Cheap flights from RDU to STL (Raleigh - Durham Intl. to Lambert-St. Louis Intl.)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from RDU to STL starting at $54 One Way, $149 Round Trip

Prices starting at $149 for return flights and $54 for one-way flights to Lambert-St. Louis Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Oct 16 - Mon, Oct 19
RDU
Raleigh
STL
St. Louis
$149 Roundtrip, found 2 days ago
$149
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Fri, Oct 16 from Raleigh to St. Louis, returning Mon, Oct 19, priced at $149 found 2 days ago
Fri, Oct 23 - Mon, Oct 26
RDU
Raleigh
STL
St. Louis
$156 Roundtrip, found 3 days ago
$156
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Fri, Oct 23 from Raleigh to St. Louis, returning Mon, Oct 26, priced at $156 found 3 days ago
Wed, Oct 7 - Wed, Oct 14
RDU
Raleigh
STL
St. Louis
$159 Roundtrip, found 4 days ago
$159
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Wed, Oct 7 from Raleigh to St. Louis, returning Wed, Oct 14, priced at $159 found 4 days ago
Sat, Oct 10 - Wed, Oct 14
RDU
Raleigh
STL
St. Louis
$170 Roundtrip, found 5 days ago
$170
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Sat, Oct 10 from Raleigh to St. Louis, returning Wed, Oct 14, priced at $170 found 5 days ago
Thu, Jan 21 - Tue, Jan 26
RDU
Raleigh
STL
St. Louis
$278 Roundtrip, found 2 days ago
$278
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Thu, Jan 21 from Raleigh to St. Louis, returning Tue, Jan 26, priced at $278 found 2 days ago

Hotel Ideas near Lambert-St. Louis Intl.

Airport Hotels near Lambert-St. Louis Intl.

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
$90 nightly
The price is $106 total per night from Sep 27 to Sep 28
$106 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (3,247 reviews)
"We got in early in the morning. We called from airport, the shuttle was prompt . Bed was comfortable. Staff was nice. My partner ate breakfast, he said was good.."

Reviewed on Sep 22, 2026

Pear Tree Inn St. Louis Airport
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
$118 nightly
The price is $138 total per night from Oct 11 to Oct 12
$138 total
Oct 11 - Oct 12
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
8.4/10 Very Good! (1,184 reviews)
"This was a great place with a welcoming atmosphere. The staff were outstanding—friendly, attentive, and professional—making the experience even more enjoyable. The people there were remarkable, contributing to a lively and positive environment."

Reviewed on Sep 22, 2026

Renaissance St. Louis Airport Hotel
Drury Inn & Suites St. Louis Airport

Drury Inn & Suites St. Louis Airport

3 out of 5
10490 Natural Bridge Rd St. Louis MO
$115 nightly
The price is $135 total per night from Sep 27 to Sep 28
$135 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Drury Inn & Suites St. Louis Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In St. Louis

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
$96 nightly
The price is $112 total per night from Oct 4 to Oct 5
$112 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
9/10 Wonderful! (3,432 reviews)
"When I arrived, the staff were so friendly and helpful. They explained about the breakfast hours and the parking. The room was clean and had a great shower. The staff were always willing to bring you fresh towels during the day , if needed.It’s located on a street that’s close to other eateries, ..."

Reviewed on Sep 22, 2026

Clayton Plaza Hotel & Extended Stay
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
$143 nightly
The price is $169 total per night from Oct 3 to Oct 4
$169 total
Oct 3 - Oct 4
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
Hyatt Regency St. Louis at The Arch
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
$90 nightly
The price is $106 total per night from Sep 27 to Sep 28
$106 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (3,247 reviews)
"We got in early in the morning. We called from airport, the shuttle was prompt . Bed was comfortable. Staff was nice. My partner ate breakfast, he said was good.."

Reviewed on Sep 22, 2026

Pear Tree Inn St. Louis Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

St. Louis Hotels With Airport Transportation

Quality Inn Saint Louis Airport

Quality Inn Saint Louis Airport

2.5 out of 5
10232 Natural Bridge Rd St. Louis MO
$65 nightly
The price is $76 total per night from Oct 2 to Oct 3
$76 total
Oct 2 - Oct 3
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a free airport shuttle, and parking (surcharge). Our guests praise the helpful staff ...
Quality Inn Saint Louis Airport
Marriott St. Louis Airport

Marriott St. Louis Airport

4 out of 5
10700 Pear Tree Lane St. Louis MO
$143 nightly
The price is $170 total per night from Oct 2 to Oct 3
$170 total
Oct 2 - Oct 3
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy breakfast (surcharge), a free airport shuttle, and room service. Our guests praise the helpful ...
8/10 Very Good! (1,003 reviews)
"On the first stay everything was great. On the second stay the room was about 95 degrees and took it 3 hours to cool off. Tried to contact desk and no answer twice. So fell asleep after 3am due to the heat. Was miserable"

