Cheap flights from GSP to EYW (Greenville-Spartanburg Intl. to Key West Intl.)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from GSP to EYW starting at $284 One Way, $381 Round Trip

Prices starting at $381 for return flights and $284 for one-way flights to Key West Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Nov 9 - Fri, Nov 13
GSP
Greenville
EYW
Key West
$381 Roundtrip, found 6 days ago
$381
Roundtrip
found 6 days ago
Select American Airlines flight, departing Mon, Nov 9 from Greenville to Key West, returning Fri, Nov 13, priced at $381 found 6 days ago
Sat, May 1 - Sat, May 8
GSP
Greenville
EYW
Key West
$398 Roundtrip, found 5 days ago
$398
Roundtrip
found 5 days ago
Select Delta flight, departing Sat, May 1 from Greenville to Key West, returning Sat, May 8, priced at $398 found 5 days ago
Wed, Nov 25 - Mon, Nov 30
GSP
Greenville
EYW
Key West
$401 Roundtrip, found 6 days ago
$401
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Nov 25 from Greenville to Key West, returning Mon, Nov 30, priced at $401 found 6 days ago
Mon, Nov 9 - Fri, Nov 13
GSP
Greenville
EYW
Key West
$416 Roundtrip, found 6 days ago
$416
Roundtrip
found 6 days ago
Select American Airlines flight, departing Mon, Nov 9 from Greenville to Key West, returning Fri, Nov 13, priced at $416 found 6 days ago
Mon, Nov 9 - Fri, Nov 13
GSP
Greenville
EYW
Key West
$417 Roundtrip, found 6 days ago
$417
Roundtrip
found 6 days ago
Select Delta flight, departing Mon, Nov 9 from Greenville to Key West, returning Fri, Nov 13, priced at $417 found 6 days ago

Hotel Ideas near Key West Intl.

Airport Hotels near Key West Intl.

Hyatt Vacation Club at Windward Pointe, Key West

Hyatt Vacation Club at Windward Pointe, Key West

3.5 out of 5
3675 South Roosevelt Boulevard Key West FL
$218 nightly
The price is $246 total per night from Oct 28 to Oct 29
$246 total
Oct 28 - Oct 29
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, free parking, and a snack bar/deli. Our guests praise the pool and the helpful staff in our reviews. Popular ...
Hyatt Vacation Club at Windward Pointe, Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$120 nightly
The price is $135 total per night from Oct 25 to Oct 26
$135 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
Hampton Inn Key West FL
DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$148 nightly
The price is $166 total per night from Oct 28 to Oct 29
$166 total
Oct 28 - Oct 29
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
DoubleTree Resort by Hilton Grand Key - Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Key West

Margaritaville Beach House Key West

Margaritaville Beach House Key West

4 out of 5
2001 South Roosevelt Blvd Key West FL
$253 nightly
The price is $285 total per night from Oct 25 to Oct 26
$285 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy breakfast (surcharge), a free airport shuttle, and room service. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (1,808 reviews)
"Great property."

Reviewed on Oct 24, 2026

Margaritaville Beach House Key West
Havana Cabana at Key West

Havana Cabana at Key West

4 out of 5
3420 N. Roosevelt Blvd Key West FL
$219 nightly
The price is $246 total per night from Nov 15 to Nov 16
$246 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the pool and the helpful ...
9/10 Wonderful! (1,890 reviews)
"We had an excellent stay! The room was clean, close to the pool, and even though we were near the action we did not have a noise issue. The staff was so helpful, friendly, and professional. We also appreciated the shuttles , way better than having to pay the other expensive car services. I would ..."

Reviewed on Oct 24, 2026

Havana Cabana at Key West
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$166 nightly
The price is $187 total per night from Oct 25 to Oct 26
$187 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
Blue Flamingo Resort Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Key West Hotels With Airport Transportation

DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$148 nightly
The price is $166 total per night from Oct 28 to Oct 29
$166 total
Oct 28 - Oct 29
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
DoubleTree Resort by Hilton Grand Key - Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$120 nightly
The price is $135 total per night from Oct 25 to Oct 26
$135 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
Hampton Inn Key West FL
Eden House

Eden House

4 out of 5
1015 Fleming St Key West FL
$159 nightly
The price is $178 total per night from Oct 25 to Oct 26
$178 total
Oct 25 - Oct 26
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, in-room massages, and a 24-hour front desk. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (1,007 reviews)
"Enjoyed the stay. Rooms are good size and they have storage for clothes. Bathroom was great. Balcony and swing porch chair such a nice touch."

