Cheap flights from CLE to STL (Hopkins Intl. to Lambert-St. Louis Intl.)

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Cheap Flights from CLE to STL starting at $80 One Way, $160 Round Trip

Prices starting at $160 for return flights and $80 for one-way flights to Lambert-St. Louis Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, May 1 - Sat, May 2
CLE
Cleveland
STL
St. Louis
$160 Roundtrip, found 1 day ago
$160
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Fri, May 1 from Cleveland to St. Louis, returning Sat, May 2, priced at $160 found 1 day ago
Thu, Apr 23 - Sun, Apr 26
CLE
Cleveland
STL
St. Louis
$161 Roundtrip, found 22 hours ago
$161
Roundtrip
found 22 hours ago
Select Frontier Airlines flight, departing Thu, Apr 23 from Cleveland to St. Louis, returning Sun, Apr 26, priced at $161 found 22 hours ago
Mon, Apr 27 - Mon, May 11
CLE
Cleveland
STL
St. Louis
$170 Roundtrip, found 8 hours ago
$170
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Mon, Apr 27 from Cleveland to St. Louis, returning Mon, May 11, priced at $170 found 8 hours ago
Tue, Apr 28 - Mon, May 11
CLE
Cleveland
STL
St. Louis
$172 Roundtrip, found 8 hours ago
$172
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Tue, Apr 28 from Cleveland to St. Louis, returning Mon, May 11, priced at $172 found 8 hours ago
Wed, Apr 15 - Mon, Apr 27
CLE
Cleveland
STL
St. Louis
$174 Roundtrip, found 8 hours ago
$174
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Wed, Apr 15 from Cleveland to St. Louis, returning Mon, Apr 27, priced at $174 found 8 hours ago

Hotel Ideas near Lambert-St. Louis Intl.

Airport Hotels near Lambert-St. Louis Intl.

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
The price is $104 total per night from Mar 25 to Mar 26
$104 total
per night
Mar 25 - Mar 26
Book a stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (2,825 reviews)
Great experience all around

Reviewed on Feb 24, 2026

Pear Tree Inn St. Louis Airport
Drury Inn & Suites St. Louis Airport

Drury Inn & Suites St. Louis Airport

3 out of 5
10490 Natural Bridge Rd St. Louis MO
The price is $130 total per night from Mar 1 to Mar 2
$130 total
per night
Mar 1 - Mar 2
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,146 reviews)
Everything was great - the staff with whom I interacted was both friendly and helpful, the room was clean and spacious and the breakfast in the morning was enjoyable. I will stay here again in the future if necessary. Thank you!

Reviewed on Feb 23, 2026

Drury Inn & Suites St. Louis Airport
Wingate by Wyndham St. Louis Airport

Wingate by Wyndham St. Louis Airport

2.5 out of 5
10820 Pear Tree Lane St. Ann MO
The price is $117 total per night from Feb 26 to Feb 27
$117 total
per night
Feb 26 - Feb 27
Book a stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,529 reviews)
Close to airport with 24 hr transportation

Reviewed on Feb 24, 2026

Wingate by Wyndham St. Louis Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In St. Louis

Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

3 out of 5
2211 Market Street St. Louis MO
$94 nightly
The price is $110 total per night from Mar 1 to Mar 2
$110 total
Mar 1 - Mar 2
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant ...
8.8/10 Excellent! (1,846 reviews)
Yes

Reviewed on Feb 25, 2026

Pear Tree Inn St. Louis Near Union Station
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
$88 nightly
The price is $104 total per night from Mar 25 to Mar 26
$104 total
Mar 25 - Mar 26
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (2,825 reviews)
Great experience all around

Reviewed on Feb 24, 2026

Pear Tree Inn St. Louis Airport
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
$131 nightly
The price is $153 total per night from Mar 23 to Mar 24
$153 total
Mar 23 - Mar 24
Total with taxes and fees
Book a stay at this luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
9/10 Wonderful! (1,622 reviews)
Nice room, the hot tub and steam room were fantastic. The staff were friendly and it was convenient to have coffee right downstairs.

Reviewed on Feb 25, 2026

21C Museum Hotel St Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

St. Louis Hotels With Airport Transportation

Quality Inn St. Louis Airport Hotel

Quality Inn St. Louis Airport Hotel

2.5 out of 5
10232 Natural Bridge Rd St. Louis MO
$60 nightly
The price is $71 total per night from Mar 8 to Mar 9
$71 total
Mar 8 - Mar 9
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a free airport shuttle, and parking (surcharge). Our guests praise the helpful staff ...
6.2/10 (1,004 reviews)
Close to airport, Clarence the morning shuttle driver is very nice and helpful

Reviewed on Feb 23, 2026

Quality Inn St. Louis Airport Hotel
Marriott St. Louis Airport

Marriott St. Louis Airport

4 out of 5
10700 Pear Tree Lane St. Louis MO
$161 nightly
The price is $192 total per night from Mar 8 to Mar 9
$192 total
Mar 8 - Mar 9
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy breakfast (surcharge), a free airport shuttle, and room service. Our guests praise the helpful ...
8/10 Very Good! (1,001 reviews)
The toilet had a leak and even though it said it was a 4 star, other than the bar, i only saw three stars

