Business Hotels in Florence, SC
Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels
Save 10% or more on select hotels with Insider Prices
Book on the app to instantly earn 5% on 350,000+ hotels
Featured Florence Business Hotels

Baymont Inn & Suites Florence by Wyndham
1826 W Lucas Street, Florence, SC
Guests of Baymont Inn & Suites Florence by Wyndham enjoy a gym, free WiFi in public areas, and meeting rooms. If you drive, take advantage of free parking. The 24-hour front desk has staff standing by to help with dry cleaning or laundry, and answer any questions about the accommodations. Additional amenities include a business center, a seasonal outdoor pool, and coffee/tea in a common area.
Pool
Pet friendly

TownePlace Suites by Marriott Florence
2650 Hospitality Boulevard, Florence, SC
Free Cancellation
Reserve now, pay when you stay
Guests staying at TownePlace Suites by Marriott Florence enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. The 24-hour front desk has staff standing by to help with dry cleaning/laundry and securing valuables. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.
Pool
Breakfast included

Home2 Suites by Hilton Florence, SC
900 Woody Jones Blvd, Florence, SC
Free Cancellation
Reserve now, pay when you stay
At Home2 Suites by Hilton Florence, SC, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. Front-desk staff can answer questions 24/7, and assist with luggage storage, securing valuables, and tours or tickets. Additional amenities include a business center, an arcade/game room, and laundry facilities.
Pool
Breakfast included

Best Western Inn
1808 W Lucas Street, Florence, SC
Free Cancellation
Reserve now, pay when you stay
Guests of Best Western Inn enjoy access to free WiFi in public areas, a business center, and a seasonal outdoor pool. Free parking is included with your stay. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include express check-out and a vending machine.
Pool
Breakfast included

Days Inn by Wyndham Florence Near Civic Center
140 Dunbarton Dr, Florence, SC
Free Cancellation
Reserve now, pay when you stay
Days Inn by Wyndham Florence Near Civic Center features free WiFi in public areas, meeting rooms, and a business center. If you drive, put free parking to good use. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. Additional amenities include a seasonal outdoor pool, laundry facilities, and a TV in a common area.
Pool
Breakfast included

Quality Inn & Suites Florence Civic Center
150 Dunbarton Dr, Florence, SC
Free Cancellation
Reserve now, pay when you stay
Guests of Quality Inn & Suites Florence Civic Center enjoy a gym, free WiFi in public areas, and a business center. Free parking is included with your stay. The 24-hour front desk has staff standing by to help with dry cleaning/laundry, securing valuables, and luggage storage. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

Fairfield Inn by Marriott Hartsville
200 S 4th St, Hartsville, SC
Free Cancellation
Reserve now, pay when you stay
At Fairfield Inn by Marriott Hartsville, guests enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. The front desk is staffed 24 hours a day to help with securing valuables and dry cleaning/laundry. Additional amenities include a business center, coffee/tea in a common area, and express check-in.
Pool
Breakfast included

Sleep Inn Florence North
1833 Florence Park Dr, Florence, SC
Free Cancellation
Reserve now, pay when you stay
Sleep Inn Florence North features a gym, free WiFi in public areas, and conference space. If you decide to drive, there's free parking. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. Additional amenities include a business center, a seasonal outdoor pool, and coffee/tea in a common area.
Pool
Breakfast included

Hotel Florence, Tapestry Collection by Hilton
126 W Evans St, Florence, SC
Free Cancellation
Reserve now, pay when you stay
Guests staying at Hotel Florence, Tapestry Collection by Hilton enjoy access to a full-service spa, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. The 24-hour front desk has staff standing by to help with securing valuables and dry cleaning/laundry. Other amenities at this spa hotel include meeting rooms, conference space, and a 24-hour business center.
Spa
Parking included

Country Inn & Suites by Radisson, Florence, SC
1739 Mandeville Rd, Florence, SC
Free Cancellation
Guests of Country Inn & Suites by Radisson, Florence, SC have access to an outdoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. Front-desk staff can answer questions 24/7, and assist with concierge services, luggage storage, and securing valuables. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include a 24-hour business center, a meeting room, and a computer station.
Pool
Breakfast included

