Cheap flights from TYS to GNV (McGhee Tyson to Gainesville Regional)

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Cheap Flights from TYS to GNV starting at $272 One Way, $399 Round Trip

Prices starting at $399 for return flights and $272 for one-way flights to Gainesville Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Sep 24 - Sun, Sep 27
TYS
Knoxville
GNV
Gainesville
$399 Roundtrip, found 4 days ago
$399
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Sep 24 from Knoxville to Gainesville, returning Sun, Sep 27, priced at $399 found 4 days ago
Thu, Sep 24 - Sun, Sep 27
TYS
Knoxville
GNV
Gainesville
$439 Roundtrip, found 4 days ago
$439
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Sep 24 from Knoxville to Gainesville, returning Sun, Sep 27, priced at $439 found 4 days ago
Thu, Sep 24 - Sun, Sep 27
TYS
Knoxville
GNV
Gainesville
$469 Roundtrip, found 4 days ago
$469
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Sep 24 from Knoxville to Gainesville, returning Sun, Sep 27, priced at $469 found 4 days ago
Thu, Sep 24 - Sun, Sep 27
TYS
Knoxville
GNV
Gainesville
$479 Roundtrip, found 4 days ago
$479
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Sep 24 from Knoxville to Gainesville, returning Sun, Sep 27, priced at $479 found 4 days ago
Thu, Sep 24 - Sun, Sep 27
TYS
Knoxville
GNV
Gainesville
$507 Roundtrip, found 4 days ago
$507
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Sep 24 from Knoxville to Gainesville, returning Sun, Sep 27, priced at $507 found 4 days ago

Hotel Ideas near Gainesville Regional

Airport Hotels near Gainesville Regional

Hyatt Place Gainesville Downtown

Hyatt Place Gainesville Downtown

3 out of 5
212 SE 1ST STREET, Gainesville FL
$104 nightly
The price is $116 total per night from Jul 7 to Jul 8
$116 total
Jul 7 - Jul 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,191 reviews)
"​Our stay at this hotel was absolutely wonderful, thanks to the fantastic breakfast, prime location, and exceptional service."

Reviewed on Jun 21, 2026

Hyatt Place Gainesville Downtown
Hampton Inn & Suites Gainesville-Downtown

Hampton Inn & Suites Gainesville-Downtown

3 out of 5
101 SE 1st Ave Gainesville FL
$93 nightly
The price is $105 total per night from Jul 2 to Jul 3
$105 total
Jul 2 - Jul 3
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff in our ...
8.6/10 Excellent! (1,002 reviews)
"Loved or stay !!! Looking at booking again"

Reviewed on Jun 18, 2026

Hampton Inn & Suites Gainesville-Downtown
Underwater Home w/Game Room ~6 min to Stadium & DT

Underwater Home w/Game Room ~6 min to Stadium & DT

Gainesville FL
$285 nightly
The price is $297 total per night from Jun 22 to Jun 23
$297 total
Jun 22 - Jun 23
Total with taxes and fees
Book a stay at this family-friendly vacation home in Gainesville. Enjoy a garden, laundry facilities, and a pool table. Popular attractions Ben Hill Griffin ...
9.8/10 Exceptional! (10 reviews)
"This home was as described in the listing. The decor was cute and enjoyed by our entire family. It slept 5 adults and 1 child very comfortably. The bath towels were extremely soft and lush which isn't always the case in VRBO's."

Reviewed on May 11, 2026

Underwater Home w/Game Room ~6 min to Stadium & DT
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Gainesville

Sleep Inn & Suites University/Shands

Sleep Inn & Suites University/Shands

2.5 out of 5
4110 SW 40th Boulevard Gainesville FL
$76 nightly
The price is $86 total per night from Jun 28 to Jun 29
$86 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,224 reviews)
"A nice place to stay. Located near restaurants and shopping stores. A nice stay."

Reviewed on Jun 21, 2026

Sleep Inn & Suites University/Shands
HOM Hotel Gainesville, SureStay Collection by Best Western

HOM Hotel Gainesville, SureStay Collection by Best Western

2.5 out of 5
3905 Sw 43Rd St Gainesville FL
$64 nightly
The price is $72 total per night from Jun 22 to Jun 23
$72 total
Jun 22 - Jun 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,992 reviews)
"Pet friendly"

Reviewed on Jun 21, 2026

HOM Hotel Gainesville, SureStay Collection by Best Western
Hilton University of Florida Conference Center Gainesville

Hilton University of Florida Conference Center Gainesville

3.5 out of 5
1714 SW 34th St Gainesville FL
$98 nightly
The price is $110 total per night from Jun 28 to Jun 29
$110 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (1,001 reviews)
"Great"

Reviewed on Jun 21, 2026

Hilton University of Florida Conference Center Gainesville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Gainesville Hotels With Airport Transportation

Best Western Gateway Grand

Best Western Gateway Grand

3 out of 5
4200 NW 97th Blvd Gainesville FL
$88 nightly
The price is $99 total per night from Jun 28 to Jun 29
$99 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant ...
8.6/10 Excellent! (1,490 reviews)
"Drove in Thursday afternoon around 3pm. Was told by the hotel staff it would be an additional $20 to check-in early. Check-in is 4pm. Lobby is well put together, very worn furniture but overall looked ok. Was checked into room 104 on the first floor. Room is tucked away from all the other rooms which ..."

