Cheap flights from FSD to EYW (Sioux Falls Regional to Key West Intl.)

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Cheap Flights from FSD to EYW starting at $369 One Way, $354 Round Trip

Prices starting at $354 for return flights and $369 for one-way flights to Key West Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Nov 26 - Tue, Dec 1
FSD
Sioux Falls
EYW
Key West
$354 Roundtrip, found 3 days ago
$354
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Nov 26 from Sioux Falls to Key West, returning Tue, Dec 1, priced at $354 found 3 days ago
Wed, May 12 - Wed, May 19
FSD
Sioux Falls
EYW
Key West
$394 Roundtrip, found 3 days ago
$394
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, May 12 from Sioux Falls to Key West, returning Wed, May 19, priced at $394 found 3 days ago
Thu, Nov 26 - Tue, Dec 1
FSD
Sioux Falls
EYW
Key West
$401 Roundtrip, found 3 days ago
$401
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Nov 26 from Sioux Falls to Key West, returning Tue, Dec 1, priced at $401 found 3 days ago
Thu, Nov 26 - Tue, Dec 1
FSD
Sioux Falls
EYW
Key West
$406 Roundtrip, found 3 days ago
$406
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Nov 26 from Sioux Falls to Key West, returning Tue, Dec 1, priced at $406 found 3 days ago
Wed, May 12 - Wed, May 19
FSD
Sioux Falls
EYW
Key West
$416 Roundtrip, found 3 days ago
$416
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, May 12 from Sioux Falls to Key West, returning Wed, May 19, priced at $416 found 3 days ago

Hotel Ideas near Key West Intl.

Airport Hotels near Key West Intl.

Hyatt Vacation Club at Windward Pointe, Key West

Hyatt Vacation Club at Windward Pointe, Key West

3.5 out of 5
3675 South Roosevelt Boulevard Key West FL
$392 nightly
The price is $441 total per night from Jul 5 to Jul 6
$441 total
Jul 5 - Jul 6
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, free parking, and a snack bar/deli. Our guests praise the pool and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,159 reviews)
"Very enjoyable and relaxing, would definitely go back"

Reviewed on Jun 29, 2026

Hyatt Vacation Club at Windward Pointe, Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$206 nightly
The price is $232 total per night from Jul 12 to Jul 13
$232 total
Jul 12 - Jul 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,407 reviews)
"Beautiful property minutes from everything. Convenient shuttle and a relaxing pool made the days seamless."

Reviewed on Jun 28, 2026

Hampton Inn Key West FL
DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$169 nightly
The price is $190 total per night from Jul 5 to Jul 6
$190 total
Jul 5 - Jul 6
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,045 reviews)
"We loved staying in New Town and enjoyed the shuttle service back and forth to Old Town"

Reviewed on Jun 26, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Key West

Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$175 nightly
The price is $197 total per night from Jun 30 to Jul 1
$197 total
Jun 30 - Jul 1
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,464 reviews)
"Everything was great! Fun clean property!! Delicious big portioned food! Didn’t love the $50 per day to use the amenities…"

Reviewed on Jun 28, 2026

Blue Flamingo Resort Key West
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$254 nightly
The price is $286 total per night from Jul 6 to Jul 7
$286 total
Jul 6 - Jul 7
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.8/10 Excellent! (3,408 reviews)
"Love the daily activity texts. Ordered the filet at Beachside cafe on the property because I received a $30 food voucher. Cooked to perfection and delicious. Location was great! Ana’s cafe was few steps from the resort and had great brunch! Will be staying if I ever come back to Key West."

Reviewed on Jun 29, 2026

Southernmost Beach Resort and Guesthouses
Hilton Garden Inn Key West / The Keys Collection

Hilton Garden Inn Key West / The Keys Collection

3.5 out of 5
3850 N Roosevelt Blvd Key West FL
$140 nightly
The price is $157 total per night from Jul 5 to Jul 6
$157 total
Jul 5 - Jul 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy 2 restaurants, breakfast (surcharge), and a free area shuttle. Our guests praise the pool and ...
8/10 Very Good! (1,252 reviews)
"We loved the stay! The hotel is great , there was a musician playing at the pool, which was very nice. They offer transportation to the center of the city, which was very convenient"

Reviewed on Jun 29, 2026

Hilton Garden Inn Key West / The Keys Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Key West Hotels With Airport Transportation

DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$169 nightly
The price is $190 total per night from Jul 5 to Jul 6
$190 total
Jul 5 - Jul 6
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,045 reviews)
"We loved staying in New Town and enjoyed the shuttle service back and forth to Old Town"

Reviewed on Jun 26, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$206 nightly
The price is $232 total per night from Jul 12 to Jul 13
$232 total
Jul 12 - Jul 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,407 reviews)
"Beautiful property minutes from everything. Convenient shuttle and a relaxing pool made the days seamless."

Reviewed on Jun 28, 2026

Hampton Inn Key West FL
Eden House

Eden House

4 out of 5
1015 Fleming St Key West FL
$159 nightly
The price is $179 total per night from Jun 30 to Jul 1
$179 total
Jun 30 - Jul 1
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, in-room massages, and a 24-hour front desk. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (1,007 reviews)
"Gemma was so helpful!! We loved staying at Eden House and will definitely be back."

