Cheap flights from CLE to STL (Hopkins Intl. to Lambert-St. Louis Intl.)

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Cheap Flights from CLE to STL starting at $60 One Way, $140 Round Trip

Prices starting at $140 for return flights and $60 for one-way flights to Lambert-St. Louis Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, May 10 - Sat, May 16
CLE
Cleveland
STL
St. Louis
$140 Roundtrip, found 2 hours ago
$140
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Sun, May 10 from Cleveland to St. Louis, returning Sat, May 16, priced at $140 found 2 hours ago
Sun, May 31 - Wed, Jun 3
CLE
Cleveland
STL
St. Louis
$142 Roundtrip, found 2 days ago
$142
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Sun, May 31 from Cleveland to St. Louis, returning Wed, Jun 3, priced at $142 found 2 days ago
Tue, May 12 - Tue, May 19
CLE
Cleveland
STL
St. Louis
$144 Roundtrip, found 6 hours ago
$144
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Tue, May 12 from Cleveland to St. Louis, returning Tue, May 19, priced at $144 found 6 hours ago
Mon, May 11 - Tue, May 12
CLE
Cleveland
STL
St. Louis
$144 Roundtrip, found 3 days ago
$144
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Mon, May 11 from Cleveland to St. Louis, returning Tue, May 12, priced at $144 found 3 days ago
Sun, May 31 - Wed, Jun 3
CLE
Cleveland
STL
St. Louis
$203 Roundtrip, found 2 days ago
$203
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Sun, May 31 from Cleveland to St. Louis, returning Wed, Jun 3, priced at $203 found 2 days ago

Hotel Ideas near Lambert-St. Louis Intl.

Airport Hotels near Lambert-St. Louis Intl.

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
The price is $113 total per night from May 3 to May 4
$113 total
per night
May 3 - May 4
Book a stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (2,939 reviews)
The room was really clean. The hotel is older and the room was pretty small. The staff was friendly and helpful.

Reviewed on Apr 17, 2026

Pear Tree Inn St. Louis Airport
Hilton St. Louis Airport

Hilton St. Louis Airport

3.5 out of 5
10330 Natural Bridge Rd St. Louis MO
The price is $165 total per night from May 3 to May 4
$165 total
per night
May 3 - May 4
Book a stay at this business-friendly hotel in St. Louis. Enjoy 2 restaurants, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
7.6/10 Good! (1,001 reviews)
.

Reviewed on Apr 16, 2026

Hilton St. Louis Airport
Drury Inn & Suites St. Louis Airport

Drury Inn & Suites St. Louis Airport

3 out of 5
10490 Natural Bridge Rd St. Louis MO
The price is $132 total per night from May 10 to May 11
$132 total
per night
May 10 - May 11
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,189 reviews)
Breakfast was amazing

Reviewed on Apr 16, 2026

Drury Inn & Suites St. Louis Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In St. Louis

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
$100 nightly
The price is $116 total per night from May 3 to May 4
$116 total
May 3 - May 4
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
9/10 Wonderful! (3,154 reviews)
The room was clean and the bed was very comfortable. I could walk from my floor into the parking lot. Very convenient. The staff was very helpful and friendly.

Reviewed on Apr 17, 2026

Clayton Plaza Hotel & Extended Stay
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3 out of 5
2 South 4th Street St. Louis MO
$162 nightly
The price is $189 total per night from May 3 to May 4
$189 total
May 3 - May 4
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in our ...
9.4/10 Exceptional! (3,381 reviews)
They had free food and drinks every afternoon we were there.

Reviewed on Apr 17, 2026

Drury Plaza Hotel St. Louis at the Arch
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
$148 nightly
The price is $173 total per night from May 10 to May 11
$173 total
May 10 - May 11
Total with taxes and fees
Book a stay at this luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
9/10 Wonderful! (1,766 reviews)
Great location, clean rooms, wonderful pool and hot tub

Reviewed on Apr 16, 2026

21C Museum Hotel St Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

St. Louis Hotels With Airport Transportation

Quality Inn Saint Louis Airport

Quality Inn Saint Louis Airport

2.5 out of 5
10232 Natural Bridge Rd St. Louis MO
The price is $84 total per night from May 3 to May 4
$84 total
per night
May 3 - May 4
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a free airport shuttle, and parking (surcharge). Our guests praise the helpful staff ...
6.2/10 (1,002 reviews)
Had room 208, one of the first rooms at the top of the stairs. Smelled marijuana all night long, had horrible water pressure, and the entire stay there was someone opening and shutting a very heavy and loud door close by, and I mean alllll night long. Woke me up several time. Only had like three ...

Reviewed on Apr 17, 2026

Quality Inn Saint Louis Airport
Marriott St. Louis Airport

Marriott St. Louis Airport

4 out of 5
10700 Pear Tree Lane St. Louis MO
The price is $173 total per night from May 8 to May 9
$173 total
per night
May 8 - May 9
Book a stay at this business-friendly hotel in St. Louis. Enjoy breakfast (surcharge), a free airport shuttle, and room service. Our guests praise the helpful ...
Marriott St. Louis Airport
Hilton St. Louis Airport

Hilton St. Louis Airport

3.5 out of 5
10330 Natural Bridge Rd St. Louis MO
The price is $165 total per night from May 3 to May 4
$165 total
per night
May 3 - May 4
Book a stay at this business-friendly hotel in St. Louis. Enjoy 2 restaurants, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
7.6/10 Good! (1,001 reviews)
.

