Cheap flights from DSM to SFO (Des Moines Intl. to San Francisco Intl.)
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Cheap Flights from DSM to SFO starting at $123 One Way, $285 Round Trip
Prices starting at $285 for return flights and $123 for one-way flights to San Francisco Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
DSM
Des Moines
SFO
San Francisco
$285 Roundtrip, found 4 days ago
$285
Roundtrip
found 4 days ago
DSM
Des Moines
SFO
San Francisco
$296 Roundtrip, found 5 days ago
$296
Roundtrip
found 5 days ago
DSM
Des Moines
SFO
San Francisco
$304 Roundtrip, found 15 hours ago
$304
Roundtrip
found 15 hours ago
DSM
Des Moines
SFO
San Francisco
$312 Roundtrip, found 6 days ago
$312
Roundtrip
found 6 days ago
DSM
Des Moines
SFO
San Francisco
$316 Roundtrip, found 1 day ago
$316
Roundtrip
found 1 day ago
Hotel Ideas near San Francisco Intl.
Airport Hotels near San Francisco Intl.
Grand Hyatt at SFO
55 S McDonnell Rd San Francisco CA
$246 nightly
The price is $274 total per night from Jul 2 to Jul 3
$274 total
Jul 2 - Jul 3
Total with taxes and fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the restaurant ...
9.8/10 Exceptional! (1,630 reviews)
"Super convenient for an early morning flight out of SFO. My go to airport hotel in SF!"
Reviewed on Jun 22, 2026
La Quinta Inn & Suites by Wyndham San Francisco Airport West
1390 El Camino Real Millbrae CA
$131 nightly
The price is $150 total per night from Jul 5 to Jul 6
$150 total
Jul 5 - Jul 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Millbrae. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,696 reviews)
"Did not like that the shuttle stopped running at night. My flight was delayed which made me arrive much later than expected & wasn’t happy having to pay a $40 uber ride for a 5minute trip. Hotel itself was fine - cleanliness is my main priority always & the room was very clean!"
Reviewed on Jun 24, 2026
The Millwood - A Boutique Hotel
1375 El Camino Real Millbrae CA
$140 nightly
The price is $161 total per night from Jul 5 to Jul 6
$161 total
Jul 5 - Jul 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Millbrae. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,003 reviews)
"Hotel was great! Breakfast for airport travelers is a little late. Creamer in rooms were soared. Maybe powered creamer would be better. Coffee machine in lobby only 1 cup in 14 minutes. Not sure how that's gonna work at breakfast"
Reviewed on Jun 24, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels In San Francisco
Hyatt Regency San Francisco
5 Embarcadero Center San Francisco CA
$218 nightly
The price is $257 total per night from Jul 12 to Jul 13
$257 total
Jul 12 - Jul 13
Total with taxes and fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
9.2/10 Wonderful! (2,303 reviews)
"Amazing hotel! Will definitely be coming back to stay here. Amazing views from the rooms!"
Reviewed on Jun 24, 2026
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
$144 nightly
The price is $169 total per night from Jun 28 to Jun 29
$169 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
9/10 Wonderful! (5,901 reviews)
"Second time I stay here. It’s been nice both times."
Reviewed on Jun 24, 2026
Hilton San Francisco Financial District
750 Kearny St San Francisco CA
$118 nightly
The price is $139 total per night from Jul 12 to Jul 13
$139 total
Jul 12 - Jul 13
Total with taxes and fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness center, and WiFi (surcharge). Our guests praise the helpful ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
San Francisco Hotels With Airport Transportation
The Dylan at SFO
110 S El Camino Real Millbrae CA
$131 nightly
The price is $155 total per night from Jul 3 to Jul 4
$155 total
Jul 3 - Jul 4
Total with taxes and fees
Book a stay at this business-friendly hotel in Millbrae. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (1,864 reviews)
"This was surprisingly a nice venue. Cozy and well-maintained."
