Cheap flights from SNA to EYW (John Wayne to Key West Intl.)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from SNA to EYW starting at $391 One Way, $389 Round Trip

Prices starting at $389 for return flights and $391 for one-way flights to Key West Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Jan 30 - Sat, Feb 6
SNA
Orange County
EYW
Key West
$389 Roundtrip, found 3 days ago
$389
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Jan 30 from Orange County to Key West, returning Sat, Feb 6, priced at $389 found 3 days ago
Sat, Jan 30 - Sat, Feb 6
SNA
Orange County
EYW
Key West
$464 Roundtrip, found 3 days ago
$464
Roundtrip
found 3 days ago
Select Delta flight, departing Sat, Jan 30 from Orange County to Key West, returning Sat, Feb 6, priced at $464 found 3 days ago
Sat, Jan 30 - Sat, Feb 6
SNA
Orange County
EYW
Key West
$499 Roundtrip, found 3 days ago
$499
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Jan 30 from Orange County to Key West, returning Sat, Feb 6, priced at $499 found 3 days ago
Sat, Jan 30 - Sat, Feb 6
SNA
Orange County
EYW
Key West
$519 Roundtrip, found 3 days ago
$519
Roundtrip
found 3 days ago
Select Delta flight, departing Sat, Jan 30 from Orange County to Key West, returning Sat, Feb 6, priced at $519 found 3 days ago
Sat, Jan 30 - Sat, Feb 6
SNA
Orange County
EYW
Key West
$531 Roundtrip, found 3 days ago
$531
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Jan 30 from Orange County to Key West, returning Sat, Feb 6, priced at $531 found 3 days ago

Hotel Ideas near Key West Intl.

Airport Hotels near Key West Intl.

Hyatt Vacation Club at Windward Pointe, Key West

Hyatt Vacation Club at Windward Pointe, Key West

3.5 out of 5
3675 South Roosevelt Boulevard Key West FL
$247 nightly
The price is $278 total per night from Aug 30 to Aug 31
$278 total
Aug 30 - Aug 31
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, free parking, and a snack bar/deli. Our guests praise the pool and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,212 reviews)
"Really nice Hotel and pool. Really good bar and food by the pool. Only complaint was the 5 nights I was there house keeping never once came to refresh my room. Good thing i brought detergent and a washer and dryer was in the room. Everything was great but that would've made it spectacular."

Reviewed on Jul 31, 2026

Hyatt Vacation Club at Windward Pointe, Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$148 nightly
The price is $166 total per night from Aug 30 to Aug 31
$166 total
Aug 30 - Aug 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
Hampton Inn Key West FL
DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$161 nightly
The price is $181 total per night from Aug 16 to Aug 17
$181 total
Aug 16 - Aug 17
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,061 reviews)
"The shuttle every hour was perfect. The pool and cabanas were great. Great location. I didn’t get a chance to rent a bike but I loved that they were available on the property."

Reviewed on Aug 1, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Key West

Beachside Resort & Residences

Beachside Resort & Residences

3.5 out of 5
3841 N Roosevelt Blvd Key West FL
$202 nightly
The price is $227 total per night from Aug 17 to Aug 18
$227 total
Aug 17 - Aug 18
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 2 restaurants, and a private beach. Our guests praise the pool and the helpful staff in our reviews. ...
8.6/10 Excellent! (2,397 reviews)
"The property was very nice but in need a daily maintenance: Lawn cleaned and mowed to keep up resort type appearance that it should. Probably should hose off the stairs and benches of chicken droppings, also to look resort worthy. All said and done, the room was exceptionally nice (ice maker didn't ..."

Reviewed on Aug 1, 2026

Beachside Resort & Residences
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$203 nightly
The price is $228 total per night from Sep 1 to Sep 2
$228 total
Sep 1 - Sep 2
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.8/10 Excellent! (3,458 reviews)
"My wife and I stayed here for 8 days/7nights for our honeymoon and the staff conveniently forgot to mention the absurd "Resort Fees" that slammed us for an almost $600 AFTER we arrived home. Resort fees were never once disclosed to us, and the whole charge seemed to be a sneaky way to extort travelers ..."

Reviewed on Aug 1, 2026

Southernmost Beach Resort and Guesthouses
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$166 nightly
The price is $187 total per night from Aug 31 to Sep 1
$187 total
Aug 31 - Sep 1
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8.6/10 Excellent! (2,598 reviews)
"Very nice"

Reviewed on Aug 1, 2026

Blue Flamingo Resort Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Key West Hotels With Airport Transportation

DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$161 nightly
The price is $181 total per night from Aug 16 to Aug 17
$181 total
Aug 16 - Aug 17
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,061 reviews)
"The shuttle every hour was perfect. The pool and cabanas were great. Great location. I didn’t get a chance to rent a bike but I loved that they were available on the property."

