$126 Cheap flight deals from Myrtle Beach (MYR) to Key West (EYW)

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This Weekend's Flight Deals from Myrtle Beach to Key West

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Jul 20 - Wed, Jul 30
MYR
Myrtle Beach Intl.
EYW
Key West Intl.
$286 Roundtrip, found 6 days ago
$286
Roundtrip
found 6 days ago
Select Delta flight, departing Sun, Jul 20 from Myrtle Beach Intl. to Key West Intl., returning Wed, Jul 30, priced at $286 found 6 days ago

Airfares from $126 One Way, $249 Round Trip from Myrtle Beach to Key West

Prices starting at $249 for return flights and $126 for one-way flights to Key West were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Oct 21 - Wed, Oct 29
MYR
Myrtle Beach
EYW
Key West
$249 Roundtrip, found 3 days ago
$249
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Oct 21 from Myrtle Beach to Key West, returning Wed, Oct 29, priced at $249 found 3 days ago
Tue, Nov 11 - Tue, Nov 18
MYR
Myrtle Beach
EYW
Key West
$255 Roundtrip, found 5 days ago
$255
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Nov 11 from Myrtle Beach to Key West, returning Tue, Nov 18, priced at $255 found 5 days ago
Mon, Jul 21 - Wed, Jul 30
MYR
Myrtle Beach
EYW
Key West
$258 Roundtrip, found 6 days ago
$258
Roundtrip
found 6 days ago
Select Delta flight, departing Mon, Jul 21 from Myrtle Beach to Key West, returning Wed, Jul 30, priced at $258 found 6 days ago
Sat, Oct 25 - Wed, Oct 29
MYR
Myrtle Beach
EYW
Key West
$274 Roundtrip, found 3 days ago
$274
Roundtrip
found 3 days ago
Select Delta flight, departing Sat, Oct 25 from Myrtle Beach to Key West, returning Wed, Oct 29, priced at $274 found 3 days ago
Fri, Oct 24 - Tue, Oct 28
MYR
Myrtle Beach
EYW
Key West
$279 Roundtrip, found 3 days ago
$279
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 24 from Myrtle Beach to Key West, returning Tue, Oct 28, priced at $279 found 3 days ago

Key West economy flight packages

Price found within the past 48 hours. Click for updated prices.
The Palms Hotel
3.0-star property

The Palms Hotel

8.6/10 Excellent! (1,009 reviews)

Aug 30 - Sep 2

3 night stay

Myrtle Beach (MYR) to Key West (EYW)

American Airlines • Non-stop • Coach

Key West (EYW) to Myrtle Beach (MYR)

Delta • Non-stop • Coach
per person
found 1 day ago
Nice pool. We loved the pool and bar.

Reviewed on Jun 27, 2025

The Grand Guesthouse
2.5-star property

The Grand Guesthouse

9.6/10 Exceptional! (1,000 reviews)

Aug 14 - Aug 17

3 night stay

Myrtle Beach (MYR) to Key West (EYW)

American Airlines • Non-stop roundtrip • Coach
per person
found 15 hours ago
Fantastic host in historic district. Loved the location. Took great care of us!!!

Reviewed on Feb 28, 2025

Coconut Beach Resort
2.5-star property

Coconut Beach Resort

9/10 Wonderful! (131 reviews)

Aug 14 - Aug 17

3 night stay

Myrtle Beach (MYR) to Key West (EYW)

American Airlines • Non-stop roundtrip • Coach
per person
found 15 hours ago
We were upgraded to the oceanfront and it’s so beautiful. The cottage is nice and spacious.

Reviewed on Apr 23, 2024

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More About Flying To Key West from Myrtle Beach

Route Information for Flights from Myrtle Beach to Key West

Origin Airport IATA Code
MYR
Destination Airport IATA Code
EYW
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Myrtle Beach to Key West

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Frequently asked questions

Am I able to catch a flight from Myrtle Beach to Key West now?
If you're agonizing over travel restrictions and quarantine requirements when catching a flight from Myrtle Beach to Key West, go right to our Covid-19 Travel Advisor.
What is the shortest flight from Myrtle Beach to Key West?
Getting from MYR to Key West, FL Airport (EYW-Key West Intl.) takes at least 3 hours and 2 minutes. Enjoy a beverage and watch a show or two --- it's the ideal opportunity to just relax.
If I am not able to travel due to COVID-19, can I cancel my flight to Key West?
We get that traveling right now has its challenges, so it's good to know that many reservations booked through us are able to be cancelled or changed. If your travel plans to Key West have been affected by COVID-19, a lot of airlines are making things easier by offering credits to use at a later date. Just sign in to your account and you'll quickly see what options are available. Our Customer Service Portal is the place to go for more information.
Are there flights to Key West with flexible change policies?
In most cases you'll have the option to reschedule your flight to Key West without a change fee. All you have to do then is pay the difference between the old flight and the new one. Look for the "no change fees" filter and book with confidence.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2020 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data the cheapest month to fly is August. Perfect for those who need a weekend getaway, or just a break from it all before the weather changes. Be aware that the most expensive time to fly is the height of summer, with ticket prices peaking in the month of June.
How can I save money on flights?
To really save big on your next vacation, think outside the box. Select two different airlines or fare types for your return trip and you'll generally get a much better deal. Those who tried this on Orbitz in 2020 saved up to 45% on their airfares. Get mixing and matching today!

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.