Cheap flights from TYS to GNV (McGhee Tyson to Gainesville Regional)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from TYS to GNV starting at $192 One Way, $253 Round Trip

Prices starting at $253 for return flights and $192 for one-way flights to Gainesville Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Jan 7 - Sun, Jan 18
TYS
Knoxville
GNV
Gainesville
$253 Roundtrip, found 4 days ago
$253
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, Jan 7 from Knoxville to Gainesville, returning Sun, Jan 18, priced at $253 found 4 days ago
Fri, Jan 9 - Sun, Jan 18
TYS
Knoxville
GNV
Gainesville
$259 Roundtrip, found 4 days ago
$259
Roundtrip
found 4 days ago
Select Delta flight, departing Fri, Jan 9 from Knoxville to Gainesville, returning Sun, Jan 18, priced at $259 found 4 days ago
Tue, Apr 14 - Tue, Apr 21
TYS
Knoxville
GNV
Gainesville
$308 Roundtrip, found 2 hours ago
$308
Roundtrip
found 2 hours ago
Select Delta flight, departing Tue, Apr 14 from Knoxville to Gainesville, returning Tue, Apr 21, priced at $308 found 2 hours ago
Thu, Jan 8 - Tue, Jan 13
TYS
Knoxville
GNV
Gainesville
$313 Roundtrip, found 4 days ago
$313
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Jan 8 from Knoxville to Gainesville, returning Tue, Jan 13, priced at $313 found 4 days ago
Wed, Jan 7 - Tue, Jan 13
TYS
Knoxville
GNV
Gainesville
$317 Roundtrip, found 4 days ago
$317
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, Jan 7 from Knoxville to Gainesville, returning Tue, Jan 13, priced at $317 found 4 days ago

Hotel Ideas near Gainesville Regional

Airport Hotels near Gainesville Regional

4 Bedroom Single Family home 5 mins to University!

4 Bedroom Single Family home 5 mins to University!

Gainesville FL
$236 nightly
The price is $262 total per night from Jan 4 to Jan 5
$262 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Stay at this vacation home in Gainesville. Enjoy free WiFi, laundry facilities, and balconies. Popular attractions Ben Hill Griffin Stadium and Matheson History ...
9/10 Wonderful! (19 reviews)
We had a very nice stay

Reviewed on Oct 11, 2025

4 Bedroom Single Family home 5 mins to University!
Hyatt Place Gainesville Downtown

Hyatt Place Gainesville Downtown

3 out of 5
212 SE 1ST STREET, Gainesville FL
$98 nightly
The price is $110 total per night from Dec 30 to Dec 31
$110 total
Dec 30 - Dec 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,108 reviews)
Always great!

Reviewed on Dec 13, 2025

Hyatt Place Gainesville Downtown
Sweetwater Branch Inn

Sweetwater Branch Inn

3.5 out of 5
625 East University Avenue Gainesville FL
$125 nightly
The price is $141 total per night from Jan 8 to Jan 9
$141 total
Jan 8 - Jan 9, 2026
Total with taxes and fees
Stay at this B&B in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (878 reviews)
The room was clean, with not even a speck of dirt on the floor. The breakfast was delicious.

Reviewed on Nov 30, 2025

Sweetwater Branch Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Gainesville

DoubleTree by Hilton Gainesville

DoubleTree by Hilton Gainesville

4 out of 5
3726 Sw 40th Blvd Gainesville FL
$81 nightly
The price is $91 total per night from Dec 28 to Dec 29
$91 total
Dec 28 - Dec 29
Total with taxes and fees
Stay at this hotel in Gainesville. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.6/10 Good! (1,006 reviews)
Excellent Staff Especially The Bartender..She Was Very Friendly And She Fixed My Drink..Tom Collins

Reviewed on Dec 19, 2025

DoubleTree by Hilton Gainesville
Hilton University of Florida Conference Center Gainesville

Hilton University of Florida Conference Center Gainesville

3.5 out of 5
1714 SW 34th St Gainesville FL
$97 nightly
The price is $109 total per night from Dec 28 to Dec 29
$109 total
Dec 28 - Dec 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (1,003 reviews)
Clean room, very nice hotel.

Reviewed on Dec 21, 2025

Hilton University of Florida Conference Center Gainesville
Hotel Eleo at the University of Florida

Hotel Eleo at the University of Florida

3 out of 5
1514 Southwest 14th Street Gainesville FL
$127 nightly
The price is $143 total per night from Dec 24 to Dec 25
$143 total
Dec 24 - Dec 25
Total with taxes and fees
Stay at this hotel in Gainesville. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the restaurant and the helpful staff in our ...
9.2/10 Wonderful! (1,289 reviews)
Dominic the valet was very nice and helpful!

Reviewed on Dec 15, 2025

Hotel Eleo at the University of Florida
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Gainesville Hotels With Airport Transportation

Best Western Gateway Grand

Best Western Gateway Grand

3 out of 5
4200 NW 97th Blvd Gainesville FL
$84 nightly
The price is $95 total per night from Dec 28 to Dec 29
$95 total
Dec 28 - Dec 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant ...
8.6/10 Excellent! (1,356 reviews)
Love the accommodations and friendly ataff

Reviewed on Dec 21, 2025

Best Western Gateway Grand
Hilton University of Florida Conference Center Gainesville

Hilton University of Florida Conference Center Gainesville

3.5 out of 5
1714 SW 34th St Gainesville FL
$97 nightly
The price is $109 total per night from Dec 28 to Dec 29
$109 total
Dec 28 - Dec 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (1,003 reviews)
Clean room, very nice hotel.

