Cheap flights from TYS to EYW (McGhee Tyson to Key West Intl.)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from TYS to EYW starting at $249 One Way, $236 Round Trip

Prices starting at $236 for return flights and $249 for one-way flights to Key West Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Feb 10 - Wed, Feb 18
TYS
Knoxville
EYW
Key West
$236 Roundtrip, found 4 days ago
$236
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Feb 10 from Knoxville to Key West, returning Wed, Feb 18, priced at $236 found 4 days ago
Mon, Feb 2 - Wed, Feb 18
TYS
Knoxville
EYW
Key West
$251 Roundtrip, found 3 days ago
$251
Roundtrip
found 3 days ago
Select Delta flight, departing Mon, Feb 2 from Knoxville to Key West, returning Wed, Feb 18, priced at $251 found 3 days ago
Sun, Jan 25 - Fri, Feb 6
TYS
Knoxville
EYW
Key West
$261 Roundtrip, found 3 days ago
$261
Roundtrip
found 3 days ago
Select Delta flight, departing Sun, Jan 25 from Knoxville to Key West, returning Fri, Feb 6, priced at $261 found 3 days ago
Tue, Jan 27 - Fri, Feb 6
TYS
Knoxville
EYW
Key West
$267 Roundtrip, found 3 days ago
$267
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Jan 27 from Knoxville to Key West, returning Fri, Feb 6, priced at $267 found 3 days ago
Thu, Jul 2 - Wed, Jul 8
TYS
Knoxville
EYW
Key West
$269 Roundtrip, found 13 hours ago
$269
Roundtrip
found 13 hours ago
Select Delta flight, departing Thu, Jul 2 from Knoxville to Key West, returning Wed, Jul 8, priced at $269 found 13 hours ago

Hotel Ideas near Key West Intl.

Airport Hotels near Key West Intl.

Hyatt Vacation Club at Windward Pointe, Key West

Hyatt Vacation Club at Windward Pointe, Key West

3.5 out of 5
3675 South Roosevelt Boulevard Key West FL
$473 nightly
The price is $532 total per night from Jan 20 to Jan 21
$532 total
Jan 20 - Jan 21
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, free parking, and a snack bar/deli. Our guests praise the pool and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,006 reviews)
Awesome all around

Reviewed on Dec 28, 2025

Hyatt Vacation Club at Windward Pointe, Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$329 nightly
The price is $370 total per night from Jan 4 to Jan 5
$370 total
Jan 4 - Jan 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,297 reviews)
Great place to view sun rise from, great pool and bar area, close to Duval street!! the breakfast and staff were excellent!

Reviewed on Dec 29, 2025

Hampton Inn Key West FL
DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$289 nightly
The price is $325 total per night from Jan 4 to Jan 5
$325 total
Jan 4 - Jan 5
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8/10 Very Good! (1,006 reviews)
Yes we loved the room and everything that went with it. I would stay there again.

Reviewed on Dec 29, 2025

DoubleTree Resort by Hilton Grand Key - Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Key West

Beachside Resort & Residences

Beachside Resort & Residences

3.5 out of 5
3841 N Roosevelt Blvd Key West FL
$323 nightly
The price is $363 total per night from Jan 6 to Jan 7
$363 total
Jan 6 - Jan 7
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 2 restaurants, and a private beach. Our guests praise the pool and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,858 reviews)
The grounds are beautiful. Our room was a smaller room and it was nice but some things didn’t work properly. The toilet didn’t flush well, the shower head would turn on when filling the bathtub, tv would turn off randomly and the floors were dirty. Reasonably price in comparison to other places in ...

Reviewed on Jan 1, 2026

Beachside Resort & Residences
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$292 nightly
The price is $329 total per night from Jan 4 to Jan 5
$329 total
Jan 4 - Jan 5
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8/10 Very Good! (1,804 reviews)
The room was very clean and comfortable. The $15.00 for parking your car was a little of the top tho! You should really give discounts for Florida Residence too, we drove 350 miles to come see Key West and to have to pay all the fees & parking fee is a bit much!

Reviewed on Dec 26, 2025

Blue Flamingo Resort Key West
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

4 out of 5
5950 Peninsular Avenue Key West FL
$275 nightly
The price is $309 total per night from Jan 6 to Jan 7
$309 total
Jan 6 - Jan 7
Total with taxes and fees
Book a stay at this luxury hotel in Key West. Enjoy free WiFi, 6 outdoor pools, and a marina. Our guests praise the pool and the restaurant in our reviews. Popular ...
8.8/10 Excellent! (1,768 reviews)
Staff was great

Reviewed on Dec 30, 2025

Oceans Edge Key West Resort, Hotel & Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Key West Hotels With Airport Transportation

DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$289 nightly
The price is $325 total per night from Jan 4 to Jan 5
$325 total
Jan 4 - Jan 5
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8/10 Very Good! (1,006 reviews)
Yes we loved the room and everything that went with it. I would stay there again.

