Cheap flights from SNA to EYW (John Wayne to Key West Intl.)

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Cheap Flights from SNA to EYW starting at $443 One Way, $508 Round Trip

Prices starting at $508 for return flights and $443 for one-way flights to Key West Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Nov 17 - Tue, Nov 24
SNA
Orange County
EYW
Key West
$508 Roundtrip, found 3 days ago
$508
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Nov 17 from Orange County to Key West, returning Tue, Nov 24, priced at $508 found 3 days ago
Tue, Nov 17 - Tue, Nov 24
SNA
Orange County
EYW
Key West
$576 Roundtrip, found 3 days ago
$576
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Nov 17 from Orange County to Key West, returning Tue, Nov 24, priced at $576 found 3 days ago
Tue, Nov 17 - Tue, Nov 24
SNA
Orange County
EYW
Key West
$618 Roundtrip, found 3 days ago
$618
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Nov 17 from Orange County to Key West, returning Tue, Nov 24, priced at $618 found 3 days ago
Mon, Oct 26 - Mon, Nov 23
SNA
Orange County
EYW
Key West
$648 Roundtrip, found 3 days ago
$648
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Oct 26 from Orange County to Key West, returning Mon, Nov 23, priced at $648 found 3 days ago
Thu, Oct 1 - Tue, Feb 2
SNA
Orange County
EYW
Key West
$666 Roundtrip, found 1 day ago
$666
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Oct 1 from Orange County to Key West, returning Tue, Feb 2, priced at $666 found 1 day ago

Hotel Ideas near Key West Intl.

Airport Hotels near Key West Intl.

Hyatt Vacation Club at Windward Pointe, Key West

Hyatt Vacation Club at Windward Pointe, Key West

3.5 out of 5
3675 South Roosevelt Boulevard Key West FL
$194 nightly
The price is $219 total per night from Oct 4 to Oct 5
$219 total
Oct 4 - Oct 5
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, free parking, and a snack bar/deli. Our guests praise the pool and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,277 reviews)
"We loved our room! It was clean and comfortable. The swimming pool was excellent. The hotel staff were super helpful and friendly. We would come back here and bring our kids next time!"

Reviewed on Sep 14, 2026

Hyatt Vacation Club at Windward Pointe, Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$134 nightly
The price is $151 total per night from Sep 22 to Sep 23
$151 total
Sep 22 - Sep 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,512 reviews)
"Hampton Inn Key West – A Fantastic Stay! As always, we had another fantastic trip to Key West, and our stay at the Hampton Inn was a big part of it. The staff are always so friendly and welcoming, which makes you feel at home from the moment you arrive. The coffee is always on tap ☕, and the breakfast ..."

Reviewed on Sep 15, 2026

Hampton Inn Key West FL
DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$133 nightly
The price is $150 total per night from Sep 27 to Sep 28
$150 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,096 reviews)
"Clean hotel, clean room, staff was very friendly. We would definitely stay here again!"

Reviewed on Sep 14, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Key West

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$239 nightly
The price is $269 total per night from Sep 28 to Sep 29
$269 total
Sep 28 - Sep 29
Total with taxes and fees
Book a stay at this spa hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.6/10 Excellent! (3,603 reviews)
"Good first impression checking in. Staff was friendly and courteous. Room was ok off of the Tranquility pool. We did not like the heavy frosted sliding bathroom door, it was loud. There also needs to be counter space or cabinet of some sort in the bathroom. We brought a table in so we could put our ..."

Reviewed on Sep 15, 2026

Southernmost Beach Resort and Guesthouses
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$160 nightly
The price is $180 total per night from Sep 16 to Sep 17
$180 total
Sep 16 - Sep 17
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
Blue Flamingo Resort Key West
Margaritaville Beach House Key West

Margaritaville Beach House Key West

4 out of 5
2001 South Roosevelt Blvd Key West FL
$234 nightly
The price is $263 total per night from Sep 29 to Sep 30
$263 total
Sep 29 - Sep 30
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy breakfast (surcharge), a free airport shuttle, and room service. Our guests praise the pool and the restaurant ...
Margaritaville Beach House Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Key West Hotels With Airport Transportation

DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$133 nightly
The price is $150 total per night from Sep 27 to Sep 28
$150 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,096 reviews)
"Clean hotel, clean room, staff was very friendly. We would definitely stay here again!"

Reviewed on Sep 14, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$134 nightly
The price is $151 total per night from Sep 22 to Sep 23
$151 total
Sep 22 - Sep 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,512 reviews)
"Hampton Inn Key West – A Fantastic Stay! As always, we had another fantastic trip to Key West, and our stay at the Hampton Inn was a big part of it. The staff are always so friendly and welcoming, which makes you feel at home from the moment you arrive. The coffee is always on tap ☕, and the breakfast ..."

