key West FL
$232 nightly
The price is $261 total per night from Jul 14 to Jul 15
$261 total
Jul 14 - Jul 15
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.8/10 Excellent! (3,430 reviews)
"Everything"
Reviewed on Jul 6, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Key West Hotels With Airport Transportation
DoubleTree Resort by Hilton Grand Key - Key West
3990 S Roosevelt Blvd Key West FL
$169 nightly
The price is $190 total per night from Jul 13 to Jul 14
$190 total
Jul 13 - Jul 14
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,047 reviews)
"I wish the pool was open later. Especially on weekends and holidays"
Reviewed on Jul 6, 2026
Hampton Inn Key West FL
3755 S Roosevelt Blvd Key West FL
$189 nightly
The price is $213 total per night from Jul 8 to Jul 9
$213 total
Jul 8 - Jul 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,419 reviews)
"Excellent"
Reviewed on Jul 5, 2026
Eden House
1015 Fleming St Key West FL
$159 nightly
The price is $179 total per night from Jul 8 to Jul 9
$179 total
Jul 8 - Jul 9
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, in-room massages, and a 24-hour front desk. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (1,005 reviews)
"Everything was excellent"
Reviewed on Jul 5, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Low Priced Key West Hotels
Southwinds Motel
1321 Simonton Street Key West FL
$165 nightly
The price is $185 total per night from Aug 2 to Aug 3
$185 total
Aug 2 - Aug 3
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,355 reviews)
"Excellent Staff bicycle rental on-site"
Reviewed on Jul 6, 2026
Seashell Motel
718 South Street Key West FL
$120 nightly
The price is $135 total per night from Jul 8 to Jul 9
$135 total
Jul 8 - Jul 9
Total with taxes and fees
Stay at this hostel in Key West. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8/10 Very Good! (1,001 reviews)
"Excelente servicio de las personas de front desk para hacer check in. Las habitaciones muy limpias no tuve ningún problema con la habitación la persona que se encargo de ir a cambiar las toallas y las sábanas excelente servicio. Volveré en unos meses lo recomiendo."
Reviewed on Jul 6, 2026
Duval House
815 Duval St Key West FL
$133 nightly
The price is $147 total per night from Jul 19 to Jul 20
$147 total
Jul 19 - Jul 20
Total with taxes and fees
Stay at this B&B in Key West. Enjoy parking (surcharge), daily housekeeping, and a garden. Our guests praise the breakfast and the pool in our reviews. Popular ...
9.4/10 Exceptional! (1,043 reviews)
"The staff and our stay at the Duval House was fantastic! Hospitality was top notch and we loved the breezy shade on our balcony under the beautiful Banyan tree after a day of sightseeing. We will be back! Loved it!"
Reviewed on Jul 6, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Family Friendly Hotels in Key West
Southernmost Beach Resort and Guesthouses
1319 Duval Street Key West FL
$232 nightly
The price is $261 total per night from Jul 14 to Jul 15
$261 total
Jul 14 - Jul 15
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.8/10 Excellent! (3,430 reviews)
"Everything"
Reviewed on Jul 6, 2026
Blue Flamingo Resort Key West
3820 North Roosevelt Boulevard Key West FL
$175 nightly
The price is $197 total per night from Jul 8 to Jul 9
$197 total
Jul 8 - Jul 9
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,499 reviews)
Families like: Outdoor pools, playground, miniature golf, game room
Travelers say...
"Need to have breakfast"
Reviewed on Jul 6, 2026
Oceans Edge Key West Resort, Hotel & Marina
5950 Peninsular Avenue Key West FL
$193 nightly
The price is $217 total per night from Aug 6 to Aug 7
$217 total
Aug 6 - Aug 7
Total with taxes and fees
Book a stay at this luxury hotel in Key West. Enjoy free WiFi, 6 outdoor pools, and a marina. Our guests praise the pool and the restaurant in our reviews. Popular ...
9/10 Wonderful! (1,860 reviews)
"It was a good experience. Thank you!"
