$112 Cheap flight deals from St. Louis (STL) to Key West (EYW)
Airfares from $112 One Way, $223 Round Trip from St. Louis to Key West
Prices starting at $223 for return flights and $112 for one-way flights to Key West were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
STL
St. Louis
EYW
Key West
$223 Roundtrip, found 1 day ago
$223
Roundtrip
found 1 day ago
STL
St. Louis
EYW
Key West
$223 Roundtrip, found 3 days ago
$223
Roundtrip
found 3 days ago
STL
St. Louis
EYW
Key West
$226 Roundtrip, found 2 days ago
$226
Roundtrip
found 2 days ago
STL
St. Louis
EYW
Key West
$227 Roundtrip, found 2 days ago
$227
Roundtrip
found 2 days ago
STL
St. Louis
EYW
Key West
$241 Roundtrip, found 1 day ago
$241
Roundtrip
found 1 day ago
Key West economy flight packages
Price found within the past 48 hours. Click for updated prices.
3.5-star property
Lighthouse Hotel - Key West Historic Inns
9/10 Wonderful! (768 reviews)
Oct 2 - Oct 6
4 night stay
St. Louis (STL) to Key West (EYW)
Delta • Non-stop • Coach
Key West (EYW) to St. Louis (STL)
American Airlines • Non-stop • Coach
per person
found 1 day ago
This place is a much better place to stay than places closer to the cruise ship pier or off or whitehead or duval
Reviewed on Sep 22, 2024
4.0-star property
Pier House Resort & Spa
9/10 Wonderful! (1,014 reviews)
Sep 19 - Sep 24
5 night stay
St. Louis (STL) to Key West (EYW)
Delta • Non-stop roundtrip • Coach
Save 100% on your flight
per person
found 1 day ago
This is a wonderful resort in Key West that has great amenities and located on Duval Street! Highly recommend.
Reviewed on Jun 24, 2025
4.0-star property
Southernmost Beach Resort and Guesthouses
8.6/10 Excellent! (2,662 reviews)
Oct 2 - Oct 6
4 night stay
St. Louis (STL) to Key West (EYW)
Delta • Non-stop • Coach
Key West (EYW) to St. Louis (STL)
American Airlines • Non-stop • Coach
per person
found 1 day ago
We visited in July and were able to upgrade to an oceanfront room with a balcony. If you get the chance, it’s worth it! Pools are beautiful and food and drinks are offered poolside. The view was incredible! The staff were all incredibly accommodating and friendly!! We can’t wait to come back!!
Reviewed on Aug 1, 2025
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