Reviewed on Oct 23, 2026

Eden House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Key West Hotels

Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street Key West FL
$169 nightly
The price is $190 total per night from Oct 26 to Oct 27
$190 total
Oct 26 - Oct 27
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,395 reviews)
"Very clean and the staff was very helpful"

Reviewed on Oct 23, 2026

Southwinds Motel
Seashell Motel

Seashell Motel

1.5 out of 5
718 South Street Key West FL
$131 nightly
The price is $147 total per night from Oct 26 to Oct 27
$147 total
Oct 26 - Oct 27
Total with taxes and fees
Stay at this hostel in Key West. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8/10 Very Good! (1,000 reviews)
"Water pressure was great in the shower, felt like a scalp massage😃 and hot water was good. New pool, not inspected so couldn't use. Plenty of places in Florida⛱️"

Reviewed on Oct 21, 2026

Seashell Motel
Duval House

Duval House

3 out of 5
815 Duval St Key West FL
$150 nightly
The price is $166 total per night from Oct 25 to Oct 26
$166 total
Oct 25 - Oct 26
Total with taxes and fees
Stay at this B&B in Key West. Enjoy parking (surcharge), daily housekeeping, and a garden. Our guests praise the breakfast and the pool in our reviews. Popular ...
Duval House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Key West

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$186 nightly
The price is $210 total per night from Oct 25 to Oct 26
$210 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this spa hotel in Key West. Enjoy 3 outdoor pools, a full-service spa, and 2 poolside bars. Our guests praise the pool and the helpful staff in ...
Southernmost Beach Resort and Guesthouses
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$166 nightly
The price is $187 total per night from Oct 25 to Oct 26
$187 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
Blue Flamingo Resort Key West
Hilton Key West Resort & Marina

Hilton Key West Resort & Marina

4 out of 5
5950 Peninsular Avenue Key West FL
$169 nightly
The price is $190 total per night from Oct 28 to Oct 29
$190 total
Oct 28 - Oct 29
Total with taxes and fees
Book a stay at this luxury hotel in Key West. Enjoy free WiFi, 6 outdoor pools, and a marina. Our guests praise the pool and the restaurant in our reviews. Popular ...
9/10 Wonderful! (1,797 reviews)
"Construction underway at the hotel site. Staff and room were fine. Beautiful view."

Reviewed on Oct 24, 2026

Hilton Key West Resort & Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

GSP to EYW Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
GSP Address & GPS
Address:
2000 GPS Drive, Suite 1
Greenville SC, 29651-9202
United States
IATA Code:
GSP
Longitude:
-82.217053
Latitude:
34.890569
Time Zone:
America/New_York
EYW Address & GPS
Address:
3491 South Roosevelt Boulevard
Key West FL, 33040-5260
United States
IATA Code:
EYW
Longitude:
-81.75501
Latitude:
24.553574
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from Roger Milliken Field to Key West Intl. Airport?
While you can't fly directly from GSP to EYW, there are plenty of carriers that service this route with only one stopover. Why not see if the dates available with American Airlines or Delta Air Lines work with your travel plans? If not, you could always try United Airlines.
What is the shortest flight from Greenville-Spartanburg Intl. Airport (GSP) to Key West Intl. Airport (EYW)?
Treat yourself to a miniature bottle of vino and settle into your seat with a fascinating book or movie. With the flight from Roger Milliken Field to EYW taking 4 hours and 54 minutes, you'll have plenty of time to kick back and enjoy the ride.
How many hours flight from Greenville-Spartanburg Intl. Airport (GSP) to EYW?
On average, it takes 4 hours and 57 minutes to jet from GSP to EYW. Breeze through the journey by watching TV shows and browsing a magazine or two. Alternatively, catch up on some Zs.
What airlines have the most flights from Roger Milliken Field to EYW?
Pick up a souvenir, grab a coffee, strike up a conversation with a stranger ... Airport stopovers don't have to irritating! If you're traveling between Greenville and Key West, there are no direct flights. Be prepared to make a stop somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

More to Explore