Reviewed on Sep 22, 2026

Marriott St. Louis Airport
Hilton St. Louis Airport

Hilton St. Louis Airport

3.5 out of 5
10330 Natural Bridge Rd St. Louis MO
$137 nightly
The price is $164 total per night from Sep 25 to Sep 26
$164 total
Sep 25 - Sep 26
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy 2 restaurants, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
7.6/10 Good! (1,003 reviews)
"If you want to stay in a dirty, rundown hotel, this is the place for you. My room was by far the dirtiest room I have ever stayed in. The carpet had not been vacuumed, and the bathtub was filthy. I was traveling from GA to MO and booked the room last minute so I could get some sleep before finishing ..."

Reviewed on Sep 21, 2026

Hilton St. Louis Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced St. Louis Hotels

Quality Inn Saint Louis Airport

Quality Inn Saint Louis Airport

2.5 out of 5
10232 Natural Bridge Rd St. Louis MO
$65 nightly
The price is $76 total per night from Oct 2 to Oct 3
$76 total
Oct 2 - Oct 3
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a free airport shuttle, and parking (surcharge). Our guests praise the helpful staff ...
Quality Inn Saint Louis Airport
Americas Best Value Inn St. Louis Downtown

Americas Best Value Inn St. Louis Downtown

2 out of 5
1100 Lumiere Place Boulevard St. Louis MO
$84 nightly
The price is $98 total per night from Sep 27 to Sep 28
$98 total
Sep 27 - Sep 28
Total with taxes and fees
Stay at this motel in St. Louis. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Gateway Arch and Busch Stadium are located ...
5.6/10 (858 reviews)
"Close to Down town and Americas Dome. Staff accommodated us to early check in and a freshly renovated room."

Reviewed on Sep 11, 2026

Americas Best Value Inn St. Louis Downtown
OYO Hotel St. Louis Downtown City Center MO

OYO Hotel St. Louis Downtown City Center MO

3.5 out of 5
400 S 14th St St. Louis MO
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...
6.6/10 (1,000 reviews)
"Definitely an older hotel. Overall the room was kinda dingy."

Reviewed on Apr 11, 2024

Get rates
OYO Hotel St. Louis Downtown City Center MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in St. Louis

Days Inn by Wyndham St. Louis Lindbergh Boulevard

Days Inn by Wyndham St. Louis Lindbergh Boulevard

2.5 out of 5
South Lindbergh Boulevard, 3660 St. Louis MO
Book a stay at this family-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Laumeier Sculpture Park and Powder ...

Families like: Indoor pool, playground, game room, cribs

Get rates
Days Inn by Wyndham St. Louis Lindbergh Boulevard
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3 out of 5
2 South 4th Street St. Louis MO
$135 nightly
The price is $158 total per night from Oct 4 to Oct 5
$158 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in our ...
9.6/10 Exceptional! (3,765 reviews)
"Great hotel, nice staff and very clean , the free drinks and food was delicious and definitely a great"

Reviewed on Sep 22, 2026

Drury Plaza Hotel St. Louis at the Arch
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

3 out of 5
2211 Market Street St. Louis MO
$117 nightly
The price is $137 total per night from Sep 27 to Sep 28
$137 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant ...
8.8/10 Excellent! (2,207 reviews)
"Staff was very friendly and helpful."

Reviewed on Sep 22, 2026

Pear Tree Inn St. Louis Near Union Station
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

RDU to STL Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

Are there non-stop flights from RDU to STL?
The awesome news is Southwest Airlines flies straight from Raleigh to St. Louis, so you won't have to worry about disembarking the plane until you reach Lambert-St. Louis Intl. Airport (STL).
What is the shortest flight from Raleigh - Durham Intl. Airport (RDU) to St. Louis Lambert International Airport?
From Raleigh, the exciting sights and sounds of St. Louis are around 5 hours and 37 minutes away. Be sure to book your favorite seat, or perhaps even one with more legroom, and fly to your destination in total comfort.
How many hours flight from Raleigh–Durham Airport to Lambert-St. Louis Intl. Airport (STL)?
It typically takes about 5 hours and 43 minutes to jet from Raleigh–Durham Airport to STL. You'll be on board for quite some time, so think about bringing your own entertainment, like a newspaper or a podcast.
What airlines have the most flights from Raleigh–Durham Airport to St. Louis Lambert International Airport?
Are you ready to hit the "book" button on your Raleigh to St. Louis airfare? Make Southwest Airlines your first pick. With 52 flights per month to choose from on this route, they've got the ticket to your next unforgettable adventure.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

More to Explore