$112 Cheap flight deals from St. Louis (STL) to Key West (EYW)

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This Weekend's Flight Deals from St. Louis to Key West

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Jul 4 - Tue, Jul 8
STL
Lambert-St. Louis Intl.
EYW
Key West Intl.
$273 Roundtrip, found 19 hours ago
$273
Roundtrip
found 19 hours ago
Select Delta flight, departing Fri, Jul 4 from Lambert-St. Louis Intl. to Key West Intl., returning Tue, Jul 8, priced at $273 found 19 hours ago

Airfares from $112 One Way, $223 Round Trip from St. Louis to Key West

Prices starting at $223 for return flights and $112 for one-way flights to Key West were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Oct 1 - Tue, Oct 7
STL
St. Louis
EYW
Key West
$223 Roundtrip, found 20 hours ago
$223
Roundtrip
found 20 hours ago
Select Delta flight, departing Wed, Oct 1 from St. Louis to Key West, returning Tue, Oct 7, priced at $223 found 20 hours ago
Sat, Jan 10 - Tue, Jan 13
STL
St. Louis
EYW
Key West
$223 Roundtrip, found 5 days ago
$223
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sat, Jan 10 from St. Louis to Key West, returning Tue, Jan 13, priced at $223 found 5 days ago
Wed, Oct 1 - Tue, Oct 7
STL
St. Louis
EYW
Key West
$226 Roundtrip, found 20 hours ago
$226
Roundtrip
found 20 hours ago
Select Delta flight, departing Wed, Oct 1 from St. Louis to Key West, returning Tue, Oct 7, priced at $226 found 20 hours ago
Sat, Oct 11 - Tue, Oct 14
STL
St. Louis
EYW
Key West
$228 Roundtrip, found 5 days ago
$228
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sat, Oct 11 from St. Louis to Key West, returning Tue, Oct 14, priced at $228 found 5 days ago
Sun, Aug 31 - Sat, Sep 6
STL
St. Louis
EYW
Key West
$230 Roundtrip, found 2 days ago
$230
Roundtrip
found 2 days ago
Select Delta flight, departing Sun, Aug 31 from St. Louis to Key West, returning Sat, Sep 6, priced at $230 found 2 days ago

Key West economy flight packages

Price found within the past 48 hours. Click for updated prices.
Oceans Edge Key West Resort, Hotel & Marina
4.0-star property

Oceans Edge Key West Resort, Hotel & Marina

8.8/10 Excellent! (1,669 reviews)

Aug 13 - Aug 16

3 night stay

St. Louis (STL) to Key West (EYW)

American Airlines • Roundtrip • Coach
per person
found 1 day ago
Beauty Property. Excellent Staff

Reviewed on Dec 14, 2024

Almond Tree Inn Hotel - Adults Only
3.5-star property

Almond Tree Inn Hotel - Adults Only

10/10 Exceptional! (1,002 reviews)

Jul 30 - Aug 3

4 night stay

St. Louis (STL) to Key West (EYW)

American Airlines • Non-stop roundtrip • Coach
Save 100% on your flight
per person
found 1 day ago
As always, Almond Tree Inn was a bright spot in our latest trip to Key West. I’ve stayed here several times over the years and everything about Almond Tree is top notch, from the superbly attentive and friendly staff to the well-appointed and maintained property. You always feel special staying here and this trip was no exception. As Florida locals, we look forward to our stays with you each and every time- THANK YOU!

Reviewed on May 26, 2025

Southernmost Beach Resort and Guesthouses
4.0-star property

Southernmost Beach Resort and Guesthouses

8.6/10 Excellent! (2,555 reviews)

Aug 13 - Aug 16

3 night stay

St. Louis (STL) to Key West (EYW)

American Airlines • Roundtrip • Coach
per person
found 1 day ago
Expansive resort and great location on the southern end. Clean with pleasant and helpful staff.

