Cheap flights from MLI to SAN (Quad City Intl. to San Diego Intl.)

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Cheap Flights from MLI to SAN starting at $126 One Way, $280 Round Trip

Prices starting at $280 for return flights and $126 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Feb 25 - Wed, Mar 4
MLI
Moline
SAN
San Diego
$280 Roundtrip, found 1 day ago
$280
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Feb 25 from Moline to San Diego, returning Wed, Mar 4, priced at $280 found 1 day ago
Sat, Feb 28 - Tue, Mar 3
MLI
Moline
SAN
San Diego
$283 Roundtrip, found 1 day ago
$283
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Feb 28 from Moline to San Diego, returning Tue, Mar 3, priced at $283 found 1 day ago
Mon, Feb 23 - Wed, Mar 4
MLI
Moline
SAN
San Diego
$293 Roundtrip, found 1 day ago
$293
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Feb 23 from Moline to San Diego, returning Wed, Mar 4, priced at $293 found 1 day ago
Thu, Feb 26 - Wed, Mar 4
MLI
Moline
SAN
San Diego
$296 Roundtrip, found 1 day ago
$296
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Feb 26 from Moline to San Diego, returning Wed, Mar 4, priced at $296 found 1 day ago
Sat, Feb 21 - Tue, Mar 3
MLI
Moline
SAN
San Diego
$297 Roundtrip, just found
$297
Roundtrip
just found
Select Delta flight, departing Sat, Feb 21 from Moline to San Diego, returning Tue, Mar 3, priced at $297 just found

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$226 nightly
The price is $260 total per night from Feb 6 to Feb 7
$260 total
Feb 6 - Feb 7
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (3,236 reviews)
The room clean, the area safe and the staff friendly

Reviewed on Jan 11, 2026

Sheraton San Diego Resort
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
$133 nightly
The price is $153 total per night from Jan 25 to Jan 26
$153 total
Jan 25 - Jan 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
9/10 Wonderful! (3,286 reviews)
Friendly staff n food is great

Reviewed on Jan 12, 2026

Bay Club Hotel & Marina
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

4 out of 5
1646 Front St San Diego CA
$127 nightly
The price is $147 total per night from Jan 19 to Jan 20
$147 total
Jan 19 - Jan 20
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.8/10 Excellent! (232 reviews)
The staff was amazing. The room was clean and very comfortable. The only complaint was not all elevators were in operation. This caused a tremendous wait time.

Reviewed on Jan 12, 2026

Courtyard by Marriott San Diego Downtown Little Italy
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$226 nightly
The price is $260 total per night from Feb 6 to Feb 7
$260 total
Feb 6 - Feb 7
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (3,236 reviews)
The room clean, the area safe and the staff friendly

Reviewed on Jan 11, 2026

Sheraton San Diego Resort
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
$133 nightly
The price is $153 total per night from Jan 25 to Jan 26
$153 total
Jan 25 - Jan 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
9/10 Wonderful! (3,286 reviews)
Friendly staff n food is great

Reviewed on Jan 12, 2026

Bay Club Hotel & Marina
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
$108 nightly
The price is $125 total per night from Jan 19 to Jan 20
$125 total
Jan 19 - Jan 20
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.8/10 Excellent! (897 reviews)
Great staff, nicely designed, convenient location.

Reviewed on Jan 12, 2026

The DEXTRO Little Italy, BW Premier Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$165 nightly
The price is $192 total per night from Jan 15 to Jan 16
$192 total
Jan 15 - Jan 16
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,006 reviews)
Check in was great. Staff really first rate. Everyone helpful and room is clean and nice.

