Business Hotels in Florence, SC
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Featured Florence Business Hotels

TownePlace Suites by Marriott Florence
2650 Hospitality Boulevard Florence SC
Free Cancellation
Reserve now, pay when you stay
$103 nightly
The price is $116 total per night
$116 total
Dec 29 - Dec 30
Total with taxes and fees
Guests staying at TownePlace Suites by Marriott Florence enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Self parking is available for USD 5.00 per day. The 24-hour front desk has staff standing by to help with securing valuables and dry cleaning/laundry. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.
Pool
Breakfast included

Home2 Suites by Hilton Florence, SC
900 Woody Jones Blvd Florence SC
Free Cancellation
Reserve now, pay when you stay
$106 nightly
The price is $119 total per night
$119 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
At Home2 Suites by Hilton Florence, SC, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. Front-desk staff can answer questions 24/7, and assist with securing valuables, dry cleaning/laundry, and tours or tickets. Additional amenities include a business center, an arcade/game room, and laundry facilities.
Pool
Breakfast included

Best Western Inn
1808 W Lucas Street Florence SC
Free Cancellation
Reserve now, pay when you stay
$89 nightly
The price is $100 total per night
$100 total
Dec 28 - Dec 29
Total with taxes and fees
Guests of Best Western Inn enjoy access to free WiFi in public areas, a business center, and a seasonal outdoor pool. Free parking is included with your stay. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include express check-out and a vending machine.
Pool
Breakfast included

Days Inn by Wyndham Florence Near Civic Center
140 Dunbarton Dr Florence SC
Free Cancellation
Reserve now, pay when you stay
$66 nightly
The price is $74 total per night
$74 total
Dec 30 - Dec 31
Total with taxes and fees
Days Inn by Wyndham Florence Near Civic Center features free WiFi in public areas, meeting rooms, and a business center. If you drive, put free parking to good use. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a seasonal outdoor pool, a computer station, and laundry facilities.
Pool
Breakfast included

Quality Inn & Suites Florence Civic Center
150 Dunbarton Dr Florence SC
Free Cancellation
Reserve now, pay when you stay
$75 nightly
The price is $84 total per night
$84 total
Jan 25 - Jan 26, 2026
Total with taxes and fees
Guests of Quality Inn & Suites Florence Civic Center enjoy a gym, free WiFi in public areas, and a business center. Free parking is included with your stay. The 24-hour front desk has staff standing by to help with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

Fairfield Inn by Marriott Hartsville
200 S 4th St Hartsville SC
Free Cancellation
Reserve now, pay when you stay
$84 nightly
The price is $94 total per night
$94 total
Jan 17 - Jan 18, 2026
Total with taxes and fees
At Fairfield Inn by Marriott Hartsville, guests enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. The front desk is staffed 24 hours a day to help with dry cleaning/laundry and securing valuables. Additional amenities include a business center, coffee/tea in a common area, and express check-in.
Pool
Breakfast included

Sleep Inn Florence North
1833 Florence Park Dr Florence SC
Free Cancellation
$68 nightly
The price is $76 total per night
$76 total
Jan 18 - Jan 19, 2026
Total with taxes and fees
Sleep Inn Florence North features a gym, free WiFi in public areas, and conference space. If you decide to drive, there's free parking. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. Additional amenities include a business center, a seasonal outdoor pool, and coffee/tea in a common area.
Pool
Breakfast included

Hotel Florence, Tapestry Collection by Hilton
126 W Evans St Florence SC
Free Cancellation
Reserve now, pay when you stay
$130 nightly
The price is $146 total per night
$146 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Guests staying at Hotel Florence, Tapestry Collection by Hilton enjoy access to a full-service spa, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. The 24-hour front desk has staff standing by to help with securing valuables and dry cleaning/laundry. Other amenities at this spa hotel include meeting rooms, conference space, and a 24-hour business center.
Spa
Parking included

