Cheap flights from SDF to EYW (Louisville Intl. to Key West Intl.)

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Cheap Flights from SDF to EYW starting at $325 One Way, $349 Round Trip

Prices starting at $349 for return flights and $325 for one-way flights to Key West Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Jul 11 - Wed, Jul 21
SDF
Louisville
EYW
Key West
$349 Roundtrip, found 6 days ago
$349
Roundtrip
found 6 days ago
Select United flight, departing Sun, Jul 11 from Louisville to Key West, returning Wed, Jul 21, priced at $349 found 6 days ago
Sun, Jul 11 - Wed, Jul 21
SDF
Louisville
EYW
Key West
$358 Roundtrip, found 6 days ago
$358
Roundtrip
found 6 days ago
Select Delta flight, departing Sun, Jul 11 from Louisville to Key West, returning Wed, Jul 21, priced at $358 found 6 days ago
Tue, Jan 5 - Sat, Jan 9
SDF
Louisville
EYW
Key West
$406 Roundtrip, found 6 days ago
$406
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Jan 5 from Louisville to Key West, returning Sat, Jan 9, priced at $406 found 6 days ago
Sun, Jul 11 - Wed, Jul 21
SDF
Louisville
EYW
Key West
$416 Roundtrip, found 6 days ago
$416
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Jul 11 from Louisville to Key West, returning Wed, Jul 21, priced at $416 found 6 days ago
Thu, Nov 19 - Mon, Nov 23
SDF
Louisville
EYW
Key West
$427 Roundtrip, found 1 day ago
$427
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Nov 19 from Louisville to Key West, returning Mon, Nov 23, priced at $427 found 1 day ago

Hotel Ideas near Key West Intl.

Airport Hotels near Key West Intl.

Hyatt Vacation Club at Windward Pointe, Key West

Hyatt Vacation Club at Windward Pointe, Key West

3.5 out of 5
3675 South Roosevelt Boulevard Key West FL
$295 nightly
The price is $332 total per night from Oct 27 to Oct 28
$332 total
Oct 27 - Oct 28
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, free parking, and a snack bar/deli. Our guests praise the pool and the helpful staff in our reviews. Popular ...
Hyatt Vacation Club at Windward Pointe, Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$166 nightly
The price is $186 total per night from Oct 7 to Oct 8
$186 total
Oct 7 - Oct 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,539 reviews)
"Great experience even with the rain. Great place to stay."

Reviewed on Oct 2, 2026

Hampton Inn Key West FL
DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$153 nightly
The price is $172 total per night from Oct 11 to Oct 12
$172 total
Oct 11 - Oct 12
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,111 reviews)
"Great shuttle service"

Reviewed on Oct 2, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Key West

Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$168 nightly
The price is $189 total per night from Oct 4 to Oct 5
$189 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
Blue Flamingo Resort Key West
Margaritaville Beach House Key West

Margaritaville Beach House Key West

4 out of 5
2001 South Roosevelt Blvd Key West FL
$265 nightly
The price is $298 total per night from Oct 4 to Oct 5
$298 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy breakfast (surcharge), a free airport shuttle, and room service. Our guests praise the pool and the restaurant ...
Margaritaville Beach House Key West
Havana Cabana at Key West

Havana Cabana at Key West

4 out of 5
3420 N. Roosevelt Blvd Key West FL
$182 nightly
The price is $205 total per night from Nov 1 to Nov 2
$205 total
Nov 1 - Nov 2
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the pool and the helpful ...
Havana Cabana at Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Key West Hotels With Airport Transportation

DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$153 nightly
The price is $172 total per night from Oct 11 to Oct 12
$172 total
Oct 11 - Oct 12
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,111 reviews)
"Great shuttle service"

Reviewed on Oct 2, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$166 nightly
The price is $186 total per night from Oct 7 to Oct 8
$186 total
Oct 7 - Oct 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,539 reviews)
"Great experience even with the rain. Great place to stay."

