Cheap flights from SNA to EYW (John Wayne to Key West Intl.)

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Cheap Flights from SNA to EYW starting at $469 One Way, $479 Round Trip

Prices starting at $479 for return flights and $469 for one-way flights to Key West Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Apr 7 - Tue, Apr 13
SNA
Orange County
EYW
Key West
$479 Roundtrip, found 14 hours ago
$479
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Wed, Apr 7 from Orange County to Key West, returning Tue, Apr 13, priced at $479 found 14 hours ago
Wed, Apr 7 - Tue, Apr 13
SNA
Orange County
EYW
Key West
$609 Roundtrip, found 14 hours ago
$609
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Wed, Apr 7 from Orange County to Key West, returning Tue, Apr 13, priced at $609 found 14 hours ago
Wed, Apr 7 - Tue, Apr 13
SNA
Orange County
EYW
Key West
$623 Roundtrip, found 14 hours ago
$623
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Wed, Apr 7 from Orange County to Key West, returning Tue, Apr 13, priced at $623 found 14 hours ago
Wed, Apr 7 - Tue, Apr 13
SNA
Orange County
EYW
Key West
$679 Roundtrip, found 14 hours ago
$679
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Wed, Apr 7 from Orange County to Key West, returning Tue, Apr 13, priced at $679 found 14 hours ago
Wed, Apr 7 - Tue, Apr 13
SNA
Orange County
EYW
Key West
$688 Roundtrip, found 14 hours ago
$688
Roundtrip
found 14 hours ago
Select Delta flight, departing Wed, Apr 7 from Orange County to Key West, returning Tue, Apr 13, priced at $688 found 14 hours ago

Hotel Ideas near Key West Intl.

Airport Hotels near Key West Intl.

Hyatt Vacation Club at Windward Pointe, Key West

Hyatt Vacation Club at Windward Pointe, Key West

3.5 out of 5
3675 South Roosevelt Boulevard Key West FL
$185 nightly
The price is $209 total per night from Oct 28 to Oct 29
$209 total
Oct 28 - Oct 29
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, free parking, and a snack bar/deli. Our guests praise the pool and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,319 reviews)
"our second time. we had to wait a few hours for our room to be ready, and the room they gave us was next to some noisy partygoers. had to complain the next day to ask for another room elsewhere and they eventually moved us, but only after alot of prodding. The vibe and atmosphere was different, so ..."

Reviewed on Oct 13, 2026

Hyatt Vacation Club at Windward Pointe, Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$169 nightly
The price is $190 total per night from Oct 25 to Oct 26
$190 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
Hampton Inn Key West FL
DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$149 nightly
The price is $168 total per night from Oct 27 to Oct 28
$168 total
Oct 27 - Oct 28
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,116 reviews)
"Beautiful resort. Very good restaurant on site. Shuttle bus to and from Old Town Key West every hour. The staff was exceptional. Highly recommend this resort."

Reviewed on Oct 13, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Key West

Margaritaville Beach House Key West

Margaritaville Beach House Key West

4 out of 5
2001 South Roosevelt Blvd Key West FL
$264 nightly
The price is $297 total per night from Oct 31 to Nov 1
$297 total
Oct 31 - Nov 1
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy breakfast (surcharge), a free airport shuttle, and room service. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (1,793 reviews)
"It is such a convenient location and beautiful place to stay. Beds are comfy! Wish they had a little more to offer on their menu though."

Reviewed on Oct 15, 2026

Margaritaville Beach House Key West
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$175 nightly
The price is $197 total per night from Oct 25 to Oct 26
$197 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
Blue Flamingo Resort Key West
Beachside Resort & Residences

Beachside Resort & Residences

3.5 out of 5
3841 N Roosevelt Blvd Key West FL
$202 nightly
The price is $227 total per night from Oct 27 to Oct 28
$227 total
Oct 27 - Oct 28
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 2 restaurants, and a private beach. Our guests praise the pool and the helpful staff in our reviews. ...
Beachside Resort & Residences
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Key West Hotels With Airport Transportation

DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$149 nightly
The price is $168 total per night from Oct 27 to Oct 28
$168 total
Oct 27 - Oct 28
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,116 reviews)
"Beautiful resort. Very good restaurant on site. Shuttle bus to and from Old Town Key West every hour. The staff was exceptional. Highly recommend this resort."

