Cheap flights from MFR to SAN (Rogue Valley Intl. to San Diego Intl.)

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Cheap Flights from MFR to SAN starting at $104 One Way, $222 Round Trip

Prices starting at $222 for return flights and $104 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Dec 16 - Thu, Dec 17
MFR
Medford
SAN
San Diego
$222 Roundtrip, found 6 days ago
$222
Roundtrip
found 6 days ago
Select United flight, departing Wed, Dec 16 from Medford to San Diego, returning Thu, Dec 17, priced at $222 found 6 days ago
Wed, Dec 16 - Thu, Dec 17
MFR
Medford
SAN
San Diego
$228 Roundtrip, found 6 days ago
$228
Roundtrip
found 6 days ago
Select United flight, departing Wed, Dec 16 from Medford to San Diego, returning Thu, Dec 17, priced at $228 found 6 days ago
Sat, Jan 16 - Sat, Jan 23
MFR
Medford
SAN
San Diego
$247 Roundtrip, found 1 day ago
$247
Roundtrip
found 1 day ago
Select Alaska Airlines flight, departing Sat, Jan 16 from Medford to San Diego, returning Sat, Jan 23, priced at $247 found 1 day ago
Sat, Jan 16 - Sat, Jan 23
MFR
Medford
SAN
San Diego
$257 Roundtrip, found 1 day ago
$257
Roundtrip
found 1 day ago
Select Alaska Airlines flight, departing Sat, Jan 16 from Medford to San Diego, returning Sat, Jan 23, priced at $257 found 1 day ago
Sun, Dec 6 - Thu, Dec 10
MFR
Medford
SAN
San Diego
$263 Roundtrip, found 1 day ago
$263
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Dec 6 from Medford to San Diego, returning Thu, Dec 10, priced at $263 found 1 day ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$160 nightly
The price is $184 total per night from Nov 22 to Nov 23
$184 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Sheraton San Diego Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$170 nightly
The price is $197 total per night from Nov 22 to Nov 23
$197 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,365 reviews)
"."

Reviewed on Nov 11, 2026

Wyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
$90 nightly
The price is $104 total per night from Dec 1 to Dec 2
$104 total
Dec 1 - Dec 2
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (3,051 reviews)
"Very easy nice hotel. Only complaint is the rooms are much smaller than expected. However the pool and hottub area is so nice that it truly makes up for this as you’ll spend more time at the pool than the rooms"

Reviewed on Nov 11, 2026

Handlery Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$170 nightly
The price is $197 total per night from Nov 22 to Nov 23
$197 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,365 reviews)
"."

Reviewed on Nov 11, 2026

Wyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
$90 nightly
The price is $104 total per night from Dec 1 to Dec 2
$104 total
Dec 1 - Dec 2
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (3,051 reviews)
"Very easy nice hotel. Only complaint is the rooms are much smaller than expected. However the pool and hottub area is so nice that it truly makes up for this as you’ll spend more time at the pool than the rooms"

Reviewed on Nov 11, 2026

Handlery Hotel
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
$211 nightly
The price is $244 total per night from Nov 22 to Nov 23
$244 total
Nov 22 - Nov 23
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
Hard Rock Hotel San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$170 nightly
The price is $197 total per night from Nov 22 to Nov 23
$197 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,365 reviews)
"."

Reviewed on Nov 11, 2026

Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$160 nightly
The price is $184 total per night from Nov 22 to Nov 23
$184 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 out of 5
1955 San Diego Ave San Diego CA
$136 nightly
The price is $156 total per night from Nov 16 to Nov 17
$156 total
Nov 16 - Nov 17
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
9.2/10 Wonderful! (1,104 reviews)
"Was convenience"

Reviewed on Nov 10, 2026

Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn

Pleasant Inn

2.5 out of 5
5550 Clairemont Mesa Blvd San Diego CA
$72 nightly
The price is $83 total per night from Dec 8 to Dec 9
$83 total
Dec 8 - Dec 9
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
8.6/10 Excellent! (1,634 reviews)
"Saw crockroaches in both times of staying."

Reviewed on Nov 10, 2026

Pleasant Inn
E-Z 8 Motel Old Town

E-Z 8 Motel Old Town

2.5 out of 5
4747 Pacific Highway San Diego CA
$73 nightly
The price is $84 total per night from Nov 12 to Nov 13
$84 total
Nov 12 - Nov 13
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
E-Z 8 Motel Old Town
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
$76 nightly
The price is $87 total per night from Dec 12 to Dec 13
$87 total
Dec 12 - Dec 13
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.8/10 Excellent! (3,846 reviews)
"Rooms are small and older. We found the rooms to be very humid. The pool area and other amenities were nice but would only stay again if the price was right."

Reviewed on Nov 11, 2026

Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
$175 nightly
The price is $202 total per night from Dec 10 to Dec 11
$202 total
Dec 10 - Dec 11
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free parking, a private beach, and a marina. Our guests praise the pool and the restaurant in our reviews. ...
8.8/10 Excellent! (2,521 reviews)

Families like: Outdoor pool, kids club, playground, game room

Travelers say...
"Should have had more staff working the beach"

Reviewed on Nov 10, 2026

Bahia Resort Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
$182 nightly
The price is $209 total per night from Dec 2 to Dec 3
$209 total
Dec 2 - Dec 3
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
The Dana on Mission Bay
Catamaran Resort and Spa

Catamaran Resort and Spa

4 out of 5
3999 Mission Boulevard San Diego CA
$245 nightly
The price is $282 total per night from Dec 10 to Dec 11
$282 total
Dec 10 - Dec 11
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,400 reviews)

Families like: Outdoor pool, game room, on the beach, bicycle rentals

Travelers say...
"Wonderful hotel right on MIssion Bay with everything you expect from a luxury hotel and more - the rooms are beautifully decorated - we stayed in a room with a patio door that opened up right to the boardwalk and the beach - go there and you won't be disppointed."

Reviewed on Nov 11, 2026

Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

MFR to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
MFR Address & GPS
Address:
1000 Terminal Spur Rd.
Medford OR, 97504
United States
IATA Code:
MFR
Longitude:
-122.87312
Latitude:
42.369025
Time Zone:
America/Los_Angeles
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from Medford Airport to San Diego Intl. Airport (SAN)?
With no direct flights currently servicing the route from MFR to San Diego Intl. Airport (SAN), your best bet is to pick an airline that offers just one easy stopover. Rack up those air miles with Alaska Airlines, United Airlines or Delta Air Lines.
What is the shortest flight from MFR to SAN?
Getting from MFR to SAN takes at least 3 hours and 56 minutes. Savor a wine and get stuck into that book — it's the ideal opportunity to simply relax.
How many hours flight from Rogue Valley Intl. Airport (MFR) to San Diego Airport?
It usually takes around 4 hours and 4 minutes to jet from Rogue Valley Intl. Airport (MFR) to San Diego Intl. Airport (SAN). You'll be in the sky for a while, so take your own entertainment, like a newspaper or some movies.
What airlines have the most flights from MFR to San Diego Intl. Airport (SAN)?
If you're wanting to book with an airline that flies direct from Rogue Valley Intl. Airport (MFR) to SAN, it's not going to happen. You'll have to book a flight with at least one stopover to get to San Diego.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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