Cheap flights from TYS to SAN (McGhee Tyson to San Diego Intl.)

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Cheap Flights from TYS to SAN starting at $90 One Way, $182 Round Trip

Prices starting at $182 for return flights and $90 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Feb 23 - Mon, Mar 2
TYS
Knoxville
SAN
San Diego
$182 Roundtrip, found 18 hours ago
$182
Roundtrip
found 18 hours ago
Select Frontier Airlines flight, departing Mon, Feb 23 from Knoxville to San Diego, returning Mon, Mar 2, priced at $182 found 18 hours ago
Mon, Feb 9 - Thu, Feb 19
TYS
Knoxville
SAN
San Diego
$190 Roundtrip, found 4 days ago
$190
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Mon, Feb 9 from Knoxville to San Diego, returning Thu, Feb 19, priced at $190 found 4 days ago
Mon, Feb 9 - Thu, Feb 12
TYS
Knoxville
SAN
San Diego
$194 Roundtrip, found 16 hours ago
$194
Roundtrip
found 16 hours ago
Select Frontier Airlines flight, departing Mon, Feb 9 from Knoxville to San Diego, returning Thu, Feb 12, priced at $194 found 16 hours ago
Mon, Mar 2 - Mon, Mar 9
TYS
Knoxville
SAN
San Diego
$214 Roundtrip, found 5 days ago
$214
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Mon, Mar 2 from Knoxville to San Diego, returning Mon, Mar 9, priced at $214 found 5 days ago
Fri, Feb 20 - Mon, Feb 23
TYS
Knoxville
SAN
San Diego
$218 Roundtrip, found 23 hours ago
$218
Roundtrip
found 23 hours ago
Select Frontier Airlines flight, departing Fri, Feb 20 from Knoxville to San Diego, returning Mon, Feb 23, priced at $218 found 23 hours ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
The price is $273 total per night from Jan 23 to Jan 24
$273 total
per night
Jan 23 - Jan 24
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (3,254 reviews)
I love that place !!! I will definitely come back again.

Reviewed on Jan 18, 2026

Sheraton San Diego Resort
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

4 out of 5
1646 Front St San Diego CA
The price is $187 total per night from Feb 22 to Feb 23
$187 total
per night
Feb 22 - Feb 23
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.8/10 Excellent! (273 reviews)
Clean, comfy beds, nice location, close to all. We didn’t try their breakfast . Noisy due to its proximity to the freeway.

Reviewed on Jan 21, 2026

Courtyard by Marriott San Diego Downtown Little Italy
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
The price is $211 total per night from Jan 25 to Jan 26
$211 total
per night
Jan 25 - Jan 26
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,004 reviews)
No breakfast bar.

Reviewed on Jan 18, 2026

Wyndham San Diego Bayside
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
The price is $274 total per night from Jan 23 to Jan 24
$274 total
per night
Jan 23 - Jan 24
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
8.8/10 Excellent! (3,248 reviews)
Great location clean place and very friendly staff

Reviewed on Jan 20, 2026

Hard Rock Hotel San Diego
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
The price is $273 total per night from Jan 23 to Jan 24
$273 total
per night
Jan 23 - Jan 24
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (3,254 reviews)
I love that place !!! I will definitely come back again.

Reviewed on Jan 18, 2026

Sheraton San Diego Resort
Pendry San Diego

Pendry San Diego

5 out of 5
550 J Street San Diego CA
The price is $395 total per night from Feb 22 to Feb 23
$395 total
per night
Feb 22 - Feb 23
Book a stay at this luxury hotel in San Diego. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (1,001 reviews)
Well decorated, super clean high touches

Reviewed on Jan 17, 2026

Pendry San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
The price is $211 total per night from Jan 25 to Jan 26
$211 total
per night
Jan 25 - Jan 26
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,004 reviews)
No breakfast bar.