Reviewed on Jun 28, 2026

Eden House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Key West Hotels

Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street Key West FL
$175 nightly
The price is $196 total per night from Jun 30 to Jul 1
$196 total
Jun 30 - Jul 1
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,347 reviews)
"Great, fun place to stay in Key West! Staff was amazing, the bar with live music was a plus!!! Very clean and cozy property."

Reviewed on Jun 28, 2026

Southwinds Motel
Seashell Motel

Seashell Motel

1.5 out of 5
718 South Street Key West FL
$131 nightly
The price is $147 total per night from Jun 30 to Jul 1
$147 total
Jun 30 - Jul 1
Total with taxes and fees
Stay at this hostel in Key West. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8/10 Very Good! (1,000 reviews)
"Loved the close proximity to walk to the popular Duvall street for shopping and dining. The bathroom was huge!! Upgraded bathroom fixtures and tile. Great water pressure. Adjustable temperature A/C unit which was cold that I chose to turn up. Comfortable plush mattress, though the bed squeaked a ..."

Reviewed on Jun 8, 2026

Seashell Motel
Duval House

Duval House

3 out of 5
815 Duval St Key West FL
$116 nightly
The price is $128 total per night from Jul 1 to Jul 2
$128 total
Jul 1 - Jul 2
Total with taxes and fees
Stay at this B&B in Key West. Enjoy parking (surcharge), daily housekeeping, and a garden. Our guests praise the breakfast and the pool in our reviews. Popular ...
9.4/10 Exceptional! (1,044 reviews)
"Heather was awesome, alongside all the other staff"

Reviewed on Jun 27, 2026

Duval House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Key West

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$254 nightly
The price is $286 total per night from Jul 6 to Jul 7
$286 total
Jul 6 - Jul 7
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.8/10 Excellent! (3,408 reviews)
"Love the daily activity texts. Ordered the filet at Beachside cafe on the property because I received a $30 food voucher. Cooked to perfection and delicious. Location was great! Ana’s cafe was few steps from the resort and had great brunch! Will be staying if I ever come back to Key West."

Reviewed on Jun 29, 2026

Southernmost Beach Resort and Guesthouses
Margaritaville Beach House Key West

Margaritaville Beach House Key West

4 out of 5
2001 South Roosevelt Blvd Key West FL
Book a stay at this beach hotel in Key West. Enjoy free parking, 2 restaurants, and breakfast (surcharge). Popular attractions Southernmost Point and Duval Street ...
8.4/10 Very Good! (999 reviews)

Families like: Outdoor pool, babysitting, close to beach, bicycle rentals

Travelers say...
"This is a beautiful resort full of amenities! Margaritas when you arrive, smoothies at the pool each day around noon, free airport and old town shuttles so we didn’t need to Uber anywhere, also coffee/water/cookies in the lobby daily. The beach is an easy walk across the street. The hotel is super ..."

Reviewed on Apr 19, 2026

Get rates
Margaritaville Beach House Key West
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$175 nightly
The price is $197 total per night from Jun 30 to Jul 1
$197 total
Jun 30 - Jul 1
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,464 reviews)

Families like: Outdoor pools, playground, miniature golf, game room

Travelers say...
"Everything was great! Fun clean property!! Delicious big portioned food! Didn’t love the $50 per day to use the amenities…"

Reviewed on Jun 28, 2026

Blue Flamingo Resort Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

FSD to EYW Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
FSD Address & GPS
Address:
2801 Jaycee Lane
Sioux Falls SD, 57104
United States
IATA Code:
FSD
Longitude:
-96.741849
Latitude:
43.58201
Time Zone:
America/Chicago
EYW Address & GPS
Address:
3491 South Roosevelt Boulevard
Key West FL, 33040-5260
United States
IATA Code:
EYW
Longitude:
-81.75501
Latitude:
24.553574
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from Joe Foss Field to EYW?
There are no direct flights on this route. But American Airlines, Delta Air Lines and Qatar Airways will fly you from Joe Foss Field to Key West Intl. Airport (EYW) with just one stopover.
What is the shortest flight from Joe Foss Field to EYW?
From Sioux Falls, the thrilling sights and sounds of Key West are around 4 hours and 58 minutes away. Choose your favorite seat, or perhaps even upgrade to one with more legroom, and fly to your destination in comfort.
How many hours flight from Joe Foss Field to Key West Intl. Airport?
On a normal day, the trip from Joe Foss Field to Key West Intl. Airport (EYW) takes 5 hours and 3 minutes. If you're eager to be as comfortable as possible, consider upgrading your seat using miles or cash.
What airlines have the most flights from Joe Foss Field to Key West Intl. Airport?
If you're hoping to book with an airline that advertises direct flights from Sioux Falls Regional Airport (FSD) to Key West Intl. Airport, it's not going to happen. You'll need to book a flight with at least one stopover to get to your destination.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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