$112 Cheap flight deals from St. Louis (STL) to Lower Keys (EYW)

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This Weekend's Flight Deals from St. Louis to Lower Keys

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Aug 23 - Sat, Aug 30
STL
Lambert-St. Louis Intl.
EYW
Key West Intl.
$286 Roundtrip, just found
$286
Roundtrip
just found
Select Delta flight, departing Sat, Aug 23 from Lambert-St. Louis Intl. to Key West Intl., returning Sat, Aug 30, priced at $286 just found

Airfares from $112 One Way, $223 Round Trip from St. Louis to Lower Keys

Prices starting at $223 for return flights and $112 for one-way flights to Lower Keys were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Oct 21 - Wed, Oct 22
STL
St. Louis
EYW
Key West
$223 Roundtrip, found 2 days ago
$223
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Oct 21 from St. Louis to Key West, returning Wed, Oct 22, priced at $223 found 2 days ago
Wed, Oct 1 - Wed, Oct 8
STL
St. Louis
EYW
Key West
$226 Roundtrip, found 4 hours ago
$226
Roundtrip
found 4 hours ago
Select Delta flight, departing Wed, Oct 1 from St. Louis to Key West, returning Wed, Oct 8, priced at $226 found 4 hours ago
Wed, Oct 1 - Wed, Oct 8
STL
St. Louis
EYW
Key West
$227 Roundtrip, found 4 hours ago
$227
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Wed, Oct 1 from St. Louis to Key West, returning Wed, Oct 8, priced at $227 found 4 hours ago
Tue, Sep 30 - Tue, Oct 7
STL
St. Louis
EYW
Key West
$227 Roundtrip, found 1 day ago
$227
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Sep 30 from St. Louis to Key West, returning Tue, Oct 7, priced at $227 found 1 day ago
Tue, Nov 4 - Thu, Nov 13
STL
St. Louis
EYW
Key West
$241 Roundtrip, found 5 days ago
$241
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Nov 4 from St. Louis to Key West, returning Thu, Nov 13, priced at $241 found 5 days ago

Lower Keys economy flight packages

Price found within the past 48 hours. Click for updated prices.
The Perry Hotel & Marina Key West
4.0-star property

The Perry Hotel & Marina Key West

9.4/10 Exceptional! (1,055 reviews)

Oct 13 - Oct 17

4 night stay

St. Louis (STL) to Key West (EYW)

Delta • Non-stop roundtrip • Coach
Price was $769, price is now $587 per person
$587
per person
found 1 day ago
Check-in was as smooth as could be. Reps made sure we had access to a luggage cart right away. Property very clean. Room staff could not have been nicer. Would certainly book again

Reviewed on Aug 12, 2025

Almond Tree Inn Hotel - Adults Only
3.5-star property

Almond Tree Inn Hotel - Adults Only

10/10 Exceptional! (1,005 reviews)

Oct 13 - Oct 17

4 night stay

St. Louis (STL) to Key West (EYW)

Delta • Non-stop roundtrip • Coach
Price was $1,428, price is now $1,056 per person
$1,056
per person
found 1 day ago
As always, Almond Tree Inn was a bright spot in our latest trip to Key West. I’ve stayed here several times over the years and everything about Almond Tree is top notch, from the superbly attentive and friendly staff to the well-appointed and maintained property. You always feel special staying here and this trip was no exception. As Florida locals, we look forward to our stays with you each and every time- THANK YOU!

Reviewed on May 26, 2025

Orchid Key Inn - Adults Only
3.5-star property

Orchid Key Inn - Adults Only

9.8/10 Exceptional! (1,006 reviews)

Oct 13 - Oct 17

4 night stay

St. Louis (STL) to Key West (EYW)

Delta • Non-stop roundtrip • Coach
Price was $1,385, price is now $1,036 per person
$1,036
per person
found 1 day ago
This is a great place to relax, great breakfast, pool, bar, steps away from everything on Duval. I would give it a perfect score other than Alex the bartender being a little….let’s call it snitty. We would stay here again.

Reviewed on Aug 1, 2025

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More About Flying To Lower Keys from St. Louis

Route Information for Flights from St. Louis to Lower Keys

Origin Airport IATA Code
STL
Destination Airport IATA Code
EYW
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

St. Louis to Lower Keys

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Best Deals At Your Fingertips

Orbitz combines low prices on St. Louis to Lower Keys flights with discounts on quality hotels. Using Orbitz’s Display Matrix, you can see all your options and savings easily. With our low price guarantee, you know you have the best deals at your fingertips.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.