Reviewed on Dec 21, 2025

Hilton University of Florida Conference Center Gainesville
Holiday Inn Gainesville - University Center by IHG

Holiday Inn Gainesville - University Center by IHG

3 out of 5
1250 W University Ave Gainesville FL
$95 nightly
The price is $107 total per night from Jan 11 to Jan 12
$107 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Book a stay at this golf hotel in Gainesville. Enjoy free WiFi, free parking, and a rooftop terrace. Our guests praise the helpful staff and the room service ...
7.6/10 Good! (1,000 reviews)
Water pressure in the shower was really bad. The room was clean and roomy, the ac worked well.

Reviewed on Dec 15, 2025

Holiday Inn Gainesville - University Center by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Gainesville Hotels

Super 8 by Wyndham Gainesville I-75 Hospital University Area

Super 8 by Wyndham Gainesville I-75 Hospital University Area

2 out of 5
4202 SW 40th Blvd Gainesville FL
$50 nightly
The price is $56 total per night from Dec 23 to Dec 24
$56 total
Dec 23 - Dec 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,005 reviews)
Everything was fine except the coffee maker in room didn't work but coffee was available at breakfast bar. No real complaints.

Reviewed on Dec 16, 2025

Super 8 by Wyndham Gainesville I-75 Hospital University Area
Travelers Inn

Travelers Inn

2 out of 5
3103 NW 13th St Gainesville FL
$70 nightly
The price is $79 total per night from Dec 23 to Dec 24
$79 total
Dec 23 - Dec 24
Total with taxes and fees
Stay at this motel in Gainesville. Enjoy free WiFi, free parking, and room service. Popular attractions Ben Hill Griffin Stadium and Stephen C. O'Connell Center ...
6.2/10 (402 reviews)
Dated but clean.
Dated but clean, well maintained property. A bargain in Gainesville. Only negative, the flood lights in the parking lot bleed into the rooms despite blackout curtains. The strong light gives the impression the area is not safe. The area is safe. Tone down those lights.

Reviewed on Oct 20, 2025

Travelers Inn
Micanopy Inn

Micanopy Inn

2 out of 5
17110 SE County Road 234 Micanopy FL
$45 nightly
The price is $51 total per night from Dec 23 to Dec 24
$51 total
Dec 23 - Dec 24
Total with taxes and fees
Stay at this motel in Micanopy. Enjoy daily housekeeping, laundry facilities, and premium TV channels. Popular attractions Micanopy Historical Society Museum ...
5/10 (462 reviews)
Awesome staff, clean rooms

Reviewed on Nov 17, 2025

Micanopy Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Gainesville

Home2 Suites by Hilton Gainesville Medical Center

Home2 Suites by Hilton Gainesville Medical Center

3 out of 5
2115 Southwest 13th Street Gainesville FL
$102 nightly
The price is $114 total per night from Dec 30 to Dec 31
$114 total
Dec 30 - Dec 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (892 reviews)
😍

Reviewed on Dec 5, 2025

Home2 Suites by Hilton Gainesville Medical Center
Homewood Suites by Hilton Gainesville

Homewood Suites by Hilton Gainesville

3 out of 5
3333 Sw 42nd St Gainesville FL
$94 nightly
The price is $106 total per night from Dec 30 to Dec 31
$106 total
Dec 30 - Dec 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in ...
8.4/10 Very Good! (927 reviews)
Good

Reviewed on Nov 29, 2025

Homewood Suites by Hilton Gainesville
DoubleTree by Hilton Gainesville

DoubleTree by Hilton Gainesville

4 out of 5
3726 Sw 40th Blvd Gainesville FL
$81 nightly
The price is $91 total per night from Dec 28 to Dec 29
$91 total
Dec 28 - Dec 29
Total with taxes and fees
Stay at this hotel in Gainesville. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.6/10 Good! (1,006 reviews)
Excellent Staff Especially The Bartender..She Was Very Friendly And She Fixed My Drink..Tom Collins

Reviewed on Dec 19, 2025

DoubleTree by Hilton Gainesville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TYS to GNV Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York
GNV Address & GPS
Address:
3400 Northeast 39th Avenue
Gainesville FL, 32609
United States
IATA Code:
GNV
Longitude:
-82.276797
Latitude:
29.686142
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from Knoxville Airport to GNV?
Flying from McGhee Tyson Airport (TYS) to GNV? Breaking up the journey is your one and only option as there are no carriers that service this route directly. However, American Airlines, Delta Air Lines and United Airlines offer the closest thing — a flight with just one stop.
What is the shortest flight from Knoxville Airport to GNV?
From Knoxville, the thrilling sights and sounds of Gainesville are 3 hours and 24 minutes away. Be sure to book your favorite seat, or maybe even one with extra legroom, and fly to your destination in total comfort.
How many hours flight from Knoxville Airport to GNV?
Typically, the flight time from Knoxville Airport to Gainesville Regional Airport (GNV) takes 3 hours and 31 minutes. If you want to be as comfy as possible, think about upgrading your seat using air miles or cash.
What airlines have the most flights from Knoxville Airport to Gainesville Regional Airport?
Do a bit of shopping, sit down for a coffee, go for a wander around .... Airport stopovers don't have to be something to dread! If you're jetting between Knoxville and Gainesville, you can't fly direct. Get ready to make a stop somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

More to Explore