$173 Cheap flight deals from St. Louis (STL) to Key West (EYW)

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This Weekend's Flight Deals from St. Louis to Key West

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Apr 28 - Mon, Apr 29
STL
Lambert-St. Louis Intl.
EYW
Key West Intl.
$1,065 Roundtrip, found 1 day ago
$1,065
Roundtrip
found 1 day ago
Select United flight, departing Sun, Apr 28 from Lambert-St. Louis Intl. to Key West Intl., returning Mon, Apr 29, priced at $1,065 found 1 day ago

Airfares from $173 One Way, $238 Round Trip from St. Louis to Key West

Prices starting at $238 for return flights and $173 for one-way flights to Key West were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, May 26 - Thu, May 30
STL
St. Louis
EYW
Key West
$238 Roundtrip, found 3 days ago
$238
Roundtrip
found 3 days ago
Select Delta flight, departing Sun, May 26 from St. Louis to Key West, returning Thu, May 30, priced at $238 found 3 days ago
Tue, May 21 - Thu, May 30
STL
St. Louis
EYW
Key West
$337 Roundtrip, found 3 days ago
$337
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, May 21 from St. Louis to Key West, returning Thu, May 30, priced at $337 found 3 days ago
Sat, May 25 - Wed, May 29
STL
St. Louis
EYW
Key West
$340 Roundtrip, found 6 days ago
$340
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, May 25 from St. Louis to Key West, returning Wed, May 29, priced at $340 found 6 days ago
Sat, May 25 - Wed, May 29
STL
St. Louis
EYW
Key West
$342 Roundtrip, found 6 days ago
$342
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, May 25 from St. Louis to Key West, returning Wed, May 29, priced at $342 found 6 days ago
Wed, May 22 - Thu, May 30
STL
St. Louis
EYW
Key West
$353 Roundtrip, found 3 days ago
$353
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, May 22 from St. Louis to Key West, returning Thu, May 30, priced at $353 found 3 days ago

Key West economy flight packages

Prices and availability subject to change. Additional terms may apply.
Pier House Resort & Spa
4.0-star property

Pier House Resort & Spa

8.8/10 Excellent! (1,003 reviews)

Jun 17 - Jun 22

5 night stay

St. Louis (STL) to Key West (EYW)

American Airlines • Non-stop roundtrip • Coach
Save 100% on your flight
per person
Great stay! So close to everything but set back and quiet on the property

Reviewed on Apr 9, 2024

Oceans Edge Key West Resort, Hotel & Marina
4.0-star property

Oceans Edge Key West Resort, Hotel & Marina

8.8/10 Excellent! (1,551 reviews)

Jun 17 - Jun 22

5 night stay

St. Louis (STL) to Key West (EYW)

American Airlines • Non-stop roundtrip • Coach
per person
What an amazing spot, the staff go out of there way to make your stay A stay. We will be going back for the 4th next spring.

Reviewed on Apr 9, 2024

Orchid Key Inn - Adults Only
3.5-star property

Orchid Key Inn - Adults Only

9.8/10 Exceptional! (1,000 reviews)

Jun 17 - Jun 22

5 night stay

St. Louis (STL) to Key West (EYW)

American Airlines • Non-stop roundtrip • Coach
per person
Very cute and close to everything. Great place to have a scooter to park and get in and out easy. Great bar and staff. They make a strong drink.

Reviewed on Jun 23, 2023

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More About Flying To Key West from St. Louis

Route Information for Flights from St. Louis to Key West

Origin Airport IATA Code
STL
Destination Airport IATA Code
EYW
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

St. Louis to Key West

If you are looking to find the best deals on St. Louis to Key West flights, look no further than Orbitz. Orbitz offers guaranteed low prices as well as cutting-edge mobile tools to help you book cheap flights from St. Louis to Key West.

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Stay Informed While You Travel

Orbitz keeps you updated on information that’s relevant to your flights from St. Louis to Key West. We can send you and six of your personal contacts free travel alerts via SMS text, voicemail, or email, so you instantly know about flight delays or changes.

Keep More Money in Your Pocket With Discount Flights

Orbitz looks for the best deals on St. Louis to Key West flights for you. Mix and match airlines for your departing and return flights to fit your travel schedule and budget.

Frequently asked questions

Am I able to catch a flight from St. Louis to Key West now?
Our Covid-19 Travel Advisor can answer all your questions about current quarantine requirements and travel restrictions when taking a flight from St. Louis to Key West.
What is the shortest flight from St. Louis to Key West?
From St. Louis, the distinctive sights and sounds of Key West are at least 3 hours and 16 minutes away. Book your favorite seat, or perhaps even upgrade to one with extra legroom, and get to your destination in comfort.
If I am not able to travel due to COVID-19, can I cancel my flight to Key West?
We get that traveling right now has its challenges, so it’s good to know that many reservations booked through us are able to be cancelled or changed. If your travel plans to Key West have been affected by COVID-19, a lot of airlines are making things easier by offering credits to use at a later date. Just sign in to your account and you’ll quickly see what options are available. Our Customer Service Portal is the place to go for more information.
Are there flights to Key West with flexible change policies?
In most cases you’ll have the option to reschedule your flight to Key West without a change fee. All you have to do then is pay the difference between the old flight and the new one. Look for the “no change fees” filter and book with confidence.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2020 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won’t keep you guessing, according to Orbitz data the cheapest month to fly is August. Perfect for those who need a weekend getaway, or just a break from it all before the weather changes. Be aware that the most expensive time to fly is the height of summer, with ticket prices peaking in the month of June.
How can I save money on flights?
To really save big on your next vacation, think outside the box. Select two different airlines or fare types for your return trip and you’ll generally get a much better deal. Those who tried this on Orbitz in 2020 saved up to 45% on their airfares. Get mixing and matching today!

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.