Cheap flights from BUF to EYW (Buffalo Niagara Intl. to Key West Intl.)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from BUF to EYW starting at $242 One Way, $269 Round Trip

Prices starting at $269 for return flights and $242 for one-way flights to Key West Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Jan 22 - Tue, Jan 27
BUF
Buffalo
EYW
Key West
$269 Roundtrip, found 4 days ago
$269
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Jan 22 from Buffalo to Key West, returning Tue, Jan 27, priced at $269 found 4 days ago
Thu, Jan 22 - Tue, Jan 27
BUF
Buffalo
EYW
Key West
$274 Roundtrip, found 4 days ago
$274
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Jan 22 from Buffalo to Key West, returning Tue, Jan 27, priced at $274 found 4 days ago
Tue, Jun 2 - Wed, Jun 10
BUF
Buffalo
EYW
Key West
$283 Roundtrip, found 1 day ago
$283
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Jun 2 from Buffalo to Key West, returning Wed, Jun 10, priced at $283 found 1 day ago
Mon, Jun 1 - Wed, Jun 10
BUF
Buffalo
EYW
Key West
$286 Roundtrip, found 1 day ago
$286
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Jun 1 from Buffalo to Key West, returning Wed, Jun 10, priced at $286 found 1 day ago
Wed, Jan 7 - Wed, Jan 14
BUF
Buffalo
EYW
Key West
$287 Roundtrip, found 17 hours ago
$287
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Wed, Jan 7 from Buffalo to Key West, returning Wed, Jan 14, priced at $287 found 17 hours ago

Hotel Ideas near Key West Intl.

Airport Hotels near Key West Intl.

Hyatt Vacation Club at Windward Pointe, Key West

Hyatt Vacation Club at Windward Pointe, Key West

3.5 out of 5
3675 South Roosevelt Boulevard Key West FL
$429 nightly
The price is $483 total per night from Dec 17 to Dec 18
$483 total
Dec 17 - Dec 18
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, free parking, and a snack bar/deli. Our guests praise the pool and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,008 reviews)
N

Reviewed on Dec 7, 2025

Hyatt Vacation Club at Windward Pointe, Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$209 nightly
The price is $235 total per night from Dec 16 to Dec 17
$235 total
Dec 16 - Dec 17
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,283 reviews)
What i like best was how clean the room was. It had ample space

Reviewed on Dec 11, 2025

Hampton Inn Key West FL
DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$176 nightly
The price is $198 total per night from Dec 18 to Dec 19
$198 total
Dec 18 - Dec 19
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8/10 Very Good! (1,013 reviews)
Shuttle service was good. Only complaint was we were notified night before mandatory fire alarm testing which was all day the next day. We would have plan our day differently. People in next room were very loud.

Reviewed on Dec 9, 2025

DoubleTree Resort by Hilton Grand Key - Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Key West

Beachside Resort & Residences

Beachside Resort & Residences

3.5 out of 5
3841 N Roosevelt Blvd Key West FL
$239 nightly
The price is $269 total per night from Dec 18 to Dec 19
$269 total
Dec 18 - Dec 19
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 2 restaurants, and a private beach. Our guests praise the pool and the helpful staff in our reviews. ...
8.6/10 Excellent! (1,780 reviews)
It was overall great but one night at 2 am the fire alarm went off for Like 25mins and no body give reasons not even a single staff member was there to provide guidance or shutdown the alarms

Reviewed on Dec 14, 2025

Beachside Resort & Residences
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$175 nightly
The price is $197 total per night from Dec 16 to Dec 17
$197 total
Dec 16 - Dec 17
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8/10 Very Good! (1,754 reviews)
Nice resort with warm pool, two bars, Starbucks. Rooms clean

Reviewed on Dec 9, 2025

Blue Flamingo Resort Key West
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$253 nightly
The price is $285 total per night from Dec 18 to Dec 19
$285 total
Dec 18 - Dec 19
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.6/10 Excellent! (2,924 reviews)
Location

Reviewed on Dec 13, 2025

Southernmost Beach Resort and Guesthouses
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Key West Hotels With Airport Transportation

DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$176 nightly
The price is $198 total per night from Dec 18 to Dec 19
$198 total
Dec 18 - Dec 19
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8/10 Very Good! (1,013 reviews)
Shuttle service was good. Only complaint was we were notified night before mandatory fire alarm testing which was all day the next day. We would have plan our day differently. People in next room were very loud.