Reviewed on Apr 16, 2026

Hilton St. Louis Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced St. Louis Hotels

Quality Inn Saint Louis Airport

Quality Inn Saint Louis Airport

2.5 out of 5
10232 Natural Bridge Rd St. Louis MO
The price is $84 total per night from May 3 to May 4
$84 total
per night
May 3 - May 4
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a free airport shuttle, and parking (surcharge). Our guests praise the helpful staff ...
6.2/10 (1,002 reviews)
Had room 208, one of the first rooms at the top of the stairs. Smelled marijuana all night long, had horrible water pressure, and the entire stay there was someone opening and shutting a very heavy and loud door close by, and I mean alllll night long. Woke me up several time. Only had like three ...

Reviewed on Apr 17, 2026

Quality Inn Saint Louis Airport
Americas Best Value Inn St. Louis Downtown

Americas Best Value Inn St. Louis Downtown

2 out of 5
1100 Lumiere Place Boulevard St. Louis MO
The price is $116 total per night from Apr 19 to Apr 20
$116 total
per night
Apr 19 - Apr 20
Stay at this motel in St. Louis. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Gateway Arch and Busch Stadium are located ...
5.6/10 (837 reviews)
Do not stay here over charged me bums outside the room toilet broke bugd

Reviewed on Apr 13, 2026

Americas Best Value Inn St. Louis Downtown
OYO Hotel St. Louis Downtown City Center MO

OYO Hotel St. Louis Downtown City Center MO

3.5 out of 5
400 S 14th St St. Louis MO
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...
6.6/10 (1,000 reviews)
Definitely an older hotel. Overall the room was kinda dingy.

Reviewed on Apr 11, 2024

Get rates
OYO Hotel St. Louis Downtown City Center MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in St. Louis

Days Inn by Wyndham St. Louis Lindbergh Boulevard

Days Inn by Wyndham St. Louis Lindbergh Boulevard

2.5 out of 5
South Lindbergh Boulevard, 3660 St. Louis MO
Book a stay at this family-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a nightclub. Popular attractions Laumeier Sculpture Park and Magic ...

Families like: Indoor pool, playground, game room, cribs

Get rates
Days Inn by Wyndham St. Louis Lindbergh Boulevard
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3 out of 5
2 South 4th Street St. Louis MO
The price is $189 total per night from May 3 to May 4
$189 total
per night
May 3 - May 4
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in our ...
9.4/10 Exceptional! (3,381 reviews)
They had free food and drinks every afternoon we were there.

Reviewed on Apr 17, 2026

Drury Plaza Hotel St. Louis at the Arch
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

3 out of 5
2211 Market Street St. Louis MO
The price is $143 total per night from May 3 to May 4
$143 total
per night
May 3 - May 4
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant ...
8.8/10 Excellent! (1,946 reviews)
Located downtown adjacent but not in the hustle and bustle. We booked this hotel because it had free breakfast, free parking, and it had a hot tub. All of which were exactly what we had hoped for! Breakfast included hot options like biscuits and gravy, eggs, and sausage. There was also a soda fountain ...

Reviewed on Apr 16, 2026

Pear Tree Inn St. Louis Near Union Station
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

CLE to STL Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
CLE Address & GPS
Address:
5300 Riverside Drive
Cleveland OH, 44135-3193
United States
IATA Code:
CLE
Longitude:
-81.83821
Latitude:
41.410856
Time Zone:
America/New_York
STL Address & GPS
Address:
10701 Lambert International Blvd.
Saint Louis MO, 63145
United States
IATA Code:
STL
Longitude:
-90.379002
Latitude:
38.748707
Time Zone:
America/Chicago

Frequently asked questions

Are there non-stop flights from Cleveland Hopkins Intl. Airport to St. Louis Lambert International Airport?
We're delighted to inform you that Southwest Airlines will fly you directly from Cleveland to St. Louis. Book your seat on the plane now and enjoy a hassle-free, nonstop flight.
What is the shortest flight from CLE to St. Louis Lambert International Airport?
Jetting from Cleveland Hopkins Intl. Airport to Lambert Field will take a minimum of 5 hours and 15 minutes. Enjoy a beverage and get stuck into that book — here's your chance to sit back and relax.
How many hours flight from CLE to STL?
It takes just 5 hours and 21 minutes on average to travel from CLE to St. Louis Lambert International Airport. Pull out your travel book and start marking all the special places you want to visit. It won't be long before you'll be seeing them in person.
What airlines have the most flights from CLE to St. Louis Lambert International Airport?
Advertising 65 monthly flights between Cleveland and St. Louis, Southwest Airlines will get you there comfortably and safely.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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