Spark by Hilton Florence North I-95, SC
1739 Mandeville Rd Florence SC
Free Cancellation
Reserve now, pay when you stay
$100 nightly
The price is $112 total per night
$112 total
Jan 8 - Jan 9, 2026
Total with taxes and fees
Guests of Spark by Hilton Florence North I-95, SC have access to an outdoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. Front-desk staff can answer questions 24/7, and assist with luggage storage, dry cleaning/laundry, and securing valuables. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include a 24-hour business center, a meeting room, and a computer station.
Pool
Breakfast included

The Inn at the Crossroads
128 West Main Street Lake City SC
Free Cancellation
Reserve now, pay when you stay
$127 nightly
The price is $143 total per night
$143 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
The Inn at the Crossroads features a 24-hour gym, free WiFi in public areas, and a conference center. There's free parking if you drive. The front desk is staffed 24/7 to help with securing valuables, tours or tickets, and luggage storage. Additional amenities include a 24-hour business center, coffee/tea in a common area, and a terrace.
Breakfast included
Parking included

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
3440 W Radio Dr Florence SC
Free Cancellation
$110 nightly
The price is $123 total per night
$123 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Guests of Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG have access to an indoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, put free parking to good use. The front desk has multilingual staff standing by 24 hours a day to assist with dry cleaning/laundry and securing valuables. Additional amenities include a hot tub, a 24-hour business center, and coffee/tea in a common area.
Pool
Hot Tub

Best Western Executive Inn
1534 Highway 38 W Latta SC
Free Cancellation
Reserve now, pay when you stay
$76 nightly
The price is $83 total per night
$83 total
Jan 22 - Jan 23, 2026
Total with taxes and fees
Guests of Best Western Executive Inn have access to an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Additional amenities include a business center and a vending machine.
Pool
Breakfast included

Clarion Inn & Suites Florence - Darlington
1819 West Lucas Street Florence SC
Free Cancellation
Reserve now, pay when you stay
$53 nightly
The price is $59 total per night
$59 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
At Clarion Inn & Suites Florence - Darlington, guests have access to a gym, free WiFi in public areas, and conference space. If you decide to drive, there's free parking. The 24-hour front desk has multilingual staff ready to help with dry cleaning or laundry, and answer any questions about the area. Additional amenities include a business center, a seasonal outdoor pool, and coffee/tea in a common area.
Pool
Breakfast included

Super 8 by Wyndham Florence
1832 1/2 Lucas Street, I95 Exit 164 Florence SC
Free Cancellation
Reserve now, pay when you stay
$58 nightly
The price is $65 total per night
$65 total
Jan 2 - Jan 3, 2026
Total with taxes and fees
Super 8 by Wyndham Florence features free WiFi in public areas, a business center, and a seasonal outdoor pool. Free parking is available if you drive. Front-desk staff are standing by 24/7 to assist with any requests. This motel also has a computer station.
Pool
Breakfast included

Suburban Studios Florence I-95
1914 W Lucas St Florence SC
Free Cancellation
Reserve now, pay when you stay
$61 nightly
The price is $68 total per night
$68 total
Dec 28 - Dec 29
Total with taxes and fees
At Suburban Studios Florence I-95, guests have access to free WiFi in public areas, coffee in a common area, and laundry facilities. If you plan to drive, free parking is available. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a vending machine and barbecue grills.
Parking included
Free WiFi
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Florence hotels essential information
Accommodation | 366 hotels |
|---|---|
Lowest Price | $59 |
Highest Price | $146 |
Popular hotels | TownePlace Suites by Marriott Florence, Home2 Suites by Hilton Florence, SC, Best Western Inn, Days Inn by Wyndham Florence Near Civic Center, Quality Inn & Suites Florence Civic Center, Fairfield Inn by Marriott Hartsville, Sleep Inn Florence North, Hotel Florence, Tapestry Collection by Hilton, Spark by Hilton Florence North I-95, SC, The Inn at the Crossroads, Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG, Best Western Executive Inn, Clarion Inn & Suites Florence - Darlington, Super 8 by Wyndham Florence, Suburban Studios Florence I-95 |
Recent Business Hotels Reviews

Howard Johnson by Wyndham Florence
5/5 Excellent
"Clean room. Quiet !!"
A verified traveler stayed at Howard Johnson by Wyndham Florence
Posted 3 days ago
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