Cheap flights from DSM to SAN (Des Moines Intl. to San Diego Intl.)

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Cheap Flights from DSM to SAN starting at $136 One Way, $260 Round Trip

Prices starting at $260 for return flights and $136 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Jul 15 - Wed, Jul 22
DSM
Des Moines
SAN
San Diego
$260 Roundtrip, found 4 days ago
$260
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Wed, Jul 15 from Des Moines to San Diego, returning Wed, Jul 22, priced at $260 found 4 days ago
Wed, Jul 15 - Wed, Jul 22
DSM
Des Moines
SAN
San Diego
$265 Roundtrip, found 4 days ago
$265
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Wed, Jul 15 from Des Moines to San Diego, returning Wed, Jul 22, priced at $265 found 4 days ago
Mon, Oct 26 - Fri, Oct 30
DSM
Des Moines
SAN
San Diego
$272 Roundtrip, found 4 days ago
$272
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Mon, Oct 26 from Des Moines to San Diego, returning Fri, Oct 30, priced at $272 found 4 days ago
Fri, Aug 7 - Wed, Aug 12
DSM
Des Moines
SAN
San Diego
$275 Roundtrip, found 1 hour ago
$275
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Fri, Aug 7 from Des Moines to San Diego, returning Wed, Aug 12, priced at $275 found 1 hour ago
Wed, Jul 15 - Mon, Jul 20
DSM
Des Moines
SAN
San Diego
$281 Roundtrip, found 2 days ago
$281
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Jul 15 from Des Moines to San Diego, returning Mon, Jul 20, priced at $281 found 2 days ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$188 nightly
The price is $216 total per night from Jun 28 to Jun 29
$216 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (3,541 reviews)
"It was ok, not worth it for the cost though. They didn't have the large urns of water with a fruit flavor unless you walked to the other side of the resort."

Reviewed on Jun 21, 2026

Sheraton San Diego Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Jun 29 to Jun 30
$211 total
Jun 29 - Jun 30
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,232 reviews)
"Both keys we received didnt work & I had to make another trip to the front to re-scan the keys. The room we stayed was on the 2nd floor right next to the elevator. Unfortunately, we had to hear loud elevator noise & sound from the street all night long. I never experienced hotel room with such noise ..."

Reviewed on Jun 22, 2026

Wyndham San Diego Bayside
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
$316 nightly
The price is $366 total per night from Jun 25 to Jun 26
$366 total
Jun 25 - Jun 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the helpful staff ...
9/10 Wonderful! (2,808 reviews)
"Manchester will always be my favorite hotel in down town SD! They take pride in the property and their customer service! We will always be a customer!"

Reviewed on Jun 22, 2026

Manchester Grand Hyatt San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
$316 nightly
The price is $366 total per night from Jun 25 to Jun 26
$366 total
Jun 25 - Jun 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the helpful staff ...
9/10 Wonderful! (2,808 reviews)
"Manchester will always be my favorite hotel in down town SD! They take pride in the property and their customer service! We will always be a customer!"

Reviewed on Jun 22, 2026

Manchester Grand Hyatt San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
$325 nightly
The price is $374 total per night from Jun 28 to Jun 29
$374 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,657 reviews)
"We’ve stayed here for over 10+ years. Still an amazing choice for us. Please work on the landscaping. It used to look more lush."

Reviewed on Jun 21, 2026

Paradise Point Resort & Spa
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Jun 29 to Jun 30
$211 total
Jun 29 - Jun 30
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,232 reviews)
"Both keys we received didnt work & I had to make another trip to the front to re-scan the keys. The room we stayed was on the 2nd floor right next to the elevator. Unfortunately, we had to hear loud elevator noise & sound from the street all night long. I never experienced hotel room with such noise ..."

Reviewed on Jun 22, 2026

Wyndham San Diego Bayside
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Jun 29 to Jun 30
$211 total
Jun 29 - Jun 30
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,232 reviews)
"Both keys we received didnt work & I had to make another trip to the front to re-scan the keys. The room we stayed was on the 2nd floor right next to the elevator. Unfortunately, we had to hear loud elevator noise & sound from the street all night long. I never experienced hotel room with such noise ..."

Reviewed on Jun 22, 2026

Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$188 nightly
The price is $216 total per night from Jun 28 to Jun 29
$216 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (3,541 reviews)
"It was ok, not worth it for the cost though. They didn't have the large urns of water with a fruit flavor unless you walked to the other side of the resort."

