Cheap flights from DSM to SAN (Des Moines Intl. to San Diego Intl.)

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Cheap Flights from DSM to SAN starting at $111 One Way, $215 Round Trip

Prices starting at $215 for return flights and $111 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Jun 10 - Wed, Jun 17
DSM
Des Moines
SAN
San Diego
$215 Roundtrip, found 1 day ago
$215
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Jun 10 from Des Moines to San Diego, returning Wed, Jun 17, priced at $215 found 1 day ago
Wed, Jul 1 - Wed, Jul 8
DSM
Des Moines
SAN
San Diego
$230 Roundtrip, found 1 day ago
$230
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Jul 1 from Des Moines to San Diego, returning Wed, Jul 8, priced at $230 found 1 day ago
Wed, May 27 - Sun, May 31
DSM
Des Moines
SAN
San Diego
$230 Roundtrip, found 6 days ago
$230
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Wed, May 27 from Des Moines to San Diego, returning Sun, May 31, priced at $230 found 6 days ago
Wed, Jun 24 - Fri, Jun 26
DSM
Des Moines
SAN
San Diego
$236 Roundtrip, found 3 days ago
$236
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Wed, Jun 24 from Des Moines to San Diego, returning Fri, Jun 26, priced at $236 found 3 days ago
Wed, Jul 15 - Wed, Jul 22
DSM
Des Moines
SAN
San Diego
$240 Roundtrip, found 19 hours ago
$240
Roundtrip
found 19 hours ago
Select Frontier Airlines flight, departing Wed, Jul 15 from Des Moines to San Diego, returning Wed, Jul 22, priced at $240 found 19 hours ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$169 nightly
The price is $194 total per night from May 25 to May 26
$194 total
May 25 - May 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (3,517 reviews)
Pay attention to your booking. They tried to give us a basic room at check after we paid $300 more to upgrade to a premium room. Also check your bill at check out. The property was okay. Staff could have been a bit more friendly. Food options were limited on the property. IMO it wasn’t worth the ...

Reviewed on May 3, 2026

Sheraton San Diego Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from May 7 to May 8
$211 total
May 7 - May 8
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,155 reviews)
The room was clean, but there was no hot water. We stayed for 5 nights and had to take a cold shower every day. It was nice to have covered parking, but for $50 a night, the spaces should not have been so tiny. I have a scratch down the left side of my car now.

Reviewed on May 4, 2026

Wyndham San Diego Bayside
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
$119 nightly
The price is $138 total per night from May 25 to May 26
$138 total
May 25 - May 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.8/10 Excellent! (1,506 reviews)
It’s my first time in San Diego and I am so glad I chose this hotel! The staff here are amazing and helpful! My luggage was delayed but the staff here helped receive it. They are kind and warm. Will recommend to friends!

Reviewed on May 4, 2026

The DEXTRO Little Italy, BW Premier Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
$254 nightly
The price is $294 total per night from May 7 to May 8
$294 total
May 7 - May 8
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (3,623 reviews)
Location was great and the rooms were very nice. Will stay there again.

Reviewed on May 4, 2026

Hard Rock Hotel San Diego
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
$170 nightly
The price is $197 total per night from May 11 to May 12
$197 total
May 11 - May 12
Total with taxes and fees
Book a stay at this historic hotel in San Diego. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (2,000 reviews)
Always a great stay at the Sophia

Reviewed on May 4, 2026

The Sofia Hotel
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
$119 nightly
The price is $138 total per night from May 25 to May 26
$138 total
May 25 - May 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.8/10 Excellent! (1,506 reviews)
It’s my first time in San Diego and I am so glad I chose this hotel! The staff here are amazing and helpful! My luggage was delayed but the staff here helped receive it. They are kind and warm. Will recommend to friends!

Reviewed on May 4, 2026

The DEXTRO Little Italy, BW Premier Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from May 7 to May 8
$211 total
May 7 - May 8
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,155 reviews)
The room was clean, but there was no hot water. We stayed for 5 nights and had to take a cold shower every day. It was nice to have covered parking, but for $50 a night, the spaces should not have been so tiny. I have a scratch down the left side of my car now.

