Unfortunately, no. You'll need to change planes if you want to travel from Charleston, SC Airport (CHS-Charleston Intl.) to Key West, FL Airport (EYW-Key West Intl.). A number of companies service this route with only one stopover, including American Airlines, Delta Air Lines and Silver Airways.
Keep that movie marathon for another day, because the trip from Charleston, SC Airport (CHS-Charleston Intl.) to Key West, FL Airport (EYW-Key West Intl.) can be as quick as 2 hours and 31 minutes.
|Origin Airport IATA Code||CHS|
|Destination Airport IATA Code||EYW|
|Direct Flight Airlines|
|Earliest Flight Arrival|
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^Savings based on all package bookings with Flight + Hotel made on Orbitz.com from January 1, 2019 to December 31, 2019 as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.