Reviewed on Oct 13, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$169 nightly
The price is $190 total per night from Oct 25 to Oct 26
$190 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
Hampton Inn Key West FL
Eden House

Eden House

4 out of 5
1015 Fleming St Key West FL
$168 nightly
The price is $189 total per night from Oct 28 to Oct 29
$189 total
Oct 28 - Oct 29
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, in-room massages, and a 24-hour front desk. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (1,000 reviews)
"Amazing staff, beautiful location, super clean rooms and great amenities. This is my 3rd stay here and will definitely be back again!"

Reviewed on Oct 12, 2026

Eden House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Key West Hotels

Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street Key West FL
$169 nightly
The price is $190 total per night from Oct 26 to Oct 27
$190 total
Oct 26 - Oct 27
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
Southwinds Motel
Seashell Motel

Seashell Motel

1.5 out of 5
718 South Street Key West FL
$159 nightly
The price is $178 total per night from Oct 18 to Oct 19
$178 total
Oct 18 - Oct 19
Total with taxes and fees
Stay at this hostel in Key West. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
Seashell Motel
Duval House

Duval House

3 out of 5
815 Duval St Key West FL
$191 nightly
The price is $212 total per night from Oct 25 to Oct 26
$212 total
Oct 25 - Oct 26
Total with taxes and fees
Stay at this B&B in Key West. Enjoy parking (surcharge), daily housekeeping, and a garden. Our guests praise the breakfast and the pool in our reviews. Popular ...
9.6/10 Exceptional! (1,121 reviews)
"I loved the gardens and pool in the back of the Inn. I also liked the fact it is located right on Duval St."

Reviewed on Oct 15, 2026

Duval House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Key West

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$225 nightly
The price is $253 total per night from Oct 25 to Oct 26
$253 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this spa hotel in Key West. Enjoy 3 outdoor pools, a full-service spa, and 2 poolside bars. Our guests praise the pool and the helpful staff in ...
8.6/10 Excellent! (3,635 reviews)
"This property is beautiful and in a great location.My husband and I were here for a ling weekend to celebrate his 60th birthday and had a wonderful time. It was awesome to wake up to the sound of ocean waves and tropical breezes. Oh and I can't forget the roosters.. We weren't sure if we needed a ..."

Reviewed on Oct 15, 2026

Southernmost Beach Resort and Guesthouses
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$175 nightly
The price is $197 total per night from Oct 25 to Oct 26
$197 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
Blue Flamingo Resort Key West
Hilton Key West Resort & Marina

Hilton Key West Resort & Marina

4 out of 5
5950 Peninsular Avenue Key West FL
$174 nightly
The price is $196 total per night from Oct 25 to Oct 26
$196 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this luxury hotel in Key West. Enjoy free WiFi, 6 outdoor pools, and a marina. Our guests praise the pool and the restaurant in our reviews. Popular ...
9/10 Wonderful! (1,793 reviews)
"Good"

Reviewed on Oct 15, 2026

Hilton Key West Resort & Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

SNA to EYW Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
SNA Address & GPS
Address:
18601 Airport Way
Santa Ana CA, 92707
United States
IATA Code:
SNA
Longitude:
-117.860538
Latitude:
33.680201
Time Zone:
America/Los_Angeles
EYW Address & GPS
Address:
3491 South Roosevelt Boulevard
Key West FL, 33040-5260
United States
IATA Code:
EYW
Longitude:
-81.75501
Latitude:
24.553574
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from SNA to EYW?
As you can't fly straight from John Wayne Airport (SNA) to Key West Intl. Airport at the moment, a flight with a single stopover is your best bet. American Airlines, United Airlines and Delta Air Lines are all respected airlines that operate on this route.
What is the shortest flight from John Wayne Airport to EYW?
The shortest flight from SNA to Key West Intl. Airport (EYW) is 6 hours and 50 minutes. Pack a few things in your carry-on to keep you occupied, like a magazine or a sketch pad.
How many hours flight from John Wayne Airport (SNA) to Key West Intl. Airport (EYW)?
From John Wayne Airport to Key West Intl. Airport (EYW), you'll be cruising the skies for roughly 6 hours and 55 minutes. Get comfy, order a glass of wine and take out your noise-canceling earphones. It's time for a movie marathon.
What airlines have the most flights from John Wayne Airport to EYW?
Do some people-watching, grab a quick meal, stretch your legs … Airport stopovers don't have to be a bore! If you're planning to travel from Santa Ana to Key West, there are no direct flights. Plan to make at least one stop somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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