$144 Cheap flight deals from Roanoke (ROA) to Key West (EYW)

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This Weekend's Flight Deals from Roanoke to Key West

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Jul 18 - Mon, Jul 21
ROA
Roanoke Regional
EYW
Key West Intl.
$568 Roundtrip, found 22 hours ago
$568
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Fri, Jul 18 from Roanoke Regional to Key West Intl., returning Mon, Jul 21, priced at $568 found 22 hours ago

Airfares from $144 One Way, $249 Round Trip from Roanoke to Key West

Prices starting at $249 for return flights and $144 for one-way flights to Key West were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Jan 24 - Tue, Jan 27
ROA
Roanoke
EYW
Key West
$249 Roundtrip, found 2 days ago
$249
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Jan 24 from Roanoke to Key West, returning Tue, Jan 27, priced at $249 found 2 days ago
Wed, Jan 21 - Wed, Jan 28
ROA
Roanoke
EYW
Key West
$259 Roundtrip, found 2 days ago
$259
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Jan 21 from Roanoke to Key West, returning Wed, Jan 28, priced at $259 found 2 days ago
Sat, Jan 24 - Tue, Jan 27
ROA
Roanoke
EYW
Key West
$266 Roundtrip, found 2 days ago
$266
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Jan 24 from Roanoke to Key West, returning Tue, Jan 27, priced at $266 found 2 days ago
Mon, Jan 19 - Wed, Jan 28
ROA
Roanoke
EYW
Key West
$284 Roundtrip, found 2 days ago
$284
Roundtrip
found 2 days ago
Select Delta flight, departing Mon, Jan 19 from Roanoke to Key West, returning Wed, Jan 28, priced at $284 found 2 days ago
Tue, Jan 6 - Tue, Jan 13
ROA
Roanoke
EYW
Key West
$287 Roundtrip, found 5 days ago
$287
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jan 6 from Roanoke to Key West, returning Tue, Jan 13, priced at $287 found 5 days ago

Key West economy flight packages

Price found within the past 48 hours. Click for updated prices.
Oceans Edge Key West Resort, Hotel & Marina
4.0-star property

Oceans Edge Key West Resort, Hotel & Marina

8.8/10 Excellent! (1,668 reviews)

Sep 4 - Sep 7

3 night stay

Roanoke (ROA) to Key West (EYW)

Delta • Non-stop roundtrip • Coach
per person
found 1 day ago
Great area for the cost. Very clean and inviting. Room had a water harbor view which was nice.

Reviewed on Jul 12, 2025

Almond Tree Inn Hotel - Adults Only
3.5-star property

Almond Tree Inn Hotel - Adults Only

10/10 Exceptional! (1,002 reviews)

Sep 4 - Sep 7

3 night stay

Roanoke (ROA) to Key West (EYW)

Delta • Non-stop roundtrip • Coach
per person
found 1 day ago
As always, Almond Tree Inn was a bright spot in our latest trip to Key West. I’ve stayed here several times over the years and everything about Almond Tree is top notch, from the superbly attentive and friendly staff to the well-appointed and maintained property. You always feel special staying here and this trip was no exception. As Florida locals, we look forward to our stays with you each and every time- THANK YOU!

Reviewed on May 26, 2025

Southernmost Beach Resort and Guesthouses
4.0-star property

Southernmost Beach Resort and Guesthouses

8.6/10 Excellent! (2,611 reviews)

Sep 4 - Sep 7

3 night stay

Roanoke (ROA) to Key West (EYW)

Delta • Non-stop roundtrip • Coach
per person
found 1 day ago
$60 resort fee per night, not worth accommodation quality.

Reviewed on Jul 16, 2025

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More About Flying To Key West from Roanoke

Route Information for Flights from Roanoke to Key West

Origin Airport IATA Code
ROA
Destination Airport IATA Code
EYW
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Roanoke to Key West

When you’re ready to take your next trip, get the most affordable prices on flights from Roanoke to Key West with Orbitz! The guaranteed low prices and cutting-edge mobile tools on Orbits make it easy for you to plan your next great vacation.

Keep Up With Sudden Flight Changes

As any traveler knows, air travel can suddenly be temporarily halted due to service disruptions. Along with offering the best fares for flights from Roanoke to Key West, Orbitz also offers free mobile phone and email alerts that help you keep up with sudden changes to your flight plans. Choose from email, text, or voice message alerts.

Get Great Prices for Roanoke to Key West Flights

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Frequently asked questions

Am I able to catch a flight from Roanoke to Key West now?
The Covid-19 Travel Advisor can help you with queries about quarantine and travel restrictions when flying from Roanoke to Key West.
What is the shortest flight from Roanoke to Key West?
If conditions are good and all goes as planned, you could be landing at EYW from Roanoke, VA Airport (ROA-Roanoke Regional) in only 2 hours and 44 minutes. With such a brief flight time, consider bringing hand luggage only.
If I am not able to travel due to COVID-19, can I cancel my flight to Key West?
We get that traveling right now has its challenges, so it's good to know that many reservations booked through us are able to be cancelled or changed. If your travel plans to Key West have been affected by COVID-19, a lot of airlines are making things easier by offering credits to use at a later date. Just sign in to your account and you'll quickly see what options are available. Our Customer Service Portal is the place to go for more information.
Are there flights to Key West with flexible change policies?
In most cases you'll have the option to reschedule your flight to Key West without a change fee. All you have to do then is pay the difference between the old flight and the new one. Look for the "no change fees" filter and book with confidence.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2020 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data the cheapest month to fly is August. Perfect for those who need a weekend getaway, or just a break from it all before the weather changes. Be aware that the most expensive time to fly is the height of summer, with ticket prices peaking in the month of June.
How can I save money on flights?
To really save big on your next vacation, think outside the box. Select two different airlines or fare types for your return trip and you'll generally get a much better deal. Those who tried this on Orbitz in 2020 saved up to 45% on their airfares. Get mixing and matching today!

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.