Cheap flights from LSE to SAN (La Crosse Municipal to San Diego Intl.)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from LSE to SAN starting at $307 One Way, $374 Round Trip

Prices starting at $374 for return flights and $307 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, May 1 - Sat, May 2
LSE
La Crosse
SAN
San Diego
$374 Roundtrip, found 22 hours ago
$374
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Fri, May 1 from La Crosse to San Diego, returning Sat, May 2, priced at $374 found 22 hours ago
Fri, May 1 - Sat, May 2
LSE
La Crosse
SAN
San Diego
$447 Roundtrip, found 22 hours ago
$447
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Fri, May 1 from La Crosse to San Diego, returning Sat, May 2, priced at $447 found 22 hours ago
Fri, Jun 12 - Tue, Jun 16
LSE
La Crosse
SAN
San Diego
$472 Roundtrip, found 2 days ago
$472
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Jun 12 from La Crosse to San Diego, returning Tue, Jun 16, priced at $472 found 2 days ago
Fri, May 1 - Sat, May 2
LSE
La Crosse
SAN
San Diego
$479 Roundtrip, found 22 hours ago
$479
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Fri, May 1 from La Crosse to San Diego, returning Sat, May 2, priced at $479 found 22 hours ago
Fri, May 1 - Sat, May 2
LSE
La Crosse
SAN
San Diego
$484 Roundtrip, found 22 hours ago
$484
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Fri, May 1 from La Crosse to San Diego, returning Sat, May 2, priced at $484 found 22 hours ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$163 nightly
The price is $188 total per night from Apr 5 to Apr 6
$188 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (3,404 reviews)
Overall, our family of 4’s stay was pleasant. The only thing was there was what I believe to be sewage gas backup coming out of the shower drain (room 440). Had the same experience at the Sheraton Toronto Airport, something about these older Sheraton hotels…

Reviewed on Mar 31, 2026

Sheraton San Diego Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Apr 2 to Apr 3
$211 total
Apr 2 - Apr 3
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,100 reviews)
Staff and on site restaurant is a plus.

Reviewed on Mar 31, 2026

Wyndham San Diego Bayside
Homewood Suites by Hilton San Diego Airport/Liberty Station

Homewood Suites by Hilton San Diego Airport/Liberty Station

3 out of 5
2576 Laning Rd San Diego CA
$192 nightly
The price is $221 total per night from Apr 7 to Apr 8
$221 total
Apr 7 - Apr 8
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the breakfast and the helpful staff in our reviews. ...
9.4/10 Exceptional! (1,445 reviews)
Friendly staff, access to multiple games for entertainment, large bright hallways, very clean facility.

Reviewed on Mar 30, 2026

Homewood Suites by Hilton San Diego Airport/Liberty Station
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
$288 nightly
The price is $331 total per night from Apr 26 to Apr 27
$331 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.6/10 Excellent! (2,493 reviews)
Very unique hotel property with lush grounds, lots of free family activities on site (e.g. mini golf, cornhole, pickleball), & 5 pools. Limited dining on site but Barefoot restaurant has great casual dining by the water.

Reviewed on Mar 31, 2026

Paradise Point Resort & Spa
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
$82 nightly
The price is $94 total per night from Apr 5 to Apr 6
$94 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
7.8/10 Good! (3,362 reviews)
clean room

Reviewed on Mar 30, 2026

Best Western Seven Seas
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
$248 nightly
The price is $287 total per night from Apr 2 to Apr 3
$287 total
Apr 2 - Apr 3
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (3,475 reviews)
Everything was amazing beginning to end. My kids enjoyed the pool. Staff was extremely friendly and helpful. Breakfast was excellent. Already planning to come back.

Reviewed on Mar 31, 2026

Hard Rock Hotel San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Apr 2 to Apr 3
$211 total
Apr 2 - Apr 3
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,100 reviews)
Staff and on site restaurant is a plus.

