Cheap flights from LSE to SAN (La Crosse Municipal to San Diego Intl.)

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Cheap Flights from LSE to SAN starting at $533 One Way, $537 Round Trip

Prices starting at $537 for return flights and $533 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, May 16 - Sat, May 23
LSE
La Crosse
SAN
San Diego
$537 Roundtrip, found 4 hours ago
$537
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Sat, May 16 from La Crosse to San Diego, returning Sat, May 23, priced at $537 found 4 hours ago
Tue, May 19 - Sat, May 23
LSE
La Crosse
SAN
San Diego
$587 Roundtrip, found 4 hours ago
$587
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Tue, May 19 from La Crosse to San Diego, returning Sat, May 23, priced at $587 found 4 hours ago
Sat, May 16 - Tue, May 19
LSE
La Crosse
SAN
San Diego
$590 Roundtrip, found 4 hours ago
$590
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Sat, May 16 from La Crosse to San Diego, returning Tue, May 19, priced at $590 found 4 hours ago
Mon, May 18 - Sat, May 23
LSE
La Crosse
SAN
San Diego
$617 Roundtrip, found 4 hours ago
$617
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Mon, May 18 from La Crosse to San Diego, returning Sat, May 23, priced at $617 found 4 hours ago
Wed, May 20 - Sat, May 23
LSE
La Crosse
SAN
San Diego
$633 Roundtrip, found 4 hours ago
$633
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Wed, May 20 from La Crosse to San Diego, returning Sat, May 23, priced at $633 found 4 hours ago
Fri, May 15 - Sat, May 23
LSE
La Crosse
SAN
San Diego
$636 Roundtrip, found 4 hours ago
$636
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Fri, May 15 from La Crosse to San Diego, returning Sat, May 23, priced at $636 found 4 hours ago
Sat, May 16 - Mon, May 18
LSE
La Crosse
SAN
San Diego
$639 Roundtrip, found 4 hours ago
$639
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Sat, May 16 from La Crosse to San Diego, returning Mon, May 18, priced at $639 found 4 hours ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$138 nightly
The price is $158 total per night from Dec 24 to Dec 25
$158 total
Dec 24 - Dec 25
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (3,155 reviews)
The hotel was clean, festive and helpful. Very accommodating. I will definitely come back.

Reviewed on Dec 16, 2025

Sheraton San Diego Resort
Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

3 out of 5
3888 Greenwood St San Diego CA
$101 nightly
The price is $116 total per night from Dec 25 to Dec 26
$116 total
Dec 25 - Dec 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Popular attractions Mission Bay and Port of ...
9/10 Wonderful! (414 reviews)
Spotless... traveling alone and after staying the night before in the 2nd worse place I have ever stayed - sounds dramatic but I really feared for my life! I could notfeare stayed

Reviewed on Dec 15, 2025

Hampton Inn & Suites by Hilton San Diego SeaWorld
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$160 nightly
The price is $186 total per night from Dec 21 to Dec 22
$186 total
Dec 21 - Dec 22
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,033 reviews)
Fantastic location for catching a cruise. Right across the street!!! Great views as well!

Reviewed on Dec 17, 2025

Wyndham San Diego Bayside
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$138 nightly
The price is $158 total per night from Dec 24 to Dec 25
$158 total
Dec 24 - Dec 25
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (3,155 reviews)
The hotel was clean, festive and helpful. Very accommodating. I will definitely come back.

Reviewed on Dec 16, 2025

Sheraton San Diego Resort
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd San Diego CA
$229 nightly
The price is $263 total per night from Dec 29 to Dec 30
$263 total
Dec 29 - Dec 30
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,342 reviews)
My favorite hotel in San Diego. Staff is always helpful, kind and professional. The rooms are comfortable, clean, eclectic and possibly the best minibar selection of top shelf products anywhere. The property invites you to discover and play and socialize. The bar and food programs are superb.

Reviewed on Dec 17, 2025

Lafayette Hotel & Club
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
$210 nightly
The price is $243 total per night from Jan 1 to Jan 2
$243 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
8.8/10 Excellent! (3,153 reviews)
the staff was very accommodating and the food options nearby were all very delicious!

Reviewed on Dec 15, 2025

Hard Rock Hotel San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

LSE to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
LSE Address & GPS
Address:
2850 Airport Road
La Crosse WI, 54601
United States
IATA Code:
LSE
Longitude:
-91.264334
Latitude:
43.875245
Time Zone:
America/Chicago
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

What is the shortest flight from LSE to SAN?
Indulge in an in-flight vino and get comfortable in your seat with a riveting movie or book. With the flight from La Crosse to San Diego taking 5 hours and 43 minutes, there's plenty of time to enjoy the flying experience.
How many hours flight from La Crosse Regional Airport to San Diego Airport?
Settle in and get comfy, because the average journey from La Crosse Municipal Airport (LSE) to San Diego Intl. Airport (SAN) is 5 hours and 47 minutes. Watch a movie or two, finally finish that book ... You'll have enough time to rest and unwind.
What airlines have the most flights from LSE to SAN?
Right now, there aren't any direct flights from LSE to San Diego Intl. Airport (SAN). However, you will be able to book flights with at least one stop. It's not all bad — use the time to stretch your travel-weary legs or sit down for a nice coffee!

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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