Cheap flights from SNA to EYW (John Wayne to Key West Intl.)

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Cheap Flights from SNA to EYW starting at $379 One Way, $526 Round Trip

Prices starting at $526 for return flights and $379 for one-way flights to Key West Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Mar 4 - Tue, Mar 9
SNA
Orange County
EYW
Key West
$526 Roundtrip, found 3 days ago
$526
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Mar 4 from Orange County to Key West, returning Tue, Mar 9, priced at $526 found 3 days ago
Thu, Mar 4 - Tue, Mar 9
SNA
Orange County
EYW
Key West
$546 Roundtrip, found 3 days ago
$546
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Mar 4 from Orange County to Key West, returning Tue, Mar 9, priced at $546 found 3 days ago
Thu, Mar 4 - Tue, Mar 9
SNA
Orange County
EYW
Key West
$604 Roundtrip, found 3 days ago
$604
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Mar 4 from Orange County to Key West, returning Tue, Mar 9, priced at $604 found 3 days ago
Fri, May 15 - Wed, May 20
SNA
Orange County
EYW
Key West
$618 Roundtrip, found 4 days ago
$618
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, May 15 from Orange County to Key West, returning Wed, May 20, priced at $618 found 4 days ago
Thu, Mar 4 - Tue, Mar 9
SNA
Orange County
EYW
Key West
$636 Roundtrip, found 3 days ago
$636
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Mar 4 from Orange County to Key West, returning Tue, Mar 9, priced at $636 found 3 days ago

Hotel Ideas near Key West Intl.

Airport Hotels near Key West Intl.

Hyatt Vacation Club at Windward Pointe, Key West

Hyatt Vacation Club at Windward Pointe, Key West

3.5 out of 5
3675 South Roosevelt Boulevard Key West FL
$407 nightly
The price is $458 total per night from Jun 1 to Jun 2
$458 total
Jun 1 - Jun 2
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, free parking, and a snack bar/deli. Our guests praise the pool and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,061 reviews)
Very helpful staff. Grounds were amazing

Reviewed on Apr 29, 2026

Hyatt Vacation Club at Windward Pointe, Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$212 nightly
The price is $238 total per night from May 31 to Jun 1
$238 total
May 31 - Jun 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,347 reviews)
Breakfast is good

Reviewed on Apr 30, 2026

Hampton Inn Key West FL
DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$201 nightly
The price is $227 total per night from May 31 to Jun 1
$227 total
May 31 - Jun 1
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,001 reviews)
Staff was helpful and friendly. Rooms were clean. Food in this area is expensive.

Reviewed on Apr 29, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Key West

Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$195 nightly
The price is $219 total per night from May 31 to Jun 1
$219 total
May 31 - Jun 1
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,160 reviews)
Loved every second of our trip! Can’t wait to come back.

Reviewed on May 1, 2026

Blue Flamingo Resort Key West
Beachside Resort & Residences

Beachside Resort & Residences

3.5 out of 5
3841 N Roosevelt Blvd Key West FL
$251 nightly
The price is $283 total per night from May 11 to May 12
$283 total
May 11 - May 12
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 2 restaurants, and a private beach. Our guests praise the pool and the helpful staff in our reviews. ...
8.6/10 Excellent! (2,191 reviews)
Elevator was broken for several days. The staff definitely helped with our luggage for checkout but the rest of the time we used the stairs. Still not so bad but the gates on the stairs did not lock properly so it gives the impression of a property that is not well maintained.

Reviewed on Apr 30, 2026

Beachside Resort & Residences
Margaritaville Beach House Key West

Margaritaville Beach House Key West

4 out of 5
2001 South Roosevelt Boulevard Key West FL
$268 nightly
The price is $302 total per night from May 26 to May 27
$302 total
May 26 - May 27
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (1,796 reviews)
Wilner was great picking us up and dropping back off at the airport. Front desk, and Stevo were great. Rooms pretty clean, but the floors were a little dirty to walk around barefoot. Free coffee each morning....I missed it except for the last day. Very good coffee. There was construction on my floor, ...

Reviewed on Apr 30, 2026

Margaritaville Beach House Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Key West Hotels With Airport Transportation

DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$201 nightly
The price is $227 total per night from May 31 to Jun 1
$227 total
May 31 - Jun 1
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,001 reviews)
Staff was helpful and friendly. Rooms were clean. Food in this area is expensive.

Reviewed on Apr 29, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$212 nightly
The price is $238 total per night from May 31 to Jun 1
$238 total
May 31 - Jun 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,347 reviews)
Breakfast is good

Reviewed on Apr 30, 2026

Hampton Inn Key West FL
Eden House

Eden House

4 out of 5
1015 Fleming St Key West FL
$227 nightly
The price is $255 total per night from May 18 to May 19
$255 total
May 18 - May 19
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, in-room massages, and a 24-hour front desk. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (1,003 reviews)
Clean room, staff were great. Only thing not to count on was the outside bar, short hours and some days not open at all, bring your own cocktails!

