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This Weekend's Flight Deals to Key West

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fares from $168 One Way, $264 Round Trip from Des Moines to Key West

Prices starting at $264 for return flights and $168 for one-way flights to Key West were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

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More About Flying To Key West from Des Moines

Route Information for Flights from Des Moines to Key West

Origin Airport IATA CodeDSM
Destination Airport IATA CodeEYW
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Des Moines to Key West

When you’re searching for Des Moines to Key West flights for your family vacation, check out the guaranteed low prices at Orbitz. If you are looking for the best prices on hotels too, you’ll be sure to find great deals to suit your budget. You’ll also benefit from the following features:

Suitable Schedules

Orbitz simplifies the process of finding and booking budget flights from Des Moines to Key West. Since we monitor hundreds of flight fares, you can compare several flights from a range of different airlines to find the best fares and most suitable departure and arrival times. Mix and match your departure and return flight for even more discounts and travel flexibility.

Mobile Apps

Taking a lunch break or waiting to pick up the kids? Orbitz’s cutting-edge mobile tools will help you search for cheap Des Moines to Key West flights anywhere you are. Get exclusive mobile deals on flights, hotels, vacation packages, and cruises too.

Flight Alerts

Orbitz won’t leave you wondering whether your flight will take off on time. We can send you free alerts about your flights from Des Moines to Key West to your mobile phone and email. Whether your flights from Des Moines to Key West are running just a few minutes to a few hours late, we will let you know.

Miles and Points

If you travel regularly, you can still earn miles and points when you book qualifying Des Moines to Key West flights. Enter your frequent flyer number with your reservation to see the miles rack up.

Flights from Des Moines to Key West - Frequently Asked Questions

Are there non-stop flights from Des Moines to Key West?

While you can't fly direct from Des Moines, IA (DSM-Des Moines Intl.) to Key West, FL (EYW-Key West Intl.), there are several carriers that service this route with just a single stopover. Why not find out if American Airlines or Delta Air Lines have flights that suit your travel plans? If they don't, try KLM.

What is the shortest flight from Des Moines to Key West?

From Des Moines, the wonderful sights and sounds of Key West are at least 3 hours and 49 minutes away. Book your favorite seat, or perhaps even one with a little more legroom, and fly to your destination in comfort.

If I am not able to travel due to COVID-19, can I cancel my flight to Key West?

We get that traveling right now has its challenges, so it's good to know that many reservations booked through us are able to be cancelled or changed. If your travel plans to Key West have been affected by COVID-19, a lot of airlines are making things easier by offering credits to use at a later date. Just sign in to your account and you'll quickly see what options are available. Our Customer Service Portal is the place to go for more information.

Are there flights to Key West with flexible change policies?

In most cases you'll have the option to reschedule your flight to Key West without a change fee. All you have to do then is pay the difference between the old flight and the new one. Look for the "no change fees" filter and book with confidence.

What is the cheapest day of the week to fly?

Consider flying out early in the week to save on your airfare. Orbitz data from 2019 shows that Tuesday is the cheapest day to depart, followed by Monday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.

What is the cheapest month to fly?

We won't keep you guessing, according to Orbitz data the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a fresh start to the new year. Be aware that the most expensive time to fly isn't the height of summer, as most people assume, but the festive month of December.

How can I save money on flights?

To really save big on your next vacation, think outside the box. Select two different airlines or fare types for your return trip and you'll generally get a much better deal. Those who tried this on Orbitz in 2019 saved over 50% on their airfares. Get mixing and matching today!

*According to flight demand on Orbitz.com from January to December 2019. Savings are subject to change based on departure location, date and destination.

^Savings based on all package bookings with Flight + Hotel made on Orbitz.com from January 1, 2019 to December 31, 2019 as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.