Reviewed on Jul 5, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
TYS to EYW Route Info
Origin Airport | |
|---|---|
Destination Airport | |
Number Of Airlines Serving | |
Distance | |
Shortest Flight Departure Time | |
Shortest Flight Departure Date |
- Airport Locations
- More Popular Flights
- Top Trending
- Flights from Other Cities
- Flights From Other Airports
- Great Travel Ideas
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York
EYW Address & GPS
Address:
3491 South Roosevelt Boulevard
Key West FL, 33040-5260
United States
IATA Code:
EYW
Longitude:
-81.75501
Latitude:
24.553574
Time Zone:
America/New_York
Other Flights from McGhee Tyson Airport (TYS)
Other Flights to Key West Intl. Airport (EYW)
- Flights from Pigeon Forge
- Flights from Gatlinburg
- Flights from Sevierville
- Flights from Knoxville
- Flights from Gatlinburg - Pigeon Forge
- Flights from Cherokee
- Flights from Townsend
- Flights from North Carolina Mountains
- Flights from Blue Ridge Mountains
- Flights from Maryville
- Flights from Kodak
- Flights from Oak Ridge
- Asheville Regional Airport (AVL)
- Chattanooga Metropolitan Airport (CHA)
- Tri-Cities Regional Airport (TRI)
- Greenville-Spartanburg Intl. Airport (GSP)
- Virginia Highlands Airport (VJI)
- DeKalb-Peachtree Airport (PDK)
- Fulton County Airport (FTY)
- Pike County - Hatcher Field Airport (PVL)
- Nashville Intl. Airport (BNA)
- Hartsfield-Jackson Atlanta Intl. Airport (ATL)
Top Trending
Flights
- Ronald Reagan Washington National (DCA) To Orlando Intl. (MCO)
- Logan Intl. (BOS) To Orlando Intl. (MCO)
- Bradley Intl. (BDL) To Orlando Intl. (MCO)
- LaGuardia (LGA) To Miami Intl. (MIA)
- LaGuardia (LGA) To Fort Lauderdale - Hollywood Intl. (FLL)
- Orlando Intl. (MCO) To Los Angeles Intl. (LAX)
- Detroit Metropolitan Wayne County (DTW) To Orlando Intl. (MCO)
- Ronald Reagan Washington National (DCA) To Miami Intl. (MIA)
- Orlando Intl. (MCO) To LaGuardia (LGA)
- Baltimore Washington Intl. Thurgood Marshall (BWI) To Miami Intl. (MIA)
- John F. Kennedy Intl. (JFK) To Fort Lauderdale - Hollywood Intl. (FLL)
- Los Angeles Intl. (LAX) To Orlando Intl. (MCO)
- Newark Liberty Intl. Airport (EWR) To Orlando Intl. (MCO)
- Hartsfield-Jackson Atlanta Intl. (ATL) To Orlando Intl. (MCO)
- LaGuardia (LGA) To Orlando Intl. (MCO)
- Minneapolis - St. Paul Intl. (MSP) To Orlando Intl. (MCO)
- Baltimore Washington Intl. Thurgood Marshall (BWI) To Fort Lauderdale - Hollywood Intl. (FLL)
- Orlando Intl. (MCO) To John F. Kennedy Intl. (JFK)
- Orlando Intl. (MCO) To Newark Liberty Intl. Airport (EWR)
- O'Hare Intl. (ORD) To Orlando Intl. (MCO)
- Orlando Intl. (MCO) To Luis Munoz Marin Intl. (SJU)
- Detroit Metropolitan Wayne County (DTW) To Miami Intl. (MIA)
- Philadelphia Intl. (PHL) To Orlando Intl. (MCO)
- Baltimore Washington Intl. Thurgood Marshall (BWI) To Orlando Intl. (MCO)
- John F. Kennedy Intl. (JFK) To Orlando Intl. (MCO)
- John F. Kennedy Intl. (JFK) To Miami Intl. (MIA)
- Fort Lauderdale - Hollywood Intl. (FLL) To John F. Kennedy Intl. (JFK)
- Ronald Reagan Washington National (DCA) To Fort Lauderdale - Hollywood Intl. (FLL)
- Raleigh - Durham Intl. (RDU) To Orlando Intl. (MCO)
- John F. Kennedy Intl. (JFK) To Tampa Intl. (TPA)
Frequently asked questions
Map To Nearby Hotels
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.
