$281 Cheap flight deals from St. Louis (STL) to Lower Keys (EYW)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
This Weekend's Flight Deals from St. Louis to Lower Keys
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $281 One Way, $223 Round Trip from St. Louis to Lower Keys
Prices starting at $223 for return flights and $281 for one-way flights to Lower Keys were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Lower Keys economy flight packages
Southernmost Beach Resort and Guesthouses
Feb 26 - Mar 1
St. Louis (STL) to Key West (EYW)
Reviewed on Nov 1, 2025
The Key West Hotel
Feb 26 - Mar 1
St. Louis (STL) to Key West (EYW)
Reviewed on Jan 5, 2025
Pier House Resort & Spa
Feb 26 - Mar 1
St. Louis (STL) to Key West (EYW)
Reviewed on Jun 24, 2025
More About Flying To Lower Keys from St. Louis
Route Information for Flights from St. Louis to Lower Keys
Origin Airport IATA Code | STL |
|---|---|
Destination Airport IATA Code | EYW |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
St. Louis to Lower Keys
When you’re ready to take your next trip, get the most affordable prices on flights from St. Louis to Lower Keys with Orbitz! The guaranteed low prices and cutting-edge mobile tools on Orbits make it easy for you to plan your next great vacation.
Keep Up With Sudden Flight Changes
As any traveler knows, air travel can suddenly be temporarily halted due to service disruptions. Along with offering the best fares for flights from St. Louis to Lower Keys, Orbitz also offers free mobile phone and email alerts that help you keep up with sudden changes to your flight plans. Choose from email, text, or voice message alerts.
Get Great Prices for St. Louis to Lower Keys Flights
Orbitz features both an Android app and an iPhone app to give you the lowest prices for St. Louis to Lower Keys flights. Use these mobile apps to get updates on your flight, the details of your itinerary, and to learn about available hotel deals in the area.
Fly for Less and Earn Miles
Did you know you can earn miles and points for your frequent flyer program with Orbitz? To do this with specific flights from St. Louis to Lower Keys, enter your frequent flyer account number when you book your ticket online. For even more convenience, keep a record of your loyalty travel program numbers directly with Orbitz by storing them in your account profile. This way, you can add your account numbers to your next reservation for St. Louis to Lower Keys flights automatically without the annoying hassle of having to look them up.
Flights from St. Louis
- St. Louis to Orlando
- St. Louis to New York
- St. Louis to Houston
- St. Louis to Dallas
- St. Louis to Phoenix
- St. Louis to Atlanta
- St. Louis to Chicago
- St. Louis to Denver
- St. Louis to Los Angeles
- St. Louis to New Orleans
- St. Louis to Toronto
- St. Louis to Detroit
- St. Louis to Washington
- St. Louis to Rome
- St. Louis to London
- St. Louis to Cleveland
- St. Louis to San Francisco
- St. Louis to Kansas City
- St. Louis to Vancouver
- St. Louis to Montreal
St. Louis Airports
More Destinations
- Flights from Boston to Cudjoe Key
- Flights from Detroit to Cudjoe Key
- Flights from Miami to Cudjoe Key
- Flights from Minneapolis - St. Paul to Cudjoe Key
- Flights from New York to Cudjoe Key
- Flights from Orlando to Cudjoe Key
- Flights from Philadelphia to Cudjoe Key
- Flights from Raleigh to Cudjoe Key
- Flights from Washington to Cudjoe Key
- Flights from Charleston to Cudjoe Key
- Flights from Pittsburgh to Cudjoe Key
- Flights from Fort Lauderdale to Cudjoe Key
- Flights from Santa Barbara to Cudjoe Key
- Flights from Daytona Beach to Cudjoe Key
- Flights from Huntsville to Cudjoe Key
- Flights from Tampa to Cudjoe Key
- Flights from Jacksonville to Cudjoe Key
- Flights from Grand Rapids to Cudjoe Key
- Flights from Albany to Cudjoe Key
- Flights from Greenville - Spartanburg to Cudjoe Key
