Cheap flights from TYS to SAN (McGhee Tyson to San Diego Intl.)

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Cheap Flights from TYS to SAN starting at $140 One Way, $279 Round Trip

Prices starting at $279 for return flights and $140 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Jan 6 - Wed, Jan 13
TYS
Knoxville
SAN
San Diego
$279 Roundtrip, found 3 days ago
$279
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Wed, Jan 6 from Knoxville to San Diego, returning Wed, Jan 13, priced at $279 found 3 days ago
Sat, Dec 12 - Thu, Jan 7
TYS
Knoxville
SAN
San Diego
$289 Roundtrip, found 4 days ago
$289
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Sat, Dec 12 from Knoxville to San Diego, returning Thu, Jan 7, priced at $289 found 4 days ago
Thu, Nov 12 - Tue, Nov 17
TYS
Knoxville
SAN
San Diego
$292 Roundtrip, found 6 days ago
$292
Roundtrip
found 6 days ago
Select United flight, departing Thu, Nov 12 from Knoxville to San Diego, returning Tue, Nov 17, priced at $292 found 6 days ago
Sat, Dec 12 - Thu, Jan 7
TYS
Knoxville
SAN
San Diego
$295 Roundtrip, found 4 days ago
$295
Roundtrip
found 4 days ago
Select United flight, departing Sat, Dec 12 from Knoxville to San Diego, returning Thu, Jan 7, priced at $295 found 4 days ago
Wed, Dec 9 - Wed, Dec 16
TYS
Knoxville
SAN
San Diego
$296 Roundtrip, found 4 days ago
$296
Roundtrip
found 4 days ago
Select United flight, departing Wed, Dec 9 from Knoxville to San Diego, returning Wed, Dec 16, priced at $296 found 4 days ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$160 nightly
The price is $184 total per night from Nov 22 to Nov 23
$184 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Sheraton San Diego Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Nov 1 to Nov 2
$211 total
Nov 1 - Nov 2
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
$97 nightly
The price is $112 total per night from Nov 15 to Nov 16
$112 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (3,031 reviews)
"Great room, easy access, cleans but it feels like it needs an update"

Reviewed on Oct 27, 2026

Handlery Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Nov 1 to Nov 2
$211 total
Nov 1 - Nov 2
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
$97 nightly
The price is $112 total per night from Nov 15 to Nov 16
$112 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (3,031 reviews)
"Great room, easy access, cleans but it feels like it needs an update"

Reviewed on Oct 27, 2026

Handlery Hotel
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
$203 nightly
The price is $235 total per night from Nov 22 to Nov 23
$235 total
Nov 22 - Nov 23
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,567 reviews)
"The room was very clean and the cleaning staff was absolutely amazing. Cleanest room I've ever seen."

Reviewed on Oct 27, 2026

Hard Rock Hotel San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Nov 1 to Nov 2
$211 total
Nov 1 - Nov 2
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$160 nightly
The price is $184 total per night from Nov 22 to Nov 23
$184 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 out of 5
1955 San Diego Ave San Diego CA
$136 nightly
The price is $156 total per night from Nov 1 to Nov 2
$156 total
Nov 1 - Nov 2
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
9.2/10 Wonderful! (1,103 reviews)
"My whole experience was very wonderful if you are goin to graduation at MCRD this is place for you and Nic is amazing 👏"

Reviewed on Oct 26, 2026

Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn

Pleasant Inn

2.5 out of 5
5550 Clairemont Mesa Blvd San Diego CA
$76 nightly
The price is $87 total per night from Nov 26 to Nov 27
$87 total
Nov 26 - Nov 27
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
8.6/10 Excellent! (1,617 reviews)
"Great Staff plus clean rooms"

Reviewed on Oct 27, 2026

Pleasant Inn
E-Z 8 Motel Old Town

E-Z 8 Motel Old Town

2.5 out of 5
4747 Pacific Highway San Diego CA
$62 nightly
The price is $71 total per night from Oct 28 to Oct 29
$71 total
Oct 28 - Oct 29
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
E-Z 8 Motel Old Town
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
$114 nightly
The price is $131 total per night from Oct 28 to Oct 29
$131 total
Oct 28 - Oct 29
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.8/10 Excellent! (3,825 reviews)
"We had a clean room that suited our needs. Would use them again."

Reviewed on Oct 27, 2026

Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
$226 nightly
The price is $254 total per night from Oct 29 to Oct 30
$254 total
Oct 29 - Oct 30
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free parking, a private beach, and a marina. Our guests praise the pool and the restaurant in our reviews. ...
8.8/10 Excellent! (2,493 reviews)

Families like: Outdoor pool, kids club, playground, game room

Travelers say...
"The Bahia Resort was a lovely stay. Staff was very friendly and accommodating. (Shoutout to Beverly for being so kind to us) Price point however is quite high if you are going in with the expectation of updated amenities. The original hotel was built sometime in the 50s and updated during the 70s ..."

Reviewed on Oct 26, 2026

Bahia Resort Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
$198 nightly
The price is $228 total per night from Nov 15 to Nov 16
$228 total
Nov 15 - Nov 16
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
9/10 Wonderful! (4,481 reviews)
"Great location and Firefly restaurant was perfect for family on the Marina"

Reviewed on Oct 27, 2026

The Dana on Mission Bay
Catamaran Resort and Spa

Catamaran Resort and Spa

4 out of 5
3999 Mission Boulevard San Diego CA
$275 nightly
The price is $316 total per night from Oct 28 to Oct 29
$316 total
Oct 28 - Oct 29
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TYS to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from TYS to San Diego Airport?
You're going to need to swap planes if you're planning to get from McGhee Tyson Airport (TYS) to SAN. Several airlines offer services on this route with only one stopover, including American Airlines, United Airlines and Delta Air Lines.
What is the shortest flight from Knoxville Airport to San Diego Airport?
The shortest flight time from Knoxville Airport to San Diego Airport is 6 hours and 39 minutes. Order a refreshment from the drink trolley, write in your travel journal or finish that podcast — you'll have the time on this medium-haul journey.
How many hours flight from McGhee Tyson Airport (TYS) to San Diego Airport?
From TYS to SAN, you'll be in your seat for roughly 6 hours and 45 minutes. Settle back, order a wine and take out your noise-canceling earphones. It's time to rewatch your favorite TV shows.
What airlines have the most flights from Knoxville Airport to San Diego Airport?
If you're wanting to book with an airline that operates direct flights from TYS to SAN, you won't have much luck. You'll need to book a flight with at least one stopover to get to San Diego.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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