Cheap flights from TYS to SNA (McGhee Tyson to John Wayne)

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Cheap Flights from TYS to SNA starting at $182 One Way, $408 Round Trip

Prices starting at $408 for return flights and $182 for one-way flights to John Wayne were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Dec 16 - Mon, Jan 4
TYS
Knoxville
SNA
Orange County
$408 Roundtrip, found 5 days ago
$408
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Dec 16 from Knoxville to Orange County, returning Mon, Jan 4, priced at $408 found 5 days ago
Tue, Dec 15 - Fri, Jan 1
TYS
Knoxville
SNA
Orange County
$421 Roundtrip, found 5 days ago
$421
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Dec 15 from Knoxville to Orange County, returning Fri, Jan 1, priced at $421 found 5 days ago
Tue, Dec 15 - Fri, Jan 1
TYS
Knoxville
SNA
Orange County
$427 Roundtrip, found 5 days ago
$427
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Tue, Dec 15 from Knoxville to Orange County, returning Fri, Jan 1, priced at $427 found 5 days ago
Wed, Dec 16 - Mon, Jan 4
TYS
Knoxville
SNA
Orange County
$428 Roundtrip, found 5 days ago
$428
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Wed, Dec 16 from Knoxville to Orange County, returning Mon, Jan 4, priced at $428 found 5 days ago
Wed, Dec 16 - Mon, Jan 4
TYS
Knoxville
SNA
Orange County
$433 Roundtrip, found 5 days ago
$433
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Wed, Dec 16 from Knoxville to Orange County, returning Mon, Jan 4, priced at $433 found 5 days ago

Hotel Ideas near John Wayne

Airport Hotels near John Wayne

Sonesta Irvine John Wayne Airport

Sonesta Irvine John Wayne Airport

3.5 out of 5
17941 Von Karman Avenue Irvine CA
$148 nightly
The price is $163 total per night from Nov 22 to Nov 23
$163 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Irvine. Enjoy breakfast (surcharge), a free airport shuttle, and a fitness center. Our guests praise the helpful ...
Sonesta Irvine John Wayne Airport
Hyatt Regency Newport Beach West

Hyatt Regency Newport Beach West

4 out of 5
4545 Macarthur Blvd Newport Beach CA
$203 nightly
The price is $224 total per night from Nov 15 to Nov 16
$224 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Newport Beach. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
Hyatt Regency Newport Beach West
Renaissance Newport Beach Hotel

Renaissance Newport Beach Hotel

4 out of 5
4500 Macarthur Blvd Newport Beach CA
$150 nightly
The price is $165 total per night from Nov 22 to Nov 23
$165 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Newport Beach. Enjoy a free airport shuttle, room service, and a 24-hour fitness center. Our guests praise the ...
9/10 Wonderful! (1,126 reviews)
"The food was great! The staff were all kind and helpful. Raphael, who drove me to the airport, was very pleasant. I was there for a conference, and we were well taken care of. Drinks and snacks were always available. I would gladly stay here again."

Reviewed on Nov 9, 2026

Renaissance Newport Beach Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Orange County

Ayres Hotel Costa Mesa/Newport Beach

Ayres Hotel Costa Mesa/Newport Beach

4 out of 5
325 Bristol Street Santa Ana CA
$143 nightly
The price is $159 total per night from Dec 11 to Dec 12
$159 total
Dec 11 - Dec 12
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free WiFi, 2 outdoor pools, and a free airport shuttle. Our guests praise the breakfast and the ...
Ayres Hotel Costa Mesa/Newport Beach
MainStay Suites John Wayne Airport by Choice Hotels

MainStay Suites John Wayne Airport by Choice Hotels

2.5 out of 5
2701 Hotel Terrace Santa Ana CA
$88 nightly
The price is $100 total per night from Dec 1 to Dec 2
$100 total
Dec 1 - Dec 2
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (2,332 reviews)
"We used to stay here when it was Quality Inn. As the "quality" went down, we stopped. When it was bought out, we gave it another try, and we were pleasantly surprised by the repairs and improvements they've made. The facilities were fine, the location was good, and the staff were very helpful."

Reviewed on Nov 10, 2026

MainStay Suites John Wayne Airport by Choice Hotels
Hilton Anaheim

Hilton Anaheim

4 out of 5
777 W Convention Way Anaheim CA
$157 nightly
The price is $184 total per night from Nov 22 to Nov 23
$184 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this family-friendly hotel in Anaheim. Enjoy 4 restaurants, 2 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff and ...
9/10 Wonderful! (3,028 reviews)
"We had an amazing stay at the Hilton Anaheim! The hotel is absolutely beautiful, spotless, and very well maintained. Every employee we encountered was incredibly kind, friendly, attentive, and welcoming. Their excellent customer service made our experience even more enjoyable. You can truly tell ..."

Reviewed on Nov 10, 2026

Hilton Anaheim
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Orange County Hotels With Airport Transportation

MainStay Suites John Wayne Airport by Choice Hotels

MainStay Suites John Wayne Airport by Choice Hotels

2.5 out of 5
2701 Hotel Terrace Santa Ana CA
$88 nightly
The price is $100 total per night from Dec 1 to Dec 2
$100 total
Dec 1 - Dec 2
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (2,332 reviews)
"We used to stay here when it was Quality Inn. As the "quality" went down, we stopped. When it was bought out, we gave it another try, and we were pleasantly surprised by the repairs and improvements they've made. The facilities were fine, the location was good, and the staff were very helpful."