Reviewed on Apr 29, 2026

Eden House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Key West Hotels

Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street Key West FL
$194 nightly
The price is $218 total per night from Jun 1 to Jun 2
$218 total
Jun 1 - Jun 2
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,326 reviews)
It’s an older place but well cared for. The room was nice and big. Heated pool was quite warm. They also had one not heated. And we loved the fact they had a small outdoor bar right out front with live music. The location was great. We would stay there again

Reviewed on Apr 30, 2026

Southwinds Motel
Seashell Motel

Seashell Motel

1.5 out of 5
718 South Street Key West FL
$197 nightly
The price is $222 total per night from May 10 to May 11
$222 total
May 10 - May 11
Total with taxes and fees
Stay at this hostel in Key West. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8/10 Very Good! (1,000 reviews)
Room was clean and the bathroom was big. The door to the room has large gaps all around it allowing light, and heat. Main concern was the b

Reviewed on Apr 29, 2026

Seashell Motel
Duval House

Duval House

3 out of 5
815 Duval St Key West FL
$200 nightly
The price is $222 total per night from May 3 to May 4
$222 total
May 3 - May 4
Total with taxes and fees
Stay at this B&B in Key West. Enjoy parking (surcharge), daily housekeeping, and a garden. Our guests praise the breakfast and the pool in our reviews. Popular ...
9.4/10 Exceptional! (1,030 reviews)
Lovely property, like Florida used to be. Wonderful location and very accommodating staff.

Reviewed on Apr 30, 2026

Duval House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Key West

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$316 nightly
The price is $356 total per night from May 28 to May 29
$356 total
May 28 - May 29
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.8/10 Excellent! (3,263 reviews)
Loved the fact that there were 3 pools, 4 if you counted the little one. Text message updates with activities going on for the day. Bartenders at the bars were friendly. Big shout out to Kasey and Amy for the festivities! Vlad and Konstentine were outstanding as well! Breakfast on the beach in the ...

Reviewed on May 1, 2026

Southernmost Beach Resort and Guesthouses
Margaritaville Beach House Key West

Margaritaville Beach House Key West

4 out of 5
2001 South Roosevelt Blvd Key West FL
Book a stay at this beach hotel in Key West. Enjoy free parking, 2 restaurants, and breakfast (surcharge). Popular attractions Duval Street and Smathers Beach ...
8.4/10 Very Good! (999 reviews)

Families like: Outdoor pool, babysitting, close to beach, bicycle rentals

Travelers say...
This is a beautiful resort full of amenities! Margaritas when you arrive, smoothies at the pool each day around noon, free airport and old town shuttles so we didn’t need to Uber anywhere, also coffee/water/cookies in the lobby daily. The beach is an easy walk across the street. The hotel is super ...

Reviewed on Apr 19, 2026

Get rates
Margaritaville Beach House Key West
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$195 nightly
The price is $219 total per night from May 31 to Jun 1
$219 total
May 31 - Jun 1
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,160 reviews)

Families like: Outdoor pools, playground, miniature golf, game room

Travelers say...
Loved every second of our trip! Can’t wait to come back.

Reviewed on May 1, 2026

Blue Flamingo Resort Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

SNA to EYW Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
SNA Address & GPS
Address:
18601 Airport Way
Santa Ana CA, 92707
United States
IATA Code:
SNA
Longitude:
-117.860538
Latitude:
33.680201
Time Zone:
America/Los_Angeles
EYW Address & GPS
Address:
3491 South Roosevelt Boulevard
Key West FL, 33040-5260
United States
IATA Code:
EYW
Longitude:
-81.75501
Latitude:
24.553574
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from SNA to EYW?
As you can't fly straight from John Wayne Airport (SNA) to Key West Intl. Airport at the moment, a flight with a single stopover is your best bet. American Airlines, United Airlines and Delta Air Lines are all respected airlines that operate on this route.
What is the shortest flight from John Wayne Airport to EYW?
The shortest flight from SNA to Key West Intl. Airport (EYW) is 6 hours and 50 minutes. Pack a few things in your carry-on to keep you occupied, like a magazine or a sketch pad.
How many hours flight from John Wayne Airport (SNA) to Key West Intl. Airport (EYW)?
From John Wayne Airport to Key West Intl. Airport (EYW), you'll be cruising the skies for roughly 6 hours and 55 minutes. Get comfy, order a glass of wine and take out your noise-canceling earphones. It's time for a movie marathon.
What airlines have the most flights from John Wayne Airport to EYW?
Do some people-watching, grab a quick meal, stretch your legs … Airport stopovers don't have to be a bore! If you're planning to travel from Santa Ana to Key West, there are no direct flights. Plan to make at least one stop somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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