More to Explore
- Flights from Wilmington to Key West
- Flights from Islip to Key West
- Flights from Atlanta to Key West
- Flights from Austin to Key West
- Flights from Baltimore to Key West
- Flights from Boston to Key West
- Flights from Charlotte to Key West
- Flights from Chicago to Key West
- Flights from Columbus to Key West
- Flights from Dallas to Key West
- Flights from Denver to Key West
- Flights from Detroit to Key West
- Flights from Houston to Key West
- Flights from Indianapolis to Key West
- Flights from Kansas City to Key West
- Flights from Las Vegas to Key West
- Flights from Los Angeles to Key West
- Flights from Memphis to Key West
- Flights from Miami to Key West
- Flights from Nashville to Key West
- Flights from New Orleans to Key West
- Flights from New York to Key West
- Flights from Orlando to Key West
- Flights from Philadelphia to Key West
- Flights from Phoenix to Key West
- Flights from Portland to Key West
- Flights from Raleigh to Key West
- Flights from Salt Lake City to Key West
- Flights from San Antonio to Key West
- Flights from San Francisco to Key West
- Flights from Seattle to Key West
- Flights from St. Louis to Key West
- Flights from St. Petersburg - Clearwater to Key West
- Flights from Toronto to Key West
- Flights from Washington to Key West
- Flights from Charleston to Key West
- Flights from Hartford to Key West
- Flights from Providence to Key West
- Flights from Portland to Key West
- Flights from Sanford to Key West
- Flights from Melbourne to Key West
- Flights from Omaha to Key West
- Flights from San Diego to Key West
- Flights from Myrtle Beach to Key West
- Flights from Des Moines to Key West
- Flights from Pittsburgh to Key West
- Flights from Fort Lauderdale to Key West
- Flights from Newark to Key West
- Flights from Richmond to Key West
- Flights from Syracuse to Key West
- Flights from Atlantic City to Key West
- Flights from Tulsa to Key West
- Flights from Panama City to Key West
- Flights from Pensacola to Key West
- Flights from Fort Walton Beach - Destin to Key West
- Flights from Vero Beach to Key West
- Flights from Daytona Beach to Key West
- Flights from Manchester to Key West
- Flights from Milwaukee to Key West
- Flights from Buffalo to Key West
- Flights from Madison to Key West
- Flights from Sarasota to Key West
- Flights from Naples to Key West
- Flights from Little Rock to Key West
- Flights from Norfolk - Virginia Beach to Key West
- Flights from Harrisburg - Hershey to Key West
- Flights from Springfield to Key West
- Flights from Rochester to Key West
- Flights from Greensboro to Key West
- Flights from Oklahoma City to Key West
- Flights from Akron to Key West
- Flights from Dayton to Key West
- Flights from Allentown to Key West
- Flights from Knoxville to Key West
- Flights from Cedar Rapids - Iowa City to Key West
- Flights from Birmingham to Key West
- Flights from Mobile to Key West
- Flights from Huntsville to Key West
- Flights from Tampa to Key West
- Flights from Jacksonville to Key West
- Flights from Louisville to Key West
- Flights from Lexington to Key West
- Flights from Grand Rapids to Key West
- Flights from Albany to Key West
- Flights from Savannah to Key West
- Flights from Asheville to Key West
- Flights from Greenville - Spartanburg to Key West
- Flights from Gainesville to Key West
- Flights from Tallahassee to Key West
- Flights from Hagerstown to Key West
- Flights from Appleton to Key West
- Flights from Boca Raton to Key West
- Flights from Columbia to Key West
- Flights from Chattanooga to Key West
- Flights from Boston to Stock Island
- Flights from Charlotte to Stock Island
- Flights from Philadelphia to Stock Island
- Flights from Fort Lauderdale to Stock Island
- Flights from Fort Myers to Stock Island
- Flights from Huntsville to Stock Island