Reviewed on Aug 1, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$148 nightly
The price is $166 total per night from Aug 30 to Aug 31
$166 total
Aug 30 - Aug 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
Hampton Inn Key West FL
Eden House

Eden House

4 out of 5
1015 Fleming St Key West FL
$171 nightly
The price is $192 total per night from Aug 24 to Aug 25
$192 total
Aug 24 - Aug 25
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, in-room massages, and a 24-hour front desk. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (1,003 reviews)
"This is a great property, well maintained and beautiful. Highly recommend."

Reviewed on Jul 31, 2026

Eden House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Key West Hotels

Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street Key West FL
$155 nightly
The price is $175 total per night from Aug 23 to Aug 24
$175 total
Aug 23 - Aug 24
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,361 reviews)
"Good location and price."

Reviewed on Jul 31, 2026

Southwinds Motel
Seashell Motel

Seashell Motel

1.5 out of 5
718 South Street Key West FL
$114 nightly
The price is $128 total per night from Aug 9 to Aug 10
$128 total
Aug 9 - Aug 10
Total with taxes and fees
Stay at this hostel in Key West. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
Seashell Motel
Duval House

Duval House

3 out of 5
815 Duval St Key West FL
$140 nightly
The price is $154 total per night from Aug 4 to Aug 5
$154 total
Aug 4 - Aug 5
Total with taxes and fees
Stay at this B&B in Key West. Enjoy parking (surcharge), daily housekeeping, and a garden. Our guests praise the breakfast and the pool in our reviews. Popular ...
Duval House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Key West

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$203 nightly
The price is $228 total per night from Sep 1 to Sep 2
$228 total
Sep 1 - Sep 2
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.8/10 Excellent! (3,458 reviews)
"My wife and I stayed here for 8 days/7nights for our honeymoon and the staff conveniently forgot to mention the absurd "Resort Fees" that slammed us for an almost $600 AFTER we arrived home. Resort fees were never once disclosed to us, and the whole charge seemed to be a sneaky way to extort travelers ..."

Reviewed on Aug 1, 2026

Southernmost Beach Resort and Guesthouses
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$166 nightly
The price is $187 total per night from Aug 31 to Sep 1
$187 total
Aug 31 - Sep 1
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8.6/10 Excellent! (2,598 reviews)

Families like: Outdoor pools, playground, miniature golf, game room

Travelers say...
"Very nice"

Reviewed on Aug 1, 2026

Blue Flamingo Resort Key West
Hilton Key West Resort & Marina

Hilton Key West Resort & Marina

4 out of 5
5950 Peninsular Avenue Key West FL
$176 nightly
The price is $197 total per night from Aug 18 to Aug 19
$197 total
Aug 18 - Aug 19
Total with taxes and fees
Book a stay at this luxury hotel in Key West. Enjoy free WiFi, 6 outdoor pools, and a marina. Our guests praise the pool and the restaurant in our reviews. Popular ...
9/10 Wonderful! (1,839 reviews)
"Stunning Resort, but Marred by Toxic Management at Check-In. Everything about this property is physically stunning. The location is amazing, the hotel itself is lovely, and the rooms offer genuine, beautiful views. Unfortunately, the arrival experience was completely ruined by an incredibly rude ..."

Reviewed on Jul 31, 2026

Hilton Key West Resort & Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

SNA to EYW Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
SNA Address & GPS
Address:
18601 Airport Way
Santa Ana CA, 92707
United States
IATA Code:
SNA
Longitude:
-117.860538
Latitude:
33.680201
Time Zone:
America/Los_Angeles
EYW Address & GPS
Address:
3491 South Roosevelt Boulevard
Key West FL, 33040-5260
United States
IATA Code:
EYW
Longitude:
-81.75501
Latitude:
24.553574
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from SNA to EYW?
As you can't fly straight from John Wayne Airport (SNA) to Key West Intl. Airport at the moment, a flight with a single stopover is your best bet. American Airlines, United Airlines and Delta Air Lines are all respected airlines that operate on this route.
What is the shortest flight from John Wayne Airport to EYW?
The shortest flight from SNA to Key West Intl. Airport (EYW) is 6 hours and 50 minutes. Pack a few things in your carry-on to keep you occupied, like a magazine or a sketch pad.
How many hours flight from John Wayne Airport (SNA) to Key West Intl. Airport (EYW)?
From John Wayne Airport to Key West Intl. Airport (EYW), you'll be cruising the skies for roughly 6 hours and 55 minutes. Get comfy, order a glass of wine and take out your noise-canceling earphones. It's time for a movie marathon.
What airlines have the most flights from John Wayne Airport to EYW?
Do some people-watching, grab a quick meal, stretch your legs … Airport stopovers don't have to be a bore! If you're planning to travel from Santa Ana to Key West, there are no direct flights. Plan to make at least one stop somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

More to Explore