Reviewed on Nov 10, 2026

MainStay Suites John Wayne Airport by Choice Hotels
Best Western Plus Orange County Airport North

Best Western Plus Orange County Airport North

2.5 out of 5
2700 Hotel Terrace Dr. Santa Ana CA
$109 nightly
The price is $123 total per night from Nov 16 to Nov 17
$123 total
Nov 16 - Nov 17
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Best Western Plus Orange County Airport North
Hotel Zessa Orange County Airport, a DoubleTree by Hilton

Hotel Zessa Orange County Airport, a DoubleTree by Hilton

4 out of 5
201 E MacArthur Blvd Santa Ana CA
$108 nightly
The price is $122 total per night from Nov 27 to Nov 28
$122 total
Nov 27 - Nov 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
9/10 Wonderful! (839 reviews)
"I've now stayed at this hotel a few times and it is definitely a better alternative than the local hotels I used to stay at. But the cleaning crew were very noisy the entire time they were on my floor. They need to be trained to keep their personal conversations out of the hallway and use of walkie ..."

Reviewed on Nov 8, 2026

Hotel Zessa Orange County Airport, a DoubleTree by Hilton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Orange County Hotels

Motel 6 Santa Ana, CA

Motel 6 Santa Ana, CA

2 out of 5
1623 East 1st Street Santa Ana CA
$77 nightly
The price is $87 total per night from Nov 15 to Nov 16
$87 total
Nov 15 - Nov 16
Total with taxes and fees
Stay at this motel in Santa Ana. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Motel 6 Santa Ana, CA
Best Western Plus Orange County Airport North

Best Western Plus Orange County Airport North

2.5 out of 5
2700 Hotel Terrace Dr. Santa Ana CA
$109 nightly
The price is $123 total per night from Nov 16 to Nov 17
$123 total
Nov 16 - Nov 17
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Best Western Plus Orange County Airport North
La Quinta Inn & Suites by Wyndham Orange County Airport

La Quinta Inn & Suites by Wyndham Orange County Airport

3 out of 5
2721 Hotel Ter Santa Ana CA
$91 nightly
The price is $102 total per night from Nov 22 to Nov 23
$102 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.8/10 Good! (2,163 reviews)
"Staff great"

Reviewed on Nov 9, 2026

La Quinta Inn & Suites by Wyndham Orange County Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Orange County

Embassy Suites by Hilton Santa Ana Orange County Airport

Embassy Suites by Hilton Santa Ana Orange County Airport

3.5 out of 5
1325 East Dyer Road Santa Ana CA
$109 nightly
The price is $123 total per night from Nov 15 to Nov 16
$123 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, a free airport shuttle, and room service. Our guests praise the breakfast and ...
6.4/10 (2,124 reviews)
"This is not the worst Hilton property but in serious need of attention. Water dripping for days costs Hilton a lot of money. Not a single plant in the building looks good and there is only a few."

Reviewed on Nov 10, 2026

Embassy Suites by Hilton Santa Ana Orange County Airport
MainStay Suites John Wayne Airport by Choice Hotels

MainStay Suites John Wayne Airport by Choice Hotels

2.5 out of 5
2701 Hotel Terrace Santa Ana CA
$88 nightly
The price is $100 total per night from Dec 1 to Dec 2
$100 total
Dec 1 - Dec 2
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (2,332 reviews)
"We used to stay here when it was Quality Inn. As the "quality" went down, we stopped. When it was bought out, we gave it another try, and we were pleasantly surprised by the repairs and improvements they've made. The facilities were fine, the location was good, and the staff were very helpful."

Reviewed on Nov 10, 2026

MainStay Suites John Wayne Airport by Choice Hotels
Best Western Plus Orange County Airport North

Best Western Plus Orange County Airport North

2.5 out of 5
2700 Hotel Terrace Dr. Santa Ana CA
$109 nightly
The price is $123 total per night from Nov 16 to Nov 17
$123 total
Nov 16 - Nov 17
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Best Western Plus Orange County Airport North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TYS to SNA Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York
SNA Address & GPS
Address:
18601 Airport Way
Santa Ana CA, 92707
United States
IATA Code:
SNA
Longitude:
-117.860538
Latitude:
33.680201
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from Knoxville Airport to SNA?
While you won't be able to fly nonstop from Knoxville Airport to John Wayne Airport at this point in time, there are plenty of airline companies that service this route with just a single stopover. Why not find out if the dates and times offered by American Airlines or United Airlines suit your travel plans? If they don't, you could always try Delta Air Lines.
What is the shortest flight from Knoxville Airport to John Wayne Airport (SNA)?
Traveling from TYS to John Wayne Airport (SNA) will take you at least 6 hours and 25 minutes. Enjoy a tipple and watch a show or two — this is the perfect opportunity to sit back and chill out.
How many hours flight from TYS to John Wayne Airport?
Typically, the trip from Knoxville Airport to John Wayne Airport takes 6 hours and 31 minutes. If you'd like to be as comfortable as you can, contemplate upgrading your seat using air miles or cash.
What airlines have the most flights from Knoxville Airport to SNA?
If you're wanting to book with an airline that offers direct flights from McGhee Tyson Airport (TYS) to John Wayne Airport, you won't have much luck. You'll need to book a flight with at least one stopover to get to Santa Ana.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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