Cheap flights from TYS to GNV (McGhee Tyson to Gainesville Regional)

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Cheap Flights from TYS to GNV starting at $293 One Way, $523 Round Trip

Prices starting at $523 for return flights and $293 for one-way flights to Gainesville Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Dec 30 - Sat, Jan 2
TYS
Knoxville
GNV
Gainesville
$523 Roundtrip, found 1 day ago
$523
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Dec 30 from Knoxville to Gainesville, returning Sat, Jan 2, priced at $523 found 1 day ago
Mon, Nov 9 - Sat, Nov 14
TYS
Knoxville
GNV
Gainesville
$557 Roundtrip, found 6 days ago
$557
Roundtrip
found 6 days ago
Select Delta flight, departing Mon, Nov 9 from Knoxville to Gainesville, returning Sat, Nov 14, priced at $557 found 6 days ago
Mon, Nov 9 - Sat, Nov 14
TYS
Knoxville
GNV
Gainesville
$562 Roundtrip, found 6 days ago
$562
Roundtrip
found 6 days ago
Select American Airlines flight, departing Mon, Nov 9 from Knoxville to Gainesville, returning Sat, Nov 14, priced at $562 found 6 days ago
Sun, Apr 25 - Fri, Apr 30
TYS
Knoxville
GNV
Gainesville
$585 Roundtrip, found 6 days ago
$585
Roundtrip
found 6 days ago
Select Delta flight, departing Sun, Apr 25 from Knoxville to Gainesville, returning Fri, Apr 30, priced at $585 found 6 days ago
Wed, Dec 30 - Sat, Jan 2
TYS
Knoxville
GNV
Gainesville
$601 Roundtrip, found 1 day ago
$601
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Dec 30 from Knoxville to Gainesville, returning Sat, Jan 2, priced at $601 found 1 day ago

Hotel Ideas near Gainesville Regional

Airport Hotels near Gainesville Regional

Hyatt Place Gainesville Downtown

Hyatt Place Gainesville Downtown

3 out of 5
212 SE 1ST STREET, Gainesville FL
$104 nightly
The price is $116 total per night from Nov 8 to Nov 9
$116 total
Nov 8 - Nov 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,244 reviews)
"They are always so accommodating. The only issue I have this time was the fact that you need to ring a door phone for them to let you in and we called four or five times and had a very hard time getting in and had to wait a while"

Reviewed on Nov 6, 2026

Hyatt Place Gainesville Downtown
Sweetwater Branch Inn

Sweetwater Branch Inn

3.5 out of 5
625 East University Avenue Gainesville FL
$158 nightly
The price is $177 total per night from Dec 2 to Dec 3
$177 total
Dec 2 - Dec 3
Total with taxes and fees
Stay at this B&B in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
Sweetwater Branch Inn
Gainesville Lodge

Gainesville Lodge

2 out of 5
413 West University Ave Gainesville FL
$93 nightly
The price is $105 total per night from Nov 18 to Nov 19
$105 total
Nov 18 - Nov 19
Total with taxes and fees
Stay at this motel in Gainesville. Enjoy free WiFi, free parking, and cable TV channels. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (127 reviews)
"Old school motel that has been redone in a nice mid-century modern theme. The biggest drawbacks were the shower, super skinny!, and the lack of a proper mini fridge."

Reviewed on Nov 1, 2026

Gainesville Lodge
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Gainesville

Drury Inn & Suites Gainesville

Drury Inn & Suites Gainesville

3 out of 5
4000 Southwest 40th Blvd Gainesville FL
$105 nightly
The price is $118 total per night from Nov 26 to Nov 27
$118 total
Nov 26 - Nov 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Drury Inn & Suites Gainesville
Country Inn & Suites by Radisson, Gainesville, FL

Country Inn & Suites by Radisson, Gainesville, FL

3 out of 5
4015 Sw 43rd St Gainesville FL
$88 nightly
The price is $99 total per night from Nov 15 to Nov 16
$99 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (2,035 reviews)
"We had a wonderful stay. The hotel was great and the staff was even better!!"

Reviewed on Nov 6, 2026

Country Inn & Suites by Radisson, Gainesville, FL
Sleep Inn & Suites University/Shands

Sleep Inn & Suites University/Shands

2.5 out of 5
4110 SW 40th Boulevard Gainesville FL
$81 nightly
The price is $91 total per night from Dec 4 to Dec 5
$91 total
Dec 4 - Dec 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,328 reviews)
"The hallways were a little smelly but everything else was great. TY"

Reviewed on Nov 5, 2026

Sleep Inn & Suites University/Shands
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Gainesville Hotels With Airport Transportation

Best Western Gateway Grand

Best Western Gateway Grand

3 out of 5
4200 NW 97th Blvd Gainesville FL
$85 nightly
The price is $95 total per night from Nov 15 to Nov 16
$95 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant ...
Best Western Gateway Grand
Hilton University of Florida Conference Center Gainesville