Reviewed on Dec 9, 2025

DoubleTree Resort by Hilton Grand Key - Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$209 nightly
The price is $235 total per night from Dec 16 to Dec 17
$235 total
Dec 16 - Dec 17
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,283 reviews)
What i like best was how clean the room was. It had ample space

Reviewed on Dec 11, 2025

Hampton Inn Key West FL
Eden House

Eden House

3.5 out of 5
1015 Fleming St Key West FL
$347 nightly
The price is $391 total per night from Dec 16 to Dec 17
$391 total
Dec 16 - Dec 17
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, in-room massages, and a 24-hour front desk. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (1,001 reviews)
Its a cozy place and very pleasant staff

Reviewed on Dec 5, 2025

Eden House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Key West Hotels

Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street Key West FL
$173 nightly
The price is $195 total per night from Dec 17 to Dec 18
$195 total
Dec 17 - Dec 18
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (1,237 reviews)
Really sweet little place with fantastic beach access. The beach is a block away but the hotel provides free towels and long chairs with umbrellas. Nice cuban deli across the street. Close to Duval but without its busy-ness.

Reviewed on Dec 9, 2025

Southwinds Motel
Seashell Motel

Seashell Motel

1.5 out of 5
718 South Street Key West FL
$164 nightly
The price is $185 total per night from Dec 16 to Dec 17
$185 total
Dec 16 - Dec 17
Total with taxes and fees
Stay at this hostel in Key West. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7.8/10 Good! (1,002 reviews)
The room was clean, looked good and was spacious. The door howevr was glass and had some kind of bamboo cover that did not cover anything and people could see straight inside if we had the lights on. The main entrance is under construction so we had to walk through gravel to get in which was okaybut ...

Reviewed on Dec 4, 2025

Seashell Motel
Duval House

Duval House

3 out of 5
815 Duval St Key West FL
$171 nightly
The price is $189 total per night from Dec 16 to Dec 17
$189 total
Dec 16 - Dec 17
Total with taxes and fees
Stay at this B&B in Key West. Enjoy parking (surcharge), daily housekeeping, and a garden. Our guests praise the breakfast and the pool in our reviews. Popular ...
9.4/10 Exceptional! (1,006 reviews)
Great spot only a 7/8 minute walk to either Mallory square and also a 7/8 minute walk to the southern most point and everything else is in between great location loved it will be back again

Reviewed on Dec 11, 2025

Duval House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Key West

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$253 nightly
The price is $285 total per night from Dec 18 to Dec 19
$285 total
Dec 18 - Dec 19
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.6/10 Excellent! (2,924 reviews)
Location

Reviewed on Dec 13, 2025

Southernmost Beach Resort and Guesthouses
Margaritaville Beach House Key West

Margaritaville Beach House Key West

4 out of 5
2001 South Roosevelt Blvd Key West FL
Book a stay at this beach hotel in Key West. Enjoy free parking, 2 restaurants, and breakfast (surcharge). Popular attractions Duval Street and Smathers Beach ...
8.2/10 Very Good! (1,000 reviews)

Families like: Outdoor pool, babysitting, close to beach, bicycle rentals

Travelers say...
Room was clean and comfortable but after first day towels were shorted. Had to ask for more twice Desk staff were very nice and helpful. Concierge was helpful with rentals Restaurant was not as good as past stays when Sheraton. Food even pancakes were tough and overcooked. Shuttle drivers were very ...

Reviewed on Dec 4, 2025

Get rates
Margaritaville Beach House Key West
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$175 nightly
The price is $197 total per night from Dec 16 to Dec 17
$197 total
Dec 16 - Dec 17
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8/10 Very Good! (1,754 reviews)

Families like: Outdoor pools, miniature golf, game room, bicycle rentals

Travelers say...
Nice resort with warm pool, two bars, Starbucks. Rooms clean

Reviewed on Dec 9, 2025

Blue Flamingo Resort Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

BUF to EYW Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
BUF Address & GPS
Address:
Genesee Street
Buffalo NY, 14225
United States
IATA Code:
BUF
Longitude:
-78.731804
Latitude:
42.933828
Time Zone:
America/New_York
EYW Address & GPS
Address:
3491 South Roosevelt Boulevard
Key West FL, 33040-5260
United States
IATA Code:
EYW
Longitude:
-81.75501
Latitude:
24.553574
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from BUF to EYW?
While you won't be able to fly direct from Buffalo Niagara International Airport to EYW, there are several companies that service this route with just a single stopover. Why not see if the dates available with American Airlines or United Airlines match your travel plans? If not, take a look at Delta Air Lines.
What is the shortest flight from BUF to Key West Intl. Airport (EYW)?
Make the most of the opportunity to chill out on the flight from Buffalo to Key West. The shortest flight time from BUF to EYW is 4 hours and 51 minutes, which gives you plenty of time to enjoy a drink or lose yourself in a good book.
How many hours flight from Buffalo Niagara Intl. Airport (BUF) to Key West Intl. Airport?
Get nice and comfortable, because the average plane trip from Buffalo Niagara Intl. Airport (BUF) to Key West Intl. Airport is 4 hours and 55 minutes. Watch a few movies, finish that book … You'll have more than enough time to sit back and enjoy the ride.
What airlines have the most flights from BUF to Key West Intl. Airport (EYW)?
Currently, there are no airlines that have direct flights between Buffalo Niagara International Airport and Key West Intl. Airport. But there's a silver lining. There are several single or multi-stop flights available.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

More to Explore