Cheap flights from MDT to SAT (Harrisburg Intl. to San Antonio Intl.)

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Cheap Flights from MDT to SAT starting at $125 One Way, $184 Round Trip

Prices starting at $184 for return flights and $125 for one-way flights to San Antonio Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Feb 21 - Mon, Feb 23
MDT
Harrisburg
SAT
San Antonio
$184 Roundtrip, found 1 day ago
$184
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, Feb 21 from Harrisburg to San Antonio, returning Mon, Feb 23, priced at $184 found 1 day ago
Sun, Feb 22 - Mon, Feb 23
MDT
Harrisburg
SAT
San Antonio
$205 Roundtrip, found 1 day ago
$205
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sun, Feb 22 from Harrisburg to San Antonio, returning Mon, Feb 23, priced at $205 found 1 day ago
Sat, Mar 7 - Tue, Mar 10
MDT
Harrisburg
SAT
San Antonio
$224 Roundtrip, found 4 days ago
$224
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sat, Mar 7 from Harrisburg to San Antonio, returning Tue, Mar 10, priced at $224 found 4 days ago
Thu, Feb 19 - Mon, Feb 23
MDT
Harrisburg
SAT
San Antonio
$242 Roundtrip, found 1 day ago
$242
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Feb 19 from Harrisburg to San Antonio, returning Mon, Feb 23, priced at $242 found 1 day ago
Sat, Mar 7 - Mon, Mar 9
MDT
Harrisburg
SAT
San Antonio
$259 Roundtrip, found 4 days ago
$259
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sat, Mar 7 from Harrisburg to San Antonio, returning Mon, Mar 9, priced at $259 found 4 days ago

Hotel Ideas near San Antonio Intl.

Airport Hotels near San Antonio Intl.

Hampton Inn & Suites San Antonio-Airport

Hampton Inn & Suites San Antonio-Airport

2.5 out of 5
8902 Jones Maltsberger Rd San Antonio TX
$83 nightly
The price is $98 total per night from Jan 18 to Jan 19
$98 total
Jan 18 - Jan 19
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and ...
8.4/10 Very Good! (1,841 reviews)
The room was very nice. It was clean and comfortable

Reviewed on Jan 4, 2026

Hampton Inn & Suites San Antonio-Airport
La Quinta Inn & Suites by Wyndham San Antonio Airport

La Quinta Inn & Suites by Wyndham San Antonio Airport

3 out of 5
850 Halm Blvd San Antonio TX
$75 nightly
The price is $89 total per night from Jan 18 to Jan 19
$89 total
Jan 18 - Jan 19
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (2,823 reviews)
Nice and comfortable stay.

Reviewed on Jan 6, 2026

La Quinta Inn & Suites by Wyndham San Antonio Airport
Heritage Inn Suites San Antonio Airpt, Trademark by Wyndham

Heritage Inn Suites San Antonio Airpt, Trademark by Wyndham

2.5 out of 5
143 NE Loop 410 San Antonio TX
$79 nightly
The price is $93 total per night from Jan 12 to Jan 13
$93 total
Jan 12 - Jan 13
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,538 reviews)
Staff was courteous and room was clean

Reviewed on Jan 5, 2026

Heritage Inn Suites San Antonio Airpt, Trademark by Wyndham
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Antonio

Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
$187 nightly
The price is $221 total per night from Jan 11 to Jan 12
$221 total
Jan 11 - Jan 12
Total with taxes and fees
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (2,347 reviews)
Check-in was quick and easy and our room was very clean. We had a few hiccups, like a clogged bathroom sink and some ants in our room but it was all resolved quickly and with such kindness and respect. I will always return to Hotel Valencia because there staff always tries to go above and beyodn ...

Reviewed on Jan 5, 2026

Hotel Valencia Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3 out of 5
303 Blum Street San Antonio TX
$86 nightly
The price is $102 total per night from Feb 8 to Feb 9
$102 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
7.8/10 Good! (3,808 reviews)
Great location

Reviewed on Jan 9, 2026

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
$109 nightly
The price is $129 total per night from Jan 11 to Jan 12
$129 total
Jan 11 - Jan 12
Total with taxes and fees
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
8/10 Very Good! (6,312 reviews)
Windows needed cleaning. Did not have a balcony but could see the river walk thru the smudged windows

Reviewed on Jan 6, 2026

Riverwalk Plaza
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Antonio Hotels With Airport Transportation

Hampton Inn & Suites San Antonio-Airport

Hampton Inn & Suites San Antonio-Airport

2.5 out of 5
8902 Jones Maltsberger Rd San Antonio TX
$83 nightly
The price is $98 total per night from Jan 18 to Jan 19
$98 total
Jan 18 - Jan 19
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and ...
8.4/10 Very Good! (1,841 reviews)
The room was very nice. It was clean and comfortable

Reviewed on Jan 4, 2026

Hampton Inn & Suites San Antonio-Airport
Hilton Garden Inn San Antonio Airport South

Hilton Garden Inn San Antonio Airport South

3 out of 5
8505 Broadway Street San Antonio TX
$86 nightly
The price is $101 total per night from Jan 18 to Jan 19
$101 total
Jan 18 - Jan 19
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
8.2/10 Very Good! (1,001 reviews)
I thought breakfast was included, it was not.