Reviewed on May 4, 2026

Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$169 nightly
The price is $194 total per night from May 25 to May 26
$194 total
May 25 - May 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (3,517 reviews)
Pay attention to your booking. They tried to give us a basic room at check after we paid $300 more to upgrade to a premium room. Also check your bill at check out. The property was okay. Staff could have been a bit more friendly. Food options were limited on the property. IMO it wasn’t worth the ...

Reviewed on May 3, 2026

Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 out of 5
1955 San Diego Ave San Diego CA
$141 nightly
The price is $162 total per night from May 10 to May 11
$162 total
May 10 - May 11
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
9.2/10 Wonderful! (1,061 reviews)
Easy check in easy checkout.

Reviewed on May 4, 2026

Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn

Pleasant Inn

2.5 out of 5
5550 Clairemont Mesa Blvd San Diego CA
$94 nightly
The price is $107 total per night from May 10 to May 11
$107 total
May 10 - May 11
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
8.6/10 Excellent! (1,388 reviews)
With my room 118 the towel handle by the sink broke off when I put the towel back, BUT besides that small dysfunction it was the best hotel I’ve stayed in forever, and the staff was absolutely amazing and incredible! The rooms were clean and smelled like a new hotel lol. If I ever have to stay at ...

Reviewed on May 4, 2026

Pleasant Inn
E-Z 8 Motel Old Town

E-Z 8 Motel Old Town

2.5 out of 5
4747 Pacific Highway San Diego CA
$62 nightly
The price is $71 total per night from May 5 to May 6
$71 total
May 5 - May 6
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
6.6/10 (2,120 reviews)
The staff was so incredibly nice and helpful.

Reviewed on Apr 30, 2026

E-Z 8 Motel Old Town
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
$94 nightly
The price is $108 total per night from May 10 to May 11
$108 total
May 10 - May 11
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.8/10 Excellent! (3,691 reviews)
The weather stripping was missing on the bottom of my door. There was a large gap between the door and floor allowing the weather to come in. I had to leave a blanket in front of the space while I was in the room.

Reviewed on May 4, 2026

Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
$217 nightly
The price is $250 total per night from May 17 to May 18
$250 total
May 17 - May 18
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
8.6/10 Excellent! (2,047 reviews)
Great time for everyone, kids and adults

Reviewed on May 3, 2026

Bahia Resort Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
$199 nightly
The price is $229 total per night from May 10 to May 11
$229 total
May 10 - May 11
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
9/10 Wonderful! (4,334 reviews)
We have stayed at the Dana a few times and we are gonna be booking in the future. We love this place

Reviewed on May 4, 2026

The Dana on Mission Bay
Catamaran Resort and Spa

Catamaran Resort and Spa

4 out of 5
3999 Mission Boulevard San Diego CA
$295 nightly
The price is $339 total per night from May 10 to May 11
$339 total
May 10 - May 11
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,240 reviews)

Families like: Outdoor pool, game room, on the beach, bicycle rentals

Travelers say...
This place is pretty much worth the price. Unique very deliberate Hawaiian vibe. The Lava Java Cafe is also great, if pricey.

Reviewed on May 3, 2026

Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

DSM to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
DSM Address & GPS
Address:
5800 Fleur Drive, Suite 201
Des Moines IA, 50321-2854
United States
IATA Code:
DSM
Longitude:
-93.648087
Latitude:
41.532434
Time Zone:
America/Chicago
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from DSM to San Diego Intl. Airport (SAN)?
You'll have to switch planes if you want to get from Des Moines Intl. Airport (DSM) to SAN. A number of companies service this route with just one stopover, including American Airlines, Southwest Airlines and United Airlines.
What is the shortest flight from Des Moines Intl. Airport (DSM) to San Diego Intl. Airport (SAN)?
Grab a glass of vino and get comfortable in your seat with a riveting movie or novel. With the journey from Des Moines to San Diego taking 5 hours and 50 minutes, there's plenty of time to enjoy the flying experience.
How many hours flight from DSM to San Diego Intl. Airport (SAN)?
On a normal day, the trip from DSM to San Diego Intl. Airport (SAN) takes 5 hours and 57 minutes. If you're eager to be as comfortable as possible, contemplate upgrading your seat using miles or cash.
What airlines have the most flights from DSM to San Diego Intl. Airport (SAN)?
Currently, no airlines fly direct between Des Moines Intl. Airport (DSM) and San Diego Airport. But never fear. There are loads of single or multi-stop flights available.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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