Cheap flights from TYS to SAN (McGhee Tyson to San Diego Intl.)

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Cheap Flights from TYS to SAN starting at $183 One Way, $356 Round Trip

Prices starting at $356 for return flights and $183 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Aug 14 - Tue, Aug 18
TYS
Knoxville
SAN
San Diego
$356 Roundtrip, found 6 days ago
$356
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Fri, Aug 14 from Knoxville to San Diego, returning Tue, Aug 18, priced at $356 found 6 days ago
Fri, Aug 14 - Tue, Aug 18
TYS
Knoxville
SAN
San Diego
$361 Roundtrip, found 6 days ago
$361
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Fri, Aug 14 from Knoxville to San Diego, returning Tue, Aug 18, priced at $361 found 6 days ago
Sat, Aug 22 - Sat, Aug 29
TYS
Knoxville
SAN
San Diego
$368 Roundtrip, found 1 day ago
$368
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Sat, Aug 22 from Knoxville to San Diego, returning Sat, Aug 29, priced at $368 found 1 day ago
Sat, Aug 22 - Sat, Aug 29
TYS
Knoxville
SAN
San Diego
$368 Roundtrip, found 1 day ago
$368
Roundtrip
found 1 day ago
Select United flight, departing Sat, Aug 22 from Knoxville to San Diego, returning Sat, Aug 29, priced at $368 found 1 day ago
Sat, Aug 22 - Sat, Aug 29
TYS
Knoxville
SAN
San Diego
$368 Roundtrip, found 1 day ago
$368
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Aug 22 from Knoxville to San Diego, returning Sat, Aug 29, priced at $368 found 1 day ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$169 nightly
The price is $194 total per night from Aug 23 to Aug 24
$194 total
Aug 23 - Aug 24
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Sheraton San Diego Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Aug 12 to Aug 13
$211 total
Aug 12 - Aug 13
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,257 reviews)
"Friendly, excellent service!!!"

Reviewed on Aug 6, 2026

Wyndham San Diego Bayside
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
$238 nightly
The price is $276 total per night from Sep 6 to Sep 7
$276 total
Sep 6 - Sep 7
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
9/10 Wonderful! (2,770 reviews)
"I enjoyed my stay and would happily return if I’m in the area."

Reviewed on Aug 6, 2026

Manchester Grand Hyatt San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
$285 nightly
The price is $328 total per night from Aug 30 to Aug 31
$328 total
Aug 30 - Aug 31
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,805 reviews)
"My key stopped working but everything else was good. Very expensive though to be on the water."

Reviewed on Aug 6, 2026

Paradise Point Resort & Spa
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
$238 nightly
The price is $276 total per night from Sep 6 to Sep 7
$276 total
Sep 6 - Sep 7
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
9/10 Wonderful! (2,770 reviews)
"I enjoyed my stay and would happily return if I’m in the area."

Reviewed on Aug 6, 2026

Manchester Grand Hyatt San Diego
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Aug 12 to Aug 13
$211 total
Aug 12 - Aug 13
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,257 reviews)
"Friendly, excellent service!!!"

Reviewed on Aug 6, 2026

Wyndham San Diego Bayside
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Aug 12 to Aug 13
$211 total
Aug 12 - Aug 13
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,257 reviews)
"Friendly, excellent service!!!"

Reviewed on Aug 6, 2026

Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$169 nightly
The price is $194 total per night from Aug 23 to Aug 24
$194 total
Aug 23 - Aug 24
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 out of 5
1955 San Diego Ave San Diego CA
$153 nightly
The price is $176 total per night from Sep 1 to Sep 2
$176 total
Sep 1 - Sep 2
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn

Pleasant Inn

2.5 out of 5
5550 Clairemont Mesa Blvd San Diego CA
$110 nightly
The price is $126 total per night from Aug 9 to Aug 10
$126 total
Aug 9 - Aug 10
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
8.6/10 Excellent! (1,525 reviews)
"Friendly and helpful staff. Very and clean place."

Reviewed on Aug 5, 2026

Pleasant Inn
E-Z 8 Motel Old Town

E-Z 8 Motel Old Town

2.5 out of 5
4747 Pacific Highway San Diego CA
$60 nightly
The price is $68 total per night from Aug 7 to Aug 8
$68 total
Aug 7 - Aug 8
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
E-Z 8 Motel Old Town
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
$130 nightly
The price is $149 total per night from Aug 31 to Sep 1
$149 total
Aug 31 - Sep 1
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.8/10 Excellent! (3,762 reviews)
"There was ants all over the bathroom and a couple of roaches in the bedroom"

Reviewed on Aug 6, 2026

Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
$287 nightly
The price is $330 total per night from Aug 30 to Aug 31
$330 total
Aug 30 - Aug 31
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (2,326 reviews)
"Nice resort in mission bay"

Reviewed on Aug 6, 2026

Bahia Resort Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
$234 nightly
The price is $269 total per night from Sep 1 to Sep 2
$269 total
Sep 1 - Sep 2
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
The Dana on Mission Bay
Catamaran Resort and Spa

Catamaran Resort and Spa

4 out of 5
3999 Mission Boulevard San Diego CA
$335 nightly
The price is $385 total per night from Sep 1 to Sep 2
$385 total
Sep 1 - Sep 2
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TYS to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from TYS to San Diego Airport?
You're going to need to swap planes if you're planning to get from McGhee Tyson Airport (TYS) to SAN. Several airlines offer services on this route with only one stopover, including American Airlines, United Airlines and Delta Air Lines.
What is the shortest flight from Knoxville Airport to San Diego Airport?
The shortest flight time from Knoxville Airport to San Diego Airport is 6 hours and 39 minutes. Order a refreshment from the drink trolley, write in your travel journal or finish that podcast — you'll have the time on this medium-haul journey.
How many hours flight from McGhee Tyson Airport (TYS) to San Diego Airport?
From TYS to SAN, you'll be in your seat for roughly 6 hours and 45 minutes. Settle back, order a wine and take out your noise-canceling earphones. It's time to rewatch your favorite TV shows.
What airlines have the most flights from Knoxville Airport to San Diego Airport?
If you're wanting to book with an airline that operates direct flights from TYS to SAN, you won't have much luck. You'll need to book a flight with at least one stopover to get to San Diego.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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