Cheap flights from MDT to SAT (Harrisburg Intl. to San Antonio Intl.)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from MDT to SAT starting at $172 One Way, $349 Round Trip

Prices starting at $349 for return flights and $172 for one-way flights to San Antonio Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Jun 15 - Sun, Jun 28
MDT
Harrisburg
SAT
San Antonio
$349 Roundtrip, found 5 days ago
$349
Roundtrip
found 5 days ago
Select Delta flight, departing Mon, Jun 15 from Harrisburg to San Antonio, returning Sun, Jun 28, priced at $349 found 5 days ago
Thu, Jun 18 - Wed, Jul 1
MDT
Harrisburg
SAT
San Antonio
$355 Roundtrip, found 5 days ago
$355
Roundtrip
found 5 days ago
Select Delta flight, departing Thu, Jun 18 from Harrisburg to San Antonio, returning Wed, Jul 1, priced at $355 found 5 days ago
Thu, Jun 4 - Sun, Jun 7
MDT
Harrisburg
SAT
San Antonio
$359 Roundtrip, found 5 days ago
$359
Roundtrip
found 5 days ago
Select United flight, departing Thu, Jun 4 from Harrisburg to San Antonio, returning Sun, Jun 7, priced at $359 found 5 days ago
Thu, Apr 30 - Mon, May 11
MDT
Harrisburg
SAT
San Antonio
$363 Roundtrip, found 5 days ago
$363
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Apr 30 from Harrisburg to San Antonio, returning Mon, May 11, priced at $363 found 5 days ago
Thu, Apr 30 - Mon, May 11
MDT
Harrisburg
SAT
San Antonio
$364 Roundtrip, found 5 days ago
$364
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Apr 30 from Harrisburg to San Antonio, returning Mon, May 11, priced at $364 found 5 days ago

Hotel Ideas near San Antonio Intl.

Airport Hotels near San Antonio Intl.

Wyndham Garden San Antonio Airport

Wyndham Garden San Antonio Airport

3 out of 5
8818 Jones Maltsberger Rd San Antonio TX
$89 nightly
The price is $105 total per night from Mar 29 to Mar 30
$105 total
Mar 29 - Mar 30
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,305 reviews)
The hotel was so dirty and the zzz staff was rushing me out. I wouldn’t be coming back.

Reviewed on Mar 28, 2026

Wyndham Garden San Antonio Airport
Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

2.5 out of 5
143 NE Loop 410 San Antonio TX
$80 nightly
The price is $95 total per night from Mar 29 to Mar 30
$95 total
Mar 29 - Mar 30
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,642 reviews)
Checking in was weird, the guy there was distracted and not very kind, breakfast was always the same, pancakes were undercooked

Reviewed on Mar 28, 2026

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham
La Quinta Inn & Suites by Wyndham San Antonio Airport

La Quinta Inn & Suites by Wyndham San Antonio Airport

3 out of 5
850 Halm Blvd San Antonio TX
$71 nightly
The price is $84 total per night from Apr 19 to Apr 20
$84 total
Apr 19 - Apr 20
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.8/10 Good! (2,752 reviews)
Breakfast good.

Reviewed on Mar 27, 2026

La Quinta Inn & Suites by Wyndham San Antonio Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Antonio

Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
$99 nightly
The price is $117 total per night from Apr 5 to Apr 6
$117 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
8/10 Very Good! (6,413 reviews)
Great location

Reviewed on Mar 28, 2026

Riverwalk Plaza
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
$167 nightly
The price is $197 total per night from Apr 1 to Apr 2
$197 total
Apr 1 - Apr 2
Total with taxes and fees
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (2,581 reviews)
Emerson checked us in, and the King room that she gave us was that of MOTEL status. I booked wanting the River Walk experience, and was not accommodated as such! Nothing chaps my hide worse than attending a vacation being met with horrendous Hotel experience! We were eventually accommodated with ...

Reviewed on Mar 28, 2026

Hotel Valencia Riverwalk
Menger Hotel

Menger Hotel

3.5 out of 5
204 Alamo Plaza San Antonio TX
$109 nightly
The price is $129 total per night from Apr 7 to Apr 8
$129 total
Apr 7 - Apr 8
Total with taxes and fees
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (3,867 reviews)
A/c was not working well but was ok overall

Reviewed on Mar 27, 2026

Menger Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Antonio Hotels With Airport Transportation

Hampton Inn & Suites San Antonio-Airport

Hampton Inn & Suites San Antonio-Airport

2.5 out of 5
8902 Jones Maltsberger Rd San Antonio TX
$91 nightly
The price is $108 total per night from Apr 5 to Apr 6
$108 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and ...
8.4/10 Very Good! (1,942 reviews)
Powdered scrambled eggs were soggy. Room was fine, shower had great water pressure. Staff was polite and had nice genuine smiles when interacting with guests.

Reviewed on Mar 28, 2026

Hampton Inn & Suites San Antonio-Airport
Hilton Garden Inn San Antonio Airport South

Hilton Garden Inn San Antonio Airport South

3 out of 5
8505 Broadway Street San Antonio TX
$86 nightly
The price is $101 total per night from Apr 5 to Apr 6
$101 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
8.4/10 Very Good! (1,000 reviews)
I would not recommend this hotel. They do charge for parking whihc is out of expectation. The bed has some many wrinkles. Not sure whether soemone slept. The water pressure is so low that you barely have water to wash without wait. Shower was ok. Toilet paper so cheap. Feel like th owner trying to ...