Reviewed on Jan 18, 2026

Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
The price is $273 total per night from Jan 23 to Jan 24
$273 total
per night
Jan 23 - Jan 24
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (3,254 reviews)
I love that place !!! I will definitely come back again.

Reviewed on Jan 18, 2026

Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 out of 5
1955 San Diego Ave San Diego CA
The price is $156 total per night from Jan 25 to Jan 26
$156 total
per night
Jan 25 - Jan 26
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,047 reviews)
Great place to stay. Room was clean, comfortable, and very spacious. King suite was fantastic! Front desk staff is excellent. Shuttle service readily available to Old Town and Marine Recruit Depot. Really fantastic service.

Reviewed on Jan 19, 2026

Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn

Pleasant Inn

2.5 out of 5
5550 Clairemont Mesa Blvd San Diego CA
The price is $107 total per night from Jan 29 to Jan 30
$107 total
per night
Jan 29 - Jan 30
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
8.4/10 Very Good! (1,302 reviews)
clean room, good service from staff.

Reviewed on Jan 17, 2026

Pleasant Inn
E-Z 8 Motel Old Town

E-Z 8 Motel Old Town

2.5 out of 5
4747 Pacific Highway San Diego CA
The price is $64 total per night from Jan 23 to Jan 24
$64 total
per night
Jan 23 - Jan 24
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
6.4/10 (2,087 reviews)
The room was spotless. The best thing was the staff. The night cleek was awesome!!

Reviewed on Jan 19, 2026

E-Z 8 Motel Old Town
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
The price is $95 total per night from Jan 25 to Jan 26
$95 total
per night
Jan 25 - Jan 26
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.8/10 Excellent! (3,607 reviews)
Excellent

Reviewed on Jan 18, 2026

Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
The price is $229 total per night from Feb 22 to Feb 23
$229 total
per night
Feb 22 - Feb 23
Book a stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
8.6/10 Excellent! (1,839 reviews)
Front desk was very helpful when checking in

Reviewed on Jan 13, 2026

Bahia Resort Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
The price is $206 total per night from Jan 25 to Jan 26
$206 total
per night
Jan 25 - Jan 26
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
8.8/10 Excellent! (3,994 reviews)
Great location. Nice property on the bay.

Reviewed on Jan 18, 2026

The Dana on Mission Bay
Catamaran Resort and Spa

Catamaran Resort and Spa

4 out of 5
3999 Mission Boulevard San Diego CA
The price is $246 total per night from Feb 22 to Feb 23
$246 total
per night
Feb 22 - Feb 23
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,134 reviews)

Families like: Outdoor pool, game room, on the beach, bicycle rentals

Travelers say...
We had a fantastic experience at the Catamaran Resort. The dated rooms will need a facelift to take them to the top tier, but the people were fantastic, and the location puts you right in the middle of the best parts of Mission and Pacific Beach. My wife and I look forward to our next stay at Catamaran ...

Reviewed on Jan 21, 2026

Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TYS to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from TYS to San Diego Airport?
You're going to need to swap planes if you're planning to get from McGhee Tyson Airport (TYS) to SAN. Several airlines offer services on this route with only one stopover, including American Airlines, United Airlines and Delta Air Lines.
What is the shortest flight from Knoxville Airport to San Diego Airport?
The shortest flight time from Knoxville Airport to San Diego Airport is 6 hours and 39 minutes. Order a refreshment from the drink trolley, write in your travel journal or finish that podcast — you'll have the time on this medium-haul journey.
How many hours flight from McGhee Tyson Airport (TYS) to San Diego Airport?
From TYS to SAN, you'll be in your seat for roughly 6 hours and 45 minutes. Settle back, order a wine and take out your noise-canceling earphones. It's time to rewatch your favorite TV shows.
What airlines have the most flights from Knoxville Airport to San Diego Airport?
If you're wanting to book with an airline that operates direct flights from TYS to SAN, you won't have much luck. You'll need to book a flight with at least one stopover to get to San Diego.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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