Cheap flights from TYS to GNV (McGhee Tyson to Gainesville Regional)

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Cheap Flights from TYS to GNV starting at $229 One Way, $408 Round Trip

Prices starting at $408 for return flights and $229 for one-way flights to Gainesville Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Sep 24 - Sun, Sep 27
TYS
Knoxville
GNV
Gainesville
$408 Roundtrip, found 3 hours ago
$408
Roundtrip
found 3 hours ago
Select Delta flight, departing Thu, Sep 24 from Knoxville to Gainesville, returning Sun, Sep 27, priced at $408 found 3 hours ago
Tue, May 26 - Wed, May 27
TYS
Knoxville
GNV
Gainesville
$437 Roundtrip, found 2 days ago
$437
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, May 26 from Knoxville to Gainesville, returning Wed, May 27, priced at $437 found 2 days ago
Tue, May 26 - Wed, May 27
TYS
Knoxville
GNV
Gainesville
$440 Roundtrip, found 2 days ago
$440
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, May 26 from Knoxville to Gainesville, returning Wed, May 27, priced at $440 found 2 days ago
Thu, Sep 24 - Sun, Sep 27
TYS
Knoxville
GNV
Gainesville
$449 Roundtrip, found 3 hours ago
$449
Roundtrip
found 3 hours ago
Select Delta flight, departing Thu, Sep 24 from Knoxville to Gainesville, returning Sun, Sep 27, priced at $449 found 3 hours ago
Tue, May 26 - Wed, May 27
TYS
Knoxville
GNV
Gainesville
$472 Roundtrip, found 2 days ago
$472
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, May 26 from Knoxville to Gainesville, returning Wed, May 27, priced at $472 found 2 days ago

Hotel Ideas near Gainesville Regional

Airport Hotels near Gainesville Regional

Hyatt Place Gainesville Downtown

Hyatt Place Gainesville Downtown

3 out of 5
212 SE 1ST STREET, Gainesville FL
$110 nightly
The price is $124 total per night from May 24 to May 25
$124 total
May 24 - May 25
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,163 reviews)
It’s a really nice hotel, the best bed to sleep on. The only thing we don’t like is parking; we have to pay the parking fee. Also, there are several homeless people roaming around . Just have to be careful, but otherwise everything’s really nice at the hotel.

Reviewed on May 5, 2026

Hyatt Place Gainesville Downtown
Great place to meet up

Great place to meet up

Gainesville FL
$348 nightly
The price is $386 total per night from May 8 to May 9
$386 total
May 8 - May 9
Total with taxes and fees
Stay at this vacation home in Gainesville. Enjoy laundry facilities, patios, and in-room fireplaces. Popular attractions Ben Hill Griffin Stadium and Matheson ...
Great place to meet up
Sweetwater Branch Inn

Sweetwater Branch Inn

3.5 out of 5
625 East University Avenue Gainesville FL
$115 nightly
The price is $130 total per night from May 26 to May 27
$130 total
May 26 - May 27
Total with taxes and fees
Stay at this B&B in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (1,009 reviews)
Excellent service and very relaxing experience! Breakfast was delicious! We will come back again!

Reviewed on May 4, 2026

Sweetwater Branch Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Gainesville

Country Inn & Suites by Radisson, Gainesville, FL

Country Inn & Suites by Radisson, Gainesville, FL

3 out of 5
4015 Sw 43rd St Gainesville FL
$90 nightly
The price is $101 total per night from May 31 to Jun 1
$101 total
May 31 - Jun 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,804 reviews)
Ample parking, calm and secure, Very good breakfast, staff excellent friendly and willing to help specially Florie and Cynthia they were so helpful... all the staff in front desk: Charles and all of the group...They make the difference of the stay....

Reviewed on May 6, 2026

Country Inn & Suites by Radisson, Gainesville, FL
Sleep Inn & Suites University/Shands

Sleep Inn & Suites University/Shands

2.5 out of 5
4110 SW 40th Boulevard Gainesville FL
$80 nightly
The price is $91 total per night from Jun 2 to Jun 3
$91 total
Jun 2 - Jun 3
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,196 reviews)
The staff is very rude!!!

Reviewed on May 6, 2026

Sleep Inn & Suites University/Shands
Drury Inn & Suites Gainesville

Drury Inn & Suites Gainesville

3 out of 5
4000 Southwest 40th Blvd Gainesville FL
$105 nightly
The price is $118 total per night from May 26 to May 27
$118 total
May 26 - May 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,462 reviews)
Yes breakfast was good and hot. The room was a little too cold but we sorted that out

Reviewed on May 7, 2026

Drury Inn & Suites Gainesville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Gainesville Hotels With Airport Transportation

Best Western Gateway Grand

Best Western Gateway Grand

3 out of 5
4200 NW 97th Blvd Gainesville FL
$92 nightly
The price is $104 total per night from May 10 to May 11
$104 total
May 10 - May 11
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant ...
8.6/10 Excellent! (1,465 reviews)
Yes

Reviewed on May 7, 2026

Best Western Gateway Grand
Hilton University of Florida Conference Center Gainesville

Hilton University of Florida Conference Center Gainesville

3.5 out of 5
1714 SW 34th St Gainesville FL
$114 nightly
The price is $128 total per night from May 17 to May 18
$128 total
May 17 - May 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (1,008 reviews)
Pros: The staff are really accommodating, respectful, and responsive—they’re great. Cons: The only issue I had was with the room sink. It was making noises at night, and I woke up to what looked like it had overflowed, leaving a lot of dirt/mud in the sink, which was pretty unpleasant. Also, my key ...

