$281 Cheap flight deals from St. Louis (STL) to Lower Keys (EYW)
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Airfares from $281 One Way, $228 Round Trip from St. Louis to Lower Keys
Prices starting at $228 for return flights and $281 for one-way flights to Lower Keys were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
STL
St. Louis
EYW
Key West
$228 Roundtrip, found 2 days ago
$228
Roundtrip
found 2 days ago
STL
St. Louis
EYW
Key West
$243 Roundtrip, found 20 hours ago
$243
Roundtrip
found 20 hours ago
STL
St. Louis
EYW
Key West
$257 Roundtrip, found 3 days ago
$257
Roundtrip
found 3 days ago
STL
St. Louis
EYW
Key West
$267 Roundtrip, found 3 days ago
$267
Roundtrip
found 3 days ago
STL
St. Louis
EYW
Key West
$271 Roundtrip, found 20 hours ago
$271
Roundtrip
found 20 hours ago
Lower Keys economy flight packages
Price found within the past 48 hours. Click for updated prices.
4.0-star property
Havana Cabana at Key West
8.8/10 Excellent! (1,749 reviews)
Mar 5 - Mar 9
4 night stay
St. Louis (STL) to Key West (EYW)
American Airlines • Coach
Key West (EYW) to St. Louis (STL)
Frontier Airlines • Coach
Save 100% on your flight
Price was $1,452, price is now $1,069 per person
$1,069
per person
found 1 day ago
The bartenders were wonderful.
Reviewed on Jul 2, 2025
4.0-star property
Oceans Edge Key West Resort, Hotel & Marina
9/10 Wonderful! (1,736 reviews)
Feb 13 - Feb 15
2 night stay
St. Louis (STL) to Key West (EYW)
American Airlines • Non-stop roundtrip • Coach
Price was $2,380, price is now $1,711 per person
$1,711
per person
found 1 day ago
We LOVED the setting and the surrounding area! Absolutely beautiful!
Be aware the hotel IS in the airport landing zone. If you like to watch/hear commercial planes you'll be very happy.
Ask for a room on the top floor only - so you can (1) look over the marina AND (2) so you won't hear people moving chairs on their balcony above you.
The max/min air conditioning is centrally controlled. If you want it colder than 67, you will not be able to. Not sure what the max heat was.
Be extra vigilant about putting a thick towel on the floor to soak up any water that gets past the shower door. It WILL happen! Please do not slip on the wet tile floor!
Be aware that if you want/need a later checkout, they will charge you an additional $50/hour past their usual checkout time of 11am.
Be prepared for onsite meal expenses. They are very good, but they ARE on the pricy side.
Our particular room smelled strongly of smoke on arrival. I'm nearly POSITIVE we asked for a nonsmoking room as we both have underlying medical problems that preclude exposre to smoke. Perhaps call ahead to ENSURE you get a nonsmoking on arrival. The entire hotel was booked so we did not have any other choice.
Reviewed on Dec 28, 2025
2.5-star property
The Key West Hotel
9.2/10 Wonderful! (505 reviews)
Feb 13 - Feb 15
2 night stay
St. Louis (STL) to Key West (EYW)
American Airlines • Non-stop roundtrip • Coach
Price was $2,570, price is now $1,991 per person
$1,991
per person
found 1 day ago
Gorgeous property right on Duval Street but hidden from the noise and bustle. Convenient to everything you want to do and see. Wonderfully helpful and friendly staff.
Reviewed on Jan 5, 2025
Don't see what you're looking for?
See all available trips from St. Louis to Lower Keys
View all tripsLower Keys packages with premium economy flights
Price found within the past 48 hours. Click for updated prices.
4.0-star property
Oceans Edge Key West Resort, Hotel & Marina
9/10 Wonderful! (1,736 reviews)
Mar 3 - Mar 9
6 night stay
St. Louis (STL) to Key West (EYW)
Delta • Non-stop roundtrip • PremiumEconomy
Save 100% on your flight
Price was $3,138, price is now $1,954 per person
$1,954
per person
found 1 day ago
We LOVED the setting and the surrounding area! Absolutely beautiful!
Be aware the hotel IS in the airport landing zone. If you like to watch/hear commercial planes you'll be very happy.
Ask for a room on the top floor only - so you can (1) look over the marina AND (2) so you won't hear people moving chairs on their balcony above you.
The max/min air conditioning is centrally controlled. If you want it colder than 67, you will not be able to. Not sure what the max heat was.
Be extra vigilant about putting a thick towel on the floor to soak up any water that gets past the shower door. It WILL happen! Please do not slip on the wet tile floor!
Be aware that if you want/need a later checkout, they will charge you an additional $50/hour past their usual checkout time of 11am.
Be prepared for onsite meal expenses. They are very good, but they ARE on the pricy side.
Our particular room smelled strongly of smoke on arrival. I'm nearly POSITIVE we asked for a nonsmoking room as we both have underlying medical problems that preclude exposre to smoke. Perhaps call ahead to ENSURE you get a nonsmoking on arrival. The entire hotel was booked so we did not have any other choice.
Reviewed on Dec 28, 2025
2.5-star property
The Key West Hotel
9.2/10 Wonderful! (505 reviews)
Mar 3 - Mar 9
6 night stay
St. Louis (STL) to Key West (EYW)
Delta • Non-stop roundtrip • PremiumEconomy
Save 100% on your flight
Price was $4,606, price is now $3,046 per person
$3,046
per person
found 1 day ago
Gorgeous property right on Duval Street but hidden from the noise and bustle. Convenient to everything you want to do and see. Wonderfully helpful and friendly staff.
Reviewed on Jan 5, 2025
4.0-star property
Pier House Resort & Spa
9/10 Wonderful! (1,006 reviews)
Mar 3 - Mar 9
6 night stay
St. Louis (STL) to Key West (EYW)
Delta • Non-stop roundtrip • PremiumEconomy
Save 100% on your flight
Price was $3,760, price is now $2,604 per person
$2,604
per person
found 1 day ago
This is a wonderful resort in Key West that has great amenities and located on Duval Street! Highly recommend.
Reviewed on Jun 24, 2025
Don't see what you're looking for?
See all available trips from St. Louis to Lower Keys
View all tripsMore About Flying To Lower Keys from St. Louis
Route Information for Flights from St. Louis to Lower Keys
Origin Airport IATA Code | STL |
|---|---|
Destination Airport IATA Code | EYW |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
St. Louis to Lower Keys
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St. Louis Airports
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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.