Hilton University of Florida Conference Center Gainesville

3.5 out of 5
1714 SW 34th St Gainesville FL
$106 nightly
The price is $119 total per night from Nov 15 to Nov 16
$119 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
Hilton University of Florida Conference Center Gainesville
Holiday Inn Gainesville - University Center by IHG

Holiday Inn Gainesville - University Center by IHG

3 out of 5
1250 W University Ave Gainesville FL
$91 nightly
The price is $102 total per night from Dec 6 to Dec 7
$102 total
Dec 6 - Dec 7
Total with taxes and fees
Book a stay at this golf hotel in Gainesville. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,003 reviews)
"Hotel was updated and clean with very helpful staff. Great location"

Reviewed on Nov 5, 2026

Holiday Inn Gainesville - University Center by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Gainesville Hotels

Super 8 by Wyndham Gainesville I-75 Hospital University Area

Super 8 by Wyndham Gainesville I-75 Hospital University Area

2 out of 5
4202 SW 40th Blvd Gainesville FL
$50 nightly
The price is $56 total per night from Nov 8 to Nov 9
$56 total
Nov 8 - Nov 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Super 8 by Wyndham Gainesville I-75 Hospital University Area
Travelers Inn

Travelers Inn

2 out of 5
3103 NW 13th St Gainesville FL
$65 nightly
The price is $73 total per night from Nov 8 to Nov 9
$73 total
Nov 8 - Nov 9
Total with taxes and fees
Stay at this motel in Gainesville. Enjoy free WiFi, free parking, and room service. Popular attractions Ben Hill Griffin Stadium and Thomas Center are located ...
6.4/10 (417 reviews)
"They hadn't cleaned the room like, at all, for many many nights previous. When I explained that my friend is disabled, the manager said we could only have 10 more minutes to check out. WOW! Just, wow. Never go there!"

Reviewed on Oct 26, 2026

Travelers Inn
Micanopy Inn

Micanopy Inn

2 out of 5
17110 SE County Road 234 Micanopy FL
$36 nightly
The price is $41 total per night from Nov 8 to Nov 9
$41 total
Nov 8 - Nov 9
Total with taxes and fees
Stay at this motel in Micanopy. Enjoy daily housekeeping, laundry facilities, and premium TV channels. Popular attractions Micanopy Historical Society Museum ...
Micanopy Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Gainesville

Home2 Suites by Hilton Gainesville Medical Center

Home2 Suites by Hilton Gainesville Medical Center

3 out of 5
2115 Southwest 13th Street Gainesville FL
$105 nightly
The price is $119 total per night from Nov 23 to Nov 24
$119 total
Nov 23 - Nov 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff in our ...
9/10 Wonderful! (1,002 reviews)
"Convenient location"

Reviewed on Nov 5, 2026

Home2 Suites by Hilton Gainesville Medical Center
Homewood Suites by Hilton Gainesville

Homewood Suites by Hilton Gainesville

3 out of 5
3333 Sw 42nd St Gainesville FL
$105 nightly
The price is $119 total per night from Nov 15 to Nov 16
$119 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in ...
8.6/10 Excellent! (1,000 reviews)
"The room was excellent. Ceiling fan above the bed, which is a major plus for me. Bri at the front desk was amazing. She was smiling every time I saw her and was extremely kind and courteous. I liked that the rooms were set away from the front desk and lobby. My biggest suggestion would to do a complete ..."

Reviewed on Nov 2, 2026

Homewood Suites by Hilton Gainesville
DoubleTree by Hilton Gainesville

DoubleTree by Hilton Gainesville

4 out of 5
3726 Sw 40th Blvd Gainesville FL
$84 nightly
The price is $95 total per night from Nov 29 to Nov 30
$95 total
Nov 29 - Nov 30
Total with taxes and fees
Stay at this hotel in Gainesville. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,001 reviews)
"This is the most “bougie” doubletree I’ve ever seen- the whole place is perfect and upscale. I had to remind myself I was at a doubletree"

Reviewed on Nov 6, 2026

DoubleTree by Hilton Gainesville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TYS to GNV Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

Are there non-stop flights from Knoxville Airport to GNV?
Flying from McGhee Tyson Airport (TYS) to GNV? Breaking up the journey is your one and only option as there are no carriers that service this route directly. However, American Airlines, Delta Air Lines and United Airlines offer the closest thing — a flight with just one stop.
What is the shortest flight from Knoxville Airport to GNV?
From Knoxville, the thrilling sights and sounds of Gainesville are 3 hours and 24 minutes away. Be sure to book your favorite seat, or maybe even one with extra legroom, and fly to your destination in total comfort.
How many hours flight from Knoxville Airport to GNV?
Typically, the flight time from Knoxville Airport to Gainesville Regional Airport (GNV) takes 3 hours and 31 minutes. If you want to be as comfy as possible, think about upgrading your seat using air miles or cash.
What airlines have the most flights from Knoxville Airport to Gainesville Regional Airport?
Do a bit of shopping, sit down for a coffee, go for a wander around .... Airport stopovers don't have to be something to dread! If you're jetting between Knoxville and Gainesville, you can't fly direct. Get ready to make a stop somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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