Reviewed on Sep 15, 2026

Hampton Inn Key West FL
Eden House

Eden House

4 out of 5
1015 Fleming St Key West FL
$128 nightly
The price is $144 total per night from Oct 11 to Oct 12
$144 total
Oct 11 - Oct 12
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, in-room massages, and a 24-hour front desk. Our guests praise the pool and the helpful staff in our reviews. ...
Eden House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Key West Hotels

Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street Key West FL
$155 nightly
The price is $174 total per night from Sep 16 to Sep 17
$174 total
Sep 16 - Sep 17
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
Southwinds Motel
Seashell Motel

Seashell Motel

1.5 out of 5
718 South Street Key West FL
$91 nightly
The price is $102 total per night from Sep 24 to Sep 25
$102 total
Sep 24 - Sep 25
Total with taxes and fees
Stay at this hostel in Key West. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8/10 Very Good! (1,000 reviews)
"Comfortable and clean."

Reviewed on Sep 10, 2026

Seashell Motel
Duval House

Duval House

3 out of 5
815 Duval St Key West FL
$108 nightly
The price is $118 total per night from Sep 20 to Sep 21
$118 total
Sep 20 - Sep 21
Total with taxes and fees
Stay at this B&B in Key West. Enjoy parking (surcharge), daily housekeeping, and a garden. Our guests praise the breakfast and the pool in our reviews. Popular ...
9.6/10 Exceptional! (1,096 reviews)
"Beautiful and with fantastic service"

Reviewed on Sep 14, 2026

Duval House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Key West

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$239 nightly
The price is $269 total per night from Sep 28 to Sep 29
$269 total
Sep 28 - Sep 29
Total with taxes and fees
Book a stay at this spa hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.6/10 Excellent! (3,603 reviews)
"Good first impression checking in. Staff was friendly and courteous. Room was ok off of the Tranquility pool. We did not like the heavy frosted sliding bathroom door, it was loud. There also needs to be counter space or cabinet of some sort in the bathroom. We brought a table in so we could put our ..."

Reviewed on Sep 15, 2026

Southernmost Beach Resort and Guesthouses
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$160 nightly
The price is $180 total per night from Sep 16 to Sep 17
$180 total
Sep 16 - Sep 17
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
Blue Flamingo Resort Key West
Hilton Key West Resort & Marina

Hilton Key West Resort & Marina

4 out of 5
5950 Peninsular Avenue Key West FL
$159 nightly
The price is $179 total per night from Sep 22 to Sep 23
$179 total
Sep 22 - Sep 23
Total with taxes and fees
Book a stay at this luxury hotel in Key West. Enjoy free WiFi, 6 outdoor pools, and a marina. Our guests praise the pool and the restaurant in our reviews. Popular ...
9/10 Wonderful! (1,827 reviews)
"Great property"

Reviewed on Sep 15, 2026

Hilton Key West Resort & Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

SNA to EYW Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
SNA Address & GPS
Address:
18601 Airport Way
Santa Ana CA, 92707
United States
IATA Code:
SNA
Longitude:
-117.860538
Latitude:
33.680201
Time Zone:
America/Los_Angeles
EYW Address & GPS
Address:
3491 South Roosevelt Boulevard
Key West FL, 33040-5260
United States
IATA Code:
EYW
Longitude:
-81.75501
Latitude:
24.553574
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from SNA to EYW?
As you can't fly straight from John Wayne Airport (SNA) to Key West Intl. Airport at the moment, a flight with a single stopover is your best bet. American Airlines, United Airlines and Delta Air Lines are all respected airlines that operate on this route.
What is the shortest flight from John Wayne Airport to EYW?
The shortest flight from SNA to Key West Intl. Airport (EYW) is 6 hours and 50 minutes. Pack a few things in your carry-on to keep you occupied, like a magazine or a sketch pad.
How many hours flight from John Wayne Airport (SNA) to Key West Intl. Airport (EYW)?
From John Wayne Airport to Key West Intl. Airport (EYW), you'll be cruising the skies for roughly 6 hours and 55 minutes. Get comfy, order a glass of wine and take out your noise-canceling earphones. It's time for a movie marathon.
What airlines have the most flights from John Wayne Airport to EYW?
Do some people-watching, grab a quick meal, stretch your legs … Airport stopovers don't have to be a bore! If you're planning to travel from Santa Ana to Key West, there are no direct flights. Plan to make at least one stop somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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