Reviewed on Jun 21, 2026

Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 out of 5
1955 San Diego Ave San Diego CA
$162 nightly
The price is $186 total per night from Jun 30 to Jul 1
$186 total
Jun 30 - Jul 1
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
9.2/10 Wonderful! (1,083 reviews)
"Overall great experience. Close to airport and they provide shuttle. Also assist with pick up after we dropped off our car rental. Staff super helpful"

Reviewed on Jun 21, 2026

Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn

Pleasant Inn

2.5 out of 5
5550 Clairemont Mesa Blvd San Diego CA
$128 nightly
The price is $146 total per night from Jul 19 to Jul 20
$146 total
Jul 19 - Jul 20
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
8.6/10 Excellent! (1,450 reviews)
"Its a decent place, especially as we only stayed one night. I'm hesitant to even leave the review because I don't know if it was just our room or if they're all the same, but our issue was how hard the beds were and the pillows were horrible. They're short and thick so we both woke up with headaches ..."

Reviewed on Jun 21, 2026

Pleasant Inn
E-Z 8 Motel Old Town

E-Z 8 Motel Old Town

2.5 out of 5
4747 Pacific Highway San Diego CA
$84 nightly
The price is $97 total per night from Jun 23 to Jun 24
$97 total
Jun 23 - Jun 24
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
6.6/10 (2,127 reviews)
"There was a leak under the flooring that made our entire floor damp all of the time. It never dried out. We wore socks all of the time to keep the dirt on the floor off of our feet. The toilet was very low. I am old and had a difficult time using it. There were unpatched holes in the walls and molding ..."

Reviewed on Jun 22, 2026

E-Z 8 Motel Old Town
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
$136 nightly
The price is $156 total per night from Jun 29 to Jun 30
$156 total
Jun 29 - Jun 30
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.8/10 Excellent! (3,737 reviews)
"It was very clean. The rooms were comfortable. The pool was great for the kids and the restaurant on site was delicious and convenient. Not to mention the staff was very nice and accommodating. It was a really good place to spend a few nights."

Reviewed on Jun 21, 2026

Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
$345 nightly
The price is $396 total per night from Jul 6 to Jul 7
$396 total
Jul 6 - Jul 7
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (2,176 reviews)
"The property grounds were OK, the room was disgusting. Carpet was dirty and stained, small room, old dingy wallpaper, leaky tub with mold on ceiling and not enough outlets. We also encountered a cockroach in the room in the middle of the night. Overall the room was gross, I advised staff the next ..."

Reviewed on Jun 21, 2026

Bahia Resort Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
$284 nightly
The price is $326 total per night from Jul 6 to Jul 7
$326 total
Jul 6 - Jul 7
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
9/10 Wonderful! (4,368 reviews)
"Loved having two pools and bar and food available. Staff very personable and friendly!"

Reviewed on Jun 21, 2026

The Dana on Mission Bay
Catamaran Resort and Spa

Catamaran Resort and Spa

4 out of 5
3999 Mission Boulevard San Diego CA
$295 nightly
The price is $339 total per night from Jun 28 to Jun 29
$339 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,282 reviews)

Families like: Outdoor pool, game room, on the beach, bicycle rentals

Travelers say...
"Nice property with a very convenient location. Could use an update but the property was clean and well maintained. Was surprised at how busy it can be. Overall great experience."

Reviewed on Jun 21, 2026

Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

DSM to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
DSM Address & GPS
Address:
5800 Fleur Drive, Suite 201
Des Moines IA, 50321-2854
United States
IATA Code:
DSM
Longitude:
-93.648087
Latitude:
41.532434
Time Zone:
America/Chicago
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from DSM to San Diego Intl. Airport (SAN)?
You'll have to switch planes if you want to get from Des Moines Intl. Airport (DSM) to SAN. A number of companies service this route with just one stopover, including American Airlines, Southwest Airlines and United Airlines.
What is the shortest flight from Des Moines Intl. Airport (DSM) to San Diego Intl. Airport (SAN)?
Grab a glass of vino and get comfortable in your seat with a riveting movie or novel. With the journey from Des Moines to San Diego taking 5 hours and 50 minutes, there's plenty of time to enjoy the flying experience.
How many hours flight from DSM to San Diego Intl. Airport (SAN)?
On a normal day, the trip from DSM to San Diego Intl. Airport (SAN) takes 5 hours and 57 minutes. If you're eager to be as comfortable as possible, contemplate upgrading your seat using miles or cash.
What airlines have the most flights from DSM to San Diego Intl. Airport (SAN)?
Currently, no airlines fly direct between Des Moines Intl. Airport (DSM) and San Diego Airport. But never fear. There are loads of single or multi-stop flights available.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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