Cheap flights from MDT to SAN (Harrisburg Intl. to San Diego Intl.)

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Cheap Flights from MDT to SAN starting at $372 One Way, $419 Round Trip

Prices starting at $419 for return flights and $372 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Jun 9 - Mon, Jun 14
MDT
Harrisburg
SAN
San Diego
$419 Roundtrip, found 3 days ago
$419
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jun 9 from Harrisburg to San Diego, returning Mon, Jun 14, priced at $419 found 3 days ago
Wed, Jan 20 - Wed, Jan 27
MDT
Harrisburg
SAN
San Diego
$424 Roundtrip, found 3 days ago
$424
Roundtrip
found 3 days ago
Select United flight, departing Wed, Jan 20 from Harrisburg to San Diego, returning Wed, Jan 27, priced at $424 found 3 days ago
Wed, Jan 20 - Wed, Jan 27
MDT
Harrisburg
SAN
San Diego
$426 Roundtrip, found 3 days ago
$426
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jan 20 from Harrisburg to San Diego, returning Wed, Jan 27, priced at $426 found 3 days ago
Wed, Jan 20 - Wed, Jan 27
MDT
Harrisburg
SAN
San Diego
$429 Roundtrip, found 3 days ago
$429
Roundtrip
found 3 days ago
Select United flight, departing Wed, Jan 20 from Harrisburg to San Diego, returning Wed, Jan 27, priced at $429 found 3 days ago
Wed, Jun 9 - Mon, Jun 14
MDT
Harrisburg
SAN
San Diego
$433 Roundtrip, found 3 days ago
$433
Roundtrip
found 3 days ago
Select United flight, departing Wed, Jun 9 from Harrisburg to San Diego, returning Mon, Jun 14, priced at $433 found 3 days ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$160 nightly
The price is $184 total per night from Nov 22 to Nov 23
$184 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Sheraton San Diego Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$170 nightly
The price is $197 total per night from Nov 22 to Nov 23
$197 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,372 reviews)
"Very friendly people and very convenient to everything"

Reviewed on Nov 12, 2026

Wyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
$82 nightly
The price is $94 total per night from Dec 13 to Dec 14
$94 total
Dec 13 - Dec 14
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (3,053 reviews)
"Great place. Clean and friendly staff"

Reviewed on Nov 11, 2026

Handlery Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$170 nightly
The price is $197 total per night from Nov 22 to Nov 23
$197 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,372 reviews)
"Very friendly people and very convenient to everything"

Reviewed on Nov 12, 2026

Wyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
$82 nightly
The price is $94 total per night from Dec 13 to Dec 14
$94 total
Dec 13 - Dec 14
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (3,053 reviews)
"Great place. Clean and friendly staff"

Reviewed on Nov 11, 2026

Handlery Hotel
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
$211 nightly
The price is $244 total per night from Nov 22 to Nov 23
$244 total
Nov 22 - Nov 23
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,594 reviews)
"The layout of the tppm was awkward with a sink in the middle. Carpet was rippled and was a trip hazard. One television did not work. There were bottle caps on the floor that were not ours, so the room had not been thoroughly cleaned prior. Don't think I would return."

Reviewed on Nov 12, 2026

Hard Rock Hotel San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$170 nightly
The price is $197 total per night from Nov 22 to Nov 23
$197 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,372 reviews)
"Very friendly people and very convenient to everything"

Reviewed on Nov 12, 2026

Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$160 nightly
The price is $184 total per night from Nov 22 to Nov 23
$184 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 out of 5
1955 San Diego Ave San Diego CA
$136 nightly
The price is $156 total per night from Nov 17 to Nov 18
$156 total
Nov 17 - Nov 18
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn

Pleasant Inn

2.5 out of 5
5550 Clairemont Mesa Blvd San Diego CA
$72 nightly
The price is $83 total per night from Nov 17 to Nov 18
$83 total
Nov 17 - Nov 18
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
8.6/10 Excellent! (1,636 reviews)
"This is a nice and clean place to stay. I’ve stayed twice. The people at the front desk are always friendly and accommodating. My last trip, the air wasn’t working right and they switched me rooms with no problems. I appreciated that. My only issue is that WiFi is trash. Very low speeds around 2-6mbps ..."

Reviewed on Nov 12, 2026

Pleasant Inn
E-Z 8 Motel Old Town

E-Z 8 Motel Old Town

2.5 out of 5
4747 Pacific Highway San Diego CA
$73 nightly
The price is $84 total per night from Nov 15 to Nov 16
$84 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
6.6/10 (2,222 reviews)
"Clean room and good service"

Reviewed on Nov 12, 2026

E-Z 8 Motel Old Town
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
$71 nightly
The price is $81 total per night from Dec 13 to Dec 14
$81 total
Dec 13 - Dec 14
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
$204 nightly
The price is $235 total per night from Dec 13 to Dec 14
$235 total
Dec 13 - Dec 14
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free parking, a private beach, and a marina. Our guests praise the pool and the restaurant in our reviews. ...
8.8/10 Excellent! (2,527 reviews)

Families like: Outdoor pool, kids club, playground, game room

Travelers say...
"Hidden fees, outdated rooms."

Reviewed on Nov 12, 2026

Bahia Resort Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
$182 nightly
The price is $209 total per night from Dec 1 to Dec 2
$209 total
Dec 1 - Dec 2
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
9/10 Wonderful! (4,490 reviews)
"Awesome stay…very quiet and relaxed atmosphere !!!!!!"

Reviewed on Nov 12, 2026

The Dana on Mission Bay
Catamaran Resort and Spa

Catamaran Resort and Spa

4 out of 5
3999 Mission Boulevard San Diego CA
$229 nightly
The price is $264 total per night from Dec 13 to Dec 14
$264 total
Dec 13 - Dec 14
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,400 reviews)

Families like: Outdoor pool, game room, on the beach, bicycle rentals

Travelers say...
"Wonderful hotel right on MIssion Bay with everything you expect from a luxury hotel and more - the rooms are beautifully decorated - we stayed in a room with a patio door that opened up right to the boardwalk and the beach - go there and you won't be disppointed."

Reviewed on Nov 11, 2026

Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

MDT to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
MDT Address & GPS
Address:
One Terminal Drive
Middletown PA, 17057
United States
IATA Code:
MDT
Longitude:
-76.756057
Latitude:
40.196008
Time Zone:
America/New_York
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from Harrisburg Intl. Airport to San Diego Intl. Airport (SAN)?
Flying from MDT to San Diego Airport means you're going to have to switch planes. But hey — that's OK. American Airlines, Delta Air Lines and United Airlines offer flights with a single stopover.
What is the shortest flight from Harrisburg Intl. Airport (MDT) to San Diego Airport?
Use the opportunity to sit back and chill out on your way from Harrisburg to San Diego. The quickest flight time from Harrisburg Intl. Airport to SAN is 7 hours and 5 minutes, which gives you loads of time to enjoy a wine or lose yourself in a good book.
How many hours flight from Harrisburg Intl. Airport to San Diego Intl. Airport (SAN)?
It usually takes around 7 hours and 9 minutes to fly from Harrisburg Intl. Airport (MDT) to San Diego Airport. You'll be airborne for a good amount of time, so take your own entertainment, like a good read or a podcast.
What airlines have the most flights from MDT to San Diego Intl. Airport (SAN)?
Right now, you can't fly nonstop from Harrisburg to San Diego. However, you will be able to book a flight with one or more stops. It's not all bad — use the break to stretch your legs or go in search of a nice meal!

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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