Reviewed on Jun 24, 2026
Hotel Skye SFO
421 El Camino Real San Bruno CA
$124 nightly
The price is $142 total per night from Jul 5 to Jul 6
$142 total
Jul 5 - Jul 6
Total with taxes and fees
Book a stay at this business-friendly hotel in San Bruno. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,834 reviews)
"I stayed at the Sens hotel for a business trip for a week and absolutely loved this little hotel and the location. There was a wonderful grocery market right next-door and the room had a refrigerator and microwave and other amenities in the room making my weeklong stay very nice and comfortable. ..."
Reviewed on Jun 24, 2026
Sfo El Rancho Inn
1100 El Camino Real Millbrae CA
Book a stay at this business-friendly hotel in Millbrae. Enjoy free breakfast, an outdoor pool, and a 24-hour fitness center. Our guests praise the breakfast ...
8.4/10 Very Good! (3,002 reviews)
"Everything was good"
Reviewed on Jun 25, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Low Priced San Francisco Hotels
Travelodge by Wyndham San Francisco Airport North
326 S Airport Blvd South San Francisco CA
$75 nightly
The price is $89 total per night from Jul 12 to Jul 13
$89 total
Jul 12 - Jul 13
Total with taxes and fees
Book a stay at this business-friendly motel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and parking (surcharge). Our guests praise the clean ...
6/10 (3,772 reviews)
"Clean room"
Reviewed on Jun 24, 2026
Hotel North Beach
935 Kearny Street San Francisco CA
$67 nightly
The price is $79 total per night from Jul 5 to Jul 6
$79 total
Jul 5 - Jul 6
Total with taxes and fees
Stay at this hotel in San Francisco. Enjoy free WiFi, a 24-hour front desk, and laundry facilities. Our guests praise the helpful staff and the clean rooms in ...
7.2/10 Good! (1,001 reviews)
"Old, and some pleaces smell bad"
Reviewed on Jun 22, 2026
Hotel Skye SFO
421 El Camino Real San Bruno CA
$124 nightly
The price is $142 total per night from Jul 5 to Jul 6
$142 total
Jul 5 - Jul 6
Total with taxes and fees
Book a stay at this business-friendly hotel in San Bruno. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,834 reviews)
"I stayed at the Sens hotel for a business trip for a week and absolutely loved this little hotel and the location. There was a wonderful grocery market right next-door and the room had a refrigerator and microwave and other amenities in the room making my weeklong stay very nice and comfortable. ..."
Reviewed on Jun 24, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Family Friendly Hotels in San Francisco
Hotel Zephyr San Francisco
250 Beach Street San Francisco CA
$168 nightly
The price is $198 total per night from Jun 28 to Jun 29
$198 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this boutique hotel in San Francisco. Enjoy free WiFi, a 24-hour fitness center, and parking (surcharge). Our guests praise the helpful staff ...
8.6/10 Excellent! (2,661 reviews)
"Location was great. Hotel itself was convinient and only 5 mins walking away from Trader Joe's. Drainage of bath tub and sink were god awful, it took forever for the water to drain As much as they want to advertise for the $35 daily extra fee for the amenities they are offering, i wish we could opted ..."
Reviewed on Jun 24, 2026
Embassy Suites by Hilton San Francisco Airport Waterfront
150 Anza Blvd Burlingame CA
$139 nightly
The price is $158 total per night from Jul 6 to Jul 7
$158 total
Jul 6 - Jul 7
Total with taxes and fees
Book a stay at this business-friendly hotel in Burlingame. Enjoy free breakfast, WiFi (surcharge), and parking (surcharge). Our guests praise the breakfast and ...
8.6/10 Excellent! (2,197 reviews)
"We loved our stay here, the breakfast was great!"
Reviewed on Jun 25, 2026
Embassy Suites by Hilton San Francisco Airport Oyster Point
250 Gateway Blvd South San Francisco CA
$135 nightly
The price is $159 total per night from Jul 10 to Jul 11
$159 total
Jul 10 - Jul 11
Total with taxes and fees
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, a 24-hour fitness center, and parking (surcharge). Our guests praise ...