Reviewed on Jan 6, 2026

Hilton Garden Inn San Antonio Airport South
Heritage Inn Suites San Antonio Airpt, Trademark by Wyndham

Heritage Inn Suites San Antonio Airpt, Trademark by Wyndham

2.5 out of 5
143 NE Loop 410 San Antonio TX
$79 nightly
The price is $93 total per night from Jan 12 to Jan 13
$93 total
Jan 12 - Jan 13
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,538 reviews)
Staff was courteous and room was clean

Reviewed on Jan 5, 2026

Heritage Inn Suites San Antonio Airpt, Trademark by Wyndham
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Antonio Hotels

Days Inn by Wyndham San Antonio Alamo/Riverwalk

Days Inn by Wyndham San Antonio Alamo/Riverwalk

2 out of 5
400 Bowie Street San Antonio TX
$59 nightly
The price is $69 total per night from Jan 25 to Jan 26
$69 total
Jan 25 - Jan 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the helpful staff and ...
7/10 Good! (1,315 reviews)
The hotel is near downtown, you can literally walk anywhere like El Alamo Museum

Reviewed on Jan 7, 2026

Days Inn by Wyndham San Antonio Alamo/Riverwalk
Red Roof Inn PLUS+ San Antonio Downtown - Riverwalk

Red Roof Inn PLUS+ San Antonio Downtown - Riverwalk

2.5 out of 5
1011 E Houston St San Antonio TX
$40 nightly
The price is $48 total per night from Feb 1 to Feb 2
$48 total
Feb 1 - Feb 2
Total with taxes and fees
Stay at this hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and parking (surcharge). Our guests praise the helpful staff and the clean rooms in our ...
7/10 Good! (1,796 reviews)
.

Reviewed on Jan 5, 2026

Red Roof Inn PLUS+ San Antonio Downtown - Riverwalk
Super 8 by Wyndham Universal City

Super 8 by Wyndham Universal City

2 out of 5
200 Palisades Dr Universal City TX
$43 nightly
The price is $50 total per night from Jan 11 to Jan 12
$50 total
Jan 11 - Jan 12
Total with taxes and fees
Book a stay at this business-friendly hotel in Universal City. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Regal Live Oak and Olympia ...
6.6/10 (1,000 reviews)
King bed was so comfy. Staff was friendly. Room was clean! It felt safe. 10 out of 10

Reviewed on Dec 26, 2025

Super 8 by Wyndham Universal City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Antonio

Hyatt Regency Hill Country Resort and Villas

Hyatt Regency Hill Country Resort and Villas

4 out of 5
9800 Hyatt Resort Dr San Antonio TX
$354 nightly
The price is $419 total per night from Jan 11 to Jan 12
$419 total
Jan 11 - Jan 12
Total with taxes and fees
Book a stay at this golf hotel in San Antonio. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (1,000 reviews)

Families like: Outdoor pools, free waterpark access, playground, game room

Travelers say...
Amazing hotel! Great service! Very relaxing and peaceful. Perfect for kids of all ages.

Reviewed on Jan 6, 2026

Hyatt Regency Hill Country Resort and Villas
Hotel Contessa

Hotel Contessa

4 out of 5
306 W Market Street San Antonio TX
$153 nightly
The price is $181 total per night from Jan 29 to Jan 30
$181 total
Jan 29 - Jan 30
Total with taxes and fees
Book a stay at this spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (3,420 reviews)
Na

Reviewed on Jan 8, 2026

Hotel Contessa
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street San Antonio TX
$120 nightly
The price is $142 total per night from Jan 11 to Jan 12
$142 total
Jan 11 - Jan 12
Total with taxes and fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
9.4/10 Exceptional! (4,175 reviews)
The room was clean. They didn't make the beds the second day, but brought fresh towels, did not bring wash cloths.

Reviewed on Jan 6, 2026

Drury Plaza Hotel San Antonio Riverwalk
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

MDT to SAT Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
MDT Address & GPS
Address:
One Terminal Drive
Middletown PA, 17057
United States
IATA Code:
MDT
Longitude:
-76.756057
Latitude:
40.196008
Time Zone:
America/New_York
SAT Address & GPS
Address:
9800 Airport Boulevard
San Antonio TX, 78216
United States
IATA Code:
SAT
Longitude:
-98.472643
Latitude:
29.524937
Time Zone:
America/Chicago

Frequently asked questions

Are there non-stop flights from MDT to San Antonio Airport?
Traveling from MDT to SAT means you'll need to change planes. But hey — there's no need to worry. American Airlines, Delta Air Lines and United Airlines offer flights with a single stopover.
What is the shortest flight from MDT to San Antonio Airport?
From Harrisburg, the wonderful sights and sounds of San Antonio are around 5 hours and 14 minutes away. Make sure you choose your favorite seat, or maybe even one with more legroom, and fly to your destination in total comfort.
How many hours flight from Harrisburg Intl. Airport to SAT?
Settle in and get comfy, because a typical plane trip from Harrisburg Intl. Airport to San Antonio Intl. Airport (SAT) is 5 hours and 19 minutes. Watch a few TV episodes, finish that book … You'll have plenty of time to sit back and enjoy the ride.
What airlines have the most flights from Harrisburg Intl. Airport (MDT) to San Antonio Intl. Airport (SAT)?
You'll need to make one or more stopovers if you're traveling from MDT to SAT. Right now, there are no airlines that advertise direct flights on this route.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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