Reviewed on Jun 20, 2026

Best Western Gateway Grand
Hilton University of Florida Conference Center Gainesville

Hilton University of Florida Conference Center Gainesville

3.5 out of 5
1714 SW 34th St Gainesville FL
$98 nightly
The price is $110 total per night from Jun 28 to Jun 29
$110 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (1,001 reviews)
"Great"

Reviewed on Jun 21, 2026

Hilton University of Florida Conference Center Gainesville
Holiday Inn Gainesville - University Center by IHG

Holiday Inn Gainesville - University Center by IHG

3 out of 5
1250 W University Ave Gainesville FL
$101 nightly
The price is $114 total per night from Jul 20 to Jul 21
$114 total
Jul 20 - Jul 21
Total with taxes and fees
Book a stay at this golf hotel in Gainesville. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,005 reviews)
"We could not get the room to cool down to a reasonable level it was basically way to warm. The amenities were fine in the room. We were only there for one night and it was what we had expected."

Reviewed on Jun 21, 2026

Holiday Inn Gainesville - University Center by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Gainesville Hotels

Super 8 by Wyndham Gainesville I-75 Hospital University Area

Super 8 by Wyndham Gainesville I-75 Hospital University Area

2 out of 5
4202 SW 40th Blvd Gainesville FL
$52 nightly
The price is $58 total per night from Jun 28 to Jun 29
$58 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (1,017 reviews)
"The staff was ABSOLUTELY amazing and helpful. They even went above and beyond and were so polite and attentive. The property and hotel was a little bit run down and not that clean but the staff made it worth the stay."

Reviewed on Jun 21, 2026

Super 8 by Wyndham Gainesville I-75 Hospital University Area
Travelers Inn

Travelers Inn

2 out of 5
3103 NW 13th St Gainesville FL
$65 nightly
The price is $73 total per night from Jul 1 to Jul 2
$73 total
Jul 1 - Jul 2
Total with taxes and fees
Stay at this motel in Gainesville. Enjoy free WiFi, free parking, and room service. Popular attractions Ben Hill Griffin Stadium and Thomas Center are located ...
6.4/10 (410 reviews)
"better than expected, good access to stadium"

Reviewed on May 26, 2026

Travelers Inn
Micanopy Inn

Micanopy Inn

2 out of 5
17110 SE County Road 234 Micanopy FL
Stay at this motel in Micanopy. Enjoy daily housekeeping, laundry facilities, and premium TV channels. Popular attractions Micanopy Historical Society Museum ...
5.2/10 (463 reviews)
"Staff very helpful"

Reviewed on Jan 23, 2026

Get rates
Micanopy Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Gainesville

Home2 Suites by Hilton Gainesville Medical Center

Home2 Suites by Hilton Gainesville Medical Center

3 out of 5
2115 Southwest 13th Street Gainesville FL
$102 nightly
The price is $114 total per night from Jul 12 to Jul 13
$114 total
Jul 12 - Jul 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff in our ...
9/10 Wonderful! (959 reviews)
"The room is very clean, but the staff are not friendly"

Reviewed on Jun 4, 2026

Home2 Suites by Hilton Gainesville Medical Center
Homewood Suites by Hilton Gainesville

Homewood Suites by Hilton Gainesville

3 out of 5
3333 Sw 42nd St Gainesville FL
$93 nightly
The price is $105 total per night from Jun 28 to Jun 29
$105 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in ...
8.6/10 Excellent! (1,003 reviews)
"Breakfast was good."

Reviewed on Jun 17, 2026

Homewood Suites by Hilton Gainesville
DoubleTree by Hilton Gainesville

DoubleTree by Hilton Gainesville

4 out of 5
3726 Sw 40th Blvd Gainesville FL
$97 nightly
The price is $109 total per night from Jun 28 to Jun 29
$109 total
Jun 28 - Jun 29
Total with taxes and fees
Stay at this hotel in Gainesville. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,001 reviews)
"Bed was extremely comfortable, But cleanliness could definitely improve. Sink was leaking, I wiped up water from floor, the the towel was black from the dirt from bathroom floor."

Reviewed on Jun 20, 2026

DoubleTree by Hilton Gainesville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TYS to GNV Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York
GNV Address & GPS
Address:
3400 Northeast 39th Avenue
Gainesville FL, 32609
United States
IATA Code:
GNV
Longitude:
-82.276797
Latitude:
29.686142
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from Knoxville Airport to GNV?
Flying from McGhee Tyson Airport (TYS) to GNV? Breaking up the journey is your one and only option as there are no carriers that service this route directly. However, American Airlines, Delta Air Lines and United Airlines offer the closest thing — a flight with just one stop.
What is the shortest flight from Knoxville Airport to GNV?
From Knoxville, the thrilling sights and sounds of Gainesville are 3 hours and 24 minutes away. Be sure to book your favorite seat, or maybe even one with extra legroom, and fly to your destination in total comfort.
How many hours flight from Knoxville Airport to GNV?
Typically, the flight time from Knoxville Airport to Gainesville Regional Airport (GNV) takes 3 hours and 31 minutes. If you want to be as comfy as possible, think about upgrading your seat using air miles or cash.
What airlines have the most flights from Knoxville Airport to Gainesville Regional Airport?
Do a bit of shopping, sit down for a coffee, go for a wander around .... Airport stopovers don't have to be something to dread! If you're jetting between Knoxville and Gainesville, you can't fly direct. Get ready to make a stop somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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