$129 Cheap flight deals from Myrtle Beach (MYR) to Key West (EYW)

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Airfares from $129 One Way, $233 Round Trip from Myrtle Beach to Key West

Prices starting at $233 for return flights and $129 for one-way flights to Key West were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Oct 31 - Wed, Nov 19
MYR
Myrtle Beach
EYW
Key West
$233 Roundtrip, found 2 days ago
$233
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Oct 31 from Myrtle Beach to Key West, returning Wed, Nov 19, priced at $233 found 2 days ago
Sat, Oct 25 - Wed, Nov 12
MYR
Myrtle Beach
EYW
Key West
$249 Roundtrip, found 2 days ago
$249
Roundtrip
found 2 days ago
Select Delta flight, departing Sat, Oct 25 from Myrtle Beach to Key West, returning Wed, Nov 12, priced at $249 found 2 days ago
Tue, Oct 7 - Wed, Oct 22
MYR
Myrtle Beach
EYW
Key West
$253 Roundtrip, found 2 days ago
$253
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Oct 7 from Myrtle Beach to Key West, returning Wed, Oct 22, priced at $253 found 2 days ago
Tue, Oct 21 - Wed, Oct 22
MYR
Myrtle Beach
EYW
Key West
$255 Roundtrip, found 2 days ago
$255
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Oct 21 from Myrtle Beach to Key West, returning Wed, Oct 22, priced at $255 found 2 days ago
Fri, Oct 31 - Tue, Nov 18
MYR
Myrtle Beach
EYW
Key West
$263 Roundtrip, found 2 days ago
$263
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Oct 31 from Myrtle Beach to Key West, returning Tue, Nov 18, priced at $263 found 2 days ago

Key West economy flight packages

Price found within the past 48 hours. Click for updated prices.
Southernmost Beach Resort and Guesthouses
4.0-star property

Southernmost Beach Resort and Guesthouses

8.6/10 Excellent! (2,697 reviews)

Sep 26 - Sep 29

3 night stay

Myrtle Beach (MYR) to Key West (EYW)

Delta • Non-stop roundtrip • Coach
Price was $925, price is now $733 per person
$733
per person
found 1 day ago
We visited in July and were able to upgrade to an oceanfront room with a balcony. If you get the chance, it’s worth it! Pools are beautiful and food and drinks are offered poolside. The view was incredible! The staff were all incredibly accommodating and friendly!! We can’t wait to come back!!

Reviewed on Aug 1, 2025

Almond Tree Inn Hotel - Adults Only
3.5-star property

Almond Tree Inn Hotel - Adults Only

10/10 Exceptional! (1,005 reviews)

Sep 26 - Sep 29

3 night stay

Myrtle Beach (MYR) to Key West (EYW)

Delta • Non-stop roundtrip • Coach
Price was $1,384, price is now $1,121 per person
$1,121
per person
found 1 day ago
As always, Almond Tree Inn was a bright spot in our latest trip to Key West. I’ve stayed here several times over the years and everything about Almond Tree is top notch, from the superbly attentive and friendly staff to the well-appointed and maintained property. You always feel special staying here and this trip was no exception. As Florida locals, we look forward to our stays with you each and every time- THANK YOU!

Reviewed on May 26, 2025

Lighthouse Hotel - Key West Historic Inns
3.5-star property

Lighthouse Hotel - Key West Historic Inns

9/10 Wonderful! (775 reviews)

Sep 26 - Sep 29

3 night stay

Myrtle Beach (MYR) to Key West (EYW)

Delta • Non-stop roundtrip • Coach
Price was $1,047, price is now $849 per person
$849
per person
found 1 day ago
This place is a much better place to stay than places closer to the cruise ship pier or off or whitehead or duval

Reviewed on Sep 22, 2024

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More About Flying To Key West from Myrtle Beach

Route Information for Flights from Myrtle Beach to Key West

Origin Airport IATA Code
MYR
Destination Airport IATA Code
EYW
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Myrtle Beach to Key West

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Not only does booking with us ensure guaranteed low prices, but Orbitz does the hard work, leaving you to relax. Just tell us what you want, from Myrtle Beach to Key West flights, to great deals on hotels and car rental, and activities and tours, and we will do all the rest.

Frequently asked questions

Am I able to catch a flight from Myrtle Beach to Key West now?
If you're agonizing over travel restrictions and quarantine requirements when catching a flight from Myrtle Beach to Key West, go right to our Covid-19 Travel Advisor.
What is the shortest flight from Myrtle Beach to Key West?
Getting from MYR to Key West, FL Airport (EYW-Key West Intl.) takes at least 3 hours and 2 minutes. Enjoy a beverage and watch a show or two — it's the ideal opportunity to just relax.
If I am not able to travel due to COVID-19, can I cancel my flight to Key West?
We get that traveling right now has its challenges, so it's good to know that many reservations booked through us are able to be cancelled or changed. If your travel plans to Key West have been affected by COVID-19, a lot of airlines are making things easier by offering credits to use at a later date. Just sign in to your account and you'll quickly see what options are available. Our Customer Service Portal is the place to go for more information.
Are there flights to Key West with flexible change policies?
In most cases you'll have the option to reschedule your flight to Key West without a change fee. All you have to do then is pay the difference between the old flight and the new one. Look for the "no change fees" filter and book with confidence.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2020 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data the cheapest month to fly is August. Perfect for those who need a weekend getaway, or just a break from it all before the weather changes. Be aware that the most expensive time to fly is the height of summer, with ticket prices peaking in the month of June.
How can I save money on flights?
To really save big on your next vacation, think outside the box. Select two different airlines or fare types for your return trip and you'll generally get a much better deal. Those who tried this on Orbitz in 2020 saved up to 45% on their airfares. Get mixing and matching today!

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.