Reviewed on Feb 21, 2026

Marriott St. Louis Airport
Hilton St. Louis Airport

Hilton St. Louis Airport

3.5 out of 5
10330 Natural Bridge Rd St. Louis MO
$133 nightly
The price is $159 total per night from Feb 28 to Mar 1
$159 total
Feb 28 - Mar 1
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy 2 restaurants, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
7.6/10 Good! (1,010 reviews)
I payed everything thru expedia and at the hotel they charged me an aditional $50 and i dont know why

Reviewed on Feb 23, 2026

Hilton St. Louis Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced St. Louis Hotels

Quality Inn St. Louis Airport Hotel

Quality Inn St. Louis Airport Hotel

2.5 out of 5
10232 Natural Bridge Rd St. Louis MO
$60 nightly
The price is $71 total per night from Mar 8 to Mar 9
$71 total
Mar 8 - Mar 9
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a free airport shuttle, and parking (surcharge). Our guests praise the helpful staff ...
6.2/10 (1,004 reviews)
Close to airport, Clarence the morning shuttle driver is very nice and helpful

Reviewed on Feb 23, 2026

Quality Inn St. Louis Airport Hotel
Americas Best Value Inn St. Louis Downtown

Americas Best Value Inn St. Louis Downtown

2 out of 5
1100 Lumiere Place Boulevard St. Louis MO
$79 nightly
The price is $92 total per night from Mar 2 to Mar 3
$92 total
Mar 2 - Mar 3
Total with taxes and fees
Stay at this motel in St. Louis. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Gateway Arch and St. Louis Union Station are located ...
5.6/10 (829 reviews)
TV didn’t work Holes were in the wall The lock was broke on the inside of the room It was styrofoam pieces in the bathroom on the floor like someone was chewing on them.

Reviewed on Feb 16, 2026

Americas Best Value Inn St. Louis Downtown
OYO Hotel St. Louis Downtown City Center MO

OYO Hotel St. Louis Downtown City Center MO

3.5 out of 5
400 S 14th St St. Louis MO
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...
6.6/10 (1,000 reviews)
Definitely an older hotel. Overall the room was kinda dingy.

Reviewed on Apr 11, 2024

Get rates
OYO Hotel St. Louis Downtown City Center MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in St. Louis

Days Inn by Wyndham St. Louis Lindbergh Boulevard

Days Inn by Wyndham St. Louis Lindbergh Boulevard

2.5 out of 5
South Lindbergh Boulevard, 3660 St. Louis MO
Book a stay at this family-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a nightclub. Popular attractions Laumeier Sculpture Park and Magic ...

Families like: Indoor pool, playground, game room, cribs

Get rates
Days Inn by Wyndham St. Louis Lindbergh Boulevard
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3 out of 5
2 South 4th Street St. Louis MO
$135 nightly
The price is $158 total per night from Mar 1 to Mar 2
$158 total
Mar 1 - Mar 2
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.4/10 Exceptional! (3,341 reviews)
The staff was very courteous! Amazing accommodations and a perfect experience.

Reviewed on Feb 24, 2026

Drury Plaza Hotel St. Louis at the Arch
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

3 out of 5
2211 Market Street St. Louis MO
$94 nightly
The price is $110 total per night from Mar 1 to Mar 2
$110 total
Mar 1 - Mar 2
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant ...
8.8/10 Excellent! (1,846 reviews)
Yes

Reviewed on Feb 25, 2026

Pear Tree Inn St. Louis Near Union Station
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

CLE to STL Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
CLE Address & GPS
Address:
5300 Riverside Drive
Cleveland OH, 44135-3193
United States
IATA Code:
CLE
Longitude:
-81.83821
Latitude:
41.410856
Time Zone:
America/New_York
STL Address & GPS
Address:
10701 Lambert International Blvd.
Saint Louis MO, 63145
United States
IATA Code:
STL
Longitude:
-90.379002
Latitude:
38.748707
Time Zone:
America/Chicago

Frequently asked questions

Are there non-stop flights from Cleveland Hopkins Intl. Airport to St. Louis Lambert International Airport?
We're delighted to inform you that Southwest Airlines will fly you directly from Cleveland to St. Louis. Book your seat on the plane now and enjoy a hassle-free, nonstop flight.
What is the shortest flight from CLE to St. Louis Lambert International Airport?
Jetting from Cleveland Hopkins Intl. Airport to Lambert Field will take a minimum of 5 hours and 15 minutes. Enjoy a beverage and get stuck into that book — here's your chance to sit back and relax.
How many hours flight from CLE to STL?
It takes just 5 hours and 21 minutes on average to travel from CLE to St. Louis Lambert International Airport. Pull out your travel book and start marking all the special places you want to visit. It won't be long before you'll be seeing them in person.
What airlines have the most flights from CLE to St. Louis Lambert International Airport?
Advertising 65 monthly flights between Cleveland and St. Louis, Southwest Airlines will get you there comfortably and safely.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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