Reviewed on Jun 16, 2025

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Key West packages with premium economy flights

Price found within the past 48 hours. Click for updated prices.
Oceans Edge Key West Resort, Hotel & Marina
4.0-star property

Oceans Edge Key West Resort, Hotel & Marina

8.8/10 Excellent! (1,669 reviews)

Aug 5 - Aug 9

4 night stay

St. Louis (STL) to Key West (EYW)

Delta • Non-stop roundtrip • PremiumEconomy
per person
found 15 hours ago
Beauty Property. Excellent Staff

Reviewed on Dec 14, 2024

Almond Tree Inn Hotel - Adults Only
3.5-star property

Almond Tree Inn Hotel - Adults Only

10/10 Exceptional! (1,002 reviews)

Aug 5 - Aug 9

4 night stay

St. Louis (STL) to Key West (EYW)

Delta • Non-stop roundtrip • PremiumEconomy
per person
found 15 hours ago
As always, Almond Tree Inn was a bright spot in our latest trip to Key West. I’ve stayed here several times over the years and everything about Almond Tree is top notch, from the superbly attentive and friendly staff to the well-appointed and maintained property. You always feel special staying here and this trip was no exception. As Florida locals, we look forward to our stays with you each and every time- THANK YOU!

Reviewed on May 26, 2025

The Perry Hotel & Marina Key West
4.0-star property

The Perry Hotel & Marina Key West

9.4/10 Exceptional! (1,009 reviews)

Aug 5 - Aug 9

4 night stay

St. Louis (STL) to Key West (EYW)

Delta • Non-stop roundtrip • PremiumEconomy
per person
found 15 hours ago
Excellent facility. The on site personnel were fabulous and the shuttle service is more than adequate.

Reviewed on Jan 5, 2025

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Key West first class flight packages

Price found within the past 48 hours. Click for updated prices.
Beachside Resort & Residences
3.5-star property

Beachside Resort & Residences

8.6/10 Excellent! (1,201 reviews)

Aug 5 - Aug 9

4 night stay

St. Louis (STL) to Key West (EYW)

American Airlines • Non-stop roundtrip • FirstClass
per person
found 15 hours ago
Staff unreal. Angel I think but ( manager / gm ). And Bob at bar made our stay unbelievable. Thank you. This place is great. Shuttle for free makes it a no brainer

Reviewed on Apr 23, 2025

Southernmost Beach Resort and Guesthouses
4.0-star property

Southernmost Beach Resort and Guesthouses

8.6/10 Excellent! (2,555 reviews)

Aug 5 - Aug 9

4 night stay

St. Louis (STL) to Key West (EYW)

American Airlines • Non-stop roundtrip • FirstClass
per person
found 15 hours ago
Expansive resort and great location on the southern end. Clean with pleasant and helpful staff.

Reviewed on Jun 16, 2025

The Porch on Frances Inn
4.5-star property

The Porch on Frances Inn

9.6/10 Exceptional! (91 reviews)

Aug 5 - Aug 9

4 night stay

St. Louis (STL) to Key West (EYW)

American Airlines • Non-stop roundtrip • FirstClass
per person
found 15 hours ago
The Porch was an absolute amazing stay! We loved our stay and hope to be back again! The staff contacted us frequently and helped us set up tours. We could not have asked for a better experience!

Reviewed on Aug 7, 2024

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More About Flying To Key West from St. Louis

Route Information for Flights from St. Louis to Key West

Origin Airport IATA Code
STL
Destination Airport IATA Code
EYW
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

St. Louis to Key West

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Frequently asked questions

Am I able to catch a flight from St. Louis to Key West now?
Our Covid-19 Travel Advisor can answer all your questions about current quarantine requirements and travel restrictions when taking a flight from St. Louis to Key West.
What is the shortest flight from St. Louis to Key West?
From St. Louis, the distinctive sights and sounds of Key West are at least 3 hours and 16 minutes away. Book your favorite seat, or perhaps even upgrade to one with extra legroom, and get to your destination in comfort.
If I am not able to travel due to COVID-19, can I cancel my flight to Key West?
We get that traveling right now has its challenges, so it's good to know that many reservations booked through us are able to be cancelled or changed. If your travel plans to Key West have been affected by COVID-19, a lot of airlines are making things easier by offering credits to use at a later date. Just sign in to your account and you'll quickly see what options are available. Our Customer Service Portal is the place to go for more information.
Are there flights to Key West with flexible change policies?
In most cases you'll have the option to reschedule your flight to Key West without a change fee. All you have to do then is pay the difference between the old flight and the new one. Look for the "no change fees" filter and book with confidence.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2020 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data the cheapest month to fly is August. Perfect for those who need a weekend getaway, or just a break from it all before the weather changes. Be aware that the most expensive time to fly is the height of summer, with ticket prices peaking in the month of June.
How can I save money on flights?
To really save big on your next vacation, think outside the box. Select two different airlines or fare types for your return trip and you'll generally get a much better deal. Those who tried this on Orbitz in 2020 saved up to 45% on their airfares. Get mixing and matching today!

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.