Reviewed on Jan 10, 2026

Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$226 nightly
The price is $260 total per night from Feb 6 to Feb 7
$260 total
Feb 6 - Feb 7
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (3,236 reviews)
The room clean, the area safe and the staff friendly

Reviewed on Jan 11, 2026

Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 out of 5
1955 San Diego Ave San Diego CA
$136 nightly
The price is $156 total per night from Jan 18 to Jan 19
$156 total
Jan 18 - Jan 19
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,059 reviews)
great stay

Reviewed on Jan 6, 2026

Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn

Pleasant Inn

2.5 out of 5
5550 Clairemont Mesa Blvd San Diego CA
$99 nightly
The price is $114 total per night from Jan 14 to Jan 15
$114 total
Jan 14 - Jan 15
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
8.4/10 Very Good! (1,295 reviews)
Easy parking and safety

Reviewed on Jan 7, 2026

Pleasant Inn
E-Z 8 Motel Old Town

E-Z 8 Motel Old Town

2.5 out of 5
4747 Pacific Highway San Diego CA
$64 nightly
The price is $73 total per night from Jan 14 to Jan 15
$73 total
Jan 14 - Jan 15
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
6.4/10 (2,069 reviews)
Yes, they were. Tooms very clean

Reviewed on Jan 4, 2026

E-Z 8 Motel Old Town
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
$86 nightly
The price is $99 total per night from Jan 19 to Jan 20
$99 total
Jan 19 - Jan 20
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.8/10 Excellent! (3,598 reviews)
Stay was great. Thank you again

Reviewed on Jan 11, 2026

Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
$200 nightly
The price is $231 total per night from Jan 14 to Jan 15
$231 total
Jan 14 - Jan 15
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
8.6/10 Excellent! (1,835 reviews)
I wish the website was more upfront about which amenities were available or not in January. For example, the Belle cruise boat was not running and the grab and go breakfast trailer was only open 2 mornings of my stay. Also, what’s the point of separate resort fees? Just include them in the room ...

Reviewed on Jan 9, 2026

Bahia Resort Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
$166 nightly
The price is $191 total per night from Jan 14 to Jan 15
$191 total
Jan 14 - Jan 15
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
8.8/10 Excellent! (3,978 reviews)
Nice place. I saw what others said about needing some updates as they could paint in bathrooms, trims, etc but let’s be real…I was on vacation and slept there and got up and hit the sights again. Was it the nicest place I’ve ever stayed? No but it was just fine! My only complaint is how early the ...

Reviewed on Jan 12, 2026

The Dana on Mission Bay
Catamaran Resort and Spa

Catamaran Resort and Spa

4 out of 5
3999 Mission Boulevard San Diego CA
$212 nightly
The price is $245 total per night from Jan 25 to Jan 26
$245 total
Jan 25 - Jan 26
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,119 reviews)

Families like: Outdoor pool, game room, on the beach, bicycle rentals

Travelers say...
Location was great. Room is getting outdated and worn and sliding glass door didn’t close all the way so rain got in. Otherwise, arcade was fun for kids.

Reviewed on Jan 6, 2026

Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

MLI to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
MLI Address & GPS
Address:
2200 69th Ave.
Moline IL, 61265
United States
IATA Code:
MLI
Longitude:
-90.506111
Latitude:
41.453897
Time Zone:
America/Chicago
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from Quad City Intl. Airport to SAN?
While you can't fly straight from Quad City Intl. Airport (MLI) to San Diego Airport, there are plenty of carriers that operate on this route with just one stop. Why not check if the dates and times available with American Airlines or United Airlines match your travel plans? If they don't, you could always check out Delta Air Lines.
What is the shortest flight from MLI to SAN?
Flying from Quad City Intl. Airport to SAN will take a minimum of 6 hours and 5 minutes. Enjoy a tipple and get stuck into that book — now's your chance to take some time out.
How many hours flight from MLI to San Diego Intl. Airport (SAN)?
Get comfy, because the average journey from Quad City Intl. Airport to SAN is 6 hours and 12 minutes. Enjoy some wine with your meal, finally finish that book ... You'll have ample time to sit back and enjoy the ride.
What airlines have the most flights from Quad City Intl. Airport to San Diego Airport?
Do a bit of shopping, tuck into some takeaway, chat with a stranger ... Airport stopovers don't have to be a drag! If you're heading from Quad City Intl. Airport to San Diego Intl. Airport (SAN), you can't fly direct. Be prepared for at least one stopover somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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