- Flights from Allentown (ABE) to Key West (EYW)
- Flights from Al-Aqiq (ABT) to Key West (EYW)
- Flights from Albany (ALB) to Key West (EYW)
- Flights from Oranjestad (AUA) to Key West (EYW)
- Flights from Austin (AUS) to Key West (EYW)
- Flights from Asheville (AVL) to Key West (EYW)
- Flights from Bangor (BGR) to Key West (EYW)
- Flights from Birmingham (BHM) to Key West (EYW)
- Flights from Bloomington (BMI) to Key West (EYW)
- Flights from Nashville (BNA) to Key West (EYW)
- Flights from Boston (BOS) to Key West (EYW)
- Flights from Columbia (CAE) to Key West (EYW)
- Flights from Concord (CON) to Key West (EYW)
- Flights from Mosinee (CWA) to Key West (EYW)
- Flights from Dayton (DAY) to Key West (EYW)
- Flights from Denver (DEN) to Key West (EYW)
- Flights from Panama City (ECP) to Key West (EYW)
- Flights from El Paso (ELP) to Key West (EYW)
- Flights from Newark Liberty Intl. Airport (EWR) to Key West (EYW)
- Flights from Sioux Falls (FSD) to Key West (EYW)
- Flights from Grand Island (GRI) to Key West (EYW)
- Flights from Greenville (GSP) to Key West (EYW)
- Flights from Hawthorne (HHR) to Key West (EYW)
- Flights from Huntington (HTS) to Key West (EYW)
- Flights from New Haven (HVN) to Key West (EYW)
- Flights from Wichita (ICT) to Key West (EYW)
- Flights from Wilmington (ILM) to Key West (EYW)
- Flights from Iron Mountain (IMT) to Key West (EYW)
- Flights from Indianapolis (IND) to Key West (EYW)
- Flights from Kirksville (IRK) to Key West (EYW)
- Flights from Jacksonville (JAX) to Key West (EYW)
- Flights from Ketchikan (KTN) to Key West (EYW)
- Flights from Los Angeles (LAX) to Key West (EYW)
- Flights from Laconia (LCI) to Key West (EYW)
- Flights from Manchester (MHT) to Key West (EYW)
- Flights from Milwaukee (MKE) to Key West (EYW)
- Flights from Misawa (MSJ) to Key West (EYW)
- Flights from New Orleans (MSY) to Key West (EYW)
- Flights from Jacksonville (OAJ) to Key West (EYW)
- Flights from Ocala (OCF) to Key West (EYW)
- Flights from Omaha (OMA) to Key West (EYW)
- Flights from Chicago (ORD) to Key West (EYW)
- Flights from Norfolk (ORF) to Key West (EYW)
- Flights from West Palm Beach (PBI) to Key West (EYW)
- Flights from Peoria (PIA) to Key West (EYW)
- Flights from St. Petersburg (PIE) to Key West (EYW)
- Flights from Pasco (PSC) to Key West (EYW)
- Flights from Punta Cana (PUJ) to Key West (EYW)
- Flights from Richmond (RIC) to Key West (EYW)
- Flights from Santa Fe (SAF) to Key West (EYW)
- Flights from Louisville (SDF) to Key West (EYW)
- Flights from Sanford (SFM) to Key West (EYW)
- Flights from San Francisco (SFO) to Key West (EYW)
- Flights from Olongapo (SFS) to Key West (EYW)
- Flights from Weyers Cave (SHD) to Key West (EYW)
- Flights from Salt Lake City (SLC) to Key West (EYW)
- Flights from Sacramento (SMF) to Key West (EYW)
- Flights from Orange County (SNA) to Key West (EYW)
- Flights from Storuman (SQO) to Key West (EYW)
- Flights from Santa Rosa (STS) to Key West (EYW)
- Flights from Sun Valley (SUN) to Key West (EYW)
- Flights from Tainan (TNN) to Key West (EYW)
- Flights from Tupelo (TUP) to Key West (EYW)
- Flights from Staniel Cay (TYM) to Key West (EYW)
- Flights from Tyler (TYR) to Key West (EYW)
- Flights from Knoxville (TYS) to Key West (EYW)
- Flights from St. Augustine (UST) to Key West (EYW)
- Flights from Victoria (VCT) to Key West (EYW)
- Flights from Vero Beach (VRB) to Key West (EYW)
- Flights from Fort McMurray (YMM) to Key West (EYW)
- Flights from New York to Little Torch Key
- Flights from Newark to Little Torch Key
- Flights from Boston to Melody Key
- Flights from Detroit to Melody Key
- Flights from New Orleans to Melody Key
- Flights from Seattle to Melody Key
- Flights from Fort Lauderdale to Melody Key
- Flights from Newark to Melody Key
- Flights from Tampa to Melody Key
- Flights from Grand Rapids to Melody Key
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.