The Inn at the Crossroads
128 West Main Street, Lake City, SC
Free Cancellation
Reserve now, pay when you stay
The Inn at the Crossroads features a 24-hour gym, free WiFi in public areas, and a conference center. There's free parking if you drive. The front desk is staffed 24/7 to help with luggage storage, concierge services, and securing valuables. Additional amenities include a 24-hour business center, coffee/tea in a common area, and a terrace.
Breakfast included
Parking included

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
3440 W Radio Dr, Florence, SC
Free Cancellation
Guests of Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG have access to an indoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, put free parking to good use. The front desk has multilingual staff standing by 24 hours a day to assist with securing valuables and dry cleaning/laundry. Additional amenities include a hot tub, a 24-hour business center, and coffee/tea in a common area.
Pool
Hot Tub

Best Western Executive Inn
1534 Highway 38 W, Latta, SC
Free Cancellation
Reserve now, pay when you stay
Guests of Best Western Executive Inn have access to an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help with luggage storage and securing valuables. Additional amenities include a business center and a vending machine.
Pool
Breakfast included

Clarion Inn & Suites
1819 West Lucas Street, Building A, Florence, SC
Free Cancellation
Reserve now, pay when you stay
At Clarion Inn & Suites, guests have access to a gym, free WiFi in public areas, and conference space. If you decide to drive, there's free parking. The 24-hour front desk has multilingual staff ready to help with dry cleaning or laundry, and answer any questions about the area. Additional amenities include a business center, a seasonal outdoor pool, and coffee/tea in a common area.
Pool
Breakfast included

Super 8 by Wyndham Florence
1832 1/2 Lucas Street, I95 Exit 164, Florence, SC
Free Cancellation
Reserve now, pay when you stay
Super 8 by Wyndham Florence features free WiFi in public areas, a business center, and a seasonal outdoor pool. Free parking is available if you drive. Front-desk staff are standing by 24/7 to assist with any requests. This motel also has a computer station.
Pool
Breakfast included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Florence hotels essential information
Accommodation | 336 hotels |
---|---|
Lowest Price | |
Highest Price | |
Popular hotels | Baymont Inn & Suites Florence by Wyndham, TownePlace Suites by Marriott Florence, Home2 Suites by Hilton Florence, SC, Best Western Inn, Days Inn by Wyndham Florence Near Civic Center, Quality Inn & Suites Florence Civic Center, Fairfield Inn by Marriott Hartsville, Sleep Inn Florence North, Hotel Florence, Tapestry Collection by Hilton, Country Inn & Suites by Radisson, Florence, SC, The Inn at the Crossroads, Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG, Best Western Executive Inn, Clarion Inn & Suites, Super 8 by Wyndham Florence |
Recent Business Hotels Reviews

Comfort Inn & Suites
5/5 Excellent
Twice as Nice!
"This was our second visit to this hotel for an overnight. Still very clean surroundings outside and inside. Friendly staff greeted us even when we checked in later in the evening. Very nice setup for water station. The breakfast area was very nicely setup for breakfast. The food selection was great for complimentary offer. It was a very nice stay and comfortable. We'd stay again. "
A verified traveler stayed at Comfort Inn & Suites
Posted 1 day ago
Other Business Hotels
Areas Of Florence
Hotels Near
Hotel Themes
Top Trending
Hotels
Beach Resorts & Hotels in CharlestonHotels in Hilton Head IslandOceanfront Hotels in Myrtle BeachHotels with Hot Tubs in CharlestonHotels in Mount PleasantCheap Hotels in ColumbiaBeach Resorts & Hotels in Myrtle BeachAll Inclusive Resorts & Hotels in Myrtle BeachCheap Hotels in CharlestonHotels with Hot Tubs in GreenvilleHotels in Myrtle BeachHotels in Folly BeachAll Inclusive Resorts & Hotels in CharlestonHotels with Hot Tubs in Myrtle BeachCheap Hotels in Myrtle BeachAll Inclusive Resorts & Hotels in Hilton Head IslandOceanfront Hotels in North Myrtle BeachHotels in CharlestonBeach Resorts & Hotels in Hilton Head IslandHotels with Hot Tubs in ColumbiaHotels in Columbia
Flights