8.8/10 Excellent! (1,525 reviews)
"The staff was great and towel service was quick. Breakfast was very good for being included. But I give this hotel a low rating because the pool is DISGUSTING. When I came into my room, it smelled like piss and we immediately changed rooms. That evening, my kids went to the pool. I did not want to ..."
Reviewed on Jun 25, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
DSM to SFO Route Info
Origin Airport | |
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Destination Airport | |
Number Of Airlines Serving | |
Distance | |
Shortest Flight Departure Time | |
Shortest Flight Departure Date |
- Airport Locations
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DSM Address & GPS
Address:
5800 Fleur Drive, Suite 201
Des Moines IA, 50321-2854
United States
IATA Code:
DSM
Longitude:
-93.648087
Latitude:
41.532434
Time Zone:
America/Chicago
SFO Address & GPS
Address:
San Francisco CA, 94128
United States
IATA Code:
SFO
Longitude:
-122.389881
Latitude:
37.615215
Time Zone:
America/Los_Angeles
Other Flights from Des Moines Intl. Airport (DSM)
Other Flights to San Francisco Intl. Airport (SFO)
- Fort Dodge Regional Airport (FOD)
- Waterloo Regional Airport (ALO)
- Eastern Iowa Airport (CID)
- Mason City Municipal Airport (MCW)
- Kirksville Municipal Airport (IRK)
- Eppley Field Airport (OMA)
- Millard Airport (MIQ)
- Southeast Iowa Regional Airport (BRL)
- Sioux Gateway Airport (SUX)
- Quad City Intl. Airport (MLI)
Top Trending
Flights
- Los Angeles Intl. (LAX) To Juan Santamaría Intl. (SJO)
- John F. Kennedy Intl. (JFK) To Los Angeles Intl. (LAX)
- Ronald Reagan Washington National (DCA) To Los Angeles Intl. (LAX)
- Los Angeles Intl. (LAX) To John F. Kennedy Intl. (JFK)
- Orlando Intl. (MCO) To Los Angeles Intl. (LAX)
- Los Angeles Intl. (LAX) To O'Hare Intl. (ORD)
- Los Angeles Intl. (LAX) To Kahului (OGG)
- Los Angeles Intl. (LAX) To Washington Dulles Intl. (IAD)
- Los Angeles Intl. (LAX) To Dallas-Fort Worth Intl. (DFW)
- Seattle - Tacoma Intl. (SEA) To San Diego Intl. (SAN)
- Los Angeles Intl. (LAX) To Daniel K. Inouye Intl. (HNL)
- Seattle - Tacoma Intl. (SEA) To John Wayne (SNA)
- Los Angeles Intl. (LAX) To Orlando Intl. (MCO)
- San Diego Intl. (SAN) To Sky Harbor Intl. (PHX)
- San Francisco Intl. (SFO) To John Wayne (SNA)
- Los Angeles Intl. (LAX) To Oakland Intl. (OAK)
- John Wayne (SNA) To San Francisco Intl. (SFO)
- John Wayne (SNA) To Harry Reid Intl. (LAS)
- Los Angeles Intl. (LAX) To Ronald Reagan Washington National (DCA)
- Washington Dulles Intl. (IAD) To Los Angeles Intl. (LAX)
- Detroit Metropolitan Wayne County (DTW) To Los Angeles Intl. (LAX)
- O'Hare Intl. (ORD) To Los Angeles Intl. (LAX)
- San Francisco Intl. (SFO) To Los Angeles Intl. (LAX)
- Portland Intl. (PDX) To John Wayne (SNA)
- Los Angeles Intl. (LAX) To Haneda (HND)
- Los Angeles Intl. (LAX) To Heathrow (LHR)
- Los Angeles Intl. (LAX) To Tan Son Nhat Intl. (SGN)
- Baltimore Washington Intl. Thurgood Marshall (BWI) To Los Angeles Intl. (LAX)
- Los Angeles Intl. (LAX) To George Bush Intercontinental (IAH)
- George Bush Intercontinental (IAH) To Los Angeles Intl. (LAX)
Frequently asked questions
Map To Nearby Hotels
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.
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