Reviewed on Dec 29, 2025

DoubleTree Resort by Hilton Grand Key - Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$329 nightly
The price is $370 total per night from Jan 4 to Jan 5
$370 total
Jan 4 - Jan 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,297 reviews)
Great place to view sun rise from, great pool and bar area, close to Duval street!! the breakfast and staff were excellent!

Reviewed on Dec 29, 2025

Hampton Inn Key West FL
Eden House

Eden House

3.5 out of 5
1015 Fleming St Key West FL
$448 nightly
The price is $504 total per night from Jan 20 to Jan 21
$504 total
Jan 20 - Jan 21
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, in-room massages, and a 24-hour front desk. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (1,004 reviews)
The rooms are not represented well on this app. Its implied that a queen will have a balcony. Bathroom extremely tiny. The property was beautiful and staff friendly

Reviewed on Dec 26, 2025

Eden House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Key West Hotels

Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street Key West FL
$281 nightly
The price is $316 total per night from Jan 5 to Jan 6
$316 total
Jan 5 - Jan 6
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,256 reviews)
Breakfast is a quick stop and go. Met expectations and was appreciated. Room and property is so clean a quaint. I really enjoyed all of the amenities and location. Ended up in that heated pool everyday. So nice! Will be back.

Reviewed on Jan 2, 2026

Southwinds Motel
Seashell Motel

Seashell Motel

1.5 out of 5
718 South Street Key West FL
$219 nightly
The price is $246 total per night from Jan 11 to Jan 12
$246 total
Jan 11 - Jan 12
Total with taxes and fees
Stay at this hostel in Key West. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7.8/10 Good! (1,001 reviews)
Great

Reviewed on Dec 22, 2025

Seashell Motel
Duval House

Duval House

3 out of 5
815 Duval St Key West FL
$271 nightly
The price is $302 total per night from Jan 6 to Jan 7
$302 total
Jan 6 - Jan 7
Total with taxes and fees
Stay at this B&B in Key West. Enjoy parking (surcharge), daily housekeeping, and a garden. Our guests praise the breakfast and the pool in our reviews. Popular ...
9.4/10 Exceptional! (1,006 reviews)
Awesome! One nice night in Key West

Reviewed on Dec 30, 2025

Duval House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Key West

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$419 nightly
The price is $472 total per night from Jan 26 to Jan 27
$472 total
Jan 26 - Jan 27
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.6/10 Excellent! (2,961 reviews)
Nice clean room, scenic views, accessible area

Reviewed on Dec 30, 2025

Southernmost Beach Resort and Guesthouses
Margaritaville Beach House Key West

Margaritaville Beach House Key West

4 out of 5
2001 South Roosevelt Blvd Key West FL
Book a stay at this beach hotel in Key West. Enjoy free parking, 2 restaurants, and breakfast (surcharge). Popular attractions Duval Street and Smathers Beach ...
8.2/10 Very Good! (999 reviews)

Families like: Outdoor pool, babysitting, close to beach, bicycle rentals

Travelers say...
Room was clean and comfortable but after first day towels were shorted. Had to ask for more twice Desk staff were very nice and helpful. Concierge was helpful with rentals Restaurant was not as good as past stays when Sheraton. Food even pancakes were tough and overcooked. Shuttle drivers were very ...

Reviewed on Dec 4, 2025

Get rates
Margaritaville Beach House Key West
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$292 nightly
The price is $329 total per night from Jan 4 to Jan 5
$329 total
Jan 4 - Jan 5
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8/10 Very Good! (1,804 reviews)

Families like: Outdoor pools, miniature golf, game room, bicycle rentals

Travelers say...
The room was very clean and comfortable. The $15.00 for parking your car was a little of the top tho! You should really give discounts for Florida Residence too, we drove 350 miles to come see Key West and to have to pay all the fees & parking fee is a bit much!

Reviewed on Dec 26, 2025

Blue Flamingo Resort Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TYS to EYW Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York
EYW Address & GPS
Address:
3491 South Roosevelt Boulevard
Key West FL, 33040-5260
United States
IATA Code:
EYW
Longitude:
-81.75501
Latitude:
24.553574
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from Knoxville Airport to Key West Intl. Airport?
As you can't fly direct from TYS to Key West Intl. Airport (EYW) at this point in time, a flight with one stopover is your best option. American Airlines, Delta Air Lines and United Airlines are all respected airlines that service this route.
What is the shortest flight from Knoxville Airport to Key West Intl. Airport (EYW)?
Make the most of the opportunity to chill out on your journey from Knoxville to Key West. The quickest flight time from McGhee Tyson Airport (TYS) to Key West Intl. Airport is 4 hours and 49 minutes, which gives you loads of time to indulge in a drink or get engrossed in a book.
How many hours flight from Knoxville Airport to Key West Intl. Airport?
On a normal day, the trip from TYS to EYW takes 4 hours and 53 minutes. If you want to be as comfortable as you can, consider upgrading your seat using air miles or cash.
What airlines have the most flights from Knoxville Airport to Key West Intl. Airport?
If you're wanting to book with an airline that offers direct flights from TYS to EYW, you won't have much luck. You'll have to book a flight with at least one stopover to get to Key West.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

More to Explore