$298 Cheap flight deals from St. Louis (STL) to Lower Keys (EYW)
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Airfares from $298 One Way, $257 Round Trip from St. Louis to Lower Keys
Prices starting at $257 for return flights and $298 for one-way flights to Lower Keys were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Lower Keys economy flight packages
The Marker Key West Harbor Resort
May 31 - Jun 5
St. Louis (STL) to Key West (EYW)
Reviewed on Nov 16, 2025
Hyatt Vacation Club at Sunset Harbor, Key West
Jun 4 - Jun 10
St. Louis (STL) to Key West (EYW)
Reviewed on Dec 1, 2024
Hyatt Vacation Club at Windward Pointe, Key West
May 22 - May 28
St. Louis (STL) to Key West (EYW)
Reviewed on Feb 12, 2026
Lower Keys first class flight packages
Winslow's Bungalows - Key West Historic Inns
May 15 - May 21
St. Louis (STL) to Key West (EYW)
Reviewed on Feb 22, 2026
The Key West Hotel
May 15 - May 21
St. Louis (STL) to Key West (EYW)
Reviewed on Jan 5, 2025
The Reach Key West, Curio Collection by Hilton
May 15 - May 21
St. Louis (STL) to Key West (EYW)
Reviewed on Jan 22, 2026
More About Flying To Lower Keys from St. Louis
Route Information for Flights from St. Louis to Lower Keys
Origin Airport IATA Code | STL |
|---|---|
Destination Airport IATA Code | EYW |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
St. Louis to Lower Keys
When you’re searching for St. Louis to Lower Keys flights for your family vacation, check out the guaranteed low prices at Orbitz. If you are looking for the best prices on hotels too, you’ll be sure to find great deals to suit your budget. You’ll also benefit from the following features:
Suitable Schedules
Orbitz simplifies the process of finding and booking budget flights from St. Louis to Lower Keys. Since we monitor hundreds of flight fares, you can compare several flights from a range of different airlines to find the best fares and most suitable departure and arrival times. Mix and match your departure and return flight for even more discounts and travel flexibility.
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Miles and Points
If you travel regularly, you can still earn miles and points when you book qualifying St. Louis to Lower Keys flights. Enter your frequent flyer number with your reservation to see the miles rack up.
Flights from St. Louis
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St. Louis Airports
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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.