Cheap flights from DSM to SFO (Des Moines Intl. to San Francisco Intl.)

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Cheap Flights from DSM to SFO starting at $120 One Way, $220 Round Trip

Prices starting at $220 for return flights and $120 for one-way flights to San Francisco Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Aug 26 - Wed, Sep 2
DSM
Des Moines
SFO
San Francisco
$220 Roundtrip, found 4 days ago
$220
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Wed, Aug 26 from Des Moines to San Francisco, returning Wed, Sep 2, priced at $220 found 4 days ago
Mon, Jun 1 - Wed, Jun 10
DSM
Des Moines
SFO
San Francisco
$230 Roundtrip, found 5 days ago
$230
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Mon, Jun 1 from Des Moines to San Francisco, returning Wed, Jun 10, priced at $230 found 5 days ago
Wed, May 27 - Fri, May 29
DSM
Des Moines
SFO
San Francisco
$236 Roundtrip, found 6 days ago
$236
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Wed, May 27 from Des Moines to San Francisco, returning Fri, May 29, priced at $236 found 6 days ago
Fri, Jun 12 - Mon, Jun 15
DSM
Des Moines
SFO
San Francisco
$250 Roundtrip, found 4 days ago
$250
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Fri, Jun 12 from Des Moines to San Francisco, returning Mon, Jun 15, priced at $250 found 4 days ago
Mon, Jun 1 - Wed, Jun 10
DSM
Des Moines
SFO
San Francisco
$256 Roundtrip, found 5 days ago
$256
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Mon, Jun 1 from Des Moines to San Francisco, returning Wed, Jun 10, priced at $256 found 5 days ago

Hotel Ideas near San Francisco Intl.

Airport Hotels near San Francisco Intl.

Grand Hyatt at SFO

Grand Hyatt at SFO

4 out of 5
55 S McDonnell Rd San Francisco CA
$309 nightly
The price is $345 total per night from May 16 to May 17
$345 total
May 16 - May 17
Total with taxes and fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the restaurant ...
9.8/10 Exceptional! (1,576 reviews)
Friendly helpful staff. Super convenient location when connecting flights are not doable. Restaurant was fabulous (lots of gluten free options).

Reviewed on May 10, 2026

Grand Hyatt at SFO
Bay Landing San Francisco Airport Hotel

Bay Landing San Francisco Airport Hotel

3 out of 5
1550 Bayshore Hwy Burlingame CA
$161 nightly
The price is $181 total per night from May 29 to May 30
$181 total
May 29 - May 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Burlingame. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (4,885 reviews)
I was sorry that my request for room was not honored. I was wakened up by mosquitoes on the first floor room; it was nice for them to change my room.

Reviewed on May 10, 2026

Bay Landing San Francisco Airport Hotel
Crowne Plaza San Francisco Airport by IHG

Crowne Plaza San Francisco Airport by IHG

3.5 out of 5
1177 Airport Blvd Burlingame CA
$114 nightly
The price is $130 total per night from May 31 to Jun 1
$130 total
May 31 - Jun 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Burlingame. Enjoy free WiFi, room service, and a fitness center. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (2,727 reviews)
Excellent price and value. Highly recommend

Reviewed on May 10, 2026

Crowne Plaza San Francisco Airport by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Francisco

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
The price is $203 total per night from May 25 to May 26
$203 total
per night
May 25 - May 26
Book a stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
9/10 Wonderful! (7,487 reviews)
Everything was great

Reviewed on May 10, 2026

Hotel Riu Plaza Fisherman's Wharf
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
The price is $134 total per night from May 25 to May 26
$134 total
per night
May 25 - May 26
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness center, and WiFi (surcharge). Our guests praise the helpful ...
8.8/10 Excellent! (2,739 reviews)
I will definitely stay here again

Reviewed on May 10, 2026

Hilton San Francisco Financial District
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
The price is $155 total per night from May 25 to May 26
$155 total
per night
May 25 - May 26
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
9/10 Wonderful! (5,722 reviews)
The property is accessible to tourists area. The parking is securedWe Love it!

Reviewed on May 10, 2026

Holiday Inn Golden Gateway by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Francisco Hotels With Airport Transportation

The Dylan at SFO

The Dylan at SFO

3 out of 5
110 S El Camino Real Millbrae CA
The price is $150 total per night from May 24 to May 25
$150 total
per night
May 24 - May 25
Book a stay at this business-friendly hotel in Millbrae. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (1,871 reviews)
Pretty decent place. I think that perhaps the bed mix up may have been on Expedia? We ordered a king bed room but got two queen beds? The lady at the desk was incredibly unhelpful with this. Said that it was because it was booked thru a third party app she couldn’t help us. Okay. BUTTTTT. Later I ...

Reviewed on May 7, 2026

The Dylan at SFO
Hotel Skye SFO

Hotel Skye SFO

3 out of 5
421 El Camino Real San Bruno CA
The price is $154 total per night from May 29 to May 30
$154 total
per night
May 29 - May 30
Book a stay at this business-friendly hotel in San Bruno. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,762 reviews)
Clean room with 2 king sized beds amply accommodated a family of 4 adults. Staff was helpful with the checkin process and allowed my daughter to check in first even though I booked the room. Airport shuttle was convenient and friendly. Got the 4 of us with 8 pieces of luggage to the airport on time ...