Reviewed on Mar 21, 2026

Hilton Garden Inn San Antonio Airport South
Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

2.5 out of 5
143 NE Loop 410 San Antonio TX
$80 nightly
The price is $95 total per night from Mar 29 to Mar 30
$95 total
Mar 29 - Mar 30
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,642 reviews)
Checking in was weird, the guy there was distracted and not very kind, breakfast was always the same, pancakes were undercooked

Reviewed on Mar 28, 2026

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Antonio Hotels

Days Inn by Wyndham San Antonio Alamo/Riverwalk

Days Inn by Wyndham San Antonio Alamo/Riverwalk

2 out of 5
400 Bowie Street San Antonio TX
$61 nightly
The price is $71 total per night from Apr 6 to Apr 7
$71 total
Apr 6 - Apr 7
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the helpful staff and ...
7.2/10 Good! (1,414 reviews)
Horrible

Reviewed on Mar 27, 2026

Days Inn by Wyndham San Antonio Alamo/Riverwalk
Red Roof Inn PLUS+ San Antonio Downtown - Riverwalk

Red Roof Inn PLUS+ San Antonio Downtown - Riverwalk

2.5 out of 5
1011 E Houston St San Antonio TX
$67 nightly
The price is $80 total per night from Apr 1 to Apr 2
$80 total
Apr 1 - Apr 2
Total with taxes and fees
Stay at this hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and parking (surcharge). Our guests praise the helpful staff and the clean rooms in our ...
7/10 Good! (1,879 reviews)
Rooms had tubs dripping water. No microwave or fridge. Pay for raggedy ass parking

Reviewed on Mar 28, 2026

Red Roof Inn PLUS+ San Antonio Downtown - Riverwalk
Super 8 by Wyndham Universal City

Super 8 by Wyndham Universal City

2 out of 5
200 Palisades Dr Universal City TX
$43 nightly
The price is $50 total per night from Mar 29 to Mar 30
$50 total
Mar 29 - Mar 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Universal City. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Regal Live Oak and Olympia ...
6.8/10 (1,007 reviews)
Internet was very poor, constantly up and down over the course of several days. Caused me to miss some important business last night as it was down completely. I called the front desk, only to hear they were working on it. Other than that, a nice place, but just don't depend on the wi-fi.

Reviewed on Mar 26, 2026

Super 8 by Wyndham Universal City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Antonio

Hyatt Regency Hill Country Resort and Villas

Hyatt Regency Hill Country Resort and Villas

4 out of 5
9800 Hyatt Resort Dr San Antonio TX
$405 nightly
The price is $479 total per night from Mar 30 to Mar 31
$479 total
Mar 30 - Mar 31
Total with taxes and fees
Book a stay at this golf hotel in San Antonio. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (1,000 reviews)

Families like: Outdoor pools, free waterpark access, playground, game room

Travelers say...
Great place to stay!! Extremely family friendly!

Reviewed on Mar 22, 2026

Hyatt Regency Hill Country Resort and Villas
Hotel Contessa

Hotel Contessa

4 out of 5
306 W Market Street San Antonio TX
$150 nightly
The price is $177 total per night from Apr 1 to Apr 2
$177 total
Apr 1 - Apr 2
Total with taxes and fees
Book a stay at this spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (3,493 reviews)
Every interaction from beginning to end was amazing! I took my girlfriend out to San Antonio for her birthday and we thoroughly enjoyed the location (right on the Riverwalk!), the restaurants breakfast was amazing, the staff was professional and kind.. The esthetic was to our liking! Wel loved it! ...

Reviewed on Mar 28, 2026

Hotel Contessa
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street San Antonio TX
$128 nightly
The price is $151 total per night from Apr 5 to Apr 6
$151 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
9.4/10 Exceptional! (4,403 reviews)
Great hotel on the riverwalk! Included free food and drinks with the kick back in the afternoon and delicious breakfast. Every single employee was friendly and helpful. We will stay here again next time we visit.

Reviewed on Mar 28, 2026

Drury Plaza Hotel San Antonio Riverwalk
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

MDT to SAT Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
MDT Address & GPS
Address:
One Terminal Drive
Middletown PA, 17057
United States
IATA Code:
MDT
Longitude:
-76.756057
Latitude:
40.196008
Time Zone:
America/New_York
SAT Address & GPS
Address:
9800 Airport Boulevard
San Antonio TX, 78216
United States
IATA Code:
SAT
Longitude:
-98.472643
Latitude:
29.524937
Time Zone:
America/Chicago

Frequently asked questions

Are there non-stop flights from MDT to San Antonio Airport?
Traveling from MDT to SAT means you'll need to change planes. But hey — there's no need to worry. American Airlines, Delta Air Lines and United Airlines offer flights with a single stopover.
What is the shortest flight from MDT to San Antonio Airport?
From Harrisburg, the wonderful sights and sounds of San Antonio are around 5 hours and 14 minutes away. Make sure you choose your favorite seat, or maybe even one with more legroom, and fly to your destination in total comfort.
How many hours flight from Harrisburg Intl. Airport to SAT?
Settle in and get comfy, because a typical plane trip from Harrisburg Intl. Airport to San Antonio Intl. Airport (SAT) is 5 hours and 19 minutes. Watch a few TV episodes, finish that book … You'll have plenty of time to sit back and enjoy the ride.
What airlines have the most flights from Harrisburg Intl. Airport (MDT) to San Antonio Intl. Airport (SAT)?
You'll need to make one or more stopovers if you're traveling from MDT to SAT. Right now, there are no airlines that advertise direct flights on this route.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

More to Explore