$60 Cheap flight deals from Chicago (CHI) to Sikeston (STL)

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This Weekend's Flight Deals from Chicago to Sikeston

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Dec 21 - Tue, Dec 30
ORD
O'Hare Intl.
CGI
Cape Girardeau Municipal
$163 Roundtrip, found 16 hours ago
$163
Roundtrip
found 16 hours ago
Select Contour Airlines flight, departing Sun, Dec 21 from O'Hare Intl. to Cape Girardeau Municipal, returning Tue, Dec 30, priced at $163 found 16 hours ago
Sun, Dec 21 - Thu, Dec 25
MDW
Midway Intl.
STL
Lambert-St. Louis Intl.
$226 Roundtrip, found 4 days ago
$226
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sun, Dec 21 from Midway Intl. to Lambert-St. Louis Intl., returning Thu, Dec 25, priced at $226 found 4 days ago
Fri, Dec 19 - Sun, Dec 21
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$515 Roundtrip, found 14 hours ago
$515
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Fri, Dec 19 from O'Hare Intl. to Lambert-St. Louis Intl., returning Sun, Dec 21, priced at $515 found 14 hours ago
Fri, Dec 19 - Sun, Dec 21
RFD
Greater Rockford
STL
Lambert-St. Louis Intl.
$617 Roundtrip, found 3 days ago
$617
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Dec 19 from Greater Rockford to Lambert-St. Louis Intl., returning Sun, Dec 21, priced at $617 found 3 days ago

Airfares from $60 One Way, $120 Round Trip from Chicago to Sikeston

Prices starting at $120 for return flights and $60 for one-way flights to Sikeston were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Jan 6 - Wed, Jan 7
ORD
Chicago
STL
St. Louis
$120 Roundtrip, found 4 days ago
$120
Roundtrip
found 4 days ago
Select United flight, departing Tue, Jan 6 from Chicago to St. Louis, returning Wed, Jan 7, priced at $120 found 4 days ago
Tue, Jan 6 - Wed, Jan 7
ORD
Chicago
STL
St. Louis
$120 Roundtrip, found 4 days ago
$120
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Jan 6 from Chicago to St. Louis, returning Wed, Jan 7, priced at $120 found 4 days ago
Thu, Dec 25 - Wed, Dec 31
ORD
Chicago
CGI
Cape Girardeau
$122 Roundtrip, just found
$122
Roundtrip
just found
Select Contour Airlines flight, departing Thu, Dec 25 from Chicago to Cape Girardeau, returning Wed, Dec 31, priced at $122 just found
Mon, Dec 29 - Tue, Jan 6
ORD
Chicago
CGI
Cape Girardeau
$139 Roundtrip, found 1 day ago
$139
Roundtrip
found 1 day ago
Select Contour Airlines flight, departing Mon, Dec 29 from Chicago to Cape Girardeau, returning Tue, Jan 6, priced at $139 found 1 day ago
Tue, Jan 6 - Wed, Jan 7
ORD
Chicago
STL
St. Louis
$139 Roundtrip, found 4 days ago
$139
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Tue, Jan 6 from Chicago to St. Louis, returning Wed, Jan 7, priced at $139 found 4 days ago

Sikeston economy flight packages

Price found within the past 48 hours. Click for updated prices.
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
4.0-star property

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

8.8/10 Excellent! (1,022 reviews)

Jan 16 - Jan 18

2 night stay

Chicago (ORD) to St. Louis (STL)

American Airlines • Roundtrip • Coach
Price was $449, price is now $385 per person
$385
per person
found 2 hours ago
This is a very unique, colorful & artistically interesting property! I would highly recommend and would definitely stay here again!

Reviewed on Sep 9, 2024

The Knight Center at Washington University
2.5-star property

The Knight Center at Washington University

9.4/10 Exceptional! (425 reviews)

Jan 16 - Jan 18

2 night stay

Chicago (ORD) to St. Louis (STL)

American Airlines • Roundtrip • Coach
Price was $479, price is now $396 per person
$396
per person
found 2 hours ago
Very nice lobby restaurant and bar

Reviewed on Sep 15, 2025

Hotel Saint Louis, Autograph Collection
4.0-star property

Hotel Saint Louis, Autograph Collection

8.8/10 Excellent! (458 reviews)

Jan 16 - Jan 18

2 night stay

Chicago (ORD) to St. Louis (STL)

American Airlines • Roundtrip • Coach
Price was $484, price is now $412 per person
$412
per person
found 2 hours ago
The receptionist at the front desk was very kind and helpful. I loved how clean my room was.

Reviewed on Aug 17, 2021

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More About Flying To Sikeston from Chicago

Route Information for Flights from Chicago to Sikeston

Origin Airport IATA Code
CHI
Destination Airport IATA Code
STL
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Chicago to Sikeston

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Frequently asked questions

Are there non-stop flights from Chicago to Sikeston?
There is. You can fly straight from Chicago to Sikeston with United Airlines. It's the only airline with nonstop services from ORD to Cape Girardeau Municipal Airport (CGI).
What is the shortest flight from Chicago to Sikeston?
The journey from Chicago to Sikeston can be as fast as 1 hour and 57 minutes. With a leisurely flight time like this, why not take off on a spur-of-the-moment getaway?
What airlines fly from Chicago to Sikeston most frequently?
Lock in your Chicago to Sikeston journey with a United Airlines flight. With 52 per month, this airline operates the most flights between these two destinations.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.