Cheap flights from DSM to SAN (Des Moines Intl. to San Diego Intl.)

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Cheap Flights from DSM to SAN starting at $131 One Way, $287 Round Trip

Prices starting at $287 for return flights and $131 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Dec 3 - Sun, Dec 6
DSM
Des Moines
SAN
San Diego
$287 Roundtrip, found 4 days ago
$287
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Thu, Dec 3 from Des Moines to San Diego, returning Sun, Dec 6, priced at $287 found 4 days ago
Thu, Dec 3 - Sun, Dec 6
DSM
Des Moines
SAN
San Diego
$302 Roundtrip, found 4 days ago
$302
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Thu, Dec 3 from Des Moines to San Diego, returning Sun, Dec 6, priced at $302 found 4 days ago
Fri, Oct 23 - Mon, Oct 26
DSM
Des Moines
SAN
San Diego
$305 Roundtrip, found 13 hours ago
$305
Roundtrip
found 13 hours ago
Select Frontier Airlines flight, departing Fri, Oct 23 from Des Moines to San Diego, returning Mon, Oct 26, priced at $305 found 13 hours ago
Thu, Sep 24 - Mon, Sep 28
DSM
Des Moines
SAN
San Diego
$306 Roundtrip, found 4 days ago
$306
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Thu, Sep 24 from Des Moines to San Diego, returning Mon, Sep 28, priced at $306 found 4 days ago
Thu, Sep 24 - Mon, Sep 28
DSM
Des Moines
SAN
San Diego
$310 Roundtrip, found 4 days ago
$310
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Thu, Sep 24 from Des Moines to San Diego, returning Mon, Sep 28, priced at $310 found 4 days ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$188 nightly
The price is $216 total per night from Sep 3 to Sep 4
$216 total
Sep 3 - Sep 4
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Sheraton San Diego Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Sep 3 to Sep 4
$211 total
Sep 3 - Sep 4
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,308 reviews)
"太旧了"

Reviewed on Aug 29, 2026

Wyndham San Diego Bayside
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
$246 nightly
The price is $285 total per night from Sep 7 to Sep 8
$285 total
Sep 7 - Sep 8
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
9/10 Wonderful! (2,817 reviews)
"Great location with great views!"

Reviewed on Aug 30, 2026

Manchester Grand Hyatt San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
$246 nightly
The price is $285 total per night from Sep 7 to Sep 8
$285 total
Sep 7 - Sep 8
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
9/10 Wonderful! (2,817 reviews)
"Great location with great views!"

Reviewed on Aug 30, 2026

Manchester Grand Hyatt San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
$254 nightly
The price is $292 total per night from Sep 7 to Sep 8
$292 total
Sep 7 - Sep 8
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Paradise Point Resort & Spa
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Sep 3 to Sep 4
$211 total
Sep 3 - Sep 4
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,308 reviews)
"太旧了"

Reviewed on Aug 29, 2026

Wyndham San Diego Bayside
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Sep 3 to Sep 4
$211 total
Sep 3 - Sep 4
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,308 reviews)
"太旧了"

Reviewed on Aug 29, 2026

Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$188 nightly
The price is $216 total per night from Sep 3 to Sep 4
$216 total
Sep 3 - Sep 4
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 out of 5
1955 San Diego Ave San Diego CA
$148 nightly
The price is $170 total per night from Sep 27 to Sep 28
$170 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
9.2/10 Wonderful! (1,088 reviews)
"So convenient, close to MCRD. Very helpful with maps and restaurants. Very friendly!"

Reviewed on Aug 29, 2026

Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn

Pleasant Inn

2.5 out of 5
5550 Clairemont Mesa Blvd San Diego CA
$109 nightly
The price is $125 total per night from Aug 31 to Sep 1
$125 total
Aug 31 - Sep 1
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
Pleasant Inn
E-Z 8 Motel Old Town

E-Z 8 Motel Old Town

2.5 out of 5
4747 Pacific Highway San Diego CA
$71 nightly
The price is $81 total per night from Aug 31 to Sep 1
$81 total
Aug 31 - Sep 1
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
6.6/10 (2,188 reviews)
"Manager was rude and unprofessional. I don’t know how he has a job"

Reviewed on Aug 30, 2026

E-Z 8 Motel Old Town
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
$108 nightly
The price is $124 total per night from Sep 30 to Oct 1
$124 total
Sep 30 - Oct 1
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.8/10 Excellent! (3,724 reviews)
"Yes it was very clean and outstanding guest services. Sandy is awesome, friendly and represents the Kings Inn professionally and positively. As a happy guest we have been staying here for 16 year's"

Reviewed on Aug 29, 2026

Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
$223 nightly
The price is $257 total per night from Sep 30 to Oct 1
$257 total
Sep 30 - Oct 1
Total with taxes and fees
Book a stay at this business-friendly resort in San Diego. Enjoy breakfast (surcharge), 24-hour room service, and a fitness center. Our guests praise the pool ...
8.6/10 Excellent! (2,370 reviews)
"Booked for a kitchenette, It was get this..,, TOASTER and MICROWAVE. I had a group of 5, 2 adults, 3 children. I wanted to save and cook breakfast found out that was NOT an option. No ventilation in bathroom so if anyone pooped the whole room smelt like poop even after buying sprayers and what not ..."

Reviewed on Aug 30, 2026

Bahia Resort Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
$186 nightly
The price is $213 total per night from Aug 31 to Sep 1
$213 total
Aug 31 - Sep 1
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
The Dana on Mission Bay
Catamaran Resort and Spa

Catamaran Resort and Spa

4 out of 5
3999 Mission Boulevard San Diego CA
$294 nightly
The price is $339 total per night from Sep 7 to Sep 8
$339 total
Sep 7 - Sep 8
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

DSM to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
DSM Address & GPS
Address:
5800 Fleur Drive, Suite 201
Des Moines IA, 50321-2854
United States
IATA Code:
DSM
Longitude:
-93.648087
Latitude:
41.532434
Time Zone:
America/Chicago
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from DSM to San Diego Intl. Airport (SAN)?
You'll have to switch planes if you want to get from Des Moines Intl. Airport (DSM) to SAN. A number of companies service this route with just one stopover, including American Airlines, Southwest Airlines and United Airlines.
What is the shortest flight from Des Moines Intl. Airport (DSM) to San Diego Intl. Airport (SAN)?
Grab a glass of vino and get comfortable in your seat with a riveting movie or novel. With the journey from Des Moines to San Diego taking 5 hours and 50 minutes, there's plenty of time to enjoy the flying experience.
How many hours flight from DSM to San Diego Intl. Airport (SAN)?
On a normal day, the trip from DSM to San Diego Intl. Airport (SAN) takes 5 hours and 57 minutes. If you're eager to be as comfortable as possible, contemplate upgrading your seat using miles or cash.
What airlines have the most flights from DSM to San Diego Intl. Airport (SAN)?
Currently, no airlines fly direct between Des Moines Intl. Airport (DSM) and San Diego Airport. But never fear. There are loads of single or multi-stop flights available.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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