Reviewed on May 10, 2026

Hotel Skye SFO
Sfo El Rancho Inn

Sfo El Rancho Inn

3 out of 5
1100 El Camino Real Millbrae CA
Book a stay at this business-friendly hotel in Millbrae. Enjoy free breakfast, an outdoor pool, and a 24-hour fitness center. Our guests praise the breakfast ...
8.4/10 Very Good! (3,080 reviews)
It feels like staying in a cheap motel.

Reviewed on May 4, 2026

Get rates
Sfo El Rancho Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Francisco Hotels

Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North

2 out of 5
326 S Airport Blvd South San Francisco CA
$60 nightly
The price is $72 total per night from May 28 to May 29
$72 total
May 28 - May 29
Total with taxes and fees
Book a stay at this business-friendly motel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and parking (surcharge). Our guests praise the clean ...
6/10 (3,590 reviews)
It’s okay

Reviewed on May 10, 2026

Travelodge by Wyndham San Francisco Airport North
Hotel North Beach

Hotel North Beach

2 out of 5
935 Kearny Street San Francisco CA
$67 nightly
The price is $79 total per night from May 11 to May 12
$79 total
May 11 - May 12
Total with taxes and fees
Stay at this hotel in San Francisco. Enjoy free WiFi, a 24-hour front desk, and laundry facilities. Our guests praise the helpful staff and the clean rooms in ...
7.2/10 Good! (1,011 reviews)
Yes

Reviewed on May 10, 2026

Hotel North Beach
Hotel Skye SFO

Hotel Skye SFO

3 out of 5
421 El Camino Real San Bruno CA
$134 nightly
The price is $154 total per night from May 29 to May 30
$154 total
May 29 - May 30
Total with taxes and fees
Book a stay at this business-friendly hotel in San Bruno. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,762 reviews)
Clean room with 2 king sized beds amply accommodated a family of 4 adults. Staff was helpful with the checkin process and allowed my daughter to check in first even though I booked the room. Airport shuttle was convenient and friendly. Got the 4 of us with 8 pieces of luggage to the airport on time ...

Reviewed on May 10, 2026

Hotel Skye SFO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Francisco

Hotel Zephyr San Francisco

Hotel Zephyr San Francisco

4 out of 5
250 Beach Street San Francisco CA
$169 nightly
The price is $198 total per night from May 25 to May 26
$198 total
May 25 - May 26
Total with taxes and fees
Book a stay at this boutique hotel in San Francisco. Enjoy free WiFi, a 24-hour fitness center, and parking (surcharge). Our guests praise the helpful staff ...
8.6/10 Excellent! (2,567 reviews)
Clean room, friendly staff. Kids loved the back patio area with the yard games and s’mores. Can’t beat the location if you plan to do a lot of sight seeing! We could watch seals in the arbor from our bay view room. So fun!

Reviewed on May 10, 2026

Hotel Zephyr San Francisco
Embassy Suites by Hilton San Francisco Airport Waterfront

Embassy Suites by Hilton San Francisco Airport Waterfront

3.5 out of 5
150 Anza Blvd Burlingame CA
$147 nightly
The price is $167 total per night from May 17 to May 18
$167 total
May 17 - May 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Burlingame. Enjoy free breakfast, WiFi (surcharge), and parking (surcharge). Our guests praise the breakfast and ...
8.6/10 Excellent! (2,087 reviews)
This property is uniquely located along the San Francisco Bay and once was the gem of the peninsula. In its hay day it was regarded as one of the finest hotels with extraordinary service, amenities, food, and views offered by any hotel conglomerate. However, due to a lack of maintenance and care ...

Reviewed on May 10, 2026

Embassy Suites by Hilton San Francisco Airport Waterfront
Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point

3.5 out of 5
250 Gateway Blvd South San Francisco CA
$143 nightly
The price is $168 total per night from May 25 to May 26
$168 total
May 25 - May 26
Total with taxes and fees
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, a 24-hour fitness center, and parking (surcharge). Our guests praise ...
8.6/10 Excellent! (1,411 reviews)
Very good overall

Reviewed on May 10, 2026

Embassy Suites by Hilton San Francisco Airport Oyster Point
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

DSM to SFO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
DSM Address & GPS
Address:
5800 Fleur Drive, Suite 201
Des Moines IA, 50321-2854
United States
IATA Code:
DSM
Longitude:
-93.648087
Latitude:
41.532434
Time Zone:
America/Chicago
SFO Address & GPS
Address:
San Francisco CA, 94128
United States
IATA Code:
SFO
Longitude:
-122.389881
Latitude:
37.615215
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from Des Moines Intl. Airport to San Francisco Intl. Airport (SFO)?
Unfortunately, nonstop flights aren't an option when it comes to flying from Des Moines Intl. Airport (DSM) to San Francisco Airport. However, there are numerous carriers that operate on this route with just one stopover, including United Airlines, American Airlines and Delta Air Lines.
What is the shortest flight from Des Moines Intl. Airport (DSM) to San Francisco Airport?
Treat yourself to a glass of vino and settle into your seat with a riveting movie or novel. With the trip from Des Moines Intl. Airport (DSM) to SFO taking 6 hours and 19 minutes, there's plenty of time to sit back and enjoy the ride.
How many hours flight from Des Moines Intl. Airport to SFO?
Get cozy, because the average plane trip from Des Moines Intl. Airport (DSM) to San Francisco Airport is 6 hours and 28 minutes. Have a wine with your meal, finish that book … There's plenty of time to relax and unwind.
What airlines have the most flights from Des Moines Intl. Airport (DSM) to San Francisco Airport?
Right now, no airlines operate direct flights from DSM to SFO. But there's a silver lining. There are several single or multi-stop flights available.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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