Reviewed on Oct 2, 2026

Hampton Inn Key West FL
Eden House

Eden House

4 out of 5
1015 Fleming St Key West FL
$192 nightly
The price is $216 total per night from Oct 6 to Oct 7
$216 total
Oct 6 - Oct 7
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, in-room massages, and a 24-hour front desk. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (1,002 reviews)
"Great stay with friendly staff"

Reviewed on Oct 2, 2026

Eden House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Key West Hotels

Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street Key West FL
$169 nightly
The price is $190 total per night from Oct 5 to Oct 6
$190 total
Oct 5 - Oct 6
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,393 reviews)
"Clean room, nice pool, nice staff. Good little Cuban restaurant and grocery store across the street. Loved it."

Reviewed on Oct 1, 2026

Southwinds Motel
Seashell Motel

Seashell Motel

1.5 out of 5
718 South Street Key West FL
$101 nightly
The price is $114 total per night from Oct 4 to Oct 5
$114 total
Oct 4 - Oct 5
Total with taxes and fees
Stay at this hostel in Key West. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8/10 Very Good! (1,000 reviews)
"Pool was not accessible, disappointing 😑 😒"

Reviewed on Sep 30, 2026

Seashell Motel
Duval House

Duval House

3 out of 5
815 Duval St Key West FL
$111 nightly
The price is $122 total per night from Oct 5 to Oct 6
$122 total
Oct 5 - Oct 6
Total with taxes and fees
Stay at this B&B in Key West. Enjoy parking (surcharge), daily housekeeping, and a garden. Our guests praise the breakfast and the pool in our reviews. Popular ...
Duval House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Key West

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$243 nightly
The price is $274 total per night from Oct 11 to Oct 12
$274 total
Oct 11 - Oct 12
Total with taxes and fees
Book a stay at this spa hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
Southernmost Beach Resort and Guesthouses
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$168 nightly
The price is $189 total per night from Oct 4 to Oct 5
$189 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
Blue Flamingo Resort Key West
Hilton Key West Resort & Marina

Hilton Key West Resort & Marina

4 out of 5
5950 Peninsular Avenue Key West FL
$178 nightly
The price is $201 total per night from Oct 12 to Oct 13
$201 total
Oct 12 - Oct 13
Total with taxes and fees
Book a stay at this luxury hotel in Key West. Enjoy free WiFi, 6 outdoor pools, and a marina. Our guests praise the pool and the restaurant in our reviews. Popular ...
9/10 Wonderful! (1,800 reviews)
"The location was good. Our room had a great view of the water. The shower had lots of water pressure which was nice. The air conditioning was not good. We could not contol temperature, our room was too warm. I did not like the coffee maker in a drawer. The staff forgot to replish the coffee, etc. ..."

Reviewed on Sep 29, 2026

Hilton Key West Resort & Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

SDF to EYW Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
SDF Address & GPS
Address:
600 Terminal Drive
Louisville KY, 40209
United States
IATA Code:
SDF
Longitude:
-85.73599
Latitude:
38.174397
Time Zone:
America/New_York
EYW Address & GPS
Address:
3491 South Roosevelt Boulevard
Key West FL, 33040-5260
United States
IATA Code:
EYW
Longitude:
-81.75501
Latitude:
24.553574
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from SDF to Key West Intl. Airport (EYW)?
Flying from Louisville Muhammad Ali Intl. Airport to Key West Intl. Airport (EYW) means you'll have to switch planes. But hey — there's no need to worry. American Airlines, United Airlines and Delta Air Lines offer flights with only one simple stopover.
What is the shortest flight from SDF to EYW?
The quickest flight from Louisville to Key West is 5 hours and 4 minutes. Grab a refreshment from the drink cart, hone your travel itinerary or get to know your seat mate — you'll have plenty of time on this medium-haul journey.
How many hours flight from Louisville Muhammad Ali Intl. Airport to EYW?
Make yourself comfortable, because a typical plane ride from Louisville Muhammad Ali Intl. Airport to Key West Intl. Airport (EYW) is 5 hours and 7 minutes. Watch a few movies, stick your nose in a book ... There's plenty of time to sit back and enjoy the ride.
What airlines have the most flights from Louisville Intl. Airport (SDF) to EYW?
At the moment, no airlines operate direct flights between Louisville Muhammad Ali Intl. Airport and Key West Intl. Airport (EYW). But don't panic! There are several single or multi-stop options available.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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