$338 Cheap flight deals from Knoxville (TYS) to Key West (EYW)

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Airfares from $338 One Way, $488 Round Trip from Knoxville to Key West

Prices starting at $488 for return flights and $338 for one-way flights to Key West were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Key West economy flight packages

The Grand Guesthouse
Ibis Bay Beach Resort
Pier House Resort & Spa
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Prices and availability subject to change. Additional terms may apply.

More About Flying To Key West from Knoxville

Route Information for Flights from Knoxville to Key West

Origin Airport IATA Code
TYS
Destination Airport IATA Code
EYW
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Knoxville to Key West

For the best available deals on flights from Knoxville to Key West, look no further than Orbitz. Offering the perfect packages with cutting-edge mobile tools, Orbitz is your ideal destination.

One Stop Travel Shop

Not only is Orbitz the best source for great deals on flights from Knoxville to Key West, we offer the complete package. From guaranteed low prices on hotels, car rentals and activities, simply decide what you want and Orbitz will put together the complete vacation package.

Searching Anywhere

Booking Knoxville to Key West flights is simple, wherever you are. Book on your computer and the Orbitz Display Matrix gives all your deals and discounts on flights from Knoxville to Key West, showing your great savings. Or if you are on the move, use m.orbitz.com on your mobile browser to find exclusive Knoxville to Key West flights for mobile users.

Worry-free Travel Planning

Orbitz is the best place for Knoxville to Key West flights at guaranteed low prices, we also take the stress out of your flight details. With our free alerts service you can quickly find out your gate number or flight delays via email or text – perfect if you are in a rush.

Miles Better

If you frequently travel on flights from Knoxville to Key West, it’s easy to rack up your air miles. Just add your frequent flyer number when booking your flights and we will do the rest. Orbitz will even store your number in your profile to automatically add on your miles each time you book.

Frequently asked questions

Am I able to catch a flight from Knoxville to Key West now?
If you’re agonizing over quarantine requirements and travel restrictions when catching a flight from Knoxville to Key West, check out our Covid-19 Travel Advisor.
What is the shortest flight from Knoxville to Key West?
It can be as a short and sweet as 2 hours and 36 minutes. If you’re of the opinion that your vacation hours should be spent ‘vacationing’ instead of flying, you’ll enjoy the trip from TYS to Key West Intl. Airport.
If I am not able to travel due to COVID-19, can I cancel my flight to Key West?
We get that traveling right now has its challenges, so it’s good to know that many reservations booked through us are able to be cancelled or changed. If your travel plans to Key West have been affected by COVID-19, a lot of airlines are making things easier by offering credits to use at a later date. Just sign in to your account and you’ll quickly see what options are available. Our Customer Service Portal is the place to go for more information.
Are there flights to Key West with flexible change policies?
In most cases you’ll have the option to reschedule your flight to Key West without a change fee. All you have to do then is pay the difference between the old flight and the new one. Look for the “no change fees” filter and book with confidence.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2020 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won’t keep you guessing, according to Orbitz data the cheapest month to fly is August. Perfect for those who need a weekend getaway, or just a break from it all before the weather changes. Be aware that the most expensive time to fly is the height of summer, with ticket prices peaking in the month of June.
How can I save money on flights?
To really save big on your next vacation, think outside the box. Select two different airlines or fare types for your return trip and you’ll generally get a much better deal. Those who tried this on Orbitz in 2020 saved up to 45% on their airfares. Get mixing and matching today!

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.