Reviewed on Mar 31, 2026

Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$163 nightly
The price is $188 total per night from Apr 5 to Apr 6
$188 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (3,404 reviews)
Overall, our family of 4’s stay was pleasant. The only thing was there was what I believe to be sewage gas backup coming out of the shower drain (room 440). Had the same experience at the Sheraton Toronto Airport, something about these older Sheraton hotels…

Reviewed on Mar 31, 2026

Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 out of 5
1955 San Diego Ave San Diego CA
$136 nightly
The price is $156 total per night from Apr 2 to Apr 3
$156 total
Apr 2 - Apr 3
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
9.2/10 Wonderful! (1,068 reviews)
Staff was great- very helpful!!

Reviewed on Mar 28, 2026

Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn

Pleasant Inn

2.5 out of 5
5550 Clairemont Mesa Blvd San Diego CA
$88 nightly
The price is $101 total per night from Apr 5 to Apr 6
$101 total
Apr 5 - Apr 6
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
8.6/10 Excellent! (1,352 reviews)
Parking was a bit tight but everything else was great!

Reviewed on Mar 31, 2026

Pleasant Inn
E-Z 8 Motel Old Town

E-Z 8 Motel Old Town

2.5 out of 5
4747 Pacific Highway San Diego CA
$74 nightly
The price is $85 total per night from Apr 1 to Apr 2
$85 total
Apr 1 - Apr 2
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
6.6/10 (2,097 reviews)
Although close to Old Town this place is tucked under the freeway. There is a reason it’s the cheapest room in SD. Room was clean, water was hot, bed was okay. Linens were bare minimum. Ice machine broken and property looks to be in various stages of repair/remodel. What one would expect for a cheap ...

Reviewed on Mar 30, 2026

E-Z 8 Motel Old Town
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
$102 nightly
The price is $118 total per night from Apr 5 to Apr 6
$118 total
Apr 5 - Apr 6
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.8/10 Excellent! (3,667 reviews)
Everything was great the staff was helpful and the hotel room was perfect

Reviewed on Mar 31, 2026

Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
$247 nightly
The price is $285 total per night from Apr 29 to Apr 30
$285 total
Apr 29 - Apr 30
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
8.6/10 Excellent! (1,950 reviews)
Pictures for this hotel were not at all what we experienced when we got there. The property was not very clean, we did not get the room and experience we thought we were going to have. The property seemed rundown. We expected the more resort like experience, with staff on hand, but that was not the ...

Reviewed on Mar 31, 2026

Bahia Resort Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
$204 nightly
The price is $234 total per night from Apr 5 to Apr 6
$234 total
Apr 5 - Apr 6
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
9/10 Wonderful! (4,217 reviews)
Great location very close (walking distance) to Sea World. Nice pools, reasonably priced drinks and a nice restaurant (the Firefly)

Reviewed on Mar 31, 2026

The Dana on Mission Bay
Catamaran Resort and Spa

Catamaran Resort and Spa

4 out of 5
3999 Mission Boulevard San Diego CA
$261 nightly
The price is $301 total per night from Apr 29 to Apr 30
$301 total
Apr 29 - Apr 30
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,207 reviews)

Families like: Outdoor pool, game room, on the beach, bicycle rentals

Travelers say...
Amazing

Reviewed on Mar 31, 2026

Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

LSE to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
LSE Address & GPS
Address:
2850 Airport Road
La Crosse WI, 54601
United States
IATA Code:
LSE
Longitude:
-91.264334
Latitude:
43.875245
Time Zone:
America/Chicago
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

What is the shortest flight from LSE to SAN?
Indulge in an in-flight vino and get comfortable in your seat with a riveting movie or book. With the flight from La Crosse to San Diego taking 5 hours and 43 minutes, there's plenty of time to enjoy the flying experience.
How many hours flight from La Crosse Regional Airport to San Diego Airport?
Settle in and get comfy, because the average journey from La Crosse Municipal Airport (LSE) to San Diego Intl. Airport (SAN) is 5 hours and 47 minutes. Watch a movie or two, finally finish that book ... You'll have enough time to rest and unwind.
What airlines have the most flights from LSE to SAN?
Right now, there aren't any direct flights from LSE to San Diego Intl. Airport (SAN). However, you will be able to book flights with at least one stop. It's not all bad — use the time to stretch your travel-weary legs or sit down for a nice coffee!

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

More to Explore