Cheap flights from TYS to EYW (McGhee Tyson to Key West Intl.)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from TYS to EYW starting at $289 One Way, $419 Round Trip

Prices starting at $419 for return flights and $289 for one-way flights to Key West Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Sep 11 - Mon, Sep 14
TYS
Knoxville
EYW
Key West
$419 Roundtrip, found 18 hours ago
$419
Roundtrip
found 18 hours ago
Select Delta flight, departing Fri, Sep 11 from Knoxville to Key West, returning Mon, Sep 14, priced at $419 found 18 hours ago
Thu, Sep 10 - Mon, Sep 14
TYS
Knoxville
EYW
Key West
$433 Roundtrip, found 9 hours ago
$433
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Thu, Sep 10 from Knoxville to Key West, returning Mon, Sep 14, priced at $433 found 9 hours ago
Fri, Sep 11 - Mon, Sep 14
TYS
Knoxville
EYW
Key West
$436 Roundtrip, found 18 hours ago
$436
Roundtrip
found 18 hours ago
Select Delta flight, departing Fri, Sep 11 from Knoxville to Key West, returning Mon, Sep 14, priced at $436 found 18 hours ago
Thu, Sep 10 - Mon, Sep 14
TYS
Knoxville
EYW
Key West
$488 Roundtrip, found 9 hours ago
$488
Roundtrip
found 9 hours ago
Select Delta flight, departing Thu, Sep 10 from Knoxville to Key West, returning Mon, Sep 14, priced at $488 found 9 hours ago
Fri, Sep 11 - Mon, Sep 14
TYS
Knoxville
EYW
Key West
$499 Roundtrip, found 18 hours ago
$499
Roundtrip
found 18 hours ago
Select Delta flight, departing Fri, Sep 11 from Knoxville to Key West, returning Mon, Sep 14, priced at $499 found 18 hours ago

Hotel Ideas near Key West Intl.

Airport Hotels near Key West Intl.

Hyatt Vacation Club at Windward Pointe, Key West

Hyatt Vacation Club at Windward Pointe, Key West

3.5 out of 5
3675 South Roosevelt Boulevard Key West FL
$434 nightly
The price is $489 total per night from May 5 to May 6
$489 total
May 5 - May 6
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, free parking, and a snack bar/deli. Our guests praise the pool and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,023 reviews)
We had a wonderful family vacation there

Reviewed on Apr 8, 2026

Hyatt Vacation Club at Windward Pointe, Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$287 nightly
The price is $323 total per night from May 10 to May 11
$323 total
May 10 - May 11
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,324 reviews)
It was a pleasant stay with our grandchildren and dogs. Staff was excellent and helpful.

Reviewed on Apr 7, 2026

Hampton Inn Key West FL
DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$235 nightly
The price is $264 total per night from May 10 to May 11
$264 total
May 10 - May 11
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,009 reviews)
The staff were all very friendly and helpful, and took time to answer questions and make sure we had what we needed. The room was smaller than what it looked like in the photos, but it was not small. There was plenty of room and the space was very clean. The breakfast, while good, was very much like ...

Reviewed on Apr 8, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Key West

Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$235 nightly
The price is $265 total per night from May 10 to May 11
$265 total
May 10 - May 11
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8.2/10 Very Good! (2,058 reviews)
No kitchen in room clean room bathrooms clean air conditioner worked good just didn't like the part about paying to park at night wont be staying there again

Reviewed on Apr 9, 2026

Blue Flamingo Resort Key West
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$415 nightly
The price is $467 total per night from May 10 to May 11
$467 total
May 10 - May 11
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.8/10 Excellent! (3,195 reviews)
Enjoyed the resort. We experienced 2 of the pools.

Reviewed on Apr 9, 2026

Southernmost Beach Resort and Guesthouses
Margaritaville Beach House Key West

Margaritaville Beach House Key West

4 out of 5
2001 South Roosevelt Boulevard Key West FL
$289 nightly
The price is $326 total per night from May 6 to May 7
$326 total
May 6 - May 7
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (1,808 reviews)
Hotel pictures online have not been updated to current condition. All room doors are located outside. Gaps under the door which can let bugs in. After checking into our room, my family brought dinner to the room. After about 15 mins our counter and food was covered in ants. Ants were also in the ...

Reviewed on Apr 8, 2026

Margaritaville Beach House Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Key West Hotels With Airport Transportation

DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$235 nightly
The price is $264 total per night from May 10 to May 11
$264 total
May 10 - May 11
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,009 reviews)
The staff were all very friendly and helpful, and took time to answer questions and make sure we had what we needed. The room was smaller than what it looked like in the photos, but it was not small. There was plenty of room and the space was very clean. The breakfast, while good, was very much like ...

