Cheap flights from TYS to SNA (McGhee Tyson to John Wayne)

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Cheap Flights from TYS to SNA starting at $139 One Way, $349 Round Trip

Prices starting at $349 for return flights and $139 for one-way flights to John Wayne were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Sep 8 - Sat, Sep 12
TYS
Knoxville
SNA
Orange County
$349 Roundtrip, found 6 days ago
$349
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Sep 8 from Knoxville to Orange County, returning Sat, Sep 12, priced at $349 found 6 days ago
Wed, Apr 15 - Mon, Apr 20
TYS
Knoxville
SNA
Orange County
$358 Roundtrip, found 6 days ago
$358
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Wed, Apr 15 from Knoxville to Orange County, returning Mon, Apr 20, priced at $358 found 6 days ago
Tue, Sep 8 - Sat, Sep 12
TYS
Knoxville
SNA
Orange County
$377 Roundtrip, found 6 days ago
$377
Roundtrip
found 6 days ago
Select United flight, departing Tue, Sep 8 from Knoxville to Orange County, returning Sat, Sep 12, priced at $377 found 6 days ago
Tue, Sep 8 - Sat, Sep 12
TYS
Knoxville
SNA
Orange County
$393 Roundtrip, found 6 days ago
$393
Roundtrip
found 6 days ago
Select United flight, departing Tue, Sep 8 from Knoxville to Orange County, returning Sat, Sep 12, priced at $393 found 6 days ago
Tue, Sep 8 - Sat, Sep 12
TYS
Knoxville
SNA
Orange County
$394 Roundtrip, found 6 days ago
$394
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Sep 8 from Knoxville to Orange County, returning Sat, Sep 12, priced at $394 found 6 days ago

Hotel Ideas near John Wayne

Airport Hotels near John Wayne

Ayres Hotel Costa Mesa/Newport Beach

Ayres Hotel Costa Mesa/Newport Beach

4 out of 5
325 Bristol Street Costa Mesa CA
$139 nightly
The price is $155 total per night from Apr 1 to Apr 2
$155 total
Apr 1 - Apr 2
Total with taxes and fees
Book a stay at this business-friendly hotel in Costa Mesa. Enjoy free WiFi, 2 outdoor pools, and a free airport shuttle. Our guests praise the breakfast and ...
9/10 Wonderful! (3,154 reviews)
Very clean and well-kept business hotel near the airport. Rooms were clean and well-appointed. There was a nice pool/courtyard area, although we didn't go.

Reviewed on Mar 29, 2026

Ayres Hotel Costa Mesa/Newport Beach
Embassy Suites by Hilton Santa Ana Orange County Airport

Embassy Suites by Hilton Santa Ana Orange County Airport

3.5 out of 5
1325 East Dyer Road Santa Ana CA
$122 nightly
The price is $138 total per night from Apr 5 to Apr 6
$138 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, a free airport shuttle, and room service. Our guests praise the breakfast and ...
6.2/10 (1,948 reviews)
Good menu, nice staff, clean spaces.

Reviewed on Mar 29, 2026

Embassy Suites by Hilton Santa Ana Orange County Airport
MainStay Suites John Wayne Airport by Choice Hotels

MainStay Suites John Wayne Airport by Choice Hotels

2.5 out of 5
2701 Hotel Terrace Santa Ana CA
$93 nightly
The price is $105 total per night from Apr 5 to Apr 6
$105 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,739 reviews)
Loved the room and atmosphere it was very warm and welcoming. Rooms were clean and very comfortable. Only thing that was not so enjoyable were the beds they were slightly uncomfortable but other than that the room was amazing

Reviewed on Mar 29, 2026

MainStay Suites John Wayne Airport by Choice Hotels
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Orange County

Embassy Suites by Hilton Santa Ana Orange County Airport

Embassy Suites by Hilton Santa Ana Orange County Airport

3.5 out of 5
1325 East Dyer Road Santa Ana CA
$122 nightly
The price is $138 total per night from Apr 5 to Apr 6
$138 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, a free airport shuttle, and room service. Our guests praise the breakfast and ...
6.2/10 (1,948 reviews)
Good menu, nice staff, clean spaces.

Reviewed on Mar 29, 2026

Embassy Suites by Hilton Santa Ana Orange County Airport
MainStay Suites John Wayne Airport by Choice Hotels

MainStay Suites John Wayne Airport by Choice Hotels

2.5 out of 5
2701 Hotel Terrace Santa Ana CA
$93 nightly
The price is $105 total per night from Apr 5 to Apr 6
$105 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,739 reviews)
Loved the room and atmosphere it was very warm and welcoming. Rooms were clean and very comfortable. Only thing that was not so enjoyable were the beds they were slightly uncomfortable but other than that the room was amazing

Reviewed on Mar 29, 2026

MainStay Suites John Wayne Airport by Choice Hotels
Hilton Anaheim

Hilton Anaheim

4 out of 5
777 W Convention Way Anaheim CA
$148 nightly
The price is $173 total per night from Apr 5 to Apr 6
$173 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this spa hotel in Anaheim. Enjoy a full-service spa, 4 restaurants, and 2 hot tubs. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (1,158 reviews)
I had one of the best breakfast entrees, and unusual. Besides being very healthy and satisfying, it had a delicious crunch and taste so the cost was justified.