Reviewed on May 6, 2026

Hilton University of Florida Conference Center Gainesville
Holiday Inn Gainesville - University Center by IHG

Holiday Inn Gainesville - University Center by IHG

3 out of 5
1250 W University Ave Gainesville FL
$118 nightly
The price is $133 total per night from May 10 to May 11
$133 total
May 10 - May 11
Total with taxes and fees
Book a stay at this golf hotel in Gainesville. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,007 reviews)
Clean and quiet.

Reviewed on May 5, 2026

Holiday Inn Gainesville - University Center by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Gainesville Hotels

Super 8 by Wyndham Gainesville I-75 Hospital University Area

Super 8 by Wyndham Gainesville I-75 Hospital University Area

2 out of 5
4202 SW 40th Blvd Gainesville FL
$54 nightly
The price is $61 total per night from May 10 to May 11
$61 total
May 10 - May 11
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (1,012 reviews)
I stayed at this hotel for my son's graduation from college. Since my husband is a Wyndham rewards member, we chose to stay here. When I made my reservation, I asked for a handicap room and a chair for the shower, as my husband is an amputee. The Reservation had all my contact information, yet it ...

Reviewed on May 5, 2026

Super 8 by Wyndham Gainesville I-75 Hospital University Area
Travelers Inn

Travelers Inn

2 out of 5
3103 NW 13th St Gainesville FL
$70 nightly
The price is $79 total per night from May 10 to May 11
$79 total
May 10 - May 11
Total with taxes and fees
Stay at this motel in Gainesville. Enjoy free WiFi, free parking, and room service. Popular attractions Ben Hill Griffin Stadium and Thomas Center are located ...
6.4/10 (407 reviews)
I got it not smoking room and it smells like smoke the lungs on the door was broken it was horrible

Reviewed on Apr 19, 2026

Travelers Inn
Micanopy Inn

Micanopy Inn

2 out of 5
17110 SE County Road 234 Micanopy FL
Stay at this motel in Micanopy. Enjoy daily housekeeping, laundry facilities, and premium TV channels. Popular attractions Micanopy Historical Society Museum ...
5.2/10 (463 reviews)
Staff very helpful

Reviewed on Jan 23, 2026

Get rates
Micanopy Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Gainesville

Home2 Suites by Hilton Gainesville Medical Center

Home2 Suites by Hilton Gainesville Medical Center

3 out of 5
2115 Southwest 13th Street Gainesville FL
$98 nightly
The price is $110 total per night from May 24 to May 25
$110 total
May 24 - May 25
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff in our ...
9/10 Wonderful! (946 reviews)
Close to hospital

Reviewed on Apr 29, 2026

Home2 Suites by Hilton Gainesville Medical Center
Homewood Suites by Hilton Gainesville

Homewood Suites by Hilton Gainesville

3 out of 5
3333 Sw 42nd St Gainesville FL
$114 nightly
The price is $128 total per night from May 19 to May 20
$128 total
May 19 - May 20
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in ...
8.6/10 Excellent! (1,003 reviews)
I was there for UF’s graduation. The hotel was clean , the staff was friendly, and the location was close to everything we needed. I will be back soon!

Reviewed on May 6, 2026

Homewood Suites by Hilton Gainesville
DoubleTree by Hilton Gainesville

DoubleTree by Hilton Gainesville

4 out of 5
3726 Sw 40th Blvd Gainesville FL
$97 nightly
The price is $109 total per night from May 14 to May 15
$109 total
May 14 - May 15
Total with taxes and fees
Stay at this hotel in Gainesville. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,012 reviews)
friendly service

Reviewed on May 6, 2026

DoubleTree by Hilton Gainesville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TYS to GNV Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York
GNV Address & GPS
Address:
3400 Northeast 39th Avenue
Gainesville FL, 32609
United States
IATA Code:
GNV
Longitude:
-82.276797
Latitude:
29.686142
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from Knoxville Airport to GNV?
Flying from McGhee Tyson Airport (TYS) to GNV? Breaking up the journey is your one and only option as there are no carriers that service this route directly. However, American Airlines, Delta Air Lines and United Airlines offer the closest thing — a flight with just one stop.
What is the shortest flight from Knoxville Airport to GNV?
From Knoxville, the thrilling sights and sounds of Gainesville are 3 hours and 24 minutes away. Be sure to book your favorite seat, or maybe even one with extra legroom, and fly to your destination in total comfort.
How many hours flight from Knoxville Airport to GNV?
Typically, the flight time from Knoxville Airport to Gainesville Regional Airport (GNV) takes 3 hours and 31 minutes. If you want to be as comfy as possible, think about upgrading your seat using air miles or cash.
What airlines have the most flights from Knoxville Airport to Gainesville Regional Airport?
Do a bit of shopping, sit down for a coffee, go for a wander around .... Airport stopovers don't have to be something to dread! If you're jetting between Knoxville and Gainesville, you can't fly direct. Get ready to make a stop somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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