Reviewed on Apr 8, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$287 nightly
The price is $323 total per night from May 10 to May 11
$323 total
May 10 - May 11
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,324 reviews)
It was a pleasant stay with our grandchildren and dogs. Staff was excellent and helpful.

Reviewed on Apr 7, 2026

Hampton Inn Key West FL
Eden House

Eden House

4 out of 5
1015 Fleming St Key West FL
$275 nightly
The price is $310 total per night from May 10 to May 11
$310 total
May 10 - May 11
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, in-room massages, and a 24-hour front desk. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (1,000 reviews)
Overall a really nice place. Easy walk and bike ride to all the local sites. Only issue, if you can call it that, is the room was very small for the price.

Reviewed on Apr 9, 2026

Eden House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Key West Hotels

Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street Key West FL
$252 nightly
The price is $284 total per night from May 10 to May 11
$284 total
May 10 - May 11
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,300 reviews)
The room was very clean and the staff was great. I really enjoyed the heated pool.

Reviewed on Apr 8, 2026

Southwinds Motel
Seashell Motel

Seashell Motel

1.5 out of 5
718 South Street Key West FL
$219 nightly
The price is $246 total per night from Apr 13 to Apr 14
$246 total
Apr 13 - Apr 14
Total with taxes and fees
Stay at this hostel in Key West. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8/10 Very Good! (1,004 reviews)
Ideal location for us, staff was very helpful, shops about 15 minutes walk away, neighborhood is nice and not far at all from the beaches where you can see beautiful sunrises.

Reviewed on Apr 5, 2026

Seashell Motel
Duval House

Duval House

3 out of 5
815 Duval St Key West FL
$271 nightly
The price is $302 total per night from Apr 20 to Apr 21
$302 total
Apr 20 - Apr 21
Total with taxes and fees
Stay at this B&B in Key West. Enjoy parking (surcharge), daily housekeeping, and a garden. Our guests praise the breakfast and the pool in our reviews. Popular ...
9.4/10 Exceptional! (1,012 reviews)
Very quaint. Great area. Staff very friendly. Pillows could use an upgrade and the sheets

Reviewed on Apr 7, 2026

Duval House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Key West

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$415 nightly
The price is $467 total per night from May 10 to May 11
$467 total
May 10 - May 11
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.8/10 Excellent! (3,195 reviews)
Enjoyed the resort. We experienced 2 of the pools.

Reviewed on Apr 9, 2026

Southernmost Beach Resort and Guesthouses
Margaritaville Beach House Key West

Margaritaville Beach House Key West

4 out of 5
2001 South Roosevelt Blvd Key West FL
Book a stay at this beach hotel in Key West. Enjoy free parking, 2 restaurants, and breakfast (surcharge). Popular attractions Duval Street and Smathers Beach ...
8.4/10 Very Good! (999 reviews)

Families like: Outdoor pool, babysitting, close to beach, bicycle rentals

Travelers say...
Great visit

Reviewed on Feb 27, 2026

Get rates
Margaritaville Beach House Key West
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$235 nightly
The price is $265 total per night from May 10 to May 11
$265 total
May 10 - May 11
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8.2/10 Very Good! (2,058 reviews)

Families like: Outdoor pools, miniature golf, game room, bicycle rentals

Travelers say...
No kitchen in room clean room bathrooms clean air conditioner worked good just didn't like the part about paying to park at night wont be staying there again

Reviewed on Apr 9, 2026

Blue Flamingo Resort Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TYS to EYW Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York
EYW Address & GPS
Address:
3491 South Roosevelt Boulevard
Key West FL, 33040-5260
United States
IATA Code:
EYW
Longitude:
-81.75501
Latitude:
24.553574
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from Knoxville Airport to Key West Intl. Airport?
As you can't fly direct from TYS to Key West Intl. Airport (EYW) at this point in time, a flight with one stopover is your best option. American Airlines, Delta Air Lines and United Airlines are all respected airlines that service this route.
What is the shortest flight from Knoxville Airport to Key West Intl. Airport (EYW)?
Make the most of the opportunity to chill out on your journey from Knoxville to Key West. The quickest flight time from McGhee Tyson Airport (TYS) to Key West Intl. Airport is 4 hours and 49 minutes, which gives you loads of time to indulge in a drink or get engrossed in a book.
How many hours flight from Knoxville Airport to Key West Intl. Airport?
On a normal day, the trip from TYS to EYW takes 4 hours and 53 minutes. If you want to be as comfortable as you can, consider upgrading your seat using air miles or cash.
What airlines have the most flights from Knoxville Airport to Key West Intl. Airport?
If you're wanting to book with an airline that offers direct flights from TYS to EYW, you won't have much luck. You'll have to book a flight with at least one stopover to get to Key West.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

More to Explore