Reviewed on Mar 29, 2026

Hilton Anaheim
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Orange County Hotels With Airport Transportation

MainStay Suites John Wayne Airport by Choice Hotels

MainStay Suites John Wayne Airport by Choice Hotels

2.5 out of 5
2701 Hotel Terrace Santa Ana CA
$93 nightly
The price is $105 total per night from Apr 5 to Apr 6
$105 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,739 reviews)
Loved the room and atmosphere it was very warm and welcoming. Rooms were clean and very comfortable. Only thing that was not so enjoyable were the beds they were slightly uncomfortable but other than that the room was amazing

Reviewed on Mar 29, 2026

MainStay Suites John Wayne Airport by Choice Hotels
Best Western Plus Orange County Airport North

Best Western Plus Orange County Airport North

2.5 out of 5
2700 Hotel Terrace Dr. Santa Ana CA
$113 nightly
The price is $128 total per night from Mar 30 to Mar 31
$128 total
Mar 30 - Mar 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,792 reviews)
My place when im out there on corporate meeting or events

Reviewed on Mar 27, 2026

Best Western Plus Orange County Airport North
Hotel Zessa Orange County Airport, a DoubleTree by Hilton

Hotel Zessa Orange County Airport, a DoubleTree by Hilton

4 out of 5
201 E MacArthur Blvd Santa Ana CA
$114 nightly
The price is $129 total per night from Apr 4 to Apr 5
$129 total
Apr 4 - Apr 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
9/10 Wonderful! (678 reviews)
Lobby was modern, very clean and open. Gym room was beautiful and clean. Hotel Room could’ve been more modern but was clean. Parking was very easy and close to get to. Staff was very accommodating.

Reviewed on Mar 22, 2026

Hotel Zessa Orange County Airport, a DoubleTree by Hilton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Orange County Hotels

Motel 6 Santa Ana, CA

Motel 6 Santa Ana, CA

2 out of 5
1623 East 1st Street Santa Ana CA
$79 nightly
The price is $89 total per night from Mar 31 to Apr 1
$89 total
Mar 31 - Apr 1
Total with taxes and fees
Stay at this motel in Santa Ana. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.4/10 Good! (1,000 reviews)
.

Reviewed on Mar 26, 2026

Motel 6 Santa Ana, CA
West Coast Inn - Near Gem Theatre

West Coast Inn - Near Gem Theatre

2 out of 5
Santa Ana CA
$104 nightly
The price is $115 total per night from Mar 30 to Mar 31
$115 total
Mar 30 - Mar 31
Total with taxes and fees
Stay at this vacation home in Santa Ana. Enjoy free WiFi, free parking, and room service. Popular attractions Anaheim Convention Center and Disney California ...
7/10 Good! (317 reviews)
Spent too much money for a jacuzzi room. Jacuzzi broken, no television, chick on drugs knocking on my window all night, what a treat.

Reviewed on Mar 21, 2026

West Coast Inn - Near Gem Theatre
Best Western Plus Orange County Airport North

Best Western Plus Orange County Airport North

2.5 out of 5
2700 Hotel Terrace Dr. Santa Ana CA
$113 nightly
The price is $128 total per night from Mar 30 to Mar 31
$128 total
Mar 30 - Mar 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,792 reviews)
My place when im out there on corporate meeting or events

Reviewed on Mar 27, 2026

Best Western Plus Orange County Airport North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Orange County

Embassy Suites by Hilton Santa Ana Orange County Airport

Embassy Suites by Hilton Santa Ana Orange County Airport

3.5 out of 5
1325 East Dyer Road Santa Ana CA
$122 nightly
The price is $138 total per night from Apr 5 to Apr 6
$138 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, a free airport shuttle, and room service. Our guests praise the breakfast and ...
6.2/10 (1,948 reviews)
Good menu, nice staff, clean spaces.

Reviewed on Mar 29, 2026

Embassy Suites by Hilton Santa Ana Orange County Airport
MainStay Suites John Wayne Airport by Choice Hotels

MainStay Suites John Wayne Airport by Choice Hotels

2.5 out of 5
2701 Hotel Terrace Santa Ana CA
$93 nightly
The price is $105 total per night from Apr 5 to Apr 6
$105 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,739 reviews)
Loved the room and atmosphere it was very warm and welcoming. Rooms were clean and very comfortable. Only thing that was not so enjoyable were the beds they were slightly uncomfortable but other than that the room was amazing

Reviewed on Mar 29, 2026

MainStay Suites John Wayne Airport by Choice Hotels
Best Western Plus Orange County Airport North

Best Western Plus Orange County Airport North

2.5 out of 5
2700 Hotel Terrace Dr. Santa Ana CA
$113 nightly
The price is $128 total per night from Mar 30 to Mar 31
$128 total
Mar 30 - Mar 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,792 reviews)
My place when im out there on corporate meeting or events

Reviewed on Mar 27, 2026

Best Western Plus Orange County Airport North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TYS to SNA Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York
SNA Address & GPS
Address:
18601 Airport Way
Santa Ana CA, 92707
United States
IATA Code:
SNA
Longitude:
-117.860538
Latitude:
33.680201
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from Knoxville Airport to SNA?
While you won't be able to fly nonstop from Knoxville Airport to John Wayne Airport at this point in time, there are plenty of airline companies that service this route with just a single stopover. Why not find out if the dates and times offered by American Airlines or United Airlines suit your travel plans? If they don't, you could always try Delta Air Lines.
What is the shortest flight from Knoxville Airport to John Wayne Airport (SNA)?
Traveling from TYS to John Wayne Airport (SNA) will take you at least 6 hours and 25 minutes. Enjoy a tipple and watch a show or two — this is the perfect opportunity to sit back and chill out.
How many hours flight from TYS to John Wayne Airport?
Typically, the trip from Knoxville Airport to John Wayne Airport takes 6 hours and 31 minutes. If you'd like to be as comfortable as you can, contemplate upgrading your seat using air miles or cash.
What airlines have the most flights from Knoxville Airport to SNA?
If you're wanting to book with an airline that offers direct flights from McGhee Tyson Airport (TYS) to John Wayne Airport, you won't have much luck. You'll need to book a flight with at least one stopover to get to Santa Ana.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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