Cheap flights from TYS to SAN (McGhee Tyson to San Diego Intl.)

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Cheap Flights from TYS to SAN starting at $146 One Way, $252 Round Trip

Prices starting at $252 for return flights and $146 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Aug 31 - Mon, Sep 8
TYS
Knoxville
SAN
San Diego
$252 Roundtrip, found 6 days ago
$252
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Sun, Aug 31 from Knoxville to San Diego, returning Mon, Sep 8, priced at $252 found 6 days ago
Sun, Aug 31 - Sun, Sep 7
TYS
Knoxville
SAN
San Diego
$264 Roundtrip, found 6 days ago
$264
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Sun, Aug 31 from Knoxville to San Diego, returning Sun, Sep 7, priced at $264 found 6 days ago
Wed, Jan 14 - Wed, Jan 21
TYS
Knoxville
SAN
San Diego
$277 Roundtrip, found 2 days ago
$277
Roundtrip
found 2 days ago
Select United flight, departing Wed, Jan 14 from Knoxville to San Diego, returning Wed, Jan 21, priced at $277 found 2 days ago
Wed, Jan 14 - Wed, Jan 21
TYS
Knoxville
SAN
San Diego
$277 Roundtrip, found 2 days ago
$277
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jan 14 from Knoxville to San Diego, returning Wed, Jan 21, priced at $277 found 2 days ago
Tue, Jul 15 - Wed, Jul 23
TYS
Knoxville
SAN
San Diego
$282 Roundtrip, found 23 hours ago
$282
Roundtrip
found 23 hours ago
Select Delta flight, departing Tue, Jul 15 from Knoxville to San Diego, returning Wed, Jul 23, priced at $282 found 23 hours ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort
Sheraton San Diego Resort
4 out of 5
1380 Harbor Island Dr, San Diego, CA
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8/10 Very Good! (2,699 reviews)
"Location"

Reviewed on Jun 12, 2025

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Sheraton San Diego Resort
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
4 out of 5
1 Market Pl, San Diego, CA
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,776 reviews)
"Recently renovated room with great view. & great lighting in the room. Did not like: Self parking was too expensive at $49/night & unable to watch local Padre game in room."

Reviewed on Jun 12, 2025

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Manchester Grand Hyatt San Diego
Marriott Marquis San Diego Marina
Marriott Marquis San Diego Marina
4 out of 5
333 W Harbor Dr, San Diego, CA
Book a stay at this spa hotel in San Diego. Enjoy 2 outdoor pools, a full-service spa, and 5 restaurants. Our guests praise the pool and the helpful staff in ...
9/10 Wonderful! (1,698 reviews)
"Great property and great service"

Reviewed on Jun 11, 2025

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Marriott Marquis San Diego Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Marriott Marquis San Diego Marina
Marriott Marquis San Diego Marina
4 out of 5
333 W Harbor Dr, San Diego, CA
Book a stay at this spa hotel in San Diego. Enjoy 2 outdoor pools, a full-service spa, and 5 restaurants. Our guests praise the pool and the helpful staff in ...
9/10 Wonderful! (1,698 reviews)
"Great property and great service"

Reviewed on Jun 11, 2025

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Marriott Marquis San Diego Marina
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
4 out of 5
1 Market Pl, San Diego, CA
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,776 reviews)
"Recently renovated room with great view. & great lighting in the room. Did not like: Self parking was too expensive at $49/night & unable to watch local Padre game in room."

Reviewed on Jun 12, 2025

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Manchester Grand Hyatt San Diego
Kings Inn San Diego
Kings Inn San Diego
2.5 out of 5
1333 Hotel Cir S, San Diego, CA
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.6/10 Excellent! (3,260 reviews)
"This is a good family oriented, budget friendly hotel. It is very clean and convenient. Staff is friendly and courteous. I would stay here again."

Reviewed on Jun 13, 2025

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Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,713 reviews)
"This is always a great place to stay. Close to everything. Clean rooms, helpful staff and very accomodating. You can't go wrong stary here...."

Reviewed on Jun 10, 2025

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Wyndham San Diego Bayside
Sheraton San Diego Resort
Sheraton San Diego Resort
4 out of 5
1380 Harbor Island Dr, San Diego, CA
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8/10 Very Good! (2,699 reviews)
"Location"

Reviewed on Jun 12, 2025

Get rates
Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG
Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 out of 5
1955 San Diego Ave, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
8.8/10 Excellent! (1,006 reviews)
Great hotel close to airport
"Close to airport. Clean and convenient. Parking on site at a charge. All good."

Reviewed on Jun 11, 2025

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Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn
Pleasant Inn
2.5 out of 5
5550 Clairemont Mesa Blvd, San Diego, CA
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
8.4/10 Very Good! (1,017 reviews)
"The trip was amazing. The hotel was clean and quiet"

Reviewed on Jun 11, 2025

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Pleasant Inn
E-Z 8 Motel Old Town
E-Z 8 Motel Old Town
2.5 out of 5
4747 Pacific Highway, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
6.2/10 (2,068 reviews)
"It a good place and it good to have a little fun with friends"

Reviewed on Jun 13, 2025

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E-Z 8 Motel Old Town
Kings Inn San Diego
Kings Inn San Diego
2.5 out of 5
1333 Hotel Cir S, San Diego, CA
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.6/10 Excellent! (3,260 reviews)
"This is a good family oriented, budget friendly hotel. It is very clean and convenient. Staff is friendly and courteous. I would stay here again."

Reviewed on Jun 13, 2025

Get rates
Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel
Bahia Resort Hotel
3.5 out of 5
998 W Mission Bay Dr, San Diego, CA
Stay at this 3.5-star beach resort in San Diego. Enjoy free parking, a beach locale, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (1,551 reviews)
"2nd time staying here. We enjoy it’s convenience and the overall property."

Reviewed on Jun 13, 2025

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Bahia Resort Hotel
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.8/10 Excellent! (3,479 reviews)
"Property is nice. Room was supposed to be on lanai and was on pool. WiFi was not private and not good at all…"

Reviewed on Jun 15, 2025

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The Dana on Mission Bay
Catamaran Resort and Spa
Catamaran Resort and Spa
4 out of 5
3999 Mission Boulevard, San Diego, CA
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (1,006 reviews)

Families like: Outdoor pool, game room, on the beach, bicycle rentals

Travelers say...
"It’s was an amazing experience on the hotel!!! I hope to come back soon!!!"

Reviewed on Jun 13, 2025

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Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TYS to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from TYS to San Diego Airport?
You’re going to need to swap planes if you’re planning to get from McGhee Tyson Airport (TYS) to SAN. Several airlines offer services on this route with only one stopover, including American Airlines, United Airlines and Delta Air Lines.
What is the shortest flight from Knoxville Airport to San Diego Airport?
The shortest flight time from Knoxville Airport to San Diego Airport is 6 hours and 39 minutes. Order a refreshment from the drink trolley, write in your travel journal or finish that podcast — you’ll have the time on this medium-haul journey.
How many hours flight from McGhee Tyson Airport (TYS) to San Diego Airport?
From TYS to SAN, you’ll be in your seat for roughly 6 hours and 45 minutes. Settle back, order a wine and take out your noise-canceling earphones. It’s time to rewatch your favorite TV shows.
What airlines have the most flights from Knoxville Airport to San Diego Airport?
If you’re wanting to book with an airline that operates direct flights from TYS to SAN, you won’t have much luck. You’ll need to book a flight with at least one stopover to get to San Diego.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.